BDBM22165 1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine::CHEMBL153260::CHEMBL281594::CHEMBL542933::CHEMBL543876::GBR 12909::GBR-12909::NCGC00015300::US9944618, Compound ID No. 175::Vanoxerine
SMILES Fc1ccc(cc1)C(OCCN1CCN(CCCc2ccccc2)CC1)c1ccc(F)cc1
InChI Key InChIKey=NAUWTFJOPJWYOT-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 92 hits for monomerid = 22165
Affinity DataIC50: 496nMAssay Description:Binding affinity towards norepinephrine transporter in rat striatum using [3H]nisoxetine as radioligandMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
Affinity DataIC50: 132nMAssay Description:Binding affinity towards serotonin transporter in rat striatum using [3H]citalopram as radioligandMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International
Curated by ChEMBL
Research Biochemicals International
Curated by ChEMBL
Affinity DataIC50: 6.63nMAssay Description:Inhibition of uptake from dopamine transporter in rat striatum using [3H]DA as radioligandMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International
Curated by ChEMBL
Research Biochemicals International
Curated by ChEMBL
Affinity DataIC50: 10.6nMAssay Description:Binding affinity towards dopamine transporter in rat striatum using [3H]WIN-35 428 as radioligandMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International
Curated by ChEMBL
Research Biochemicals International
Curated by ChEMBL
Affinity DataIC50: 10.6nMAssay Description:Inhibition of [3H]WIN-35428 binding to dopamine transporter of rat striatumMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
Affinity DataIC50: 132nMAssay Description:Inhibition of [3H]citalopram binding to serotonin transporter of rat cerebral cortexMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International
Curated by ChEMBL
Research Biochemicals International
Curated by ChEMBL
Affinity DataIC50: 0.430nMAssay Description:Displacement of [125I]RTI-55 dopamine transporter binding in rat striatal membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 496nMAssay Description:Inhibition of [3H]nisoxetine binding to norepinephrine transporter of rat cerebral cortexMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto
Curated by PDSP Ki Database
University of Toronto
Curated by PDSP Ki Database
Affinity DataIC50: 190nMAssay Description:Inhibition of human DAT expressed in HEK293 cells assessed as inhibition of dopamine reuptake after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.46E+3nMAssay Description:Inhibition of human NET expressed in HEK293 cells assessed as inhibition of noradrenaline reuptake after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.84E+3nMAssay Description:Inhibition of human SERT expressed in HEK293 cells assessed as inhibition of serotonin reuptake after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:The compound was tested for affinity towards sigma-3 receptorMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto
Curated by PDSP Ki Database
University of Toronto
Curated by PDSP Ki Database
Affinity DataIC50: 7.20nMAssay Description:Inhibition of human dopamine transporterMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International
Curated by ChEMBL
Research Biochemicals International
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inhibition of [3H]GBR-12935 binding to the dopamine transporter.More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International
Curated by ChEMBL
Research Biochemicals International
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of [125I]RTI-55 cocaine binding to the dopamine transporter.More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International
Curated by ChEMBL
Research Biochemicals International
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of dopamine uptake at dopamine transporter.More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International
Curated by ChEMBL
Research Biochemicals International
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibition of [3H]cocaine binding to the dopamine transporter.More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International
Curated by ChEMBL
Research Biochemicals International
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of [3H]GBR-12935 binding to the dopamine transporter.More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International
Curated by ChEMBL
Research Biochemicals International
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of [3H]BTCP binding to the dopamine transporter.More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto
Curated by PDSP Ki Database
University of Toronto
Curated by PDSP Ki Database
Affinity DataIC50: 43nMAssay Description:Inhibition of [3H]-5-dopamine reuptake in human DAT expressed in HEK293 cells by microbeta liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of [3H]-5-norepinephrine reuptake in human NET expressed in HEK293 cells by microbeta liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Mayo Foundation
US Patent
Mayo Foundation
US Patent
Affinity DataIC50: 470nMAssay Description:HERG: The pre- and post-compound hERG current was evoked by a single voltage pulse consisting of a 20 s period holding at −70 mV, a 160 ms step...More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto
Curated by PDSP Ki Database
University of Toronto
Curated by PDSP Ki Database
Affinity DataIC50: 0.710nMAssay Description:Displacement of [125I]RTI-55 from recombinant human DAT expressed in CHOK1 cells after 3 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of re-uptake of [3H]-NE at human NET expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto
Curated by PDSP Ki Database
University of Toronto
Curated by PDSP Ki Database
Affinity DataIC50: 40nMAssay Description:Inhibition of re-uptake of [3H]-DA at human DAT expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto
Curated by PDSP Ki Database
University of Toronto
Curated by PDSP Ki Database
Affinity DataIC50: 14nMAssay Description:Displacement of [3H]Win35428 from human recombinant DAT over-expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto
Curated by PDSP Ki Database
University of Toronto
Curated by PDSP Ki Database
Affinity DataIC50: 2nMAssay Description:Inhibition of dopamine transporter (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 8.00E+3nMT: 2°CAssay Description:Briefly, 3 uL of enzyme (approximately 20 nM LoxA, final concentration) or buffer (no-enzyme control) was dispensed into 1536-well Greiner black clea...More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International
Curated by ChEMBL
Research Biochemicals International
Curated by ChEMBL
Affinity DataIC50: 4.30nMAssay Description:Inhibition of dopamine DA reuptakeMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International
Curated by ChEMBL
Research Biochemicals International
Curated by ChEMBL
Affinity DataIC50: 2.60nMAssay Description:Binding affinity was determined at the dopamine transporter labeled with radioligand [125 I] RTI-55 in nonstandard conditionsMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International
Curated by ChEMBL
Research Biochemicals International
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Reuptake inhibition was determined at the dopamine transporter labeled with radioligand [3H]-dopamine in nonstandard conditions on brain membranes ob...More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International
Curated by ChEMBL
Research Biochemicals International
Curated by ChEMBL
Affinity DataIC50: 7.30nMAssay Description:Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]-dopamine on synaptosomes obtained from rat caudate.More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International
Curated by ChEMBL
Research Biochemicals International
Curated by ChEMBL
Affinity DataIC50: 3.70nMAssay Description:Binding affinity was determined at the dopamine transporter labeled with radioligand [125 I] RTI-55More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto
Curated by PDSP Ki Database
University of Toronto
Curated by PDSP Ki Database
Affinity DataIC50: 43nMAssay Description:Affinity of the compound was evaluated using [3H]-WIN- 35,428 (radioligand) on Cloned human Dopamine transporter expressed in HEK cellsMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International
Curated by ChEMBL
Research Biochemicals International
Curated by ChEMBL
Affinity DataIC50: 2.30nMAssay Description:Inhibition of Dopamine uptake in male Sprague-Dawley rats using [3H]DA ligandMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
Affinity DataIC50: 82nMAssay Description:Binding affinity at serotonin transporter from rat brain striatal membrane by [3H]-citalopram displacement.More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International
Curated by ChEMBL
Research Biochemicals International
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Binding affinity at dopamine transporter from rat striatal membrane tissue by [3H]-CFT displacement.More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International
Curated by ChEMBL
Research Biochemicals International
Curated by ChEMBL
Affinity DataIC50: 73nMAssay Description:Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]-5-HT on synaptosomes obtained from whole rat brain minus cerebellum.More data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:Sigma receptor binding was determined by labeling with radioligand [3H]-(+)-pentazocine on frozen membranes obtained from frozen guinea pig brainMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
Affinity DataIC50: 126nMAssay Description:Binding affinity was determined at the Serotonin transporter labeled with radioligand [125 I] RTI-55More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
Affinity DataIC50: 82nMAssay Description:In vitro inhibition of [3H]-citalopram binding to serotonin transporter on rat striatal membranes.More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International
Curated by ChEMBL
Research Biochemicals International
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:In vitro inhibition of [3H]-WIN- 35, 428 binding to dopamine transporter on rat striatal membranes.More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
Affinity DataIC50: 86.6nMAssay Description:Inhibitory activity against serotonin transporter (SERT) labeled with [3H]-citalopram in rat brain striatal membrane.More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International
Curated by ChEMBL
Research Biochemicals International
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibitory activity against dopamine transporter (DAT) labeled with [3H]-WIN- 35,428 in rat brain striatal membrane.More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International
Curated by ChEMBL
Research Biochemicals International
Curated by ChEMBL
Affinity DataIC50: 19.3nMAssay Description:IC50 value of the compound was evaluated using [3H]-WIN- 35,428 (radioligand) on Dopamine transporter in rat striatum.More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
Affinity DataIC50: 87nMAssay Description:IC50 value of the compound was evaluated using [3H]-citalopram (radioligand) on serotonin transporter in rat striatum.More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto
Curated by PDSP Ki Database
University of Toronto
Curated by PDSP Ki Database
Affinity DataIC50: 26nMAssay Description:Affinity of the compound was evaluated using [3H]-DA (radioligand) on Cloned human Dopamine transporter expressed in HEK cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 741nMAssay Description:Affinity of the compound was evaluated using [3H]-citalopram (radioligand) on human serotonin transporter expressed in HEK cellsMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International
Curated by ChEMBL
Research Biochemicals International
Curated by ChEMBL
Affinity DataIC50: 4.30nMAssay Description:Compound was tested for its ability to inhibit the uptake of [3H]-dopamine in DAT (dopamine transporter system) expressing cell lineMore data for this Ligand-Target Pair