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TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50443016(CHEMBL3087498)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of DNMT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM588052((2R)-7-chloro-2-[trans-4-(dimethylamino)cyclohexyl...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human DNMT1 using Poly (dl-dC) and [3H]SAM as substrate incubated for 30 mins to 1 hr by HotSpot kinase assayMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50590375(CHEMBL5187396)
Affinity DataIC50: 1nMAssay Description:Inhibition of human DNMT1 using Poly (dl-dC) and [3H]SAM as substrate incubated for 30 mins to 1 hr by HotSpot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50396980(CHEMBL2171169)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of DNMT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50575636(CHEMBL4848955)
Affinity DataIC50: 10nMAssay Description:Inhibition of human DNMT1 enzyme using polydeoxy-inosine polydeoxy-cytosine DNA as substrate incubated for 15 mins in presence of SAM by TR-FRET assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50575637(CHEMBL4845706)
Affinity DataIC50: 10nMAssay Description:Inhibition of human DNMT1 enzyme using polydeoxy-inosine polydeoxy-cytosine DNA as substrate incubated for 15 mins in presence of SAM by TR-FRET assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50575638(CHEMBL4847870)
Affinity DataIC50: 10nMAssay Description:Inhibition of human DNMT1 enzyme using polydeoxy-inosine polydeoxy-cytosine DNA as substrate incubated for 15 mins in presence of SAM by TR-FRET assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50575639(CHEMBL4858828)
Affinity DataIC50: 10nMAssay Description:Inhibition of human DNMT1 enzyme using polydeoxy-inosine polydeoxy-cytosine DNA as substrate incubated for 15 mins in presence of SAM by TR-FRET assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50575640(CHEMBL4850570)
Affinity DataIC50: 10nMAssay Description:Inhibition of human DNMT1 enzyme using polydeoxy-inosine polydeoxy-cytosine DNA as substrate incubated for 15 mins in presence of SAM by TR-FRET assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50575641(CHEMBL4871621)
Affinity DataIC50: 10nMAssay Description:Inhibition of human DNMT1 enzyme using polydeoxy-inosine polydeoxy-cytosine DNA as substrate incubated for 15 mins in presence of SAM by TR-FRET assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50575642(CHEMBL4854765)
Affinity DataIC50: 10nMAssay Description:Inhibition of human DNMT1 enzyme using polydeoxy-inosine polydeoxy-cytosine DNA as substrate incubated for 15 mins in presence of SAM by TR-FRET assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50117090(3-(3-bromo-4-hydroxy-phenyl)-N-[2-(2-{3-(3-bromo-4...)
Affinity DataIC50: 18.6nMAssay Description:Inhibition of semi-purified DNMT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50457722(CHEMBL4215326)
Affinity DataIC50: 21nMAssay Description:Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50646368(CHEMBL5591775)
Affinity DataKd:  28nMAssay Description:Binding affinity to human DNMT1 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM96274(cid_451668 | SMR000857076 | 5-Aza-2'-deoxycyti...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50457746(CHEMBL4208004)
Affinity DataIC50: 32nMAssay Description:Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50457746(CHEMBL4208004)
Affinity DataIC50: 32nMAssay Description:Inhibition of human DNMT1 enzyme using polydeoxy-inosine polydeoxy-cytosine DNA as substrate incubated for 15 mins in presence of SAM by TR-FRET assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50457746(CHEMBL4208004)
Affinity DataIC50: 32nMAssay Description:Inhibition of DNMT1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50646362(CHEMBL5584171)
Affinity DataKd:  35nMAssay Description:Binding affinity to human DNMT1 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50646367(CHEMBL5595428)
Affinity DataKd:  36nMAssay Description:Binding affinity to human DNMT1 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50646366(CHEMBL5592841)
Affinity DataKd:  37nMAssay Description:Binding affinity to human DNMT1 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM491199(US10975056, Example 143)
Affinity DataEC50:  40nMAssay Description:Inhibition of NLuc-fused DNMT1 expressed hypomorphic in human HCT-116 cells assessed as TSG repoter activation at 3 uM incubated for 72 hrs by Nano-G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50457723(CHEMBL4212905)
Affinity DataIC50: 40nMAssay Description:Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50646361(CHEMBL5591922)
Affinity DataKd:  40nMAssay Description:Binding affinity to human DNMT1 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50646365(CHEMBL5594440)
Affinity DataKd:  49nMAssay Description:Binding affinity to human DNMT1 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM621246(US11771711, Example 2)
Affinity DataIC50: 54nMAssay Description:This assay used Scintillation Proximity technology in a signal increase format to evaluate the potency of compounds. Full-length human DNMT1, hemi-me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2023
Entry Details
US Patent

TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50646363(CHEMBL5592699)
Affinity DataKd:  55nMAssay Description:Binding affinity to human DNMT1 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50646364(CHEMBL5593675)
Affinity DataKd:  56nMAssay Description:Binding affinity to human DNMT1 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50009672(AdoHcy | S-[1-(adenin-9-yl)-1,5-dideoxy-beta-D-rib...)
Affinity DataIC50: 71nMAssay Description:Inhibition of recombinant human DNMT1 using poly(dl-dC) as substrate by hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50457721(CHEMBL4208010)
Affinity DataIC50: 73nMAssay Description:Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1 [601-1600](Human)
Glaxosmithkline Intellectual Property Development

US Patent
LigandPNGBDBM491448(US10975056, Example 422 | US11771711, Reference co...)
Affinity DataIC50: 79nMAssay Description:This assay used Scintillation Proximity technology in a signal increase format to evaluate the potency of compounds. Human truncated DNMT1(601-1600),...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2023
Entry Details
US Patent

TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50457750(CHEMBL4211688)
Affinity DataIC50: 80nMAssay Description:Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50457753(CHEMBL4215862)
Affinity DataIC50: 83nMAssay Description:Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50457739(CHEMBL4203133)
Affinity DataIC50: 83nMAssay Description:Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM491120(US10975056, Example 64 | US10975056, Example 308 |...)
Affinity DataIC50: 89nMAssay Description:This assay used Scintillation Proximity technology in a signal increase format to evaluate the potency of compounds. Full-length human DNMT1, hemi-me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2023
Entry Details
US Patent

TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM621248(US11771711, Example 4 | 4-(2-amino-1-((3,5-dicyano...)
Affinity DataIC50: 107nMAssay Description:This assay used Scintillation Proximity technology in a signal increase format to evaluate the potency of compounds. Full-length human DNMT1, hemi-me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2023
Entry Details
US Patent

TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50389497(CHEMBL1564869)
Affinity DataIC50: 115nMAssay Description:Inhibition of DNMT (unknown origin) by densitometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50448484(CHEMBL3126646)
Affinity DataIC50: 120nMAssay Description:Inhibition of human N-terminal 600 residues-deleted DNMT1 using poly(dI-dC) as substrate in presence of AdoMetMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50457727(CHEMBL4208812)
Affinity DataIC50: 123nMAssay Description:Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50457727(CHEMBL4208812)
Affinity DataIC50: 123nMAssay Description:Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50646368(CHEMBL5591775)
Affinity DataKd:  127nMAssay Description:Binding affinity to human DNMT1 expressed in Escherichia coli assessed as equilibrium dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50281307(CHEMBL4163329)
Affinity DataIC50: 137nMAssay Description:Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50457718(CHEMBL4206035)
Affinity DataIC50: 140nMAssay Description:Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50646362(CHEMBL5584171)
Affinity DataKd:  145nMAssay Description:Binding affinity to human DNMT1 expressed in Escherichia coli assessed as equilibrium dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50536666(CHEMBL4588797)
Affinity DataIC50: 150nMAssay Description:Inhibition of DNMT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM491224(US10975056, Example 168 | US11771711, Reference co...)
Affinity DataIC50: 156nMAssay Description:This assay used Scintillation Proximity technology in a signal increase format to evaluate the potency of compounds. Full-length human DNMT1, hemi-me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2023
Entry Details
US Patent

TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50646366(CHEMBL5592841)
Affinity DataKd:  160nMAssay Description:Binding affinity to human DNMT1 expressed in Escherichia coli assessed as equilibrium dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50575612(CHEMBL4856184)
Affinity DataIC50: 167nMAssay Description:Inhibition of human DNMT1 enzyme using polydeoxy-inosine polydeoxy-cytosine DNA as substrate incubated for 15 mins in presence of SAM by TR-FRET assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50646367(CHEMBL5595428)
Affinity DataKd:  183nMAssay Description:Binding affinity to human DNMT1 expressed in Escherichia coli assessed as equilibrium dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50457754(CHEMBL4216593)
Affinity DataIC50: 187nMAssay Description:Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
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