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Patent code US10301286

Compile Data Set for Download or QSAR
Found 79 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM392659
PNG
(US10301286, Example 11)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C(C)(C)C)[C@@H](Cc1ccc(C)cc1)C(O)=O
Show InChI InChI=1S/C30H39ClFN3O3/c1-19-6-8-21(9-7-19)14-27(29(37)38)33-12-13-35(20(2)16-33)28(36)25-18-34(30(3,4)5)17-24(25)23-11-10-22(31)15-26(23)32/h6-11,15,20,24-25,27H,12-14,16-18H2,1-5H3,(H,37,38)/t20-,24-,25+,27-/m0/s1
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UniChem
US Patent
n/an/an/an/a 860n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM392661
PNG
(US10301286, Example 87)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C1CCOCC1)[C@@H](Cc1ccc(C)cc1F)C(O)=O
Show InChI InChI=1S/C31H38ClF2N3O4/c1-19-3-4-21(27(33)13-19)14-29(31(39)40)35-9-10-37(20(2)16-35)30(38)26-18-36(23-7-11-41-12-8-23)17-25(26)24-6-5-22(32)15-28(24)34/h3-6,13,15,20,23,25-26,29H,7-12,14,16-18H2,1-2H3,(H,39,40)/t20-,25-,26+,29-/m0/s1
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PC sid
UniChem
US Patent
n/an/an/an/a 1.10E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM392662
PNG
(US10301286, Example 88)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C1CCOCC1)[C@@H](Cc1c(C)cc(C)cc1F)C(O)=O
Show InChI InChI=1S/C32H40ClF2N3O4/c1-19-12-20(2)25(28(34)13-19)15-30(32(40)41)36-8-9-38(21(3)16-36)31(39)27-18-37(23-6-10-42-11-7-23)17-26(27)24-5-4-22(33)14-29(24)35/h4-5,12-14,21,23,26-27,30H,6-11,15-18H2,1-3H3,(H,40,41)/t21-,26-,27+,30-/m0/s1
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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/an/an/a 2.70E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM392663
PNG
(US10301286, Example 89)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C(C)(C)C)[C@@H](Cc1c(C)cc(C)cc1C)C(O)=O
Show InChI InChI=1S/C32H43ClFN3O3/c1-19-12-20(2)25(21(3)13-19)15-29(31(39)40)35-10-11-37(22(4)16-35)30(38)27-18-36(32(5,6)7)17-26(27)24-9-8-23(33)14-28(24)34/h8-9,12-14,22,26-27,29H,10-11,15-18H2,1-7H3,(H,39,40)/t22-,26-,27+,29-/m0/s1
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PC sid
UniChem
US Patent
n/an/an/an/a 1.30E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))
BDBM392663
PNG
(US10301286, Example 89)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C(C)(C)C)[C@@H](Cc1c(C)cc(C)cc1C)C(O)=O
Show InChI InChI=1S/C32H43ClFN3O3/c1-19-12-20(2)25(21(3)13-19)15-29(31(39)40)35-10-11-37(22(4)16-35)30(38)27-18-36(32(5,6)7)17-26(27)24-9-8-23(33)14-28(24)34/h8-9,12-14,22,26-27,29H,10-11,15-18H2,1-7H3,(H,39,40)/t22-,26-,27+,29-/m0/s1
UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 780n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392665
PNG
(US10301286, Example 13)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C)[C@@H](Cc1ccc(cc1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C30H36F5N3O3/c1-18-15-36(26(28(40)41)13-19-5-7-20(8-6-19)30(33,34)35)11-12-38(18)27(39)24-17-37(29(2,3)4)16-23(24)22-10-9-21(31)14-25(22)32/h5-10,14,18,23-24,26H,11-13,15-17H2,1-4H3,(H,40,41)/t18-,23-,24+,26-/m0/s1
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PC cid
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UniChem
US Patent
n/an/an/an/a 48n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392666
PNG
(US10301286, Example 15 | US10301286, Example 16)
Show SMILES C[C@@H]1CN(CCN1C(Cc1ccc(Cl)c(Cl)c1)C(O)=O)C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C
Show InChI InChI=1S/C29H35Cl2F2N3O3/c1-17-14-34(9-10-36(17)26(28(38)39)12-18-5-8-23(30)24(31)11-18)27(37)22-16-35(29(2,3)4)15-21(22)20-7-6-19(32)13-25(20)33/h5-8,11,13,17,21-22,26H,9-10,12,14-16H2,1-4H3,(H,38,39)/t17-,21+,22-,26?/m1/s1
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UniChem
US Patent
n/an/an/an/a 4.90E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392672
PNG
(US10301286, Example 28)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)CO)[C@@H](Cc1ccc2CCCc2c1)C(O)=O
Show InChI InChI=1S/C32H41F2N3O4/c1-20-16-35(29(31(40)41)14-21-7-8-22-5-4-6-23(22)13-21)11-12-37(20)30(39)27-18-36(32(2,3)19-38)17-26(27)25-10-9-24(33)15-28(25)34/h7-10,13,15,20,26-27,29,38H,4-6,11-12,14,16-19H2,1-3H3,(H,40,41)/t20-,26-,27+,29-/m0/s1
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PC sid
UniChem
US Patent
n/an/an/an/a 150n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392676
PNG
(US10301286, Example 45)
Show SMILES COc1ccc(cc1)C1CN(CC1C(=O)N1CCN(C[C@@H]1C)[C@@H](Cc1ccc2CCCc2c1)C(O)=O)C(C)(C)C
Show InChI InChI=1S/C33H45N3O4/c1-22-19-34(30(32(38)39)18-23-9-10-24-7-6-8-26(24)17-23)15-16-36(22)31(37)29-21-35(33(2,3)4)20-28(29)25-11-13-27(40-5)14-12-25/h9-14,17,22,28-30H,6-8,15-16,18-21H2,1-5H3,(H,38,39)/t22-,28?,29?,30-/m0/s1
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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.10E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392684
PNG
