Compile Data Set for Download or QSAR
Report error Found 90 Enz. Inhib. hit(s) with Target = 'Carnitine O-palmitoyltransferase 1, liver isoform'
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  1.40nMAssay Description:Binding affinity to human CPT1A incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50403039(CHEMBL2216778)
Affinity DataIC50: 16nMAssay Description:Inhibition of human CPT1AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50403037(CHEMBL2216774)
Affinity DataIC50: 20nMAssay Description:Inhibition of human CPT1AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50024430((R) (R) -2-Tetradecyl-oxirane-2-carboxylic acid-Co...)
Affinity DataIC50: 20nMAssay Description:Inhibition of carnitine palmitoyl transferase (CPT), assessed with isolated rat liver mitochondriaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50403040(CHEMBL2216779)
Affinity DataIC50: 21nMAssay Description:Inhibition of human CPT1AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50403041(CHEMBL2216776)
Affinity DataIC50: 26nMAssay Description:Inhibition of human CPT1AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50024434((+/-) 2-Tetradecyl-oxirane-2-carboxylic acid-Coenz...)
Affinity DataIC50: 30nMAssay Description:Inhibition of carnitine palmitoyl transferase (CPT), assessed with isolated rat liver mitochondriaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50024432((R)-(+)2-Tetradecyl-oxirane-2-carboxylic acid | CH...)
Affinity DataIC50: 30nMAssay Description:Inhibition of carnitine palmitoyl transferase (CPT), assessed with isolated rat liver mitochondriaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50024431((+/-)2-Tetradecyl-oxirane-2-carboxylic acid | 2-Te...)
Affinity DataIC50: 40nMAssay Description:Inhibition of carnitine palmitoyl transferase (CPT), assessed with isolated rat liver mitochondriaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50024429((R)-(+)2-Tetradecyl-oxirane-2-carboxylic acid meth...)
Affinity DataIC50: 40nMAssay Description:Inhibition of carnitine palmitoyl transferase (CPT), assessed with isolated rat liver mitochondriaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50403042(CHEMBL2216775)
Affinity DataIC50: 65nMAssay Description:Inhibition of human CPT1AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  68nMAssay Description:Binding affinity to human CPT1A incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50024433(2-Tetradecyl-oxirane-2-carboxylic acid methyl este...)
Affinity DataIC50: 90nMAssay Description:Inhibition of carnitine palmitoyl transferase (CPT), assessed with isolated rat liver mitochondriaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50403032(CHEMBL2216785)
Affinity DataIC50: 130nMAssay Description:Inhibition of CPT1A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50403038(CHEMBL2216777)
Affinity DataIC50: 160nMAssay Description:Inhibition of human CPT1AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50403043(CHEMBL2216780)
Affinity DataIC50: 190nMAssay Description:Inhibition of human CPT1AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50403028(CHEMBL2216769)
Affinity DataIC50: 240nMAssay Description:Inhibition of CPT1AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50403030(CHEMBL2216768)
Affinity DataIC50: 250nMAssay Description:Inhibition of CPT1AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50122836([3-Carboxy-2-(3-tetradecyl-ureido)-propyl]-trimeth...)
Affinity DataKi:  360nMAssay Description:Inhibition of rat liver carnitine palmitoyltransferase IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50122839([3-Carboxy-2-(3-tetradecyl-ureido)-propyl]-trimeth...)
Affinity DataKi:  360nMAssay Description:Binding affinity to CPT1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50122839([3-Carboxy-2-(3-tetradecyl-ureido)-propyl]-trimeth...)
Affinity DataIC50: 680nMAssay Description:Inhibition of CPT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50101604([3-Carboxy-2-(dodecane-1-sulfonylamino)-propyl]-tr...)
Affinity DataIC50: 700nMAssay Description:Inhibition of [14C]palmitoyl-CoA and carnitine binding to carnitine palmitoyltransferase I from rat liver mitochondriaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101598([3-Carboxy-2-(dodecane-1-sulfonylamino)-propyl]-tr...)
Affinity DataIC50: 700nMAssay Description:Inhibition of rat liver mitochondrial carnitine palmitoyltransferase 1 using [14C]palmitoyl-CoA radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50403029(CHEMBL2216792)
Affinity DataIC50: 700nMAssay Description:Inhibition of rat CPT1A expressed in intact Saccharomyces cerevisiae using [methyl-3H]carnitine by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50101591([3-Carboxy-2-(undecylaminosulphonyl-amino)-propyl]...)
Affinity DataIC50: 800nMAssay Description:Inhibition of rat liver mitochondrial carnitine palmitoyltransferase 1 using [14C]palmitoyl-CoA radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101591([3-Carboxy-2-(undecylaminosulphonyl-amino)-propyl]...)
Affinity DataIC50: 800nMAssay Description:Inhibition of [14C]palmitoyl-CoA and carnitine binding to carnitine palmitoyltransferase I from rat liver mitochondriaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50122839([3-Carboxy-2-(3-tetradecyl-ureido)-propyl]-trimeth...)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of human CPT1AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50403040(CHEMBL2216779)
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of rat hepatocytes CPT1AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50240113(CHEMBL4081425)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of rat wild-type CPT1A expressed in yeast mitochondrial extracts using L-[methyl-3H]carnitine and palmitoyl-CoA as substrates preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2019
Entry Details Article
PubMed
LigandPNGBDBM50122839([3-Carboxy-2-(3-tetradecyl-ureido)-propyl]-trimeth...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of [14C]palmitoyl-CoA and carnitine binding to carnitine palmitoyltransferase I from rat liver mitochondriaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50403039(CHEMBL2216778)
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of rat hepatocytes CPT1AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50101594([3-Carboxy-2-(decane-1-sulfonylamino)-propyl]-trim...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of rat liver mitochondrial carnitine palmitoyltransferase 1 using [14C]palmitoyl-CoA radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50403032(CHEMBL2216785)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human CPT1AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50122834([3-Carboxy-2-(3-dodecyl-ureido)-propyl]-trimethyl-...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of [14C]palmitoyl-CoA and carnitine binding to carnitine palmitoyltransferase I from rat liver mitochondriaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101589([3-Carboxy-2-(nonylaminosulphonyl-amino)-propyl]-t...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of rat liver mitochondrial carnitine palmitoyltransferase 1 using [14C]palmitoyl-CoA radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50403031(CHEMBL2216771)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human CPT1AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50403033(CHEMBL1231507)
Affinity DataIC50: 2.67E+3nMAssay Description:Inhibition of human CPT1AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50639700(CHEMBL5561479)
Affinity DataKi:  2.80E+3nMAssay Description:Binding affinity to rat heart mitochondria CPT1 assessed as inhibition constant incubated for 3 to 6 mins by Liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50403044(CHEMBL179241)
Affinity DataEC50:  3.00E+3nMAssay Description:Increase in CPT1 activity in human MCF7 cells assessed as increase in radiolabeled palmitoylcarnitineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50403044(CHEMBL179241)
Affinity DataEC50:  3.00E+3nMAssay Description:Activation of CPT-1 in digitonin-permeabilized human MCF7 cells preincubated for 2 hrs followed by digitonin addition for 6 mins by liquid scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM50122828([3-Carboxy-2-(3-undecyl-ureido)-propyl]-trimethyl-...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of [14C]palmitoyl-CoA and carnitine binding to carnitine palmitoyltransferase I from rat liver mitochondriaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50033117([3-Carboxy-2-(hydroxy-tetradecyloxy-phosphoryloxy)...)
Affinity DataKi:  3.60E+3nMAssay Description:In vitro inhibition of carnitine palmitoyltransferase I with respect to palmitoyl CoA in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50046145(2-[6-hydroxy-4,4-dimethyl-6-pentadecyl-(2R,6S)-1,4...)
Affinity DataKi:  4.20E+3nMAssay Description:Compound was evaluated for its ability to inhibit carnitine palmitoyltransferase I activity in intact mitochondria from rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50639700(CHEMBL5561479)
Affinity DataKi:  4.20E+3nMAssay Description:Binding affinity to rat liver mitochondria CPT1 assessed as inhibition constant incubated for 3 to 6 mins by Liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50101604([3-Carboxy-2-(dodecane-1-sulfonylamino)-propyl]-tr...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of rat liver mitochondrial carnitine palmitoyltransferase 1 using [14C]palmitoyl-CoA radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101600([3-Carboxy-2-(undecylaminosulphonyl-amino)-propyl]...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of [14C]palmitoyl-CoA and carnitine binding to carnitine palmitoyltransferase I from rat liver mitochondriaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101598([3-Carboxy-2-(dodecane-1-sulfonylamino)-propyl]-tr...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of [14C]palmitoyl-CoA and carnitine binding to carnitine palmitoyltransferase I from rat liver mitochondriaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101600([3-Carboxy-2-(undecylaminosulphonyl-amino)-propyl]...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of rat liver mitochondrial carnitine palmitoyltransferase 1 using [14C]palmitoyl-CoA radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50122833((3-Carboxy-2-octyloxycarbonylamino-propyl)-trimeth...)
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of [14C]palmitoyl-CoA and carnitine binding to carnitine palmitoyltransferase I from rat liver mitochondriaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50403046(CHEMBL2216772)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat CPT1AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
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