Compile Data Set for Download or QSAR
Report error Found 8147 Enz. Inhib. hit(s) with Target = 'Bcl-2-like protein 1'
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM209097(US9266877, 43)
Affinity DataKi:  0.00800nMAssay Description:Inhibition of F-Bak (GQVGRQLAIIGDK(6-FAM)INR-amide probe binding to BCL-xl (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50030752(CHEMBL3342333)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50162797(CHEMBL3793424)
Affinity DataKi: <0.0100nMAssay Description:Inhibition of F-Bak (GQVGRQLAIIGDK(6-FAM)INR-amide probe binding to BCL-xl (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50561528(CHEMBL4762875)
Affinity DataKi: <0.0100nMAssay Description:Inhibition of F-Bak (GQVGRQLAIIGDK(6-FAM)INR-amide probe binding to BCL-xl (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50030759(CHEMBL3342194)
Affinity DataKi: <0.0100nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50162797(CHEMBL3793424)
Affinity DataKi: <0.0100nMAssay Description:Inhibition of Bcl-xL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50030758(CHEMBL3342195)
Affinity DataKi: <0.0100nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50030757(CHEMBL3342196)
Affinity DataKi: <0.0100nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50162797(CHEMBL3793424)
Affinity DataKi: <0.0100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50030754(CHEMBL3342332)
Affinity DataKi: <0.0100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50030754(CHEMBL3342332)
Affinity DataKi: <0.0100nMAssay Description:Binding affinity to Bcl-XL (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2017
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50030754(CHEMBL3342332)
Affinity DataKi: <0.0100nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50162797(CHEMBL3793424)
Affinity DataKi: <0.0100nMAssay Description:Binding affinity to Bcl-XL (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2017
Entry Details Article
PubMed
LigandPNGBDBM605286(US11667652, Example 81)
Affinity DataIC50: 0.0110nMAssay Description:Inhibition of the MCL1 and Bim interaction was measured in the following AlphaLISA assay.Recombinant human MCL1 protein (C-terminal 6×His Tagged MCL1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2023
Entry Details
US Patent

LigandPNGBDBM542562((1S,3′R,6′R,7′S,8′E,15R...)
Affinity DataKi:  0.0140nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
US Patent

LigandPNGBDBM449620(US10703733, Example 233 | US10988451, Example 233)
Affinity DataIC50: 0.0160nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
US Patent

LigandPNGBDBM449685(US10703733, Example 298 | US11643400, Example 298)
Affinity DataIC50: 0.0160nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
US Patent

LigandPNGBDBM449685(US10703733, Example 298 | US11643400, Example 298)
Affinity DataIC50: 0.0160nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
US Patent

LigandPNGBDBM602144(US11643400, Example 233)
Affinity DataIC50: 0.0160nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
US Patent

LigandPNGBDBM602151(US11643400, Example 240)
Affinity DataIC50: 0.0180nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
US Patent

LigandPNGBDBM449659(US10703733, Example 272 | US10988451, Example 272 ...)
Affinity DataIC50: 0.0180nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
US Patent

LigandPNGBDBM449627(US10703733, Example 240 | US10988451, Example 240)
Affinity DataIC50: 0.0180nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
US Patent

LigandPNGBDBM449659(US10703733, Example 272 | US10988451, Example 272 ...)
Affinity DataIC50: 0.0180nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
US Patent

LigandPNGBDBM449730(US10703733, Example 343 | US10988451, Example 343 ...)
Affinity DataIC50: 0.0190nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
US Patent

LigandPNGBDBM449730(US10703733, Example 343 | US10988451, Example 343 ...)
Affinity DataIC50: 0.0190nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
US Patent

LigandPNGBDBM605237(US11667652, Example 33)
Affinity DataIC50: 0.0190nMAssay Description:Inhibition of the MCL1 and Bim interaction was measured in the following AlphaLISA assay.Recombinant human MCL1 protein (C-terminal 6×His Tagged MCL1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2023
Entry Details
US Patent

LigandPNGBDBM605397(US11667652, Example 191)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of the MCL1 and Bim interaction was measured in the following AlphaLISA assay.Recombinant human MCL1 protein (C-terminal 6×His Tagged MCL1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2023
Entry Details
US Patent