(US10301286, Example 72)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C(C)(C)C)[C@@H](Cc1ccc(OC(F)F)cc1)C(O)=O
Show InChI InChI=1S/C30H37ClF3N3O4/c1-18-15-35(26(28(39)40)13-19-5-8-21(9-6-19)41-29(33)34)11-12-37(18)27(38)24-17-36(30(2,3)4)16-23(24)22-10-7-20(31)14-25(22)32/h5-10,14,18,23-24,26,29H,11-13,15-17H2,1-4H3,(H,39,40)/t18-,23-,24+,26-/m0/s1
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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 40n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392662
PNG
(US10301286, Example 88)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C1CCOCC1)[C@@H](Cc1c(C)cc(C)cc1F)C(O)=O
Show InChI InChI=1S/C32H40ClF2N3O4/c1-19-12-20(2)25(28(34)13-19)15-30(32(40)41)36-8-9-38(21(3)16-36)31(39)27-18-37(23-6-10-42-11-7-23)17-26(27)24-5-4-22(33)14-29(24)35/h4-5,12-14,21,23,26-27,30H,6-11,15-18H2,1-3H3,(H,40,41)/t21-,26-,27+,30-/m0/s1
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PC cid
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US Patent
n/an/an/an/a 12n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))
BDBM392662
PNG
(US10301286, Example 88)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C1CCOCC1)[C@@H](Cc1c(C)cc(C)cc1F)C(O)=O
Show InChI InChI=1S/C32H40ClF2N3O4/c1-19-12-20(2)25(28(34)13-19)15-30(32(40)41)36-8-9-38(21(3)16-36)31(39)27-18-37(23-6-10-42-11-7-23)17-26(27)24-5-4-22(33)14-29(24)35/h4-5,12-14,21,23,26-27,30H,6-11,15-18H2,1-3H3,(H,40,41)/t21-,26-,27+,30-/m0/s1
UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 880n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM392670
PNG
(US10301286, Example 24)
Show SMILES CN(C)CC[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)c1ccc(=O)n(C)n1)[C@@H](Cc1ccc2ccccc2c1)C(O)=O
Show InChI InChI=1S/C37H42F2N6O4/c1-41(2)15-14-28-21-43(33(37(48)49)19-24-8-9-25-6-4-5-7-26(25)18-24)16-17-45(28)36(47)31-23-44(34-12-13-35(46)42(3)40-34)22-30(31)29-11-10-27(38)20-32(29)39/h4-13,18,20,28,30-31,33H,14-17,19,21-23H2,1-3H3,(H,48,49)/t28-,30-,31+,33-/m0/s1
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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.50E+4n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Rattus norvegicus)
BDBM392656
PNG
(US10301286, Example 4)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C(C)(C)C)[C@@H](Cc1ccc(C)cc1F)C(O)=O
Show InChI InChI=1S/C30H38ClF2N3O3/c1-18-6-7-20(25(32)12-18)13-27(29(38)39)34-10-11-36(19(2)15-34)28(37)24-17-35(30(3,4)5)16-23(24)22-9-8-21(31)14-26(22)33/h6-9,12,14,19,23-24,27H,10-11,13,15-17H2,1-5H3,(H,38,39)/t19-,23-,24+,27-/m0/s1
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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.30n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Rat MC4 Receptor-Expressing VectorA rat MC4 receptor gene (GenBank Accession No.: NM_013099.2) was introduced in...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Rattus norvegicus)
BDBM392660
PNG
(US10301286, Example 76)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C(C)(C)C)[C@@H](Cc1c(F)cc(C)cc1F)C(O)=O
Show InChI InChI=1S/C30H37ClF3N3O3/c1-17-10-24(32)21(25(33)11-17)13-27(29(39)40)35-8-9-37(18(2)14-35)28(38)23-16-36(30(3,4)5)15-22(23)20-7-6-19(31)12-26(20)34/h6-7,10-12,18,22-23,27H,8-9,13-16H2,1-5H3,(H,39,40)/t18-,22-,23+,27-/m0/s1
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PC sid
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US Patent
n/an/an/an/a 1.70n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Rat MC4 Receptor-Expressing VectorA rat MC4 receptor gene (GenBank Accession No.: NM_013099.2) was introduced in...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392658
PNG
(US10301286, Example 9)
Show SMILES CCC[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C)[C@@H](Cc1ccc2ccccc2c1)C(O)=O
Show InChI InChI=1S/C35H43F2N3O3/c1-5-8-27-20-38(32(34(42)43)18-23-11-12-24-9-6-7-10-25(24)17-23)15-16-40(27)33(41)30-22-39(35(2,3)4)21-29(30)28-14-13-26(36)19-31(28)37/h6-7,9-14,17,19,27,29-30,32H,5,8,15-16,18,20-22H2,1-4H3,(H,42,43)/t27-,29-,30+,32-/m0/s1
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PC sid
UniChem
US Patent
n/an/an/an/a 3.20n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM392660
PNG
(US10301286, Example 76)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C(C)(C)C)[C@@H](Cc1c(F)cc(C)cc1F)C(O)=O
Show InChI InChI=1S/C30H37ClF3N3O3/c1-17-10-24(32)21(25(33)11-17)13-27(29(39)40)35-8-9-37(18(2)14-35)28(38)23-16-36(30(3,4)5)15-22(23)20-7-6-19(31)12-26(20)34/h6-7,10-12,18,22-23,27H,8-9,13-16H2,1-5H3,(H,39,40)/t18-,22-,23+,27-/m0/s1
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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 100n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392663
PNG
(US10301286, Example 89)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C(C)(C)C)[C@@H](Cc1c(C)cc(C)cc1C)C(O)=O
