Compile Data Set for Download or QSAR
Report error Found 77 of affinity data for UniProtKB/TrEMBL: O70196
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50155838((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of POP in Han/Wistar rat brain using Suc-Gly-Pro-AMC substrate incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051495((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
Affinity DataIC50: 0.100nMAssay Description:Inhibitory activity was evaluated against Post-proline cleaving enzyme from rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50274983(2-{3-[(2S)-4,4-difluoro-2-(pyrrolidin-1-ylcarbonyl...)
Affinity DataIC50: 0.810nMAssay Description:Inhibition of POP in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051495((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
Affinity DataIC50: 0.830nMAssay Description:Inhibition of POP in rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50274985(1-{3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrol...)
Affinity DataIC50: 0.880nMAssay Description:Inhibition of POP in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051520([(2S,3aS,7aS)-2-(Pyrrolidine-1-carbonyl)-octahydro...)
Affinity DataIC50: 0.900nMAssay Description:Inhibitory activity was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50005864(CHEMBL3236270)
Affinity DataKi:  0.950nMAssay Description:Competitive inhibition of rat brain prolyl oligopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50038881([2-(8-Dimethylamino-octylsulfanyl)-6-isopropyl-pyr...)
Affinity DataKi:  0.950nMAssay Description:Inhibition of POP in rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051511([(1R,2S)-2-(4-Fluoro-phenyl)-cyclopropyl]-[(2S,3aS...)
Affinity DataIC50: 1.10nMAssay Description:Inhibitory activity was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051523(((1R,2S)-2-Phenyl-cyclopropyl)-[(2S,3aS,7aS)-2-(py...)
Affinity DataIC50: 1.20nMAssay Description:Inhibitory activity was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316823(((2S,3aS,7aS)-1-((1R,2R)-2-phenylcyclopropanecarbo...)
Affinity DataIC50: 1.20nMAssay Description:inhibition of rat cortex POPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316818(((2S,3aS,7aS)-1-((1R,2R)-2-phenylcyclopropanecarbo...)
Affinity DataKi:  1.30nMAssay Description:inhibition of rat cortex POPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051515([(2S,3aS,7aS)-2-(Pyrrolidine-1-carbonyl)-octahydro...)
Affinity DataIC50: 1.30nMAssay Description:Inhibitory activity was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051504(((1R,2S)-2-Phenyl-cyclopropyl)-[(2S,3aS,7aS)-2-(th...)
Affinity DataIC50: 1.30nMAssay Description:Inhibitory activity was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051506(((1R,2S)-2-Phenyl-cyclopropyl)-[(S)-3-(pyrrolidine...)
Affinity DataIC50: 1.40nMAssay Description:Inhibitory activity was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051516([(2S,3aS,7aS)-2-(Pyrrolidine-1-carbonyl)-octahydro...)
Affinity DataIC50: 1.40nMAssay Description:Inhibitory activity was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316829(isoxazolidin-2-yl((2S,3aS,7aS)-1-((1R,2R)-2-phenyl...)
Affinity DataIC50: 2nMAssay Description:inhibition of rat cortex POPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051508([(2S,3aS,7aS)-2-(Isoxazolidine-2-carbonyl)-octahyd...)
Affinity DataIC50: 2nMAssay Description:Inhibitory activity was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051489(((1R,2S)-2-Phenyl-cyclopropyl)-[(2S,3aS,7aS)-2-(py...)
Affinity DataIC50: 2.30nMAssay Description:Inhibitory activity was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316830(((2S,3aS,7aS)-2-(1H-pyrrole-1-carbonyl)octahydro-1...)
Affinity DataIC50: 2.30nMAssay Description:inhibition of rat cortex POPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051483([(2S,3aS,7aS)-2-(2,5-Dihydro-pyrrole-1-carbonyl)-o...)
Affinity DataIC50: 2.40nMAssay Description:Inhibitory activity was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316831((2,5-dihydro-1H-pyrrol-1-yl)((2S,3aS,7aS)-1-((1R,2...)
Affinity DataIC50: 2.40nMAssay Description:inhibition of rat cortex POPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051544([(2S,3aS,7aS)-2-(2,3-Dihydro-pyrrole-1-carbonyl)-o...)
Affinity DataIC50: 2.70nMAssay Description:Inhibitory activity was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316832((2,3-dihydro-1H-pyrrol-1-yl)((2S,3aS,7aS)-1-((1R,2...)
Affinity DataIC50: 2.70nMAssay Description:inhibition of rat cortex POPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50274959((S)-2-(3-oxo-3-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Affinity DataIC50: 3nMAssay Description:Inhibition of POP in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051513(((1R,2S)-2-Phenyl-cyclopropyl)-[(S)-3-(thiazolidin...)
