Compile Data Set for Download or QSAR
Report error Found 41 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK1/JAK2'
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545650BDBM50545650(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)
Affinity DataIC50: 25nMAssay Description:Inhibition of JAK1/JAK2 in human A549 assessed as reduction in IL31-induced Stat3 phosphorylation preincubated for 30 mins followed by IL31 stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50355501BDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 31nMAssay Description:Inhibition of JAK2/1 in human T cells expressing CD3 assessed as inhibition of IFNgamma-stimulated STAT1 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545650BDBM50545650(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)
Affinity DataIC50: 33nMAssay Description:Inhibition of JAK1/JAK2 in human PBMC assessed as reduction in IL6-induced Stat3 phosphorylation in CD3- CD4+ cells preincubated for 30 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50193995BDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 51nMAssay Description:Inhibition of JAK1/JAK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IL-27 induced STAT3 phosphorylation preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50193995BDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 51nMAssay Description:Inhibition of JAK1/JAK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IL-27 induced STAT3 phosphorylation preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50193995BDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 52nMAssay Description:Inhibition of JAK1/JAK2 signaling pathway in human CD14 +ve cells of whole blood assessed as reduction in IFN-gamma induced STAT1 phosphorylation pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50193995BDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 52nMAssay Description:Inhibition of JAK1/JAK2 signaling pathway in human CD14 +ve cells of whole blood assessed as reduction in IFN-gamma induced STAT1 phosphorylation pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50193995BDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 54nMAssay Description:Inhibition of JAK1/JAK2 signaling pathway in human CD3 +ve cells of whole blood assessed as reduction in IL-6 induced STAT1 phosphorylation preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50193995BDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 54nMAssay Description:Inhibition of JAK1/JAK2 signaling pathway in human CD3 +ve cells of whole blood assessed as reduction in IL-6 induced STAT1 phosphorylation preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 329924BDBM329924(US9663526, Example 7 | US10463675, Example 7 | US1...)
Affinity DataIC50: 81nMAssay Description:Inhibition of JAK1/JAK2 signaling pathway in human CD3 +ve cells of whole blood assessed as reduction in IL-6 induced STAT1 phosphorylation preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 329924BDBM329924(US9663526, Example 7 | US10463675, Example 7 | US1...)
Affinity DataIC50: 81nMAssay Description:Inhibition of JAK1/JAK2 signaling pathway in human CD3 +ve cells of whole blood assessed as reduction in IL-6 induced STAT1 phosphorylation preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 329924BDBM329924(US9663526, Example 7 | US10463675, Example 7 | US1...)
Affinity DataIC50: 86nMAssay Description:Inhibition of JAK1/JAK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IL-27 induced STAT3 phosphorylation preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 329924BDBM329924(US9663526, Example 7 | US10463675, Example 7 | US1...)
Affinity DataIC50: 86nMAssay Description:Inhibition of JAK1/JAK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IL-27 induced STAT3 phosphorylation preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 159748BDBM159748(US9035074, 2 | US10966980, Example 2)
Affinity DataIC50: 163nMAssay Description:Inhibition of JAK2/JAK1 in human whole blood assessed as reduction in IFNgamma induced STAT1 phosphorylation preincubated for 45 mins followed by IFN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50193995BDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 170nMAssay Description:Inhibition of JAK2/1 in human T cells expressing CD3 assessed as inhibition of IFNgamma-stimulated STAT1 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50193995BDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 170nMAssay Description:Inhibition of JAK1/2 in human PBMC expressing CD14 assessed as inhibition of IFNgamma-induced STAT1 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50433253BDBM50433253(CHEMBL2376143)
Affinity DataIC50: 230nMAssay Description:Inhibition of JAK2/1 in human T cells expressing CD3 assessed as inhibition of IFNgamma-stimulated STAT1 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 159748BDBM159748(US9035074, 2 | US10966980, Example 2)
Affinity DataIC50: 271nMAssay Description:Inhibition of JAK2/JAK1 in human whole blood assessed as reduction in IL-27 induced STAT3 phosphorylation preincubated for 45 mins followed by IL-27 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50426601BDBM50426601(CHEMBL2325895)
Affinity DataIC50: 290nMAssay Description:Inhibition of JAK2/1 in human T cells expressing CD3 assessed as inhibition of IFNgamma-stimulated STAT1 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 329924BDBM329924(US9663526, Example 7 | US10463675, Example 7 | US1...)
Affinity DataIC50: 298nMAssay Description:Inhibition of JAK1/JAK2 signaling pathway in human CD14 +ve cells of whole blood assessed as reduction in IFN-gamma induced STAT1 phosphorylation pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 329924BDBM329924(US9663526, Example 7 | US10463675, Example 7 | US1...)
