Compile Data Set for Download or QSAR
Report error Found 683 for UniProtKB: P08922
LigandPNGBDBM50448785(CHEMBL3128069)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of ROS1 (unknown origin) by Pfizer mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)
Affinity DataKi: <0.0200nMAssay Description:Inhibition of ROS1 (unknown origin) by off-chip mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
LigandPNGBDBM50653010(CHEMBL5712062)
Affinity DataKi: <0.0250nMAssay Description:Binding affinity to recombinant human ROS1 assessed as inhibition constant in presence of ATP by microfluidic mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)
Affinity DataKi: <0.0250nMAssay Description:Inhibition of ROS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)
Affinity DataKi: <0.0250nMAssay Description:Inhibition of wild type ROS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of human ROS1 by discoverX kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50519598(CHEMBL4436406)
Affinity DataKi: <0.0700nMAssay Description:Inhibition of ROS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50059889(3-methoxy-2-methyl-4-methylamino-(2S,3S,4S,6R)-29-...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of ROS1 by HotSpot assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of ROS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of human ROS1 using KKKSPGEYVNIEFG as substrate in presence of ATP by radiometric HotSpot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of ROS1 L2026M mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50653010(CHEMBL5712062)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to recombinant human ROS1 L2026M mutant assessed as inhibition constant in presence of ATP by microfluidic mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.145nMAssay Description:Inhibition of human ROS using KKKSPGEYVNIEFG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.149nMAssay Description:Inhibition of human ROS using KKKSPGEYVNIEFG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.170nMAssay Description:The compound powder was dissolved in 100% DMSO (Sigma, Cat. D8418-1l) to prepare a 10 mM storage solution. The compounds had an initial test concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of ROS1 (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of SLC34A2-ROS1 (unknown origin) expressed in human HCC78 cells assessed as reduction in cell viabilityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of ROS (unknown origin) incubated for 1 hr by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2017
Entry Details Article
PubMed
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of wild type ROS1 (unknown origin) expressed in BaF3 cells incubated for 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50581357(CHEMBL5093999)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of ROS1 (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of ROS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS [D2033N](Human)
Array Biopharma

US Patent
LigandPNGBDBM267453(US9718822, 36 | US9750744, Example 36 | US9902741,...)
Affinity DataIC50: 0.200nMAssay Description:The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS [G2032R](Human)
Array Biopharma

US Patent
LigandPNGBDBM267453(US9718822, 36 | US9750744, Example 36 | US9902741,...)
Affinity DataIC50: 0.200nMAssay Description:The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
US Patent

LigandPNGBDBM130912(US8822500, [1])
Affinity DataIC50: 0.205nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
US Patent

LigandPNGBDBM144323(US8969336, 567)
Affinity DataIC50: 0.230nMAssay Description:A partial protein of only a kinase domain of ROS protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Exampl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2015
Entry Details
US Patent

LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of CD74-ROS1 (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell viabilityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
LigandPNGBDBM139540(US8889696, Staurosporine | US9051313, Staurosporin...)
Affinity DataIC50: 0.246nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM139540(US8889696, Staurosporine | US9051313, Staurosporin...)
Affinity DataIC50: 0.246nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2026
Entry Details
US Patent

LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 0.248nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
US Patent

LigandPNGBDBM702001(US12129258, Example 24)
Affinity DataIC50: 0.290nMAssay Description:The compound powder was dissolved in 100% DMSO (Sigma, Cat. D8418-1l) to prepare a 10 mM storage solution. The compounds had an initial test concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

LigandPNGBDBM144318(US8969336, 580 | US8969336, 553)
Affinity DataIC50: 0.290nMAssay Description:A partial protein of only a kinase domain of ROS protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Exampl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2015
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS [D2033N](Human)
Array Biopharma

US Patent
LigandPNGBDBM267407(US9718822, 3 | US9750744, Example 3 | US9902741, E...)
Affinity DataIC50: 0.300nMAssay Description:The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS [G2032R](Human)
Array Biopharma

US Patent
LigandPNGBDBM446700((6R)-9-fluoro-13-oxa-2,11,17,21,22,25- hexaazapent...)
Affinity DataIC50: 0.300nMAssay Description:The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
US Patent

LigandPNGBDBM130910(US8822500, [4])
Affinity DataIC50: 0.300nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
US Patent

LigandPNGBDBM669891(US20240132517, Comparative Compound 42 | US1212925...)
Affinity DataIC50: 0.330nMAssay Description:The compound powder was dissolved in 100% DMSO (Sigma, Cat. D8418-1l) to prepare a 10 mM storage solution. The compounds had an initial test concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

LigandPNGBDBM50649924(CHEMBL5630153)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of recombinant human ROS1 G2032R mutant preincubated for 5 to 10 mins followed by substrate and ATP addition and measured after 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS [G2032R](Human)
Array Biopharma

US Patent
LigandPNGBDBM769500((3R,11R)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,...)
Affinity DataIC50: 0.340nMAssay Description:Table 6: The experimental flow was briefly described as follows: a test compound was first dissolved in DMSO to prepare a storage solution, and then ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS [G2032R](Human)
Array Biopharma

US Patent
LigandPNGBDBM669891(US20240132517, Comparative Compound 42 | US1212925...)
Affinity DataIC50: 0.360nMAssay Description:Based on LanceUltra (Perkin Elmer, CR97-100) principle, ROS1-G2032R kinase activity detection platform was established to determine the inhibitory ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

LigandPNGBDBM769500((3R,11R)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,...)
Affinity DataIC50: 0.360nMAssay Description:Table 6: The experimental flow was briefly described as follows: a test compound was first dissolved in DMSO to prepare a storage solution, and then ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

LigandPNGBDBM144328(US8969336, 572)
Affinity DataIC50: 0.370nMAssay Description:A partial protein of only a kinase domain of ROS protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Exampl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2015
Entry Details
US Patent

LigandPNGBDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of ROS1 L2026M mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM144321(US8969336, 565)
Affinity DataIC50: 0.400nMAssay Description:A partial protein of only a kinase domain of ROS protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Exampl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2015
Entry Details
US Patent

LigandPNGBDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to recombinant human ROS1 L2026M mutant assessed as inhibition constant in presence of ATP by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM144319(US8969336, 581 | US8969336, 554)
Affinity DataIC50: 0.410nMAssay Description:A partial protein of only a kinase domain of ROS protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Exampl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2015
Entry Details
US Patent

LigandPNGBDBM50512149(CHEMBL4470529)
Affinity DataIC50: 0.430nMAssay Description:Inhibition of N-terminal GST-tagged human ROS1 cytoplasmic domain (1883 to 2347 residues) expressed in Baculovirus expression system using IRS1 as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandPNGBDBM130911(US8822500, [2])
Affinity DataIC50: 0.436nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
US Patent

LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataKd:  0.490nMAssay Description:Binding constant for ROS1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
LigandPNGBDBM50649925(CHEMBL5624610 | US12435089, Example 10)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human ROS1 G2032R mutant using KKKSPGEYVNIEFG as substrate incubated for 120 mins in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM647658(US20240025908, Example 26)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM50649927(CHEMBL5630447)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human ROS1 using KKKSPGEYVNIEFG as substrate incubated for 120 mins in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
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