Show InChI InChI=1S/C32H43ClFN3O3/c1-19-12-20(2)25(21(3)13-19)15-29(31(39)40)35-10-11-37(22(4)16-35)30(38)27-18-36(32(5,6)7)17-26(27)24-9-8-23(33)14-28(24)34/h8-9,12-14,22,26-27,29H,10-11,15-18H2,1-7H3,(H,39,40)/t22-,26-,27+,29-/m0/s1
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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))
BDBM392665
PNG
(US10301286, Example 13)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C)[C@@H](Cc1ccc(cc1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C30H36F5N3O3/c1-18-15-36(26(28(40)41)13-19-5-7-20(8-6-19)30(33,34)35)11-12-38(18)27(39)24-17-37(29(2,3)4)16-23(24)22-10-9-21(31)14-25(22)32/h5-10,14,18,23-24,26H,11-13,15-17H2,1-4H3,(H,40,41)/t18-,23-,24+,26-/m0/s1
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n/an/an/an/a 5.00E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392679
PNG
(US10301286, Example 53)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C)[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1/C31H38F2N4O3/c1-19-16-35(28(30(39)40)13-20-15-34-27-8-6-5-7-22(20)27)11-12-37(19)29(38)25-18-36(31(2,3)4)17-24(25)23-10-9-21(32)14-26(23)33/h5-10,14-15,19,24-25,28,34H,11-13,16-18H2,1-4H3,(H,39,40)/t19-,24-,25+,28-/s2
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))
BDBM392681
PNG
(US10301286, Example 57)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C(C)(C)C)[C@@H](CC1CCCCC1)C(O)=O
Show InChI InChI=1S/C29H43ClFN3O3/c1-19-16-32(26(28(36)37)14-20-8-6-5-7-9-20)12-13-34(19)27(35)24-18-33(29(2,3)4)17-23(24)22-11-10-21(30)15-25(22)31/h10-11,15,19-20,23-24,26H,5-9,12-14,16-18H2,1-4H3,(H,36,37)/t19-,23-,24+,26-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM392683
PNG
(US10301286, Example 69)
Show SMILES COc1ccc(C[C@H](N2CCN([C@@H](C)C2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(Cl)cc2F)C(C)(C)C)C(O)=O)c(F)c1
Show InChI InChI=1S/C30H38ClF2N3O4/c1-18-15-34(27(29(38)39)12-19-6-8-21(40-5)14-25(19)32)10-11-36(18)28(37)24-17-35(30(2,3)4)16-23(24)22-9-7-20(31)13-26(22)33/h6-9,13-14,18,23-24,27H,10-12,15-17H2,1-5H3,(H,38,39)/t18-,23-,24+,27-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))
BDBM392684
PNG
(US10301286, Example 72)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C(C)(C)C)[C@@H](Cc1ccc(OC(F)F)cc1)C(O)=O
Show InChI InChI=1S/C30H37ClF3N3O4/c1-18-15-35(26(28(39)40)13-19-5-8-21(9-6-19)41-29(33)34)11-12-37(18)27(38)24-17-36(30(2,3)4)16-23(24)22-10-7-20(31)14-25(22)32/h5-10,14,18,23-24,26,29H,11-13,15-17H2,1-4H3,(H,39,40)/t18-,23-,24+,26-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Rattus norvegicus)
BDBM392661
PNG
(US10301286, Example 87)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C1CCOCC1)[C@@H](Cc1ccc(C)cc1F)C(O)=O
Show InChI InChI=1S/C31H38ClF2N3O4/c1-19-3-4-21(27(33)13-19)14-29(31(39)40)35-9-10-37(20(2)16-35)30(38)26-18-36(23-7-11-41-12-8-23)17-25(26)24-6-5-22(32)15-28(24)34/h3-6,13,15,20,23,25-26,29H,7-12,14,16-18H2,1-2H3,(H,39,40)/t20-,25-,26+,29-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Rat MC4 Receptor-Expressing VectorA rat MC4 receptor gene (GenBank Accession No.: NM_013099.2) was introduced in...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Rattus norvegicus)
BDBM392663
PNG
(US10301286, Example 89)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C(C)(C)C)[C@@H](Cc1c(C)cc(C)cc1C)C(O)=O
Show InChI InChI=1S/C32H43ClFN3O3/c1-19-12-20(2)25(21(3)13-19)15-29(31(39)40)35-10-11-37(22(4)16-35)30(38)27-18-36(32(5,6)7)17-26(27)24-9-8-23(33)14-28(24)34/h8-9,12-14,22,26-27,29H,10-11,15-18H2,1-7H3,(H,39,40)/t22-,26-,27+,29-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Rat MC4 Receptor-Expressing VectorA rat MC4 receptor gene (GenBank Accession No.: NM_013099.2) was introduced in...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392656
PNG
(US10301286, Example 4)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C(C)(C)C)[C@@H](Cc1ccc(C)cc1F)C(O)=O
Show InChI InChI=1S/C30H38ClF2N3O3/c1-18-6-7-20(25(32)12-18)13-27(29(38)39)34-10-11-36(19(2)15-34)28(37)24-17-35(30(3,4)5)16-23(24)22-9-8-21(31)14-26(22)33/h6-9,12,14,19,23-24,27H,10-11,13,15-17H2,1-5H3,(H,38,39)/t19-,23-,24+,27-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM392656
PNG
(US10301286, Example 4)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C(C)(C)C)[C@@H](Cc1ccc(C)cc1F)C(O)=O
Show InChI InChI=1S/C30H38ClF2N3O3/c1-18-6-7-20(25(32)12-18)13-27(29(38)39)34-10-11-36(19(2)15-34)28(37)24-17-35(30(3,4)5)16-23(24)22-9-8-21(31)14-26(22)33/h6-9,12,14,19,23-24,27H,10-11,13,15-17H2,1-5H3,(H,38,39)/t19-,23-,24+,27-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM392657
PNG
(US10301286, Example 5)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C)[C@@H](Cc1ccc2CCCc2c1)C(O)=O
Show InChI InChI=1S/C32H41F2N3O3/c1-20-17-35(29(31(39)40)15-21-8-9-22-6-5-7-23(22)14-21)12-13-37(20)30(38)27-19-36(32(2,3)4)18-26(27)25-11-10-24(33)16-28(25)34/h8-11,14,16,20,26-27,29H,5-7,12-13,15,17-19H2,1-4H3,(H,39,40)/t20-,26-,27+,29-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392659
PNG
