Compile Data Set for Download or QSAR
Report error Found 165 Enz. Inhib. hit(s) with Target = 'High affinity choline transporter 1'
TargetHigh affinity choline transporter 1(Rat)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50323515BDBM50323515(Hemicholinium | CHEMBL1209714)
Affinity DataKi:  10nMAssay Description:Binding affinity to rat choline transporter 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Rat)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 85206BDBM85206(CAS_312-45-8 | NSC_9399 | Hemicholinium-3)
Affinity DataIC50: 12nMAssay Description:Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 87576BDBM87576(SMR000658847 | MLS001100779 | cid_24793407 | N-[(3...)
Affinity DataIC50: 18.9nMAssay Description:Data Source (MLPCN Center Name): Johns Hopkins Ion Channel Center (JHICC) Center Affiliation: Johns Hopkins University, School of Medicine Screening ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2012
Entry Details
PCBioAssay
TargetHigh affinity choline transporter 1(Mouse)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50416502BDBM50416502(CHEMBL1209654)
Affinity DataKi:  20.0nMAssay Description:Inhibition of [3H]choline uptake at choline transporter 1 in mouse brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Mouse)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50416489BDBM50416489(CHEMBL1209507)
Affinity DataKi:  50nMAssay Description:Inhibition of [3H]choline uptake at choline transporter 1 in mouse brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50451447BDBM50451447(CHEMBL4217988)
Affinity DataKi:  68nMAssay Description:Displacement of [3H]hemicholinium-3 from recombinant human choline transporter after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50067207BDBM50067207(CHEMBL3304438)
Affinity DataIC50: 72nMAssay Description:Inhibition of [3H]choline uptake at human choline transporter expressed in HEK293 cells preincubated for 15 mins followed by [3H]choline addition mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50067207BDBM50067207(CHEMBL3304438)
Affinity DataIC50: 90nMAssay Description:Inhibition of human CHT Leu530Ala and Val531Ala mutant expressed in HEK293 cells assessed as remaining transporter activity in presence of 10 uM [3H]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHigh affinity choline transporter 1(Mouse)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50416490BDBM50416490(CHEMBL1209508)
Affinity DataKi:  90.0nMAssay Description:Inhibition of [3H]choline uptake at choline transporter 1 in mouse brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50067202BDBM50067202(CHEMBL1872483)
Affinity DataIC50: 100nMAssay Description:Inhibition of human CHT Leu530Ala and Val531Ala mutant expressed in HEK293 cells assessed as remaining transporter activity in presence of 10 uM [3H]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50451447BDBM50451447(CHEMBL4217988)
Affinity DataIC50: 120nMAssay Description:Displacement of [3H]hemicholinium-3 from recombinant human choline transporter after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Mouse)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50416491BDBM50416491(CHEMBL1209577)
Affinity DataKi:  180nMAssay Description:Inhibition of [3H]choline uptake at choline transporter 1 in mouse brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Mouse)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50416508BDBM50416508(CHEMBL1209578)
Affinity DataKi:  200nMAssay Description:Inhibition of [3H]choline uptake at choline transporter 1 in mouse brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Mouse)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50416504BDBM50416504(CHEMBL1209579)
Affinity DataKi:  230nMAssay Description:Inhibition of [3H]choline uptake at choline transporter 1 in mouse brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50067202BDBM50067202(CHEMBL1872483)
Affinity DataIC50: 240nMAssay Description:Inhibition of human CHT Leu530Ala and Val531Ala mutant expressed in HEK293 cells assessed as remaining transporter activity in presence of 100 nM [3H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50067207BDBM50067207(CHEMBL3304438)
Affinity DataIC50: 270nMAssay Description:Inhibition of human CHT Leu530Ala and Val531Ala mutant expressed in HEK293 cells assessed as remaining transporter activity in presence of 100 nM [3H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50196412BDBM50196412(CHEMBL3933906)
Affinity DataIC50: 270nMAssay Description:Inhibition of [3H]choline uptake at human choline transporter expressed in HEK293 cells preincubated for 15 mins followed by [3H]choline addition mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2018
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 87575BDBM87575(N-[(4,5-dimethyl-1,3-thiazol-2-yl)methyl]-4-methox...)
