Compile Data Set for Download or QSAR
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Report error Found 82 Enz. Inhib. hit(s) with all data for entry = 50017428
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50601872(CHEMBL5174733)
Affinity DataKi:  0.600nMAssay Description:Binding affinity to GSK-3 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50072352(CHEMBL3409318)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to human CB2R assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50601864(CHEMBL5171821)
Affinity DataKi:  2.90nMAssay Description:Binding affinity to human P2X7R assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50601855(CHEMBL5189391)
Affinity DataKi:  2.90nMAssay Description:Binding affinity to human MAO-B assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50601854(CHEMBL4117628)
Affinity DataKi:  3.30nMAssay Description:Binding affinity to human CB2R assessed as inhibition constant and incubated for 90 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50506752(CHEMBL4441693)
Affinity DataKi:  4.30nMAssay Description:Binding affinity to human CB2R assessed as inhibition constant and incubated for 90 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50397745(CHEMBL2177161)
Affinity DataKi:  4.90nMAssay Description:Binding affinity to GSK-3 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50601865(CHEMBL5180946)
Affinity DataKi:  8nMAssay Description:Binding affinity to CSF1R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM8296(3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-...)
Affinity DataKi:  9nMAssay Description:Binding affinity to GSK-3 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50312837(CHEMBL1081610 | [11C]8-butoxy-N-cyclohexyl-7-metho...)
Affinity DataKi:  9.60nMAssay Description:Binding affinity to human CB2R assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50249570(CHEMBL4066660)
Affinity DataKi:  90nMAssay Description:Binding affinity to human melatonin MT1 assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50285227(2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-t...)
Affinity DataKi:  250nMAssay Description:Binding affinity to COX2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM15579(CHEMBL972 | DEPRENYL | L-Deprenyl | N-methyl-N-[(2...)
Affinity DataKi:  970nMAssay Description:Reversible inhibition of MAO-B in Wistar rat assessed as inhibition constant followed by using clorgyline as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50601854(CHEMBL4117628)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity to human CB1R assessed as inhibition constant and incubated for 90 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50506752(CHEMBL4441693)
Affinity DataKi:  1.10E+3nMAssay Description:Binding affinity to human CB1R assessed as inhibition constant and incubated for 90 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50272095(4-(3-(4-methoxyphenyl)-1H-indol-2-yl)benzenesulfon...)
Affinity DataIC50:  0.00600nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50601869(CHEMBL5184286)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50233715(5-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(piperidin...)
Affinity DataIC50:  0.800nMAssay Description:Binding affinity to CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50601851(CHEMBL5200454)
Affinity DataIC50:  1nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50601852(CHEMBL5206077)
Affinity DataIC50:  1nMAssay Description:Inhibition of human COX1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50601860(CHEMBL5186767)
Affinity DataIC50:  1nMAssay Description:Inhibition of human P2X7RMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50057581(4-(4-Fluoro-5-phenyl-3-trifluoromethyl-pyrazol-1-y...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50601873(CHEMBL5190086)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of GSK-3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50601414(CHEMBL5173945)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of recombinant human GSK-3betaMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM450758(US10676467, Compound TZ 33 21)
Affinity DataIC50:  2.10nMAssay Description:Binding affinity to recombinant human S1PR1 expressed in cell membraneMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50601866(CHEMBL5197130)
Affinity DataIC50:  2.5nMAssay Description:Binding affinity to MERTK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50601871(CHEMBL5207508)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50416603(CHEMBL1222883)
Affinity DataIC50:  3nMAssay Description:Inhibition of human P2X7RMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50601870(CHEMBL5181462)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50601853(CHEMBL5184826)
Affinity DataIC50:  4nMAssay Description:Inhibition of human COX1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50601850(CHEMBL5178995)
Affinity DataIC50:  4nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50029825(3-[5-(4-Benzyloxy-phenyl)-2-oxo-[1,3,4]oxadiazol-3...)
Affinity DataIC50:  4nMAssay Description:Inhibition of MAO-B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50601859(CHEMBL5200183)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of human P2X7RMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50601848(CHEMBL5169729)
Affinity DataIC50:  5nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50084631(CHEMBL3427203)
Affinity DataIC50:  5nMAssay Description:Inhibition of human COX1More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50601868(CHEMBL5172644)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50601865(CHEMBL5180946)
Affinity DataIC50:  6nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50436963(CHEMBL2402255)
Affinity DataIC50:  6nMAssay Description:Inhibition of human P2Y12More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM450730(US10676467, Compound 8c | US10676467, Compound TZ ...)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of S1PR1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50601862(CHEMBL5194016)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of human P2X7RMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50057589(4-[5-(4-Methoxy-phenyl)-3-trifluoromethyl-pyrazol-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50601867(CHEMBL5191424)
Affinity DataIC50:  8.70nMAssay Description:Inhibition of sEH (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50601858(CHEMBL5186556)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of S1PR2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM450739(US10676467, Compound 12a)
Affinity DataIC50:  14nMAssay Description:Inhibition of S1PR1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM450736(US10676467, Compound 8k)
Affinity DataIC50:  15nMAssay Description:Inhibition of S1PR1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataIC50:  18nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
Affinity DataIC50:  20nMAssay Description:Inhibition of MAO-B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50601863(CHEMBL5179763)
Affinity DataIC50:  25nMAssay Description:Inhibition of human P2X7RMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM8296(3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-...)
Affinity DataIC50:  34nMAssay Description:Inhibition of GSK-3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50297675(CHEMBL551148 | N-(4-fluorobenzyl)-4-(4-(methylsulf...)
Affinity DataIC50:  40nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
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