Affinity DataIC50: 3.10nMAssay Description:Inhibitory activity was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051496([(S)-3-(Pyrrolidine-1-carbonyl)-2-aza-bicyclo[2.2....)
Affinity DataIC50: 3.20nMAssay Description:Inhibitory activity was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051537([(1R,2S)-2-(4-Fluoro-phenyl)-cyclopropyl]-[(S)-3-(...)
Affinity DataIC50: 4nMAssay Description:Inhibitory activity was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051543((2-Benzyl-cyclopropyl)-[(S)-3-(pyrrolidine-1-carbo...)
Affinity DataIC50: 4.20nMAssay Description:Inhibitory activity was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051484([(S)-3-(Pyrrolidine-1-carbonyl)-2-aza-bicyclo[2.2....)
Affinity DataIC50: 4.80nMAssay Description:Inhibitory activity was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051486(((1R,2S)-2-Naphthalen-2-yl-cyclopropyl)-[(S)-3-(py...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316841(((S)-2-((1R,2R)-2-phenylcyclopropanecarbonyl)-2-az...)
Affinity DataIC50: 5nMAssay Description:inhibition of rat cortex POPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051488(((1R,2S)-2-Phenyl-cyclopropyl)-[(S)-3-(pyrrolidine...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051539(4-Phenyl-1-[2-(pyrrolidine-1-carbonyl)-pyrrolidin-...)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of rat brain POPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051491([(2S,3aS,7aS)-2-(3-Hydroxy-pyrrolidine-1-carbonyl)...)
Affinity DataIC50: 11nMAssay Description:Inhibitory activity was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50240495(1-[(R)-4-(Pyrrolidine-1-carbonyl)-thiazolidin-3-yl...)
Affinity DataIC50: 11nMAssay Description:Inhibition of POP in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50240495(1-[(R)-4-(Pyrrolidine-1-carbonyl)-thiazolidin-3-yl...)
Affinity DataIC50: 11nMAssay Description:Inhibitory activity against rat brain Prolyl endopeptidase (PEP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316819((S)-1-(4-(4-chlorobenzylamino)-4-oxobutanoyl)pyrro...)
Affinity DataKi:  12nMAssay Description:inhibition of rat cortex POPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051481([(1R,2S)-2-(4-Methoxy-phenyl)-cyclopropyl]-[(S)-3-...)
Affinity DataIC50: 16nMAssay Description:Inhibitory activity was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50289645(1-[(R)-4-(Pyrrolidine-1-carbonyl)-thiazolidin-3-yl...)
Affinity DataIC50: 17nMAssay Description:Inhibitory activity against rat brain Prolyl endopeptidase (PEP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50240498(1-[(S)-2-(Pyrrolidine-1-carbonyl)-pyrrolidin-1-yl]...)
Affinity DataIC50: 20nMAssay Description:Inhibitory activity against rat brain Prolyl endopeptidase (PEP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50240498(1-[(S)-2-(Pyrrolidine-1-carbonyl)-pyrrolidin-1-yl]...)
Affinity DataIC50: 20nMAssay Description:Inhibition of POP in rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051479((3-Phenyl-cyclobutyl)-[(S)-3-(pyrrolidine-1-carbon...)
Affinity DataIC50: 27nMAssay Description:Inhibitory activity was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051479((3-Phenyl-cyclobutyl)-[(S)-3-(pyrrolidine-1-carbon...)
Affinity DataIC50: 27nMAssay Description:Inhibitory activity was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051539(4-Phenyl-1-[2-(pyrrolidine-1-carbonyl)-pyrrolidin-...)
Affinity DataIC50: 30nMAssay Description:Inhibitory activity against rat brain Prolyl endopeptidase (PEP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051539(4-Phenyl-1-[2-(pyrrolidine-1-carbonyl)-pyrrolidin-...)
Affinity DataIC50: 30nMAssay Description:Inhibition of POP in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051527(((1S,2R)-2-Phenyl-cyclopropyl)-[(2S,3aS,7aS)-2-(py...)
Affinity DataIC50: 33nMAssay Description:Inhibitory activity was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50289634((E)-1-[(S)-2-(Pyrrolidine-1-carbonyl)-pyrrolidin-1...)
Affinity DataIC50: 34nMAssay Description:Inhibitory activity against rat brain Prolyl endopeptidase (PEP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50289636(1-[(R)-4-(Pyrrolidine-1-carbonyl)-thiazolidin-3-yl...)
Affinity DataIC50: 37nMAssay Description:Inhibitory activity against rat brain Prolyl endopeptidase (PEP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50289643(1-[(R)-4-(Pyrrolidine-1-carbonyl)-thiazolidin-3-yl...)
Affinity DataIC50: 37nMAssay Description:Inhibitory activity against rat brain Prolyl endopeptidase (PEP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

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