(US10301286, Example 11)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C(C)(C)C)[C@@H](Cc1ccc(C)cc1)C(O)=O
Show InChI InChI=1S/C30H39ClFN3O3/c1-19-6-8-21(9-7-19)14-27(29(37)38)33-12-13-35(20(2)16-33)28(36)25-18-34(30(3,4)5)17-24(25)23-11-10-22(31)15-26(23)32/h6-11,15,20,24-25,27H,12-14,16-18H2,1-5H3,(H,37,38)/t20-,24-,25+,27-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392661
PNG
(US10301286, Example 87)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C1CCOCC1)[C@@H](Cc1ccc(C)cc1F)C(O)=O
Show InChI InChI=1S/C31H38ClF2N3O4/c1-19-3-4-21(27(33)13-19)14-29(31(39)40)35-9-10-37(20(2)16-35)30(38)26-18-36(23-7-11-41-12-8-23)17-25(26)24-6-5-22(32)15-28(24)34/h3-6,13,15,20,23,25-26,29H,7-12,14,16-18H2,1-2H3,(H,39,40)/t20-,25-,26+,29-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392668
PNG
(US10301286, Example 17)
Show SMILES CC(C)(C)N1C[C@H]([C@@H](C1)c1ccc(F)cc1F)C(=O)N1CCN(CC11CC1)[C@@H](Cc1ccc2ccccc2c1)C(O)=O
Show InChI InChI=1S/C34H39F2N3O3/c1-33(2,3)38-19-27(26-11-10-25(35)18-29(26)36)28(20-38)31(40)39-15-14-37(21-34(39)12-13-34)30(32(41)42)17-22-8-9-23-6-4-5-7-24(23)16-22/h4-11,16,18,27-28,30H,12-15,17,19-21H2,1-3H3,(H,41,42)/t27-,28+,30-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392670
PNG
(US10301286, Example 24)
Show SMILES CN(C)CC[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)c1ccc(=O)n(C)n1)[C@@H](Cc1ccc2ccccc2c1)C(O)=O
Show InChI InChI=1S/C37H42F2N6O4/c1-41(2)15-14-28-21-43(33(37(48)49)19-24-8-9-25-6-4-5-7-26(25)18-24)16-17-45(28)36(47)31-23-44(34-12-13-35(46)42(3)40-34)22-30(31)29-11-10-27(38)20-32(29)39/h4-13,18,20,28,30-31,33H,14-17,19,21-23H2,1-3H3,(H,48,49)/t28-,30-,31+,33-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392674
PNG
(US10301286, Example 35)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(=O)C1CC1)[C@@H](Cc1ccc2CCCc2c1)C(O)=O
Show InChI InChI=1S/C32H37F2N3O4/c1-19-16-35(29(32(40)41)14-20-5-6-21-3-2-4-23(21)13-20)11-12-37(19)31(39)27-18-36(30(38)22-7-8-22)17-26(27)25-10-9-24(33)15-28(25)34/h5-6,9-10,13,15,19,22,26-27,29H,2-4,7-8,11-12,14,16-18H2,1H3,(H,40,41)/t19-,26-,27+,29-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392677
PNG
(US10301286, Example 47)
Show SMILES C[C@H]1CN(CCN1C(=O)C1CN(CC1c1ccc(cc1F)C#N)C(C)(C)C)[C@@H](Cc1ccc2CCCc2c1)C(O)=O
Show InChI InChI=1S/C33H41FN4O3/c1-21-18-36(30(32(40)41)16-22-8-10-24-6-5-7-25(24)14-22)12-13-38(21)31(39)28-20-37(33(2,3)4)19-27(28)26-11-9-23(17-35)15-29(26)34/h8-11,14-15,21,27-28,30H,5-7,12-13,16,18-20H2,1-4H3,(H,40,41)/t21-,27?,28?,30-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392680
PNG
(US10301286, Example 55)
Show SMILES C[C@H]1CN(CCN1C(=O)C1CN(CC1c1ccc(Cl)s1)C(C)(C)C)[C@@H](Cc1ccc2CCCc2c1)C(O)=O
Show InChI InChI=1S/C30H40ClN3O3S/c1-19-16-32(25(29(36)37)15-20-8-9-21-6-5-7-22(21)14-20)12-13-34(19)28(35)24-18-33(30(2,3)4)17-23(24)26-10-11-27(31)38-26/h8-11,14,19,23-25H,5-7,12-13,15-18H2,1-4H3,(H,36,37)/t19-,23?,24?,25-/m0/s1
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n/an/an/an/a 270n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))
BDBM392686
PNG
(US10301286, Example 78)
Show SMILES C[C@H]([C@H](N1CCN([C@@H](C)C1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C1CCOCC1)C(O)=O)c1ccc(C)cc1
Show InChI InChI=1S/C32H41ClFN3O4/c1-20-4-6-23(7-5-20)22(3)30(32(39)40)35-12-13-37(21(2)17-35)31(38)28-19-36(25-10-14-41-15-11-25)18-27(28)26-9-8-24(33)16-29(26)34/h4-9,16,21-22,25,27-28,30H,10-15,17-19H2,1-3H3,(H,39,40)/t21-,22-,27-,28+,30-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392688
PNG
(US10301286, Example 84)
Show SMILES C[C@H]1CN(CCN1C(=O)C1CN(CC1c1ccc(F)cc1F)C1(C)CCOCC1)[C@@H](Cc1ccc(C)cc1F)C(O)=O
Show InChI InChI=1S/C32H40F3N3O4/c1-20-4-5-22(27(34)14-20)15-29(31(40)41)36-10-11-38(21(2)17-36)30(39)26-19-37(32(3)8-12-42-13-9-32)18-25(26)24-7-6-23(33)16-28(24)35/h4-7,14,16,21,25-26,29H,8-13,15,17-19H2,1-3H3,(H,40,41)/t21-,25?,26?,29-/m0/s1
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n/an/an/an/a 18n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM392689
PNG
(US10301286, Example 92)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C1CCOCC1)[C@@H](Cc1ccc(cc1F)C1CC1)C(O)=O
Show InChI InChI=1S/C33H40ClF2N3O4/c1-20-17-37(31(33(41)42)15-23-5-4-22(14-29(23)35)21-2-3-21)10-11-39(20)32(40)28-19-38(25-8-12-43-13-9-25)18-27(28)26-7-6-24(34)16-30(26)36/h4-7,14,16,20-21,25,27-28,31H,2-3,8-13,15,17-19H2,1H3,(H,41,42)/t20-,27-,28+,31-/m0/s1
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n/an/an/an/a 1.70E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392657
PNG
(US10301286, Example 5)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C)[C@@H](Cc1ccc2CCCc2c1)C(O)=O
Show InChI InChI=1S/C32H41F2N3O3/c1-20-17-35(29(31(39)40)15-21-8-9-22-6-5-7-23(22)14-21)12-13-37(20)30(38)27-19-36(32(2,3)4)18-26(27)25-11-10-24(33)16-28(25)34/h8-11,14,16,20,26-27,29H,5-7,12-13,15,17-19H2,1-4H3,(H,39,40)/t20-,26-,27+,29-/m0/s1
