BDBM50118233 2'-deoxyadenosine 5'-(tetrahydrogen triphosphate)::ATP,2'-deoxy::CHEMBL335538::dATP
SMILES: Nc1ncnc2n(cnc12)[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1
InChI Key: InChIKey=SUYVUBYJARFZHO-RRKCRQDMSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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P2X purinoceptor 2 (Homo sapiens (Human)) | BDBM50118233 (2'-deoxyadenosine 5'-(tetrahydrogen triphosphate) ...) | Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars | Article PubMed | 47.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by PDSP Ki Database | J Pharmacol Exp Ther 310: 407-16 (2004) Article DOI: 10.1124/jpet.103.064907 BindingDB Entry DOI: 10.7270/Q2SQ8XZR | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 3 (Homo sapiens (Human)) | BDBM50118233 (2'-deoxyadenosine 5'-(tetrahydrogen triphosphate) ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars | Article PubMed | 180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by PDSP Ki Database | J Pharmacol Exp Ther 310: 407-16 (2004) Article DOI: 10.1124/jpet.103.064907 BindingDB Entry DOI: 10.7270/Q2SQ8XZR | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase (Human immunodeficiency virus 1) | BDBM50118233 (2'-deoxyadenosine 5'-(tetrahydrogen triphosphate) ...) | PDB MMDB UniProtKB/TrEMBL GoogleScholar | Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 7.50E+3 | n/a | n/a | n/a | n/a | n/a |
AFMB-CNRS-ESIL Curated by ChEMBL | Assay Description Binding affinity to HIV1 wild type reverse transcriptase p66/p51 expressed in Escherichia coli assessed as incorporation of drug to DNA by gel electr... | Antimicrob Agents Chemother 51: 3162-7 (2007) Article DOI: 10.1128/aac.00145-07 BindingDB Entry DOI: 10.7270/Q20004WX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse Transcriptase (Human immunodeficiency virus 1) | BDBM50118233 (2'-deoxyadenosine 5'-(tetrahydrogen triphosphate) ...) | PDB MMDB UniProtKB/TrEMBL GoogleScholar | Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 6.60E+3 | n/a | n/a | n/a | n/a | n/a |
Yale University Curated by ChEMBL | Assay Description Binding affinity to HIV1 reverse transcriptase K65R mutant by pre-steady state kinetics study | Bioorg Med Chem Lett 22: 4064-7 (2012) Article DOI: 10.1016/j.bmcl.2012.04.078 BindingDB Entry DOI: 10.7270/Q25D8VQ3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase (Human immunodeficiency virus 1) | BDBM50118233 (2'-deoxyadenosine 5'-(tetrahydrogen triphosphate) ...) | PDB MMDB UniProtKB/TrEMBL GoogleScholar | Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a |
Yale University Curated by ChEMBL | Assay Description Binding affinity to wild type HIV1 reverse transcriptase by pre-steady state kinetics study | Bioorg Med Chem Lett 22: 4064-7 (2012) Article DOI: 10.1016/j.bmcl.2012.04.078 BindingDB Entry DOI: 10.7270/Q25D8VQ3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse Transcriptase (Human immunodeficiency virus 1) | BDBM50118233 (2'-deoxyadenosine 5'-(tetrahydrogen triphosphate) ...) | PDB MMDB UniProtKB/TrEMBL GoogleScholar | Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a |
Veterans Affairs Medical Center Curated by ChEMBL | Assay Description Binding affinity to HIV1 reverse transcriptase M184V mutant assessed as L-3'-azido-NTP incorporation in nascent DNA | Eur J Med Chem 46: 3832-44 (2011) Article DOI: 10.1016/j.ejmech.2011.05.051 BindingDB Entry DOI: 10.7270/Q2RN3BQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase (Human immunodeficiency virus 1) | BDBM50118233 (2'-deoxyadenosine 5'-(tetrahydrogen triphosphate) ...) | PDB MMDB UniProtKB/TrEMBL GoogleScholar | Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a |
Veterans Affairs Medical Center Curated by ChEMBL | Assay Description Binding affinity to HIV1 reverse transcriptase assessed as L-3'-azido-NTP incorporation in nascent DNA | Eur J Med Chem 46: 3832-44 (2011) Article DOI: 10.1016/j.ejmech.2011.05.051 BindingDB Entry DOI: 10.7270/Q2RN3BQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purinergic receptor P2Y11 (Homo sapiens (Human)) | BDBM50118233 (2'-deoxyadenosine 5'-(tetrahydrogen triphosphate) ...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a |
National Institute of Diabetes Curated by ChEMBL | Assay Description The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11) | J Med Chem 45: 4057-93 (2002) Article DOI: 10.1021/jm020046y BindingDB Entry DOI: 10.7270/Q2VX0H71 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2Y purinoceptor 1 (Meleagris gallopavo) | BDBM50118233 (2'-deoxyadenosine 5'-(tetrahydrogen triphosphate) ...) | MMDB KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.90E+4 | n/a | n/a | n/a | n/a |
National Institute of Diabetes Curated by ChEMBL | Assay Description Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytes | J Med Chem 45: 4057-93 (2002) Article DOI: 10.1021/jm020046y BindingDB Entry DOI: 10.7270/Q2VX0H71 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase (Human immunodeficiency virus 1) | BDBM50118233 (2'-deoxyadenosine 5'-(tetrahydrogen triphosphate) ...) | PDB MMDB UniProtKB/TrEMBL GoogleScholar | Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh School of Medicine Curated by ChEMBL | Assay Description Binding affinity to HIV1 reverse transcriptase | Antimicrob Agents Chemother 53: 3715-9 (2009) Article DOI: 10.1128/aac.00392-09 BindingDB Entry DOI: 10.7270/Q2KD21R2 | |||||||||||
More data for this Ligand-Target Pair |