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Found 151 with Last Name = 'santoro' and Initial = 'm'
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM374727((7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14- tetrah...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of TRKA G595R mutant (unknown origin)More data for this Ligand-Target Pair
TargetCoiled-coil domain-containing protein 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50514844(CHEMBL4473213)
Affinity DataIC50:  0.670nMAssay Description:Inhibition of CCDC6/RET in human TPC1 cells assessed as reduction in cell proliferation supplemented with fresh medium containing compound for every ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50514844(CHEMBL4473213)
Affinity DataIC50:  0.670nMAssay Description:Inhibition of RET isoform 9 C634W mutant in human TT cells assessed as reduction in cell proliferation supplemented with fresh medium containing comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50514844(CHEMBL4473213)
Affinity DataIC50:  0.670nMAssay Description:Inhibition of RET isoform 9 M918T mutant in human MZ-CRC-1 cells assessed as reduction in cell proliferation supplemented with fresh medium containin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoiled-coil domain-containing protein 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50514844(CHEMBL4473213)
Affinity DataIC50:  0.670nMAssay Description:Inhibition of CCDC6/RET in human LC2/ad cells assessed as reduction in cell proliferation supplemented with fresh medium containing compound for ever...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50193395(Altiratinib | DCC-2701 | DP-5164)
Affinity DataIC50:  0.850nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50:  0.980nMAssay Description:Inhibition of TRKA G667C mutant (unknown origin) using poly-EAY peptide as substrate in presence of gamma-33ATP by LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50514844(CHEMBL4473213)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant human GST-tagged RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus expression system using 5'FAM-EPLYW...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of GST-3C fused human RET (705 to 1013 residues) expressed in sf9 baculovirus expression system using 5-FAM- peptide as substrate preincub...More data for this Ligand-Target Pair
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of RON (unknown origin) by FISH assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50467574(MG-516 | MG-91516 | MGCD-516 | MGCD516 | Sitravati...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50514844(CHEMBL4473213)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of RET isoform 15 M918T mutant (unknown origin) expressed in mouse BAF3 cells assessed as reduction in cell proliferation supplemented wit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50299148((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of IR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50514844(CHEMBL4473213)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of RET isoform 15 C634R mutant (unknown origin) expressed in mouse BAF3 cells assessed as reduction in cell proliferation supplemented wit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50299148((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of IGF-1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM136597(US10005783, 14 | US10047097, 14 | US10774085, Exam...)
Affinity DataIC50:  2nMAssay Description:Inhibition of TRKA (unknown origin) by FISH assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50:  2nMAssay Description:Inhibition of TRKA G595R mutant (unknown origin) using poly-EAY peptide as substrate in presence of gamma-33ATP by LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of recombinant His-tagged human TRKA (441 to 796 residues) expressed in baculovirus expression system using 5-FAM-EEPLYWSFPAKKK-CONH2 as s...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50193395(Altiratinib | DCC-2701 | DP-5164)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of cMET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50514844(CHEMBL4473213)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant human His-tagged VEGFR2 cytoplasmic domain (789 to 1356 residues) expressed in baculovirus expression system using peptide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50396243(CHEMBL2172308 | US10370379, Compound TSR-011)
Affinity DataIC50: <3nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50396243(CHEMBL2172308 | US10370379, Compound TSR-011)
Affinity DataIC50: <3nMAssay Description:Inhibition of TRKB (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50396243(CHEMBL2172308 | US10370379, Compound TSR-011)
Affinity DataIC50: <3nMAssay Description:Inhibition of TRKC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50299148((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...)
Affinity DataIC50:  4nMAssay Description:Inhibition of TRKB (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50514844(CHEMBL4473213)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of RET isoform 9 C634R mutant (unknown origin) expressed in mouse NIH/3T3 cells assessed as reduction in cell proliferation supplemented w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50193395(Altiratinib | DCC-2701 | DP-5164)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of TRKB (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of cMET (unknown origin) by FISH assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50467574(MG-516 | MG-91516 | MGCD-516 | MGCD516 | Sitravati...)
Affinity DataIC50:  5nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50467574(MG-516 | MG-91516 | MGCD-516 | MGCD516 | Sitravati...)
Affinity DataIC50:  5nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50585629(CHEMBL5087283)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of GST-3C fused human RET (705 to 1013 residues) expressed in sf9 baculovirus expression system using 5-FAM- peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50585635(CHEMBL5074882)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of GST-3C fused human RET (705 to 1013 residues) expressed in sf9 baculovirus expression system using 5-FAM- peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50585640(CHEMBL5080296)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of GST-3C fused human RET (705 to 1013 residues) expressed in sf9 baculovirus expression system using 5-FAM- peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50585633(CHEMBL5073804)
Affinity DataIC50:  6nMAssay Description:Inhibition of GST-3C fused human RET (705 to 1013 residues) expressed in sf9 baculovirus expression system using 5-FAM- peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50467574(MG-516 | MG-91516 | MGCD-516 | MGCD516 | Sitravati...)
Affinity DataIC50:  6nMAssay Description:Inhibition of cKIT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50585632(CHEMBL5070593)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of GST-3C fused human RET (705 to 1013 residues) expressed in sf9 baculovirus expression system using 5-FAM- peptide as substrate preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50585631(CHEMBL5078090)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of GST-3C fused human RET (705 to 1013 residues) expressed in sf9 baculovirus expression system using 5-FAM- peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50299148((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...)
Affinity DataIC50:  7nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50585644(CHEMBL5094848)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of GST-3C fused human RET (705 to 1013 residues) expressed in sf9 baculovirus expression system using 5-FAM- peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50585630(CHEMBL5089911)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of GST-3C fused human RET (705 to 1013 residues) expressed in sf9 baculovirus expression system using 5-FAM- peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50193395(Altiratinib | DCC-2701 | DP-5164)
Affinity DataIC50:  8nMAssay Description:Inhibition of TIE2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50467574(MG-516 | MG-91516 | MGCD-516 | MGCD516 | Sitravati...)
Affinity DataIC50:  8nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50514844(CHEMBL4473213)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant human N-terminal GST/His-tagged RET V804M mutant (658 to 1114 residues) expressed in Sf9 insect cells using 5'FAM-EPLYWSFPA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50585641(CHEMBL5093057)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of GST-3C fused human RET (705 to 1013 residues) expressed in sf9 baculovirus expression system using 5-FAM- peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50193395(Altiratinib | DCC-2701 | DP-5164)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of TRKC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM374727((7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14- tetrah...)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of ROS1 G2032R mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50467574(MG-516 | MG-91516 | MGCD-516 | MGCD516 | Sitravati...)
Affinity DataIC50:  9nMAssay Description:Inhibition of TRKB (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50193395(Altiratinib | DCC-2701 | DP-5164)
Affinity DataIC50:  9.20nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50585645(CHEMBL5085579)
Affinity DataIC50:  11nMAssay Description:Inhibition of GST-3C fused human RET (705 to 1013 residues) expressed in sf9 baculovirus expression system using 5-FAM- peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50585637(CHEMBL5094196)
Affinity DataIC50:  12nMAssay Description:Inhibition of GST-3C fused human RET (705 to 1013 residues) expressed in sf9 baculovirus expression system using 5-FAM- peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50585630(CHEMBL5089911)
Affinity DataIC50:  12nMAssay Description:Inhibition of human RET V804M mutant using 5-FAM- peptide as substrate preincubated for 1 hr followed by substrate addition in presence of ATP by Lin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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