Affinity DataIC50: 303nMAssay Description:Data Source (MLPCN Center Name): Johns Hopkins Ion Channel Center (JHICC) Center Affiliation: Johns Hopkins University, School of Medicine Screening ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2012
Entry Details
PCBioAssay
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 87579BDBM87579(cid_1744440 | N-[4-[(2,6-dimethylpyrimidin-4-yl)su...)
Affinity DataIC50: 447nMAssay Description:Data Source (MLPCN Center Name): Johns Hopkins Ion Channel Center (JHICC) Center Affiliation: Johns Hopkins University, School of Medicine Screening ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2012
Entry Details
PCBioAssay
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50196416BDBM50196416(CHEMBL3899143)
Affinity DataIC50: 467nMAssay Description:Inhibition of [3H]choline uptake at human choline transporter expressed in HEK293 cells preincubated for 15 mins followed by [3H]choline addition mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2018
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Mouse)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50416506BDBM50416506(CHEMBL1209581)
Affinity DataKi:  521nMAssay Description:Inhibition of [3H]choline uptake at choline transporter 1 in mouse brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50067209BDBM50067209(CHEMBL3303792)
Affinity DataIC50: 530nMAssay Description:Inhibition of human CHT Leu530Ala and Val531Ala mutant expressed in HEK293 cells assessed as remaining transporter activity in presence of 10 uM [3H]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 87576BDBM87576(SMR000658847 | MLS001100779 | cid_24793407 | N-[(3...)
Affinity DataIC50: 600nMAssay Description:Inhibition of human CHT Leu530Ala and Val531Ala mutant expressed in HEK293 cells by membrane depolarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50196414BDBM50196414(CHEMBL3959257)
Affinity DataIC50: 640nMAssay Description:Inhibition of [3H]choline uptake at human choline transporter expressed in HEK293 cells preincubated for 15 mins followed by [3H]choline addition mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2018
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Mouse)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50416503BDBM50416503(CHEMBL1209713)
Affinity DataKi:  640nMAssay Description:Inhibition of [3H]choline uptake at choline transporter 1 in mouse brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Mouse)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50026220BDBM50026220(2-hydroxy-N,N,N-trimethylethanaminium | CHEMBL920 ...)
Affinity DataKi:  681nMAssay Description:Inhibition of [3H]choline uptake at choline transporter 1 in mouse brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHigh affinity choline transporter 1(Mouse)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50416501BDBM50416501(CHEMBL1209653)
Affinity DataKi:  701nMAssay Description:Inhibition of [3H]choline uptake at choline transporter 1 in mouse brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 87575BDBM87575(N-[(4,5-dimethyl-1,3-thiazol-2-yl)methyl]-4-methox...)
Affinity DataIC50: 760nMAssay Description:Inhibition of human CHT Leu530Ala and Val531Ala mutant expressed in HEK293 cells by membrane depolarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50067209BDBM50067209(CHEMBL3303792)
Affinity DataIC50: 760nMAssay Description:Inhibition of human CHT Leu530Ala and Val531Ala mutant expressed in HEK293 cells assessed as remaining transporter activity in presence of 100 nM [3H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 87581BDBM87581(MLS001081265 | cid_24979281 | SMR000716369 | 2,4-b...)
Affinity DataIC50: 864nMAssay Description:Data Source (MLPCN Center Name): Johns Hopkins Ion Channel Center (JHICC) Center Affiliation: Johns Hopkins University, School of Medicine Screening ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2012
Entry Details
PCBioAssay
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50067203BDBM50067203(CHEMBL3182315)
Affinity DataIC50: 910nMAssay Description:Inhibition of human CHT Leu530Ala and Val531Ala mutant expressed in HEK293 cells assessed as remaining transporter activity in presence of 10 uM [3H]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50326218BDBM50326218(N-{1-[3-(3-Oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)pr...)
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity to human choline transporter (CHT1) by radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50326219BDBM50326219(CHEMBL1242950 | CHEMBL2206334 | 4-(4-butylpiperidi...)
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity to human choline transporter (CHT1) by radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50067199BDBM50067199(CHEMBL3187862)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of human CHT Leu530Ala and Val531Ala mutant expressed in HEK293 cells assessed as remaining transporter activity in presence of 10 uM [3H]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50067208BDBM50067208(CHEMBL3303292)
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of human CHT Leu530Ala and Val531Ala mutant expressed in HEK293 cells assessed as remaining transporter activity in presence of 100 nM [3H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 87569BDBM87569(N-(1-phenylethyl)-4-{[1-(pyridin-2-ylmethyl)piperi...)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of human CHT Leu530Ala and Val531Ala mutant expressed in HEK293 cells by membrane depolarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Mouse)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50026216BDBM50026216(1-Ethyl-1-(2-hydroxy-ethyl)-aziridinium; chloride ...)
