40 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Structure-activity relationships and pharmacophore model of a noncompetitive pyrazoline containing class of GluN2C/GluN2D selective antagonists.
Emory University
General synthesis ofß-alanine-containing spider polyamine toxins and discovery of nephila polyamine toxins 1 and 8 as highly potent inhibitors of ionotropic glutamate receptors.
University of Copenhagen
Development of a three-dimensional model for the N-methyl-D-aspartate NR2A subunit.
University of Milan
2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity.
Astrazeneca Pharmaceuticals
Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors.
University of Utah
Discovery of triazole-bridged aryl adamantane analogs as an intriguing class of multifunctional agents for treatment of Alzheimer's disease.
Indian Institute of Technology (Banaras Hindu University)
Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists.
University Paris Descartes
Identification and characterization of 4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an orally bioavailable, brain penetrant NR2B selective N-methyl-D-aspartate receptor antagonist.
Merck Research Laboratories
Benzomorphan skeleton, a versatile scaffold for different targets: A comprehensive review.
University of Catania
Recent developments on synthesis and biological activities of γ-carboline.
Northwest A&F University
Design and synthesis of 6-methylpyridin-2-one derivatives as novel and potent GluN2A positive allosteric modulators for the treatment of cognitive impairment.
Takeda Pharmaceutical
Inhibition of Histone Deacetylase 6 (HDAC6) as a therapeutic strategy for Alzheimer's disease: A review (2010-2020).
Nanjing University of Chinese Medicine
Discovery of Pyrazolo[1,5-a]pyrazin-4-ones as Potent and Brain Penetrant GluN2A-Selective Positive Allosteric Modulators Reducing AMPA Receptor Binding Activity.
Takeda Pharmaceutical
Advancements in the development of multi-target directed ligands for the treatment of Alzheimer's disease.
Central University of Punjab
Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities.
Central South University
1-Benzyloxy-4,5-dihydro-1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists.
F. Hoffmann-La Roche
Orally efficacious NR2B-selective NMDA receptor antagonists.
Merck Research Laboratories
Discovery of (R)-1-[2-hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol: a novel NR1/2B subtype selective NMDA receptor antagonist.
F. Hoffmann-La Roche
Parallel synthesis of a series of subtype-selective NMDA receptor antagonists.
Parke-Davis Pharmaceutical Research
Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases.
Palack£
Ketamine esters and amides as short-acting anaesthetics: Structure-activity relationships for the side-chain.
University of Auckland
Advancement of multi-target drug discoveries and promising applications in the field of Alzheimer's disease.
Jining Medical University
Multi-target design strategies for the improved treatment of Alzheimer's disease.
China Pharmaceutical University
Improving the inhibitory activity of arylidenaminoguanidine compounds at the N-methyl-D-aspartate receptor complex from a recursive computational-experimental structure-activity relationship study.
University of Kentucky
SPIROCYCLIC MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION
Genentech
DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO
Arena Pharmaceuticals
2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors
Ideaya Bioscience
Isoxazole compounds as inhibitors of heat shock proteins
The Institute of Cancer Research
Synthesis and carbonic anhydrase inhibitory properties of novel 1,4-dihydropyrimidinone substituted diarylureas.
Sakarya University
The efficient expression of human fibroblast collagenase in Escherichia coli and the discovery of flavonoid inhibitors.
East China University of Science and Technology
2-amino 6-(difluoromethyl)-5,5-difluoro-6-phenyl-3,4,5,6-tetrahydropyridines as BACE1 inhibitors
H. Lundbeck