152 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
Northwestern University
2-Aminopyridines with a Truncated Side Chain To Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity.
Northwestern University
Cell-permeable inhibitors of neuronal nitric oxide synthase open new prospects for the treatment of neurological disorders.
Vibrant Pharma
Novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase.
Northwestern University
Structure-based design of bacterial nitric oxide synthase inhibitors.
University of California
Combination of chiral linkers with thiophenecarboximidamide heads to improve the selectivity of inhibitors of neuronal nitric oxide synthase.
Northwestern University
Nitric oxide synthase inhibitors that interact with both heme propionate and tetrahydrobiopterin show high isoform selectivity.
Northwestern University
Simplified 2-aminoquinoline-based scaffold for potent and selective neuronal nitric oxide synthase inhibition.
Northwestern University
Potent and selective double-headed thiophene-2-carboximidamide inhibitors of neuronal nitric oxide synthase for the treatment of melanoma.
Northwestern University
An Accessible Chiral Linker to Enhance Potency and Selectivity of Neuronal Nitric Oxide Synthase Inhibitors.
Northwestern University
Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors.
Northwestern University
In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures.
Northwestern University
Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers.
Northwestern University
Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase.
University of California
Structure-guided design of selective inhibitors of neuronal nitric oxide synthase.
Northwestern University
Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights.
Nycomed
Discovery of a potent, orally bioavailable and highly selective human neuronal nitric oxide synthase (nNOS) inhibitor, N-(1-(piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide as a pre-clinical development candidate for the treatment of migraine.
Neuraxon
1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors: lead optimization studies resulting in the identification of N-(1-(2-(methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a preclinical development candidate.
Neuraxon
New hypotheses for the binding mode of 4- and 7-substituted indazoles in the active site of neuronal nitric oxide synthase.
Universit£
NOpiates: Novel Dual Action Neuronal Nitric Oxide Synthase Inhibitors with µ-Opioid Agonist Activity.
TBA
First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain.
Neuraxon
Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS).
Neuraxon
Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain.
Neuraxon
Synthesis and evaluation of pyrido[1,2-a]pyrimidines as inhibitors of nitric oxide synthases.
Christian-Albrechts-University of Kiel
N(delta)-Methylated L-arginine derivatives and their effects on the nitric oxide generating system.
Christian-Albrechts-University of Kiel
6-Acetyl-7,7-dimethyl-5,6,7,8-tetrahydropterin is an activator of nitric oxide synthases.
University of Strathclyde
Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors.
Neuraxon
Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors.
Queen'S University
Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase.
Merck Research Laboratory
Substituted 6-phenyl-pyridin-2-ylamines: selective and potent inhibitors of neuronal nitric oxide synthase.
Pfizer
5-Fluorinated L-lysine analogues as selective induced nitric oxide synthase inhibitors.
Pfizer
Potent and selective conformationally restricted neuronal nitric oxide synthase inhibitors.
Northwestern University
Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase.
Northwestern University
1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo.
Astrazeneca R&D Charnwood
Synthesis and biological characterization of L-N(6)-(1-iminoethyl)lysine 5-tetrazole-amide, a prodrug of a selective iNOS inhibitor.
Pfizer
Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase.
Northwestern University
Synthesis and evaluation of peptidomimetics as selective inhibitors and active site probes of nitric oxide synthases.
Northwestern University
N(omega)-Nitroarginine-containing dipeptide amides. Potent and highly selective inhibitors of neuronal nitric oxide synthase.
Northwestern University
2-Iminohomopiperidinium salts as selective inhibitors of inducible nitric oxide synthase (iNOS).
Pfizer
2-Iminopyrrolidines as potent and selective inhibitors of human inducible nitric oxide synthase.
Pfizer
N-Phenylamidines as selective inhibitors of human neuronal nitric oxide synthase: structure-activity studies and demonstration of in vivo activity.
Glaxo Wellcome Research and Development
Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine.