LigandPNGBDBM449679(US10703733, Example 292 | US11643400, Example 292)
Affinity DataIC50: 0.0200nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
US Patent

TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50030756(CHEMBL3342197)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
LigandPNGBDBM449679(US10703733, Example 292 | US11643400, Example 292)
Affinity DataIC50: 0.0200nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
US Patent

LigandPNGBDBM542561((1S,3′R,6′R,7′S,8′E,15R...)
Affinity DataKi:  0.0210nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
US Patent

LigandPNGBDBM449559(US10703733, Example 172 | US10988451, Example 172 ...)
Affinity DataIC50: 0.0220nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
US Patent

LigandPNGBDBM449559(US10703733, Example 172 | US10988451, Example 172 ...)
Affinity DataIC50: 0.0220nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
US Patent

LigandPNGBDBM449698(US10703733, Example 311 | US10988451, Example 311 ...)
Affinity DataIC50: 0.0240nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
US Patent

LigandPNGBDBM449749(US10703733, Example 362 | US10988451, Example 362 ...)
Affinity DataIC50: 0.0240nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
US Patent

LigandPNGBDBM449698(US10703733, Example 311 | US10988451, Example 311 ...)
Affinity DataIC50: 0.0240nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
US Patent

LigandPNGBDBM449749(US10703733, Example 362 | US10988451, Example 362 ...)
Affinity DataIC50: 0.0240nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
US Patent

LigandPNGBDBM449548(US10703733, Example 161 | US10988451, Example 161 ...)
Affinity DataIC50: 0.0250nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
US Patent

LigandPNGBDBM449548(US10703733, Example 161 | US10988451, Example 161 ...)
Affinity DataIC50: 0.0250nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
US Patent

LigandPNGBDBM449736(US10703733, Example 349 | US10988451, Example 349 ...)
Affinity DataIC50: 0.0260nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
US Patent

LigandPNGBDBM449687(US10703733, Example 300 | US10988451, Example 300 ...)
Affinity DataIC50: 0.0260nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
US Patent

LigandPNGBDBM449687(US10703733, Example 300 | US10988451, Example 300 ...)
Affinity DataIC50: 0.0260nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
US Patent

LigandPNGBDBM471418(US10821115, Example 100433 | US11224601, Example 1...)
Affinity DataIC50: 0.0260nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandPNGBDBM605307(US11667652, Example 102 | US11667652, Example 111)
Affinity DataIC50: 0.0260nMAssay Description:Inhibition of the MCL1 and Bim interaction was measured in the following AlphaLISA assay.Recombinant human MCL1 protein (C-terminal 6×His Tagged MCL1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2023
Entry Details
US Patent

LigandPNGBDBM605306(US11667652, Example 101)
Affinity DataIC50: 0.0260nMAssay Description:Inhibition of the MCL1 and Bim interaction was measured in the following AlphaLISA assay.Recombinant human MCL1 protein (C-terminal 6×His Tagged MCL1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2023
Entry Details
US Patent

LigandPNGBDBM449736(US10703733, Example 349 | US10988451, Example 349 ...)
Affinity DataIC50: 0.0260nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
US Patent

LigandPNGBDBM605229(US11667652, Example 24)
Affinity DataIC50: 0.0260nMAssay Description:Inhibition of the MCL1 and Bim interaction was measured in the following AlphaLISA assay.Recombinant human MCL1 protein (C-terminal 6×His Tagged MCL1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2023
Entry Details
US Patent

LigandPNGBDBM602141(US11643400, Example 230)
Affinity DataIC50: 0.0270nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
US Patent

LigandPNGBDBM449617(US10703733, Example 230 | US10988451, Example 230)
Affinity DataIC50: 0.0270nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
US Patent

LigandPNGBDBM605358(US11667652, Example 152)
Affinity DataIC50: 0.0270nMAssay Description:Inhibition of the MCL1 and Bim interaction was measured in the following AlphaLISA assay.Recombinant human MCL1 protein (C-terminal 6×His Tagged MCL1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2023
Entry Details
US Patent

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