81 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Design, synthesis, and evaluation of (2S,4R)-Ketoconazole sulfonamide analogs as potential treatments for Metabolic Syndrome.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Temple University
Exploiting the Chromone Scaffold for the Development of Inhibitors of Corticosteroid Biosynthesis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Bologna
Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb Research and Development
Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Research Laboratories
Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Research Laboratories
Novel pyridyl substituted 4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines as potent and selective aldosterone synthase inhibitors with improved in vitro metabolic stability.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Saarland University and Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
Discovery and development of Galeterone (TOK-001 or VN/124-1) for the treatment of all stages of prostate cancer.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Maryland
Heteroatom insertion into 3,4-dihydro-1H-quinolin-2-ones leads to potent and selective inhibitors of human and rat aldosterone synthase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Saarland University
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4'-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11ß-hydroxylase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Highly-selective 4-(1,2,3-triazole)-based P450c17a 17,20-lyase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Viamet Pharmaceuticals
Design, synthesis, and structure-activity relationships of azolylmethylpyrroloquinolines as nonsteroidal aromatase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Padova
Highly potent and selective nonsteroidal dual inhibitors of CYP17/CYP11B2 for the treatment of prostate cancer to reduce risks of cardiovascular diseases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
Systematic structure modifications of multitarget prostate cancer drug candidate galeterone to produce novel androgen receptor down-regulating agents as an approach to treatment of advanced prostate cancer.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Maryland
Modulation of cytochromes P450 with xanthone-based molecules: from aromatase to aldosterone synthase and steroid 11ß-hydroxylase inhibition.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Bologna
Selective dual inhibitors of CYP19 and CYP11B2: targeting cardiovascular diseases hiding in the shadow of breast cancer.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
Novel imidazol-1-ylmethyl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-ones as potent and selective CYP11B1 inhibitors for the treatment of Cushing's syndrome.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Saarland University and Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
Substituted benzimidazole and imidazopyridine compounds useful as cyp17 modulators: patent highlight.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
17,20-lyase inhibitors. Part 4: design, synthesis and structure-activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Takeda Pharmaceutical
Isopropylidene substitution increases activity and selectivity of biphenylmethylene 4-pyridine type CYP17 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Saarland University
Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Bologna
Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Saarland University
Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Maryland
Three dimensional pharmacophore modeling of human CYP17 inhibitors. Potential agents for prostate cancer therapy.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Accelrys
Synthesis and evaluation of novel steroidal oxime inhibitors of P450 17 (17 alpha-hydroxylase/C17-20-lyase) and 5 alpha-reductase types 1 and 2.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of The Saarland
The 16,17-double bond is needed for irreversible inhibition of human cytochrome p45017alpha by abiraterone (17-(3-pyridyl)androsta-5, 16-dien-3beta-ol) and related steroidal inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Institute of Cancer Research
Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Takeda Pharmaceutical
17,20-Lyase inhibitors. Part 3: Design, synthesis, and structure-activity relationships of biphenylylmethylimidazole derivatives as novel 17,20-lyase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Takeda Pharmaceutical
Fine-tuning the selectivity of aldosterone synthase inhibitors: structure-activity and structure-selectivity insights from studies of heteroaryl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-one derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Saarland University
Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-a-hydroxylase/C17-20 lyase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universita` Degli Studi Di Bari Aldo Moro
N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland
Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Saarland University
Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Saarland University
In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Saarland University
Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Saarland University
Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17)--part II: Core rigidification and influence of substituents at the methylene bridge.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Saarland University
Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Saarland University
Synthesis, biological evaluation and molecular modelling studies of novel ACD- and ABD-ring steroidomimetics as inhibitors of CYP17.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Saarland University
Design, Synthesis, and Biological Evaluations of Pyridyl 4,5,6,7-Tetrahydro-4,7-Methanobenzo[![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Guangzhou University of Chinese Medicine
Design, Synthesis, and Biological Evaluation of Androgen Receptor Degrading and Antagonizing Bifunctional Steroidal Analogs for the Treatment of Advanced Prostate Cancer.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Shanghai Institute of Materia Medica
A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Bologna
Multistep Binding of the Non-Steroidal Inhibitors Orteronel and Seviteronel to Human Cytochrome P450 17A1 and Relevance to Inhibition of Enzyme Activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Vanderbilt University School of Medicine
Synthesis and evaluation of 17-aliphatic heterocycle-substituted steroidal inhibitors of 17alpha-hydroxylase/C17-20-lyase (P450 17).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of The Saarland
Identification of Novel Steroidal Androgen Receptor Degrading Agents Inspired by Galeterone 3?-Imidazole Carbamate.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Maryland
Novel 17-azolyl steroids, potent inhibitors of human cytochrome 17 alpha-hydroxylase-C17,20-lyase (P450(17) alpha): potential agents for the treatment of prostate cancer.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Maryland
17-Imidazolyl, pyrazolyl, and isoxazolyl androstene derivatives. Novel steroidal inhibitors of human cytochrome C17,20-lyase (P450(17 alpha).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Maryland
Synthesis and evaluation of pregnane derivatives as inhibitors of human testicular 17 alpha-hydroxylase/C17,20-lyase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Maryland
3- and 4-pyridylalkyl adamantanecarboxylates: inhibitors of human cytochrome P450(17 alpha) (17 alpha-hydroxylase/C17,20-lyase). Potential nonsteroidal agents for the treatment of prostatic cancer.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Cancer Research Campaign Centre For Cancer Therapeutics
Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Syntex Discovery Research
Novel steroidal inhibitors of human cytochrome P45017 alpha (17 alpha-hydroxylase-C17,20-lyase): potential agents for the treatment of prostatic cancer.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Institute of Cancer Research
Esters of 3-pyridylacetic acid that combine potent inhibition of 17 alpha-hydroxylase/C17,20-lyase (cytochrome P45017 alpha) with resistance to esterase hydrolysis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Crc Laboratory
Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Kansas
Dihydrobenzisoxazole-4-one compounds are novel selective inhibitors of aldosterone synthase (CYP11B2) with in vivo activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Boehringer Ingelheim Pharmaceuticals
Design and synthesis of functionalized piperazin-1yl-(E)-stilbenes as inhibitors of 17?-hydroxylase-C17,20-lyase (Cyp17).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Temple University
Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Viamet Pharmaceuticals
Synthesis and aromatase inhibitory activity of novel 1-(4-aminophenyl)-3-azabicyclo[3.1.0]hexane- and -[3.1.1]heptane-2,4- diones.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Ciba-Geigy
Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Research Laboratories
Discovery of novel 1,2,3,4-tetrahydrobenzo[4, 5]thieno[2, 3-c]pyridine derivatives as potent and selective CYP17 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Fudan University
gamma-Aminobutyric acidA receptor heterogeneity in rat central nervous system: studies with clonazepam and other benzodiazepine ligands.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Georgetown University
Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H4 receptor ligands.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Abbott Laboratories
Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Bryn Mawr College
Chemically induced dimerization of human nonpancreatic secretory phospholipase A2 by bis-indole derivatives.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Peking University
Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
The Scripps Research Institute
4-benzyl-1H-imidazoles with oxazoline termini as histamine H3 receptor agonists.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Vu University Amsterdam
2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Enzyme-Ligand Co-Crystal Structure and Demonstration of Pharmacodynamic Effects in C57Bl/6 Mice.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Biovitrum