Northwestern University
Selective inhibition of neuronal nitric oxide synthase by N omega-nitroarginine-and phenylalanine-containing dipeptides and dipeptide esters.
Northwestern University
Substituted N-phenylisothioureas: potent inhibitors of human nitric oxide synthase with neuronal isoform selectivity.
Glaxo Wellcome Research and Development
2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms.
G. D. Searle Research and Development
Novel inhibitors of neuronal nitric oxide synthase with potent antioxidant properties.
Institut Henri Beaufour
Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors.
Schering
Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine.
Glaxo Wellcome Research and Development
1H-pyrazole-1-carboxamidines: new inhibitors of nitric oxide synthase.
Northwestern University
Intramolecular hydrogen bonding: a potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase.
Northwestern University
3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors.
Neuraxon
Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities.
Neuraxon
Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors.
Neuraxon
Identification and SAR of selective inducible nitric oxide synthase (iNOS) dimerization inhibitors.
Kalypsys
1,6-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors.
Neuraxon
1,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors.
Neuraxon
Improved synthesis of chiral pyrrolidine inhibitors and their binding properties to neuronal nitric oxide synthase.
Northwestern University
Discovery of dual inducible/neuronal nitric oxide synthase (iNOS/nNOS) inhibitor development candidate 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) part 2: identification of a novel, potent, and selective series of benzimidazole-quinolinone iNOS/nNO
Kalypsys
Synthesis and evaluation of fluorescent heterocyclic aminoadamantanes as multifunctional neuroprotective agents.
North-West University
Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor.
Glaxosmithkline
Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthase.
Northwestern University
Exploration of the active site of neuronal nitric oxide synthase by the design and synthesis of pyrrolidinomethyl 2-aminopyridine derivatives.
Northwestern University
N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase.
Università
Peripheral but crucial: a hydrophobic pocket (Tyr(706), Leu(337), and Met(336)) for potent and selective inhibition of neuronal nitric oxide synthase.
Northwestern University
Structure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthase.
Northwestern University
2-aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase I.
University of Pennsylvania
Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability.
Northwestern University
Fluorinated indazoles as novel selective inhibitors of nitric oxide synthase (NOS): synthesis and biological evaluation.
Uned
Eusynstyelamides A, B, and C, nNOS inhibitors, from the ascidian Eusynstyela latericius.
Institute of Marine Science
1,2-diaminobenzimidazoles : Selective inhibitors of nitric oxide synthase derived from aminoguanidine
TBA
L337H mutant of rat neuronal nitric oxide synthase resembles human neuronal nitric oxide synthase toward inhibitors.
Northwestern University
Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fluoropropyl)-4-methyl-pyridin-2-amine as a potential PET tracer for inducible nitric oxide synthase.
Washington University
Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability.
Northwestern University
Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping.
Northwestern University
Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile.
Université
Design, synthesis, and evaluation of potential inhibitors of nitric oxide synthase.
Instituto De QuíMica MéDica
4-substituted indazoles as new inhibitors of neuronal nitric oxide synthase.
Upres-Ea 3915
Selective L-nitroargininylaminopyrrolidine and L-nitroargininylaminopiperidine neuronal nitric oxide synthase inhibitors.
Northwestern University
Conformationally restricted dipeptide amides as potent and selective neuronal nitric oxide synthase inhibitors.
Northwestern University
Structural analysis of isoform-specific inhibitors targeting the tetrahydrobiopterin binding site of human nitric oxide synthases.
Sanofi-Aventis
Evaluation of 3-substituted arginine analogs as selective inhibitors of human nitric oxide synthase isozymes.
Nagoya City University
2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors.
Northwestern University
Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inhibitors of inducible nitric oxide synthase.
Merck Research Laboratories
Novel and orally bioavailable inducible nitric oxide synthase inhibitors: synthesis and evaluation of optically active 4,5-dialkyl-2-iminoselenazolidine derivatives.
Dainippon Pharmaceutical
Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases.
Merck Research Laboratories
2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution.
