BindingDB PrimarySearch_ki

Found 712 with Last Name = 'dai' and Initial = 'l'

Alpha-1D adrenergic receptor(Homo sapiens (Human))
Guangzhou Medical University

Curated by ChEMBL

PNG

BDBM50773(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)

Ki: 1.20nMAssay Description:Displacement of [125I-HEAT from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes incubated for 60 minsMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Purchase CHEMBL MCE
PC cid PC sid Similars

Details Article PubMed

Alpha-1A adrenergic receptor(Homo sapiens (Human))
Guangzhou Medical University

Curated by ChEMBL

PNG

BDBM50773(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)

Ki: 3.70nMAssay Description:Displacement of [125I-HEAT from human alpha1A-adrenoreceptor expressed in CHOK1 cell membranes incubated for 60 minsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Purchase CHEMBL MCE
PC cid PC sid Similars

Details Article PubMed

Signal transducer and activator of transcription 3(Homo sapiens (Human))
TBA

Curated by ChEMBL

PNG

BDBM50514305(CHEMBL4560429)

Ki: 7nMAssay Description:Binding affinity to recombinant human His/SUMO-tagged STAT3 (127 to 688 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by f...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Signal transducer and activator of transcription 3(Homo sapiens (Human))
TBA

Curated by ChEMBL

PNG

BDBM50514306(CHEMBL4471887)

Ki: 12nMAssay Description:Binding affinity to recombinant human His/SUMO-tagged STAT3 (127 to 688 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by f...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Signal transducer and activator of transcription 3(Homo sapiens (Human))
TBA

Curated by ChEMBL

PNG

BDBM50514297(CHEMBL4575382)

Ki: 14nMAssay Description:Binding affinity to recombinant human His/SUMO-tagged STAT3 (127 to 688 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by f...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Purchase PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Signal transducer and activator of transcription 3(Homo sapiens (Human))
TBA

Curated by ChEMBL

PNG

BDBM50514299(CHEMBL4515406)

Ki: 14nMAssay Description:Binding affinity to recombinant human His/SUMO-tagged STAT3 (127 to 688 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by f...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Signal transducer and activator of transcription 3(Homo sapiens (Human))
TBA

Curated by ChEMBL

PNG

BDBM50514303(CHEMBL4443339)

Ki: 14nMAssay Description:Binding affinity to recombinant human His/SUMO-tagged STAT3 (127 to 688 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by f...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Alpha-1B adrenergic receptor(Homo sapiens (Human))
Guangzhou Medical University

Curated by ChEMBL

PNG

BDBM50773(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)

Ki: 20nMAssay Description:Displacement of [125I-HEAT from human alpha1B-adrenoreceptor expressed in CHOK1 cell membranes incubated for 60 minsMore data for this Ligand-Target Pair

Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Purchase CHEMBL MCE
PC cid PC sid Similars

Details Article PubMed

Signal transducer and activator of transcription 3(Homo sapiens (Human))
TBA

Curated by ChEMBL

PNG

BDBM50514298(CHEMBL4571181)

Ki: 25nMAssay Description:Binding affinity to recombinant human His/SUMO-tagged STAT3 (127 to 688 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by f...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Signal transducer and activator of transcription 3(Homo sapiens (Human))
TBA

Curated by ChEMBL

PNG

BDBM50514296(CHEMBL4443240)

Ki: 33nMAssay Description:Binding affinity to recombinant human His/SUMO-tagged STAT3 (127 to 688 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by f...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Signal transducer and activator of transcription 3(Homo sapiens (Human))
TBA

Curated by ChEMBL

PNG

BDBM50514304(CHEMBL4538737)

Ki: 164nMAssay Description:Binding affinity to recombinant human His/SUMO-tagged STAT3 (127 to 688 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by f...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Signal transducer and activator of transcription 3(Homo sapiens (Human))
TBA

Curated by ChEMBL

PNG

BDBM50514300(CHEMBL4567312)

Ki: 584nMAssay Description:Binding affinity to recombinant human His/SUMO-tagged STAT3 (127 to 688 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by f...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Signal transducer and activator of transcription 3(Homo sapiens (Human))
TBA

Curated by ChEMBL

PNG

BDBM50514301(CHEMBL4461538)

Ki: 761nMAssay Description:Binding affinity to STAT3 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

High affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515356((13E,14E,22R,24S)-12-amino-24,35- difluoro-4-oxa-7...)

IC50: 0.120nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details US Patent

High affinity nerve growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515368((13E,14E,22R,24S)-12-amino- 24,35-difluoro-7-aza-1...)

