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Found 1634 with Last Name = 'golebiowski' and Initial = 'a'
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50554340(CHEMBL4788866)
Affinity DataKi:  4.80nMAssay Description:Inhibition of full-length C-terminal his-tagged human AMCase expressed in CHO-K1 cells assessed as reduction in chitinolytic activity using 4-methylu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Mus musculus)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50554340(CHEMBL4788866)
Affinity DataKi:  5.70nMAssay Description:Inhibition of full-length C-terminal his-tagged mouse AMCase expressed in expressed in CHO-K1 cells assessed as reduction in chitinolytic activity us...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataKi:  8.5nMAssay Description:Inhibition of human Arg2 at pH 7.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50561046(CHEMBL4790798)
Affinity DataKi: <10nMAssay Description:Inhibition of human Arg2 using L-arginine as substrate after 60 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50561046(CHEMBL4790798)
Affinity DataKi: <10nMAssay Description:Inhibition of human Arg1 using L-arginine as substrate after 60 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50561045(CHEMBL4758805)
Affinity DataKi: <10nMAssay Description:Inhibition of human Arg1 using L-arginine as substrate after 60 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50561045(CHEMBL4758805)
Affinity DataKi: <10nMAssay Description:Inhibition of human Arg2 using L-arginine as substrate after 60 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Mus musculus)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50243745(CHEMBL4076989)
Affinity DataKi:  11nMAssay Description:Inhibition of mouse recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50243745(CHEMBL4076989)
Affinity DataKi:  14nMAssay Description:Inhibition of human recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitotriosidase-1(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50554340(CHEMBL4788866)
Affinity DataKi:  17nMAssay Description:Inhibition of full-length C-terminal his-tagged human recombinant CHIT1 catalytic domain (1 to 386 residues) expressed in HEK293F cells assessed as r...More data for this Ligand-Target Pair
TargetChitotriosidase-1(Mus musculus)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50554340(CHEMBL4788866)
Affinity DataKi:  26nMAssay Description:Inhibition of recombinant full-length C-terminal his-tagged mouse CHIT1 expressed in CHO-K1 cells assessed as reduction in chitinolytic activity usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50561034(CHEMBL4244287)
Affinity DataKi:  30nMAssay Description:Inhibition of human Arg2 at pH 7.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50008099(CHEMBL1234777)
Affinity DataKi:  51nMAssay Description:Inhibition of human Arg2 at pH 7.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitotriosidase-1(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50243745(CHEMBL4076989)
Affinity DataKi:  312nMAssay Description:Inhibition of human recombinant full length C-terminal His-tagged chitotriosidase expressed in CHO-K1 cells using 4-methylumbelliferyl-beta-D-N,N',N\...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50230418(CHEMBL260629 | N(gamma)-hydroxy-L-arginine | N-OME...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of human Arg2 at pH 7.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitotriosidase-1(Mus musculus)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50243745(CHEMBL4076989)
Affinity DataKi:  3.40E+3nMAssay Description:Inhibition of mouse recombinant full length C-terminal His-tagged chitotriosidase expressed in CHO-K1 cells using 4-methylumbelliferyl-beta-D-N,N',N\...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50561047(CHEMBL4764455)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human Arg1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50561047(CHEMBL4764455)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human Arg2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50474810(CHEMBL92082)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of LPS-stimulated p38-related TNF-alpha production in human peripheral blood mononuclear cells (PBMC)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50541950(CHEMBL4643001)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of full length recombinant C-terminal His-tagged human acidic mammalian chitinase expressed in CHOK1 cells assessed as reduction in chitin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50561042(CHEMBL4748950)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human Arg1 by TOGA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50474810(CHEMBL92082)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of LPS-stimulated p38-related IL1-beta production in human peripheral blood mononuclear cells (PBMC)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50561040(CHEMBL4754637)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human Arg1 by TOGA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50561053(CHEMBL4750602)
Affinity DataIC50:  1nMAssay Description:Inhibition of human Arg1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Mus musculus)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50554344(CHEMBL4756869)
Affinity DataIC50:  1nMAssay Description:Inhibition of full-length C-terminal his-tagged mouse AMCase expressed in expressed in CHO-K1 cells assessed as reduction in chitinolytic activity us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50561052(CHEMBL4755855)
Affinity DataIC50:  1nMAssay Description:Inhibition of human Arg1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50561051(CHEMBL4749434)
Affinity DataIC50:  1nMAssay Description:Inhibition of human Arg1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50561049(CHEMBL4793482)
Affinity DataIC50:  1nMAssay Description:Inhibition of human Arg1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Mus musculus)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50554342(CHEMBL4776610)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of full-length C-terminal his-tagged mouse AMCase expressed in expressed in CHO-K1 cells assessed as reduction in chitinolytic activity us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50541949(CHEMBL4635305)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of full length recombinant C-terminal His-tagged human acidic mammalian chitinase expressed in CHOK1 cells assessed as reduction in chitin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50554344(CHEMBL4756869)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of full-length C-terminal his-tagged human AMCase expressed in CHO-K1 cells assessed as reduction in chitinolytic activity using 4-methylu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50561041(CHEMBL4791224)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human Arg1 by TOGA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50188343(4-(2,6-dichloro-phenyl)-8-[4-(2-diethylamino-ethox...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant Lck in presence of 10 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50474826(CHEMBL330282)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against LPS-stimulated TNF-alpha production in human monocytic cells (THP-1)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50541930(CHEMBL4637417)
Affinity DataIC50:  2nMAssay Description:Inhibition of full length recombinant C-terminal His-tagged human acidic mammalian chitinase expressed in CHOK1 cells assessed as reduction in chitin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50541931(CHEMBL4634943)
Affinity DataIC50:  2nMAssay Description:Inhibition of full length recombinant C-terminal His-tagged human acidic mammalian chitinase expressed in CHOK1 cells assessed as reduction in chitin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Mus musculus)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50554343(CHEMBL4794014)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of full-length C-terminal his-tagged mouse AMCase expressed in expressed in CHO-K1 cells assessed as reduction in chitinolytic activity us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50243795(CHEMBL4077644)
Affinity DataIC50:  3nMAssay Description:Inhibition of full length recombinant C-terminal His-tagged human acidic mammalian chitinase expressed in CHOK1 cells assessed as reduction in chitin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50186560(1-(6-(4-(2-(diethylamino)ethoxy)phenylamino)pyrimi...)
Affinity DataIC50:  3nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50186557(1-(6-(4-(2-(diethylamino)ethoxy)phenylamino)pyrimi...)
Affinity DataIC50:  3nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50188343(4-(2,6-dichloro-phenyl)-8-[4-(2-diethylamino-ethox...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant Src in presence of 10 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50188342(4-(2,6-dichloro-phenyl)-8-(4-morpholin-4-yl-phenyl...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant Lck in presence of 10 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50561039(CHEMBL4749355 | US11420984, Example 23)
Affinity DataIC50:  3nMAssay Description:Inhibition of human Arg1 by TOGA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human PKCalpha activity using kemptide as a substrate in presence of 50 uM ATP by mass spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50474810(CHEMBL92082)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against LPS-stimulated TNF-alpha production in human monocytic cells (THP-1)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195334(3-(2-(1H-benzo[d]imidazol-1-yl)-6-(2-(diethylamino...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant Lck by ProFlour assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195345(3-(2-(1H-benzo[d]imidazol-1-yl)-6-(4-methylpiperaz...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant Lck by ProFlour assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195351(1-(3-(2,5-dimethylbenzyl)-5-(3-cyclohexylpropyl)ph...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant Lck by ProFlour assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50561035(CHEMBL4763578)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human Arg1 by TOGA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50243685(CHEMBL4084573)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of human recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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