Astrazeneca R&D Charnwood
Structure-activity relationships of potent, selective inhibitors of neuronal nitric oxide synthase based on the 6-phenyl-2-aminopyridine structure.
Pfizer
4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor.
Dainippon Pharmaceutical
Huprine Y - Tryptophan heterodimers with potential implication to Alzheimer's disease treatment.
University Hospital Hradec Kralove
Synthesis, bioevaluation and docking studies of new imidamide derivatives as nitric oxide synthase inhibitors.
Universidad De Granada
3-Hydroxy-4-methyl-5-pentyl-2-iminopyrrolidine: a potent and highly selective inducible nitric oxide synthase inhibitor.
Pharmacia
Structural requirements for inhibition of the neuronal nitric oxide synthase (NOS-I): 3D-QSAR analysis of 4-oxo- and 4-amino-pteridine-based inhibitors.
Aventis Pharma
Inhibition of nNOS activity in rat brain by synthetic kynurenines: structure-activity dependence.
Universidad De Granada
Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase.
Pharmacia
Antiglioma Activity of Aryl and Amido-Aryl Acetamidine Derivatives Targeting iNOS: Synthesis and Biological Evaluation.
University "G. D'Annunzio" of Chieti-Pescara
Inhibition of neuronal nitric oxide synthase by 7-methoxyindazole and related substituted indazoles.
Université
Thienopyridines: nitric oxide synthase inhibitors with potent in vivo activity.
Astrazeneca R&D Charnwood
3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency.
Astrazeneca R&D Charnwood
Evaluation of new L-thiocitrulline derivatives as inhibitors of nitric oxide synthase.
Wake Forest University
Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.
Merck Research Laboratories
Guanidine-substituted imidazoles as inhibitors of nitric oxide synthase.
Wake Forest University Winston-Salem
Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold.
Northwestern University
A new class of selective and potent inhibitors of neuronal nitric oxide synthase.
Pfizer
Synthesis and evaluation of new sulfur-containing L-arginine-derived inhibitors of nitric oxide synthase.
Wake Forest University
Synthesis of boronic acid analogs of L-arginine as alternate substrates or inhibitors of nitric oxide synthase.
Université
First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate.
Northwestern University
Nitroaromatic amino acids as inhibitors of neuronal nitric oxide synthase.
Abbott Laboratories
Acetamidine lysine derivative, N-(5(S)-amino-6,7-dihydroxyheptyl)ethanimidamide dihydrochloride: a highly selective inhibitor of human inducible nitric oxide synthase.
Searle
Substituted 2-iminopiperidines as inhibitors of human nitric oxide synthase isoforms.
G. D. Searle Research and Development
Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase.
Northwestern University
Synthesis and biological evaluation of 4,5-dihydro-1H-pyrazole derivatives as potential nNOS/iNOS selective inhibitors. Part 2: Influence of diverse substituents in both the phenyl moiety and the acyl group.
Universidad De Granada
Discovery of N-{3-[(ethanimidoylamino)methyl]benzyl}-l-prolinamide dihydrochloride: A new potent and selective inhibitor of the inducible nitric oxide synthase as a promising agent for the therapy of malignant glioma.
University of Chieti "G. D'Annunzio
Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.
Northwestern University
Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors.
Northwestern University
Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.
Northwestern University
Electrostatic Control of Isoform Selective Inhibitor Binding in Nitric Oxide Synthase.
University of California Irvine
The mobility of a conserved tyrosine residue controls isoform-dependent enzyme-inhibitor interactions in nitric oxide synthases.
University of California Irvine
Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide.
The University of Texas
Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
University of California Irvine
N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties.
Pudue Pharma Discovery Research
Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder.
Eli Lilly
Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors.
Eli Lilly
Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.
The Scripps Research Institute
Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.
Kalypsys
Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors.
University of California Irvine
Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.
University of California Irvine
Hydroxyethylene isosteres of selective neuronal nitric oxide synthase inhibitors.
Northwestern University