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n/an/an/an/a 25n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))
BDBM392657
PNG
(US10301286, Example 5)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C)[C@@H](Cc1ccc2CCCc2c1)C(O)=O
Show InChI InChI=1S/C32H41F2N3O3/c1-20-17-35(29(31(39)40)15-21-8-9-22-6-5-7-23(22)14-21)12-13-37(20)30(38)27-19-36(32(2,3)4)18-26(27)25-11-10-24(33)16-28(25)34/h8-11,14,16,20,26-27,29H,5-7,12-13,15,17-19H2,1-4H3,(H,39,40)/t20-,26-,27+,29-/m0/s1
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n/an/an/an/a 4.20E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))
BDBM392661
PNG
(US10301286, Example 87)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C1CCOCC1)[C@@H](Cc1ccc(C)cc1F)C(O)=O
Show InChI InChI=1S/C31H38ClF2N3O4/c1-19-3-4-21(27(33)13-19)14-29(31(39)40)35-9-10-37(20(2)16-35)30(38)26-18-36(23-7-11-41-12-8-23)17-25(26)24-6-5-22(32)15-28(24)34/h3-6,13,15,20,23,25-26,29H,7-12,14,16-18H2,1-2H3,(H,39,40)/t20-,25-,26+,29-/m0/s1
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n/an/an/an/a 920n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392671
PNG
(US10301286, Example 27)
Show SMILES COC[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)c1ccc(F)cc1)[C@@H](Cc1ccc2CCCc2c1)C(O)=O
Show InChI InChI=1S/C35H38F3N3O4/c1-45-21-28-18-39(33(35(43)44)16-22-5-6-23-3-2-4-24(23)15-22)13-14-41(28)34(42)31-20-40(27-10-7-25(36)8-11-27)19-30(31)29-12-9-26(37)17-32(29)38/h5-12,15,17,28,30-31,33H,2-4,13-14,16,18-21H2,1H3,(H,43,44)/t28-,30+,31-,33+/m1/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM392672
PNG
(US10301286, Example 28)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)CO)[C@@H](Cc1ccc2CCCc2c1)C(O)=O
Show InChI InChI=1S/C32H41F2N3O4/c1-20-16-35(29(31(40)41)14-21-7-8-22-5-4-6-23(22)13-21)11-12-37(20)30(39)27-18-36(32(2,3)19-38)17-26(27)25-10-9-24(33)15-28(25)34/h7-10,13,15,20,26-27,29,38H,4-6,11-12,14,16-19H2,1-3H3,(H,40,41)/t20-,26-,27+,29-/m0/s1
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n/an/an/an/a 3.90E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392673
PNG
(US10301286, Example 33)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)c1ccc(nn1)C(F)(F)F)[C@@H](Cc1ccc2CCCc2c1)C(O)=O
Show InChI InChI=1S/C33H34F5N5O3/c1-19-16-41(28(32(45)46)14-20-5-6-21-3-2-4-22(21)13-20)11-12-43(19)31(44)26-18-42(30-10-9-29(39-40-30)33(36,37)38)17-25(26)24-8-7-23(34)15-27(24)35/h5-10,13,15,19,25-26,28H,2-4,11-12,14,16-18H2,1H3,(H,45,46)/t19-,25-,26+,28-/m0/s1
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n/an/an/an/a 610n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))
BDBM392677
PNG
(US10301286, Example 47)
Show SMILES C[C@H]1CN(CCN1C(=O)C1CN(CC1c1ccc(cc1F)C#N)C(C)(C)C)[C@@H](Cc1ccc2CCCc2c1)C(O)=O
Show InChI InChI=1S/C33H41FN4O3/c1-21-18-36(30(32(40)41)16-22-8-10-24-6-5-7-25(24)14-22)12-13-38(21)31(39)28-20-37(33(2,3)4)19-27(28)26-11-9-23(17-35)15-29(26)34/h8-11,14-15,21,27-28,30H,5-7,12-13,16,18-20H2,1-4H3,(H,40,41)/t21-,27?,28?,30-/m0/s1
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n/an/an/an/a 1.10E+4n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392678
PNG
(US10301286, Example 50)
Show SMILES CC[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)=O)[C@@H](Cc1ccc2ccccc2c1)C(O)=O
Show InChI InChI=1S/C32H35F2N3O4/c1-3-25-17-35(30(32(40)41)15-21-8-9-22-6-4-5-7-23(22)14-21)12-13-37(25)31(39)28-19-36(20(2)38)18-27(28)26-11-10-24(33)16-29(26)34/h4-11,14,16,25,27-28,30H,3,12-13,15,17-19H2,1-2H3,(H,40,41)/t25-,27-,28+,30-/m0/s1
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n/an/an/an/a 64n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392683
PNG
(US10301286, Example 69)
Show SMILES COc1ccc(C[C@H](N2CCN([C@@H](C)C2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(Cl)cc2F)C(C)(C)C)C(O)=O)c(F)c1
Show InChI InChI=1S/C30H38ClF2N3O4/c1-18-15-34(27(29(38)39)12-19-6-8-21(40-5)14-25(19)32)10-11-36(18)28(37)24-17-35(30(2,3)4)16-23(24)22-9-7-20(31)13-26(22)33/h6-9,13-14,18,23-24,27H,10-12,15-17H2,1-5H3,(H,38,39)/t18-,23-,24+,27-/m0/s1
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n/an/an/an/a 5.10n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))
BDBM392683
PNG
(US10301286, Example 69)
Show SMILES COc1ccc(C[C@H](N2CCN([C@@H](C)C2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(Cl)cc2F)C(C)(C)C)C(O)=O)c(F)c1
Show InChI InChI=1S/C30H38ClF2N3O4/c1-18-15-34(27(29(38)39)12-19-6-8-21(40-5)14-25(19)32)10-11-36(18)28(37)24-17-35(30(2,3)4)16-23(24)22-9-7-20(31)13-26(22)33/h6-9,13-14,18,23-24,27H,10-12,15-17H2,1-5H3,(H,38,39)/t18-,23-,24+,27-/m0/s1
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n/an/an/an/a 2.90E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))
BDBM392685
PNG
(US10301286, Example 74)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C1CCOCC1)[C@@](C)(Cc1ccc(C)cc1F)C(O)=O
Show InChI InChI=1S/C32H40F3N3O4/c1-20-4-5-22(28(34)14-20)16-32(3,31(40)41)37-10-11-38(21(2)17-37)30(39)27-19-36(24-8-12-42-13-9-24)18-26(27)25-7-6-23(33)15-29(25)35/h4-7,14-15,21,24,26-27H,8-13,16-19H2,1-3H3,(H,40,41)/t21-,26-,27+,32-/m0/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392689
