Compile Data Set for Download or QSAR
maximum 50k data
Found 948 with Last Name = 'meyer' and Initial = 'mj'
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466897(CHEMBL4287715)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]-25-hydroxycholesterol from human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466891(CHEMBL4281109)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]-25-hydroxycholesterol from human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466893(CHEMBL4291727)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]-25-hydroxycholesterol from human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466892(CHEMBL4283871)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [3H]-25-hydroxycholesterol from human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466913(CHEMBL4289304)
Affinity DataKi:  1.90E+4nMAssay Description:Displacement of [3H]-25-hydroxycholesterol from human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297122((R)-10-Methyl-9,10,11,12-tetrahydro-7-thia-4,9,12-...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297120((R)-9-Methyl-8,9,10,11-tetrahydro-3-oxa-6-thia-8,1...)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50531540(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
Affinity DataIC50: <1nMAssay Description:Inhibition of MEK in human KYSE-520 cells assessed as reduction in p-ERK levelsMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297122((R)-10-Methyl-9,10,11,12-tetrahydro-7-thia-4,9,12-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50208999((R)-1-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50:  1.5nMAssay Description:Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50013412(CHEMBL3263752)
Affinity DataIC50:  1.80nMAssay Description:Binding affinity to mineralocorticoid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Saint Louis University

US Patent
LigandPNGBDBM234547(US9353089, 304)
Affinity DataIC50:  1.88nMpH: 4.5 T: 2°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasmepsin II(Plasmodium falciparum)
Saint Louis University

US Patent
LigandPNGBDBM234527(US9353089, 206)
Affinity DataIC50:  2nMpH: 4.5 T: 2°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297124((R)-3-Chloro-10-methyl-9,10,11,12-tetrahydro-7-thi...)
Affinity DataIC50:  2nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324200(4-[(5R)-1-(3-Chloro-4-cyanophenyl)-5-cyclopentyl-4...)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at Gal4-tagged mineralocorticoid receptor expressed in human Huh7 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Saint Louis University

US Patent
LigandPNGBDBM234565(US9353089, 311)
Affinity DataIC50:  2nMpH: 4.5 T: 2°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasmepsin II(Plasmodium falciparum)
Saint Louis University

US Patent
LigandPNGBDBM234542(US9353089, 276)
Affinity DataIC50:  2nMpH: 4.5 T: 2°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMineralocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50013430(CHEMBL3263768)
Affinity DataIC50:  2.20nMAssay Description:Antagonist activity at mineralocorticoid receptor (unknown origin) by Gal4-based cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Saint Louis University

US Patent
LigandPNGBDBM234537(US9353089, 238)
Affinity DataIC50:  2.20nMpH: 4.5 T: 2°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasmepsin II(Plasmodium falciparum)
Saint Louis University

US Patent
LigandPNGBDBM234534(US9353089, 220)
Affinity DataIC50:  2.37nMpH: 4.5 T: 2°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasmepsin II(Plasmodium falciparum)
Saint Louis University

US Patent
LigandPNGBDBM234535(US9353089, 221)
Affinity DataIC50:  2.39nMpH: 4.5 T: 2°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMineralocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50013422(CHEMBL3263760)
Affinity DataIC50:  2.70nMAssay Description:Antagonist activity at mineralocorticoid receptor (unknown origin) by Gal4-based cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Saint Louis University

US Patent
LigandPNGBDBM234527(US9353089, 206)
Affinity DataIC50:  2.76nMpH: 4.5 T: 2°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasmepsin II(Plasmodium falciparum)
Saint Louis University

US Patent
LigandPNGBDBM234544(US9353089, 278)
Affinity DataIC50:  2.76nMpH: 4.5 T: 2°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMineralocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50013428(CHEMBL3263766)
Affinity DataIC50:  2.80nMAssay Description:Antagonist activity at mineralocorticoid receptor (unknown origin) by Gal4-based cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Saint Louis University

US Patent
LigandPNGBDBM234536(US9353089, 228)
Affinity DataIC50:  2.89nMpH: 4.5 T: 2°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50325723((R)-2-(4-(4-chlorobenzyl)-5-methyl-4H-1,2,4-triazo...)
Affinity DataIC50:  2.90nMAssay Description:Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Saint Louis University

US Patent
LigandPNGBDBM234546(US9353089, 303)
Affinity DataIC50:  3.10nMpH: 4.5 T: 2°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMineralocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50013426(CHEMBL3263764)
Affinity DataIC50:  3.30nMAssay Description:Antagonist activity at mineralocorticoid receptor (unknown origin) by Gal4-based cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466890(CHEMBL4290728)
Affinity DataIC50:  3.30nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL17A production after 6 days by sandwich ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMineralocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50013424(CHEMBL3263762)
Affinity DataIC50:  3.70nMAssay Description:Antagonist activity at mineralocorticoid receptor (unknown origin) by Gal4-based cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Saint Louis University

US Patent
LigandPNGBDBM234497(US9353089, 117)
Affinity DataIC50:  3.96nMpH: 4.5 T: 2°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasmepsin II(Plasmodium falciparum)
Saint Louis University

US Patent
LigandPNGBDBM234497(US9353089, 117)
Affinity DataIC50:  4nMpH: 4.5 T: 2°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMineralocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324215((+/-)-(3SR,3aRS)-2-(4-Cyano-3-methylphenyl)-3-cycl...)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at Gal4-tagged mineralocorticoid receptor expressed in human Huh7 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50325722((R)-2-(4-(4-chlorobenzyl)-4H-1,2,4-triazol-3-yl)-N...)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50013429(CHEMBL3263767)
Affinity DataIC50:  4.10nMAssay Description:Antagonist activity at mineralocorticoid receptor (unknown origin) by Gal4-based cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM189877(US10227346, Example 5 | US10426135, Example 5 | US...)
Affinity DataIC50:  4.10nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50013425(CHEMBL3263763)
Affinity DataIC50:  4.30nMAssay Description:Antagonist activity at mineralocorticoid receptor (unknown origin) by Gal4-based cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Saint Louis University

US Patent
LigandPNGBDBM234543(US9353089, 277)
Affinity DataIC50:  4.39nMpH: 4.5 T: 2°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMineralocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50013419(CHEMBL3263757)
Affinity DataIC50:  4.40nMAssay Description:Antagonist activity at mineralocorticoid receptor (unknown origin) by Gal4-based cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50013412(CHEMBL3263752)
Affinity DataIC50:  4.5nMAssay Description:Antagonist activity at mineralocorticoid receptor (unknown origin) by Gal4-based cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466912(CHEMBL4283051)
Affinity DataIC50:  4.80nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297119((R)-10-Methyl-3-(4-methyl-pyridin-3-yl)-9,10,11,12...)
Affinity DataIC50:  5nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466890(CHEMBL4290728)
Affinity DataIC50:  5nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466891(CHEMBL4281109)
Affinity DataIC50:  5nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297113((R)-10-Methyl-3-pyridin-3-yl-9,10,11,12-tetrahydro...)
Affinity DataIC50:  5nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297121((R)-9-Methyl-1,2,8,9,10,11-hexahydro-3-oxa-6-thia-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297151((3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466897(CHEMBL4287715)
Affinity DataIC50:  5nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Saint Louis University

US Patent
LigandPNGBDBM234539(US9353089, 252)
Affinity DataIC50:  5.28nMpH: 4.5 T: 2°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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