Compile Data Set for Download or QSAR
Report error Found 594 of affinity data for UniProtKB/TrEMBL: Q8JZL5
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257967BDBM50257967(N-(2-(7-(4-chloro-3-(trifluoromethyl)benzylamino)-...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of SCD in rat microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257967BDBM50257967(N-(2-(7-(4-chloro-3-(trifluoromethyl)benzylamino)-...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of stearoyl-CoA delta9 desaturase in rat microsomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50312702BDBM50312702((3-(2-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-y...)
Affinity DataIC50: 1nMAssay Description:Inhibition of SCD1 in Wistar rat liver microsome assessed as [3H]stearoyl-CoA to [3H]oleoyl-CoA conversion pretreated 1 hr before [3H]stearoyl-CoA ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50354682BDBM50354682(CHEMBL1834455)
Affinity DataIC50: 1nMAssay Description:Inhibition of rat SCD1 in rat liver microsomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50354672BDBM50354672(CHEMBL1834453)
Affinity DataIC50: 1nMAssay Description:Inhibition of rat SCD1 in rat liver microsomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50425256BDBM50425256(CHEMBL2315179)
Affinity DataIC50: 1nMAssay Description:Inhibition of rat SCD1 by rat microsomal assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50298907BDBM50298907(N-(2-(6-(3,4-dichlorobenzylamino)-3-oxo-2H-benzo[b...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of stearoyl-CoA delta9 desaturase in rat microsomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50298904BDBM50298904(2-hydroxy-N-(2-(2-oxo-3-(trifluoromethyl)-7-(3-(tr...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of stearoyl-CoA delta9 desaturase in rat microsomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50305768BDBM50305768(2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piper...)
Affinity DataIC50: 2nMAssay Description:Inhibition of rat SCD by rat microsomal assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50364041BDBM50364041(CHEMBL1950551)
Affinity DataIC50: 2nMAssay Description:Inhibition of rat liver microsome SCD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50354677BDBM50354677(CHEMBL1834443)
Affinity DataIC50: 2nMAssay Description:Inhibition of rat SCD1 in rat liver microsomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50305768BDBM50305768(2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piper...)
Affinity DataIC50: 2nMAssay Description:Inhibition of SCD-1 activity in Sprague-Dawley rat microsome assessed as reduction in [I-14C] stearoyl CoA desaturation by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50305768BDBM50305768(2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piper...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of SCD1 in rat liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50305767BDBM50305767((5-(6-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-y...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of SCD1 in rat liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50312684BDBM50312684(2-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)th...)
Affinity DataIC50: 3nMAssay Description:Inhibition of SCD1 in Wistar rat liver microsome assessed as [3H]stearoyl-CoA to [3H]oleoyl-CoA conversion pretreated 1 hr before [3H]stearoyl-CoA ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50362592BDBM50362592(CHEMBL1938870)
Affinity DataIC50: 3nMAssay Description:Inhibition of SCD-1 activity in Sprague-Dawley rat microsome assessed as reduction in [I-14C] stearoyl CoA desaturation by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50425258BDBM50425258(CHEMBL2315181)
Affinity DataIC50: 3nMAssay Description:Inhibition of rat SCD1 by rat microsomal assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50425259BDBM50425259(CHEMBL2315473)
Affinity DataIC50: 3nMAssay Description:Inhibition of rat SCD1 by rat microsomal assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50354671BDBM50354671(CHEMBL1834452)
Affinity DataIC50: 3nMAssay Description:Inhibition of rat SCD1 in rat liver microsomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50312688BDBM50312688(5-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)-1...)
Affinity DataIC50: 3nMAssay Description:Inhibition of SCD1 in Wistar rat liver microsome assessed as [3H]stearoyl-CoA to [3H]oleoyl-CoA conversion pretreated 1 hr before [3H]stearoyl-CoA ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50362592BDBM50362592(CHEMBL1938870)
Affinity DataIC50: 3nMAssay Description:Inhibition of rat SCD-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50305773BDBM50305773((5-(6-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-y...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of SCD1 in rat liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50305764BDBM50305764(2-isopropyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)pi...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of SCD1 in rat liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50354674BDBM50354674(CHEMBL1834457)
Affinity DataIC50: 4nMAssay Description:Inhibition of rat SCD1 in rat liver microsomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50312683BDBM50312683(2-(4-(2-(trifluoromethyl)phenylthio)piperidin-1-yl...)
Affinity DataIC50: 4nMAssay Description:Inhibition of SCD1 in Wistar rat liver microsome assessed as [3H]stearoyl-CoA to [3H]oleoyl-CoA conversion pretreated 1 hr before [3H]stearoyl-CoA ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50305760BDBM50305760(3-(1H-imidazol-1-yl)-6-(4-(2-(trifluoromethyl)phen...)
Affinity DataIC50: 4nMAssay Description:Inhibition of SCD1 in rat liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50425266BDBM50425266(CHEMBL2315480)
Affinity DataIC50: 4nMAssay Description:Inhibition of rat SCD1 by rat microsomal assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50312700BDBM50312700(3-(2-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl...)
Affinity DataIC50: 4nMAssay Description:Inhibition of SCD1 in Wistar rat liver microsome assessed as [3H]stearoyl-CoA to [3H]oleoyl-CoA conversion pretreated 1 hr before [3H]stearoyl-CoA ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50425257BDBM50425257(CHEMBL2315472)
Affinity DataIC50: 4nMAssay Description:Inhibition of rat SCD1 by rat microsomal assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 174861BDBM174861(US9102669, 24)
Affinity DataIC50: 4nMT: 2°CAssay Description:The SCD1 enzymatic assay was done in a volume of 50 μL using 10 μg of RLM (prepared as described above) in a 96-well polypropylene plate (e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/5/2016
Entry Details
US Patent

TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50305750BDBM50305750(3-(4-(2-ethylphenoxy)piperidin-1-yl)-6-(1H-imidazo...)
Affinity DataIC50: 4nMAssay Description:Inhibition of SCD1 in rat liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50364040BDBM50364040(CHEMBL1950550)
Affinity DataIC50: 5nMAssay Description:Inhibition of rat liver microsome SCD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50305758BDBM50305758(3-(4-(2-bromophenoxy)piperidin-1-yl)-6-(1H-imidazo...)
Affinity DataIC50: 5nMAssay Description:Inhibition of SCD1 in rat liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50356891BDBM50356891(CHEMBL1915541)
Affinity DataIC50: 6nMAssay Description:Inhibition of rat SCD by rat microsomal assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 60550BDBM60550(US9102669, 53 | BDBM50448682)
Affinity DataIC50: 6nMT: 2°CAssay Description:The SCD1 enzymatic assay was done in a volume of 50 μL using 10 μg of RLM (prepared as described above) in a 96-well polypropylene plate (e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/5/2016
Entry Details
US Patent

TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50305774BDBM50305774(2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piper...)
Affinity DataIC50: 6nMAssay Description:Inhibition of SCD1 in rat liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 174891BDBM174891(US9102669, 83)
Affinity DataIC50: 6nMT: 2°CAssay Description:The SCD1 enzymatic assay was done in a volume of 50 μL using 10 μg of RLM (prepared as described above) in a 96-well polypropylene plate (e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/5/2016
Entry Details
US Patent

TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50305772BDBM50305772(5-(6-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl...)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of SCD1 in rat liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50467582BDBM50467582(CHEMBL4276719)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of rat liver microsome SCD assessed as reduction in [3H]H2O production using stearoyl [9,10-3H]CoA as substrate in presence of NADH incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 174867BDBM174867(US9102669, 33)
Affinity DataIC50: 7nMT: 2°CAssay Description:The SCD1 enzymatic assay was done in a volume of 50 μL using 10 μg of RLM (prepared as described above) in a 96-well polypropylene plate (e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/5/2016
Entry Details
US Patent

TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50448659BDBM50448659(CHEMBL3127654)
Affinity DataIC50: 7nMAssay Description:Inhibition of SCD1 in Sprague-Dawley rat liver microsomes using stearoyl-[9,10-3H]-CoA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443712BDBM50443712(CHEMBL3093861 | US9238658, 33)
Affinity DataIC50: 7nMT: 2°CAssay Description:The SCD1 enzymatic assay was done in a volume of 50 uL using 10 ug of RLM (prepared as described above) in a 96-well polypropylene plate (enzyme reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50354667BDBM50354667(CHEMBL1834456)
Affinity DataIC50: 7nMAssay Description:Inhibition of rat SCD1 in rat liver microsomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50448657BDBM50448657(CHEMBL3127530 | US9102669, 29)
Affinity DataIC50: 7nMT: 2°CAssay Description:The SCD1 enzymatic assay was done in a volume of 50 μL using 10 μg of RLM (prepared as described above) in a 96-well polypropylene plate (e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/5/2016
Entry Details
US Patent

TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50354676BDBM50354676(CHEMBL1834262)
Affinity DataIC50: 7nMAssay Description:Inhibition of rat SCD1 in rat liver microsomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50393166BDBM50393166(CHEMBL2153601)
Affinity DataIC50: 7nMAssay Description:Inhibition of SCD-1 activity in Sprague-Dawley rat microsome assessed as reduction in [I-14C] stearoyl CoA desaturation by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443716BDBM50443716(CHEMBL3093874 | US9238658, 50)
Affinity DataIC50: 8nMT: 2°CAssay Description:The SCD1 enzymatic assay was done in a volume of 50 uL using 10 ug of RLM (prepared as described above) in a 96-well polypropylene plate (enzyme reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50312692BDBM50312692(3-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)is...)
Affinity DataIC50: 8nMAssay Description:Inhibition of SCD1 in Wistar rat liver microsome assessed as [3H]stearoyl-CoA to [3H]oleoyl-CoA conversion pretreated 1 hr before [3H]stearoyl-CoA ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 174869BDBM174869(US9102669, 35)
Affinity DataIC50: 8nMT: 2°CAssay Description:The SCD1 enzymatic assay was done in a volume of 50 μL using 10 μg of RLM (prepared as described above) in a 96-well polypropylene plate (e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/5/2016
Entry Details
US Patent

TargetAcyl-CoA desaturase 1(Rat)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443716BDBM50443716(CHEMBL3093874 | US9238658, 50)
Affinity DataIC50: 8nMAssay Description:Inhibition of SCD1 in Sprague-Dawley rat liver microsomes using Stearoyl-[9,10-3H]-CoA as substrate assessed as [3H2O] generationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
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