PNG
(US10301286, Example 92)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C1CCOCC1)[C@@H](Cc1ccc(cc1F)C1CC1)C(O)=O
Show InChI InChI=1S/C33H40ClF2N3O4/c1-20-17-37(31(33(41)42)15-23-5-4-22(14-29(23)35)21-2-3-21)10-11-39(20)32(40)28-19-38(25-8-12-43-13-9-25)18-27(28)26-7-6-24(34)16-30(26)36/h4-7,14,16,20-21,25,27-28,31H,2-3,8-13,15,17-19H2,1H3,(H,41,42)/t20-,27-,28+,31-/m0/s1
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n/an/an/an/a 12n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Rattus norvegicus)
BDBM392659
PNG
(US10301286, Example 11)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C(C)(C)C)[C@@H](Cc1ccc(C)cc1)C(O)=O
Show InChI InChI=1S/C30H39ClFN3O3/c1-19-6-8-21(9-7-19)14-27(29(37)38)33-12-13-35(20(2)16-33)28(36)25-18-34(30(3,4)5)17-24(25)23-11-10-22(31)15-26(23)32/h6-11,15,20,24-25,27H,12-14,16-18H2,1-5H3,(H,37,38)/t20-,24-,25+,27-/m0/s1
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n/an/an/an/a 21n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Rat MC4 Receptor-Expressing VectorA rat MC4 receptor gene (GenBank Accession No.: NM_013099.2) was introduced in...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))
BDBM392659
PNG
(US10301286, Example 11)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C(C)(C)C)[C@@H](Cc1ccc(C)cc1)C(O)=O
Show InChI InChI=1S/C30H39ClFN3O3/c1-19-6-8-21(9-7-19)14-27(29(37)38)33-12-13-35(20(2)16-33)28(36)25-18-34(30(3,4)5)17-24(25)23-11-10-22(31)15-26(23)32/h6-11,15,20,24-25,27H,12-14,16-18H2,1-5H3,(H,37,38)/t20-,24-,25+,27-/m0/s1
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n/an/an/an/a 3.70E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))
BDBM392660
PNG
(US10301286, Example 76)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C(C)(C)C)[C@@H](Cc1c(F)cc(C)cc1F)C(O)=O
Show InChI InChI=1S/C30H37ClF3N3O3/c1-17-10-24(32)21(25(33)11-17)13-27(29(39)40)35-8-9-37(18(2)14-35)28(38)23-16-36(30(3,4)5)15-22(23)20-7-6-19(31)12-26(20)34/h6-7,10-12,18,22-23,27H,8-9,13-16H2,1-5H3,(H,39,40)/t18-,22-,23+,27-/m0/s1
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n/an/an/an/a 330n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM392664
PNG
(US10301286, Example 6)
Show SMILES C[C@H]1CN(C[C@@H](C)N1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C)[C@@H](Cc1ccc2ccccc2c1)C(O)=O
Show InChI InChI=1S/C34H41F2N3O3/c1-21-17-37(31(33(41)42)15-23-10-11-24-8-6-7-9-25(24)14-23)18-22(2)39(21)32(40)29-20-38(34(3,4)5)19-28(29)27-13-12-26(35)16-30(27)36/h6-14,16,21-22,28-29,31H,15,17-20H2,1-5H3,(H,41,42)/t21-,22+,28-,29+,31-/m0/s1
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n/an/an/an/a 6.40E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))
BDBM392664
PNG
(US10301286, Example 6)
Show SMILES C[C@H]1CN(C[C@@H](C)N1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C)[C@@H](Cc1ccc2ccccc2c1)C(O)=O
Show InChI InChI=1S/C34H41F2N3O3/c1-21-17-37(31(33(41)42)15-23-10-11-24-8-6-7-9-25(24)14-23)18-22(2)39(21)32(40)29-20-38(34(3,4)5)19-28(29)27-13-12-26(35)16-30(27)36/h6-14,16,21-22,28-29,31H,15,17-20H2,1-5H3,(H,41,42)/t21-,22+,28-,29+,31-/m0/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392666
PNG
(US10301286, Example 15 | US10301286, Example 16)
Show SMILES C[C@@H]1CN(CCN1C(Cc1ccc(Cl)c(Cl)c1)C(O)=O)C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C
Show InChI InChI=1S/C29H35Cl2F2N3O3/c1-17-14-34(9-10-36(17)26(28(38)39)12-18-5-8-23(30)24(31)11-18)27(37)22-16-35(29(2,3)4)15-21(22)20-7-6-19(32)13-25(20)33/h5-8,11,13,17,21-22,26H,9-10,12,14-16H2,1-4H3,(H,38,39)/t17-,21+,22-,26?/m1/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392669
PNG
(US10301286, Example 21)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C)[C@@H](Cc1ccc(cc1)C#N)C(O)=O
Show InChI InChI=1S/C30H36F2N4O3/c1-19-16-34(27(29(38)39)13-20-5-7-21(15-33)8-6-20)11-12-36(19)28(37)25-18-35(30(2,3)4)17-24(25)23-10-9-22(31)14-26(23)32/h5-10,14,19,24-25,27H,11-13,16-18H2,1-4H3,(H,38,39)/t19-,24-,25+,27-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392675
PNG
(US10301286, Example 36)
Show SMILES CC(C)(C)N1C[C@H]([C@@H](C1)c1ccc(F)cc1F)C(=O)N1CCN(C[C@@H]1CC1CC1)[C@@H](Cc1ccc2CCCc2c1)C(O)=O
Show InChI InChI=1S/C35H45F2N3O3/c1-35(2,3)39-20-29(28-12-11-26(36)18-31(28)37)30(21-39)33(41)40-14-13-38(19-27(40)16-22-7-8-22)32(34(42)43)17-23-9-10-24-5-4-6-25(24)15-23/h9-12,15,18,22,27,29-30,32H,4-8,13-14,16-17,19-21H2,1-3H3,(H,42,43)/t27-,29-,30+,32-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM392681
PNG
(US10301286, Example 57)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C(C)(C)C)[C@@H](CC1CCCCC1)C(O)=O
Show InChI InChI=1S/C29H43ClFN3O3/c1-19-16-32(26(28(36)37)14-20-8-6-5-7-9-20)12-13-34(19)27(35)24-18-33(29(2,3)4)17-23(24)22-11-10-21(30)15-25(22)31/h10-11,15,19-20,23-24,26H,5-9,12-14,16-18H2,1-4H3,(H,36,37)/t19-,23-,24+,26-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392686