Affinity DataIC50: 1.50E+3nMAssay Description:In vitro ability to inhibit the transport of [3H]choline in to high affinity choline transport system HAChTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50067205BDBM50067205(CHEMBL3183447)
Affinity DataIC50: 1.56E+3nMAssay Description:Inhibition of human CHT Leu530Ala and Val531Ala mutant expressed in HEK293 cells assessed as remaining transporter activity in presence of 10 uM [3H]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50067203BDBM50067203(CHEMBL3182315)
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibition of human CHT Leu530Ala and Val531Ala mutant expressed in HEK293 cells assessed as remaining transporter activity in presence of 100 nM [3H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Mouse)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50026220BDBM50026220(2-hydroxy-N,N,N-trimethylethanaminium | CHEMBL920 ...)
Affinity DataIC50: 1.60E+3nMAssay Description:In vitro ability to inhibit the transport of [3H]choline in to high affinity choline transport system HAChTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50067200BDBM50067200(CHEMBL3187348)
Affinity DataIC50: 1.64E+3nMAssay Description:Inhibition of human CHT Leu530Ala and Val531Ala mutant expressed in HEK293 cells assessed as remaining transporter activity in presence of 10 uM [3H]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50067206BDBM50067206(CHEMBL3188567)
Affinity DataIC50: 1.73E+3nMAssay Description:Inhibition of human CHT Leu530Ala and Val531Ala mutant expressed in HEK293 cells assessed as remaining transporter activity in presence of 10 uM [3H]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50067210BDBM50067210(CHEMBL3303803)
Affinity DataIC50: 1.77E+3nMAssay Description:Inhibition of human CHT Leu530Ala and Val531Ala mutant expressed in HEK293 cells assessed as remaining transporter activity in presence of 10 uM [3H]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 89137BDBM89137(N-(furan-2-ylmethyl)-2-piperidin-1-yl-quinazolin-4...)
Affinity DataEC50:  1.79E+3nMAssay Description:Data Source (MLPCN Center Name): Johns Hopkins Ion Channel Center (JHICC) Center Affiliation: Johns Hopkins University, School of Medicine Screening ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2012
Entry Details
PCBioAssay
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 87569BDBM87569(N-(1-phenylethyl)-4-{[1-(pyridin-2-ylmethyl)piperi...)
Affinity DataIC50: 1.79E+3nMAssay Description:Data Source (MLPCN Center Name): Johns Hopkins Ion Channel Center (JHICC) Center Affiliation: Johns Hopkins University, School of Medicine Screening ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2012
Entry Details
PCBioAssay
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50196411BDBM50196411(CHEMBL3923550)
Affinity DataIC50: 1.84E+3nMAssay Description:Inhibition of [3H]choline uptake at human choline transporter expressed in HEK293 cells preincubated for 15 mins followed by [3H]choline addition mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2018
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50067204BDBM50067204(CHEMBL3183383)
Affinity DataIC50: 1.85E+3nMAssay Description:Inhibition of human CHT Leu530Ala and Val531Ala mutant expressed in HEK293 cells assessed as remaining transporter activity in presence of 10 uM [3H]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Mouse)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50416488BDBM50416488(CHEMBL1209506)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of [3H]choline uptake at choline transporter 1 in mouse brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 87572BDBM87572(N-(2,3-dihydro-1H-inden-1-yl)-4-methoxy-3-[(1-prop...)
Affinity DataIC50: 2.12E+3nMAssay Description:Data Source (MLPCN Center Name): Johns Hopkins Ion Channel Center (JHICC) Center Affiliation: Johns Hopkins University, School of Medicine Screening ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2012
Entry Details
PCBioAssay
TargetHigh affinity choline transporter 1(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50067205BDBM50067205(CHEMBL3183447)
Affinity DataIC50: 2.13E+3nMAssay Description:Inhibition of human CHT Leu530Ala and Val531Ala mutant expressed in HEK293 cells assessed as remaining transporter activity in presence of 100 nM [3H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
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