48 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
Organization
35
Discovery of potent and orally bioavailable inhibitors of Human Uric Acid Transporter 1 (hURAT1) and binding mode prediction using homology model.
Shanghai Hengrui Pharmaceutical
4
Morin (3,5,7,2',4'-pentahydroxyflavone) exhibits potent inhibitory actions on urate transport by the human urate anion transporter (hURAT1) expressed in human embryonic kidney cells.
The Chinese University of Hong Kong
24
Developing potent human uric acid transporter 1 (hURAT1) inhibitors.
University of Colorado Anschutz Medical Campus
17
Design, synthesis and biological evaluation of 2-[1-(pyridin-2-ylmethyl)-1H-pyrazole-3-carboxamido]benzoic acids as promising urate transporter 1 inhibitors with potential nephroprotective efficacy for the treatment of hyperuricemic nephropathy.
Shenyang Pharmaceutical University
20
Identification of N-phenyl-N-(quinolin-4-yl) amino carboxylic acids as URAT1 inhibitors with hypouricemic effects.
Peking Union Medical College
29
Recent Progress and Future Perspectives on Anti-Hyperuricemic Agents.
Southern Medical University
31
Design, synthesis and bioactivity evaluation of isobavachin derivatives as hURAT1 inhibitors for hyperuricemia agents.
Southern Medical University
22
Discovery of a Potent and Orally Bioavailable Xanthine Oxidase/Urate Transporter 1 Dual Inhibitor as a Potential Treatment for Hyperuricemia and Gout.
HEC Research and Development Center
9
Discovery of a Novel Thienopyrimidine Compound as a Urate Transporter 1 and Glucose Transporter 9 Dual Inhibitor with Improved Efficacy and Favorable Druggability.
Shandong University
32
Design, synthesis, and biological evaluation of 3-phenyl substituted pyridine derivatives as potential dual inhibitors of XOR and URAT1.
South China University of Technology
15
Proline-derived quinoline formamide compounds as human urate transporter 1 inhibitors with potent uric acid-lowering activities.
Peking Union Medical College
19
Agents for the Treatment of Gout: Current Advances and Future Perspectives.
Shenyang Pharmaceutical University
5
Discovery and Characterization of Moracin C as an Anti-Gouty Arthritis/Hyperuricemia Candidate by Docking-Based Virtual Screening and Pharmacological Evaluation.
Southern Medical University
80
Past, present and future of xanthine oxidase inhibitors: design strategies, structural and pharmacological insights, patents and clinical trials.
Guru Nanak Dev University
23
Discovery of novel benzbromarone analogs with improved pharmacokinetics and benign toxicity profiles as antihyperuricemic agents.
Southern Medical University
33
Design, synthesis and activity evaluation of novel lesinurad analogues containing thienopyrimidinone or pyridine substructure as human urate transporter 1 inhibitors.
Shandong University
14
Discovery of Novel Bicyclic Imidazolopyridine-Containing Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Improved Efficacy and Favorable Druggability.
Shandong University
37
Discovery of novel verinurad analogs as dual inhibitors of URAT1 and GLUT9 with improved Druggability for the treatment of hyperuricemia.
Southern Medical University
26
Discovery of Dotinurad (FYU-981), a New Phenol Derivative with Highly Potent Uric Acid Lowering Activity.
Fuji Yakuhin
11
Novel Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Favorable Druggability.
Shandong University
17
Pharmacological urate-lowering approaches in chronic kidney disease.
West China Hospital of Sichuan University
21
Synthesis, biological evaluation and 3D-QSAR studies of 1,2,4-triazole-5-substituted carboxylic acid bioisosteres as uric acid transporter 1 (URAT1) inhibitors for the treatment of hyperuricemia associated with gout.
Tianjin Medical University
27
Synthesis and evaluation of sulfonamide derivatives as potent Human Uric Acid Transporter 1 (hURAT1) inhibitors.
Chinese Academy of Sciences
4
SERIES OF PIPERIDINE-SUBSTITUTED BENZOIC ACID COMPOUNDS, AND USE THEREOF
Medshine Discovery
155
Compounds and methods for modulating interleukin-2-inducible t-cell kinase
Corvus Pharmaceuticals
2
Crystal of DPP-IV long-acting inhibitor and salt
Chia Tai Tianqing Pharmaceutical Group
9
Chromone containing sulfonamides as potent carbonic anhydrase inhibitors.
Ondokuz Mayis University
25
Polyphenol fatty acid esters as serine protease inhibitors: a quantum-chemical QSAR analysis.
Slovak University of Technology
10
Compounds having activating effect on subtypes of peroxisome proliferator-activated receptors and its preparation method and uses
Zhejiang Hisun Pharmaceutical
5
First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib.
University of Manchester
1
Small-Molecule Chemical Probe Rescues Cells from Mono-ADP-Ribosyltransferase ARTD10/PARP10-Induced Apoptosis and Sensitizes Cancer Cells to DNA Damage.
University of Oulu
15
Development of 2-(Substituted Benzylamino)-4-Methyl-1, 3-Thiazole-5-Carboxylic Acid Derivatives as Xanthine Oxidase Inhibitors and Free Radical Scavengers.
Jamia Hamdard
8
Non-ATP dependent inhibitors of extracellular signal-regulated kinase (ERK)
University of Maryland, Baltimore
27
Benzimidazole derivatives as new a-glucosidase inhibitors and in silico studies.
Universiti Teknologi Mara (Uitm)
8
In vitro binding properties in rat brain of [3H]Ro 25-6981, a potent and selective antagonist of NMDA receptors containing NR2B subunits.
F. Hoffmann-La Roche
39
A binding site model and structure-activity relationships for the rat A3 adenosine receptor.
National Institute of Diabetes, Digestive and Kidney Diseases