PNG
(US10301286, Example 78)
Show SMILES C[C@H]([C@H](N1CCN([C@@H](C)C1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C1CCOCC1)C(O)=O)c1ccc(C)cc1
Show InChI InChI=1S/C32H41ClFN3O4/c1-20-4-6-23(7-5-20)22(3)30(32(39)40)35-12-13-37(21(2)17-35)31(38)28-19-36(25-10-14-41-15-11-25)18-27(28)26-9-8-24(33)16-29(26)34/h4-9,16,21-22,25,27-28,30H,10-15,17-19H2,1-3H3,(H,39,40)/t21-,22-,27-,28+,30-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392687
PNG
(US10301286, Example 83)
Show SMILES C[C@H]1CN(CCN1C(=O)C1CN(CC1c1ccc2CCCc2c1)C(C)(C)C)[C@@H](Cc1ccc2CCCc2c1)C(O)=O
Show InChI InChI=1S/C35H47N3O3/c1-23-20-36(32(34(40)41)18-24-11-12-25-7-5-9-27(25)17-24)15-16-38(23)33(39)31-22-37(35(2,3)4)21-30(31)29-14-13-26-8-6-10-28(26)19-29/h11-14,17,19,23,30-32H,5-10,15-16,18,20-22H2,1-4H3,(H,40,41)/t23-,30?,31?,32-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Rattus norvegicus)
BDBM392662
PNG
(US10301286, Example 88)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C1CCOCC1)[C@@H](Cc1c(C)cc(C)cc1F)C(O)=O
Show InChI InChI=1S/C32H40ClF2N3O4/c1-19-12-20(2)25(28(34)13-19)15-30(32(40)41)36-8-9-38(21(3)16-36)31(39)27-18-37(23-6-10-42-11-7-23)17-26(27)24-5-4-22(33)14-29(24)35/h4-5,12-14,21,23,26-27,30H,6-11,15-18H2,1-3H3,(H,40,41)/t21-,26-,27+,30-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Rat MC4 Receptor-Expressing VectorA rat MC4 receptor gene (GenBank Accession No.: NM_013099.2) was introduced in...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))
BDBM392656
PNG
(US10301286, Example 4)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C(C)(C)C)[C@@H](Cc1ccc(C)cc1F)C(O)=O
Show InChI InChI=1S/C30H38ClF2N3O3/c1-18-6-7-20(25(32)12-18)13-27(29(38)39)34-10-11-36(19(2)15-34)28(37)24-17-35(30(3,4)5)16-23(24)22-9-8-21(31)14-26(22)33/h6-9,12,14,19,23-24,27H,10-11,13,15-17H2,1-5H3,(H,38,39)/t19-,23-,24+,27-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392660
PNG
(US10301286, Example 76)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C(C)(C)C)[C@@H](Cc1c(F)cc(C)cc1F)C(O)=O
Show InChI InChI=1S/C30H37ClF3N3O3/c1-17-10-24(32)21(25(33)11-17)13-27(29(39)40)35-8-9-37(18(2)14-35)28(38)23-16-36(30(3,4)5)15-22(23)20-7-6-19(31)12-26(20)34/h6-7,10-12,18,22-23,27H,8-9,13-16H2,1-5H3,(H,39,40)/t18-,22-,23+,27-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))
BDBM392672
PNG
(US10301286, Example 28)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)CO)[C@@H](Cc1ccc2CCCc2c1)C(O)=O
Show InChI InChI=1S/C32H41F2N3O4/c1-20-16-35(29(31(40)41)14-21-7-8-22-5-4-6-23(22)13-21)11-12-37(20)30(39)27-18-36(32(2,3)19-38)17-26(27)25-10-9-24(33)15-28(25)34/h7-10,13,15,20,26-27,29,38H,4-6,11-12,14,16-19H2,1-3H3,(H,40,41)/t20-,26-,27+,29-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM392677
PNG
(US10301286, Example 47)
Show SMILES C[C@H]1CN(CCN1C(=O)C1CN(CC1c1ccc(cc1F)C#N)C(C)(C)C)[C@@H](Cc1ccc2CCCc2c1)C(O)=O
Show InChI InChI=1S/C33H41FN4O3/c1-21-18-36(30(32(40)41)16-22-8-10-24-6-5-7-25(24)14-22)12-13-38(21)31(39)28-20-37(33(2,3)4)19-27(28)26-11-9-23(17-35)15-29(26)34/h8-11,14-15,21,27-28,30H,5-7,12-13,16,18-20H2,1-4H3,(H,40,41)/t21-,27?,28?,30-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392681
PNG
(US10301286, Example 57)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C(C)(C)C)[C@@H](CC1CCCCC1)C(O)=O
Show InChI InChI=1S/C29H43ClFN3O3/c1-19-16-32(26(28(36)37)14-20-8-6-5-7-9-20)12-13-34(19)27(35)24-18-33(29(2,3)4)17-23(24)22-11-10-21(30)15-25(22)31/h10-11,15,19-20,23-24,26H,5-9,12-14,16-18H2,1-4H3,(H,36,37)/t19-,23-,24+,26-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392685
PNG
(US10301286, Example 74)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C1CCOCC1)[C@@](C)(Cc1ccc(C)cc1F)C(O)=O
Show InChI InChI=1S/C32H40F3N3O4/c1-20-4-5-22(28(34)14-20)16-32(3,31(40)41)37-10-11-38(21(2)17-37)30(39)27-19-36(24-8-12-42-13-9-24)18-26(27)25-7-6-23(33)15-29(25)35/h4-7,14-15,21,24,26-27H,8-13,16-19H2,1-3H3,(H,40,41)/t21-,26-,27+,32-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Rattus norvegicus)
BDBM392658
PNG
(US10301286, Example 9)
Show SMILES CCC[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C)[C@@H](Cc1ccc2ccccc2c1)C(O)=O
Show InChI InChI=1S/C35H43F2N3O3/c1-5-8-27-20-38(32(34(42)43)18-23-11-12-24-9-6-7-10-25(24)17-23)15-16-40(27)33(41)30-22-39(35(2,3)4)21-29(30)28-14-13-26(36)19-31(28)37/h6-7,9-14,17,19,27,29-30,32H,5,8,15-16,18,20-22H2,1-4H3,(H,42,43)/t27-,29-,30+,32-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Rat MC4 Receptor-Expressing VectorA rat MC4 receptor gene (GenBank Accession No.: NM_013099.2) was introduced in...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392664
PNG
(US10301286, Example 6)
Show SMILES C[C@H]1CN(C[C@@H](C)N1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C)[C@@H](Cc1ccc2ccccc2c1)C(O)=O