IC50: 0.210nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details US Patent

High affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515377((13E,14E,22R,24S)-12-amino- 24,35-difluoro-4-oxa-7...)

IC50: 0.210nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details US Patent

High affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515357((13E,14E,22R,24S,5S)-12-amino-24,35-difluoro- 5-me...)

IC50: 0.220nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details US Patent

High affinity nerve growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515367(US11098060, Example 26)

IC50: 0.230nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details US Patent

High affinity nerve growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515365(US11098060, Example 23)

IC50: 0.230nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details US Patent

High affinity nerve growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515370((13E,14E,22R,24S,6S)-12-amino- 24,35-difluoro-6-me...)

IC50: 0.25nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details US Patent

High affinity nerve growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515369((13E,14E,22R,6R)-12-amino-35- fluoro-6-methyl-7-az...)

IC50: 0.310nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details US Patent

High affinity nerve growth factor receptor [G595R](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515354(US11098060, Example 12 | US11098060, Example 34)

IC50: 0.340nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details US Patent

High affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515375((13E,14E,22R,24S)-12-amino-24,35,6,6- tetrafluoro-...)

IC50: 0.360nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details US Patent

High affinity nerve growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515348((R,13E,14E)-12-amino-4-oxa-7-aza-1(5,3)- pyrazolo[...)

IC50: 0.370nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details US Patent

High affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515361((13E,14E,22R,24S,6R)-12-amino-24, 35-difluoro-6-me...)

IC50: 0.380nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details US Patent

High affinity nerve growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515363(US11098060, Example 21)

IC50: 0.400nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details US Patent

High affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515360((13E,14E,22R,24S)-12-amino-24,35-difluoro- 6,6-dim...)

IC50: 0.400nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details US Patent

High affinity nerve growth factor receptor [G595R](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515356((13E,14E,22R,24S)-12-amino-24,35- difluoro-4-oxa-7...)

IC50: 0.400nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details US Patent

High affinity nerve growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515350((R,13E,14E)-12-amino-35-fluro-4-oxa-7-aza- 1(5,3)-...)

IC50: 0.410nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details US Patent

High affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515372((13E,14E,22R,5S)-12-amino-35- fluoro-5-methyl-4-ox...)

IC50: 0.430nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details US Patent

High affinity nerve growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515351((13E,14E,22R,24R)-12-amino-35fluoro-24- hydroxy-4-...)

IC50: 0.440nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details US Patent

High affinity nerve growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515357((13E,14E,22R,24S,5S)-12-amino-24,35-difluoro- 5-me...)

IC50: 0.450nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details US Patent

High affinity nerve growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515349((R,13E,14E)-12-amino-4-oxa-8-aza-1(5,3)- pyrazolo[...)

IC50: 0.470nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details US Patent

High affinity nerve growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515358((13E,14E,22R,24S)-12-amino-24,35-difluoro- 4-oxa-9...)

IC50: 0.510nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details US Patent

High affinity nerve growth factor receptor [G595R](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515357((13E,14E,22R,24S,5S)-12-amino-24,35-difluoro- 5-me...)

IC50: 0.530nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details US Patent

High affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515358((13E,14E,22R,24S)-12-amino-24,35-difluoro- 4-oxa-9...)

IC50: 0.550nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details US Patent

High affinity nerve growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515346((13E,14E)-12-amino-35-fluoro-4-oxa-8-aza-1 (5,3)-p...)

IC50: 0.570nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details US Patent

High affinity nerve growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515364(US11098060, Example 22)

IC50: 0.570nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details US Patent

High affinity nerve growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515359((13E,14E,22R,24S)-12-amino-24,35-difluoro- 8-methy...)

IC50: 0.610nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details US Patent

High affinity nerve growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515355((13E,14E, 22R,24R)-12-amino-24,35- difluoro-4-oxa-...)

IC50: 0.640nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details US Patent

High affinity nerve growth factor receptor [G595R](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515367(US11098060, Example 26)

IC50: 0.680nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details US Patent

High affinity nerve growth factor receptor [G595R](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515368((13E,14E,22R,24S)-12-amino- 24,35-difluoro-7-aza-1...)

IC50: 0.680nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details US Patent

High affinity nerve growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515356((13E,14E,22R,24S)-12-amino-24,35- difluoro-4-oxa-7...)

IC50: 0.680nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details US Patent

High affinity nerve growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515354(US11098060, Example 12 | US11098060, Example 34)

IC50: 0.720nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details US Patent

High affinity nerve growth factor receptor [G595R](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515361((13E,14E,22R,24S,6R)-12-amino-24, 35-difluoro-6-me...)

IC50: 0.730nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details US Patent

High affinity nerve growth factor receptor [G595R](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515358((13E,14E,22R,24S)-12-amino-24,35-difluoro- 4-oxa-9...)

IC50: 0.760nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details US Patent

High affinity nerve growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515352((R,13E,14E)-12-amino-35-fluro-4-oxa-8-aza- 1(5,3)-...)

IC50: 0.800nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details US Patent

High affinity nerve growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515345(US11098060, Example 1)

IC50: 0.800nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details US Patent

High affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515354(US11098060, Example 12 | US11098060, Example 34)

IC50: 0.820nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details US Patent

High affinity nerve growth factor receptor [G595R](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

PNG

BDBM515351((13E,14E,22R,24R)-12-amino-35fluoro-24- hydroxy-4-...)

IC50: 0.840nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details US Patent

Displayed 1 to 50 (of 712 total ) | Next | Last >>

Filter my 712 hits

Targets 40▿
- High affinity nerve growth factor receptor 79
- Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] 64
- Peroxisome proliferator-activated receptor gamma 49
- Peroxisome proliferator-activated receptor delta 49
- Peroxisome proliferator-activated receptor alpha 49
- Ubiquitin carboxyl-terminal hydrolase 7 48
- Monoglyceride lipase 44
- Runt-related transcription factor 1 38
- High affinity nerve growth factor receptor [G667C] 36
- Tyrosine-protein kinase JAK2 28
- Bromodomain-containing protein 4 27
- Serine/threonine-protein kinase PLK1 25
- Fatty-acid amide hydrolase 1 [30-579] 20
- Bromodomain testis-specific protein 20
- High affinity nerve growth factor receptor [G595R] 19
- Tyrosine-protein phosphatase non-receptor type 1 16
- Potassium voltage-gated channel subfamily H member 2 13
- Signal transducer and activator of transcription 3 11
- Egl nine homolog 1 10
- Plasmepsin IV [1-448] 7
- Beta-secretase 1 7
- Plasmepsin II 7
- NT-3 growth factor receptor 5
- BDNF/NT-3 growth factors receptor 5
- Tyrosine-protein phosphatase non-receptor type 6 3
- Cytochrome P450 1A2 3
- Tyrosine-protein kinase JAK2 [V617F] 3
- Receptor-type tyrosine-protein phosphatase F 3
- Tyrosine-protein phosphatase non-receptor type 2 3
- Cytochrome P450 2C9 3
- Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] 3
- Cytochrome P450 2C19 3
- Cytochrome P450 2D6 3
- Cytochrome P450 3A4 3
- Signal transducer and activator of transcription 1-alpha/beta 1
- Alpha-1B adrenergic receptor 1
- Signal transducer and activator of transcription 4 1
- Alpha-1A adrenergic receptor 1
- Alpha-1D adrenergic receptor 1
- Stromelysin-1 1
- ...
Publications 17▿
- J Med Chem 65: 2571-2592 (2022) 147
- US Patent US11098060 (2021) 76
- US Patent US10829492 (2020) 73
- J Med Chem 61: 7785-7795 (2018) 72
- Bioorg Med Chem 27: 55-64 (2019) 64
- J Med Chem 65: 16622-16639 (2022) 48
- Chem Biol 14: 1186-97 (2007) 38
- US Patent US11203586 (2021) 38
- J Med Chem 62: 3503-3512 (2019) 31
- US Patent US11111240 (2021) 29
- US Patent US10561657 (2020) 26
- Bioorg Med Chem Lett 22: 7440-3 (2012) 25
- ACS Med Chem Lett 10: 966-971 (2019) 18
- J Med Chem 62: 11280-11300 (2019) 13
- Bioorg Med Chem Lett 76: (2022) 10
- Bioorg Med Chem Lett 28: 547-551 (2018) 3
- J Nat Prod 84: 1656-1665 (2021) 1
Institutions 12▿
- China Pharmaceutical University 195
- Chia Tai Tianqing Pharmaceutical Group 187
- University Of Massachusetts-Boston 72
- Mak Scientific 64
- Saint Louis University 49
- University of Virginia At Charlottesville 38
- Chai Tai Tianqing Pharmaceutical Group 29
- Centaurus Biophrama 26
- East China University Of Science And Technology 25
- TBA 14
- Tianjin Institute Of Medical & Pharmaceutical Sciences 10
- Guangzhou Medical University 3
Affinity: 0.12 to 1.0E+6 nM▿
- Ki 13
- IC50 525
- Kd 11
- EC50 157
- Affinity ≤ nM
Xtal structures: 12
Docked structures: 0
Catalog Cmpds: 40