Affinity DataIC50: 298nMAssay Description:Inhibition of JAK1/JAK2 signaling pathway in human CD14 +ve cells of whole blood assessed as reduction in IFN-gamma induced STAT1 phosphorylation pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50193995BDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 367nMAssay Description:Inhibition of JAK1/JAK2 signaling pathway in human CD3 +ve cells of whole blood assessed as reduction in IL-6 induced STAT3 phosphorylation preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50193995BDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 367nMAssay Description:Inhibition of JAK1/JAK2 signaling pathway in human CD3 +ve cells of whole blood assessed as reduction in IL-6 induced STAT3 phosphorylation preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593320BDBM50593320(IFIDANCITINIB | Ifidancitinib | Ati-502 | A-301 | ...)
Affinity DataIC50: 417nMAssay Description:Inhibition of JAK1/JAK2 signaling pathway in human U-937 cells assessed as reduction of IFN-gamma induced ICAM1 expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50433254BDBM50433254(CHEMBL2376040)
Affinity DataIC50: 490nMAssay Description:Inhibition of JAK2/1 in human T cells expressing CD3 assessed as inhibition of IFNgamma-stimulated STAT1 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50507816BDBM50507816(Bms-986165 | Deucravacitinib | US12351572, Example...)
Affinity DataIC50: 609nMAssay Description:Inhibition of JAK1/JAK2 in in human whole blood assessed as decrease in IL6-induced STAT3 phosphorylation in CD3+ T cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 329924BDBM329924(US9663526, Example 7 | US10463675, Example 7 | US1...)
Affinity DataIC50: 641nMAssay Description:Inhibition of JAK1/JAK2 signaling pathway in human CD3 +ve cells of whole blood assessed as reduction in IL-6 induced STAT3 phosphorylation preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 329924BDBM329924(US9663526, Example 7 | US10463675, Example 7 | US1...)
Affinity DataIC50: 641nMAssay Description:Inhibition of JAK1/JAK2 signaling pathway in human CD3 +ve cells of whole blood assessed as reduction in IL-6 induced STAT3 phosphorylation preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50583442BDBM50583442(CHEMBL5077096)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of JAK1/JAK2 signalling in human PBMC assessed as inhibition of IL-27 stimulated phosphorylation of STAT3 preincubated for 60 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50572395BDBM50572395(CHEMBL4864387)
Affinity DataIC50: 1.17E+3nMAssay Description:Inhibition of JAK1/JAK2 signaling pathway in human whole blood assessed as reduction in IL-27 induced STAT3 phosphorylation incubated for 60 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50433249BDBM50433249(CHEMBL2376147)
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of JAK2/1 in human T cells expressing CD3 assessed as inhibition of IFNgamma-stimulated STAT1 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 139694BDBM139694(US8895544, 4)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of JAK1/JAK2 in human whole blood assessed as inhibition of IL-6 induced STAT3 phosphorylation preincubated for 45 mins followed by Il-6 a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 305821BDBM305821(US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...)
Affinity DataIC50: 2.22E+3nMAssay Description:Inhibition of JAK1/JAK2 signaling pathway in human whole blood spiked with CD14 +ve cells assessed as reduction in IFN-gamma induced STAT1 phosphoryl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50433247BDBM50433247(CHEMBL2376149)
Affinity DataIC50: 2.61E+3nMAssay Description:Inhibition of JAK2/1 in human T cells expressing CD3 assessed as inhibition of IFNgamma-stimulated STAT1 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50433240BDBM50433240(CHEMBL2376157)
Affinity DataIC50: 2.86E+3nMAssay Description:Inhibition of JAK2/1 in human T cells expressing CD3 assessed as inhibition of IFNgamma-stimulated STAT1 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50433239BDBM50433239(CHEMBL2376158)
Affinity DataIC50: 1.29E+4nMAssay Description:Inhibition of JAK2/1 in human T cells expressing CD3 assessed as inhibition of IFNgamma-stimulated STAT1 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50433297BDBM50433297(CHEMBL2376436)
Affinity DataIC50: 1.44E+4nMAssay Description:Inhibition of JAK1/2 in human PBMC expressing CD14 assessed as inhibition of IFNgamma-induced STAT1 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50433296BDBM50433296(CHEMBL2376437)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of JAK1/2 in human PBMC expressing CD14 assessed as inhibition of IFNgamma-induced STAT1 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50433295BDBM50433295(CHEMBL2376439)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of JAK1/2 in human PBMC expressing CD14 assessed as inhibition of IFNgamma-induced STAT1 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50433244BDBM50433244(CHEMBL2376152)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of JAK2/1 in human T cells expressing CD3 assessed as inhibition of IFNgamma-stimulated STAT1 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Japan Tobacco

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50433252BDBM50433252(CHEMBL2376144)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of JAK2/1 in human T cells expressing CD3 assessed as inhibition of IFNgamma-stimulated STAT1 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed