TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human GSK3alphaMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human GSK3alphaMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of recombinant GSK3-beta (unknown origin) assessed as decrease in phosphorylation of CREB at serine-129 in presence of ATP[gamma-33P] by f...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant GSK3-beta (unknown origin) assessed as decrease in phosphorylation of CREB at serine-129 in presence of ATP[gamma-33P] by f...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant GSK3-beta (unknown origin) assessed as decrease in phosphorylation of CREB at serine-129 in presence of ATP[gamma-33P] by f...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of HADC1 (unknown origin)More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant GSK3-beta (unknown origin) assessed as decrease in phosphorylation of CREB at serine-129 in presence of ATP[gamma-33P] by f...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of HADC6 (unknown origin)More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant GSK3-beta (unknown origin) assessed as decrease in phosphorylation of CREB at serine-129 in presence of ATP[gamma-33P] by f...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of HADC6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Inhibition of HADC1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in Sf9 cells using ZMAL (Z-(Ac)Lys-AMC as substrate measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.90nMAssay Description:Inhibition of HADC2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Antagonist activity at 5-HT3 receptor in guinea pig ileum muscleMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human GSK3alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of HADC6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4.70nMAssay Description:Inhibition of HADC6 (unknown origin)More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human GSK3beta by scintillation proximity assayMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human GSK3alphaMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
Affinity DataIC50: 5.20nMAssay Description:Inhibition of recombinant GSK3-beta (unknown origin) assessed as decrease in phosphorylation of CREB at serine-129 in presence of ATP[gamma-33P] by f...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of HADC1 (unknown origin)More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
Affinity DataIC50: 6.20nMAssay Description:Inhibition of human GSK3alpha using biotin-Ahx-AAAKRREILSRRP-S(PO3)YR-amide as substrate after 40 mins in presence of [33gammaP]-ATP by SPAMore data for this Ligand-Target Pair
Affinity DataIC50: 6.90nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)Lys-AMC as substrate ...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of GSK-3beta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 7.5nMAssay Description:Inhibition of HADC6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 8.60nMAssay Description:Inhibition of HADC6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)Lys-AMC as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: <15nMAssay Description:Inhibition of HADC1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of HADC6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: <15nMAssay Description:Inhibition of HADC6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: <15nMAssay Description:Inhibition of HADC3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in Sf9 cells using ZMAL (Z-(Ac)Lys-AMC as substrate measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of HADC3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in Sf9 cells using ZMAL (Z-(Ac)Lys-AMC as substrate measured after ...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Inhibition of GSK-3beta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)Lys-AMC as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Antagonist activity at Alpha-1B adrenoceptor in Wistar rat spleen assessed as phenylephrine induced contractions after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of full length N-terminal GST-tagged human HDAC6 expressed in baculovirus expression system using ZMAL as substrate incubated for 90 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Antagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Antagonist activity at 5-HT3 receptor in guinea pig ileum muscleMore data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)Lys-AMC as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of HADC1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of HADC6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Inhibition of full length N-terminal GST-tagged human HDAC6 expressed in baculovirus expression system using ZMAL as substrate incubated for 90 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Inhibition of recombinant human HDAC8 using FLUOR DE LYS as substrate preincubated for 15 mins followed by substrate addition measured after 1 hrs by...More data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Antagonist activity at alpha1A adrenoceptor in Wistar rat vas deferans assessed as noradrenaline induced contractions after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 45nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)Lys-AMC as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)Lys-AMC as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of HADC2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 49nMAssay Description:Inhibition of full length N-terminal GST-tagged human HDAC6 expressed in baculovirus expression system using ZMAL as substrate incubated for 90 mins ...More data for this Ligand-Target Pair