Show InChI InChI=1S/C34H41F2N3O3/c1-21-17-37(31(33(41)42)15-23-10-11-24-8-6-7-9-25(24)14-23)18-22(2)39(21)32(40)29-20-38(34(3,4)5)19-28(29)27-13-12-26(35)16-30(27)36/h6-14,16,21-22,28-29,31H,15,17-20H2,1-5H3,(H,41,42)/t21-,22+,28-,29+,31-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))
BDBM392670
PNG
(US10301286, Example 24)
Show SMILES CN(C)CC[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)c1ccc(=O)n(C)n1)[C@@H](Cc1ccc2ccccc2c1)C(O)=O
Show InChI InChI=1S/C37H42F2N6O4/c1-41(2)15-14-28-21-43(33(37(48)49)19-24-8-9-25-6-4-5-7-26(25)18-24)16-17-45(28)36(47)31-23-44(34-12-13-35(46)42(3)40-34)22-30(31)29-11-10-27(38)20-32(29)39/h4-13,18,20,28,30-31,33H,14-17,19,21-23H2,1-3H3,(H,48,49)/t28-,30-,31+,33-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM392682
PNG
(US10301286, Example 68)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C1(C)CC1)[C@@H](Cc1ccc2CCCc2c1)C(O)=O
Show InChI InChI=1S/C32H39ClFN3O3/c1-20-17-35(29(31(39)40)15-21-6-7-22-4-3-5-23(22)14-21)12-13-37(20)30(38)27-19-36(32(2)10-11-32)18-26(27)25-9-8-24(33)16-28(25)34/h6-9,14,16,20,26-27,29H,3-5,10-13,15,17-19H2,1-2H3,(H,39,40)/t20-,26-,27+,29-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM392684
PNG
(US10301286, Example 72)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C(C)(C)C)[C@@H](Cc1ccc(OC(F)F)cc1)C(O)=O
Show InChI InChI=1S/C30H37ClF3N3O4/c1-18-15-35(26(28(39)40)13-19-5-8-21(9-6-19)41-29(33)34)11-12-37(18)27(38)24-17-36(30(2,3)4)16-23(24)22-10-7-20(31)14-25(22)32/h5-10,14,18,23-24,26,29H,11-13,15-17H2,1-4H3,(H,39,40)/t18-,23-,24+,26-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM392685
PNG
(US10301286, Example 74)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C1CCOCC1)[C@@](C)(Cc1ccc(C)cc1F)C(O)=O
Show InChI InChI=1S/C32H40F3N3O4/c1-20-4-5-22(28(34)14-20)16-32(3,31(40)41)37-10-11-38(21(2)17-37)30(39)27-19-36(24-8-12-42-13-9-24)18-26(27)25-7-6-23(33)15-29(25)35/h4-7,14-15,21,24,26-27H,8-13,16-19H2,1-3H3,(H,40,41)/t21-,26-,27+,32-/m0/s1
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n/an/an/an/a 1.40E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM392686
PNG
(US10301286, Example 78)
Show SMILES C[C@H]([C@H](N1CCN([C@@H](C)C1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C1CCOCC1)C(O)=O)c1ccc(C)cc1
Show InChI InChI=1S/C32H41ClFN3O4/c1-20-4-6-23(7-5-20)22(3)30(32(39)40)35-12-13-37(21(2)17-35)31(38)28-19-36(25-10-14-41-15-11-25)18-27(28)26-9-8-24(33)16-29(26)34/h4-9,16,21-22,25,27-28,30H,10-15,17-19H2,1-3H3,(H,39,40)/t21-,22-,27-,28+,30-/m0/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))
BDBM392689
PNG
(US10301286, Example 92)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C1CCOCC1)[C@@H](Cc1ccc(cc1F)C1CC1)C(O)=O
Show InChI InChI=1S/C33H40ClF2N3O4/c1-20-17-37(31(33(41)42)15-23-5-4-22(14-29(23)35)21-2-3-21)10-11-39(20)32(40)28-19-38(25-8-12-43-13-9-25)18-27(28)26-7-6-24(34)16-30(26)36/h4-7,14,16,20-21,25,27-28,31H,2-3,8-13,15,17-19H2,1H3,(H,41,42)/t20-,27-,28+,31-/m0/s1
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n/an/an/an/a 1.80E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Rattus norvegicus)
BDBM392657
PNG
(US10301286, Example 5)
Show SMILES C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C)[C@@H](Cc1ccc2CCCc2c1)C(O)=O
Show InChI InChI=1S/C32H41F2N3O3/c1-20-17-35(29(31(39)40)15-21-8-9-22-6-5-7-23(22)14-21)12-13-37(20)30(38)27-19-36(32(2,3)4)18-26(27)25-11-10-24(33)16-28(25)34/h8-11,14,16,20,26-27,29H,5-7,12-13,15,17-19H2,1-4H3,(H,39,40)/t20-,26-,27+,29-/m0/s1
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n/an/an/an/a 26n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Rat MC4 Receptor-Expressing VectorA rat MC4 receptor gene (GenBank Accession No.: NM_013099.2) was introduced in...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM392658
PNG
(US10301286, Example 9)
Show SMILES CCC[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C)[C@@H](Cc1ccc2ccccc2c1)C(O)=O
Show InChI InChI=1S/C35H43F2N3O3/c1-5-8-27-20-38(32(34(42)43)18-23-11-12-24-9-6-7-10-25(24)17-23)15-16-40(27)33(41)30-22-39(35(2,3)4)21-29(30)28-14-13-26(36)19-31(28)37/h6-7,9-14,17,19,27,29-30,32H,5,8,15-16,18,20-22H2,1-4H3,(H,42,43)/t27-,29-,30+,32-/m0/s1
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n/an/an/an/a 390n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))
BDBM392658
PNG
(US10301286, Example 9)
Show SMILES CCC[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C)[C@@H](Cc1ccc2ccccc2c1)C(O)=O
Show InChI InChI=1S/C35H43F2N3O3/c1-5-8-27-20-38(32(34(42)43)18-23-11-12-24-9-6-7-10-25(24)17-23)15-16-40(27)33(41)30-22-39(35(2,3)4)21-29(30)28-14-13-26(36)19-31(28)37/h6-7,9-14,17,19,27,29-30,32H,5,8,15-16,18,20-22H2,1-4H3,(H,42,43)/t27-,29-,30+,32-/m0/s1
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n/an/an/an/a 910n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
Experiment Method(1) Construction of Human MC Receptor-Expressing VectorA human MC4 receptor gene (GenBank Accession No.: NM_005912.2), a human MC1 r...


US Patent US10301286 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%