Compile Data Set for Download or QSAR
Found 62 of ec50 for UniProtKB: P28705
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50290192(3-Methyl-5-[5-(5,5,8,8-tetramethyl-5,6,7,8-tetrahy...)
Show SMILES C\C(\C=C\[C@]12CC1(CCC2)c1ccc2c(c1)C(C)(C)CCC2(C)C)=C/C(O)=O
Show InChI InChI=1S/C26H34O2/c1-18(15-22(27)28)9-12-25-10-6-11-26(25,17-25)19-7-8-20-21(16-19)24(4,5)14-13-23(20,2)3/h7-9,12,15-16H,6,10-11,13-14,17H2,1-5H3,(H,27,28)/b12-9+,18-15+/t25-,26?/m1/s1
Affinity DataEC50:  3nMAssay Description:Effective potency in transcriptional activation assay in CV-1 cells expressing Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPH...)
Show SMILES Cc1cc2c(cc1C1(CC1)c1ccc(cn1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H29NO2/c1-15-12-18-19(23(4,5)9-8-22(18,2)3)13-17(15)24(10-11-24)20-7-6-16(14-25-20)21(26)27/h6-7,12-14H,8-11H2,1-5H3,(H,26,27)
Affinity DataEC50:  4nMAssay Description:Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.More data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50032666(6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Show SMILES Cc1cc2c(cc1C(=C)c1ccc(cn1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H27NO2/c1-14-11-18-19(23(5,6)10-9-22(18,3)4)12-17(14)15(2)20-8-7-16(13-24-20)21(25)26/h7-8,11-13H,2,9-10H2,1,3-6H3,(H,25,26)
Affinity DataEC50:  5nMAssay Description:Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.More data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM31883(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O
Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
Affinity DataEC50:  6nMAssay Description:Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50290187((2E,4E)-3-Methyl-5-[(1R,2S)-2-(5,5,8,8-tetramethyl...)
Show SMILES C\C(\C=C\[C@H]1CCC[C@@H]1c1ccc2c(c1)C(C)(C)CCC2(C)C)=C/C(O)=O
Show InChI InChI=1S/C25H34O2/c1-17(15-23(26)27)9-10-18-7-6-8-20(18)19-11-12-21-22(16-19)25(4,5)14-13-24(21,2)3/h9-12,15-16,18,20H,6-8,13-14H2,1-5H3,(H,26,27)/b10-9+,17-15+/t18-,20+/m1/s1
Affinity DataEC50:  6nMAssay Description:Effective potency in transcriptional activation assay in CV-1 cells expressing Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50122351((2E,4E)-3-Methyl-6-[1-(5,5,8,8-tetramethyl-5,6,7,8...)
Show SMILES C\C(\C=C\CC1(CC1)c1ccc2c(c1)C(C)(C)CCC2(C)C)=C/C(O)=O
Show InChI InChI=1S/C24H32O2/c1-17(15-21(25)26)7-6-10-24(13-14-24)18-8-9-19-20(16-18)23(4,5)12-11-22(19,2)3/h6-9,15-16H,10-14H2,1-5H3,(H,25,26)/b7-6+,17-15+
Affinity DataEC50:  14nMAssay Description:Transcriptional activation in CV-1 cells expresing mouse Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50290186((2E,4E)-3-Methyl-5-[(1R,2R)-1-methyl-2-(5,5,8,8-te...)
Show SMILES C\C(\C=C\[C@@]1(C)CCC[C@@H]1c1ccc2c(c1)C(C)(C)CCC2(C)C)=C/C(O)=O
Show InChI InChI=1S/C26H36O2/c1-18(16-23(27)28)11-13-26(6)12-7-8-20(26)19-9-10-21-22(17-19)25(4,5)15-14-24(21,2)3/h9-11,13,16-17,20H,7-8,12,14-15H2,1-6H3,(H,27,28)/b13-11+,18-16+/t20-,26-/m1/s1
Affinity DataEC50:  16nMAssay Description:Effective potency in transcriptional activation assay in CV-1 cells expressing Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50032664(4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Show SMILES Cc1cc2c(cc1C1(CC1)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C25H30O2/c1-16-14-20-21(24(4,5)11-10-23(20,2)3)15-19(16)25(12-13-25)18-8-6-17(7-9-18)22(26)27/h6-9,14-15H,10-13H2,1-5H3,(H,26,27)
Affinity DataEC50:  17nMAssay Description:Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.More data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50032675(4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaph...)
Show SMILES Cc1cc2c(cc1C(=C)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)
Affinity DataEC50:  20nMAssay Description:Inhibition of [3H]-ATRA binding to retinoic acid receptor RAR betaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50032675(4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaph...)
Show SMILES Cc1cc2c(cc1C(=C)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)
Affinity DataEC50:  20nMAssay Description:Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.More data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50122349((2E,4E)-6-[1-(6-tert-Butyl-1,1-dimethyl-indan-4-yl...)
Show SMILES C\C(\C=C\CC1(CC1)c1cc(cc2c1CCC2(C)C)C(C)(C)C)=C/C(O)=O
Show InChI InChI=1S/C25H34O2/c1-17(14-22(26)27)8-7-10-25(12-13-25)21-16-18(23(2,3)4)15-20-19(21)9-11-24(20,5)6/h7-8,14-16H,9-13H2,1-6H3,(H,26,27)/b8-7+,17-14+
Affinity DataEC50:  20nMAssay Description:Transcriptional activation in CV-1 cells expresing mouse Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50080526(1,4,4-Trimethyl-1,2,3,4-tetrahydro-quinoline-6-car...)
Show SMILES CCOC(=O)c1ccc(OC(=O)c2ccc3N(C)CCC(C)(C)c3c2)cc1
Show InChI InChI=1S/C22H25NO4/c1-5-26-20(24)15-6-9-17(10-7-15)27-21(25)16-8-11-19-18(14-16)22(2,3)12-13-23(19)4/h6-11,14H,5,12-13H2,1-4H3
Affinity DataEC50:  20nMAssay Description:Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50122348((2E,4E)-6-[1-(3,5-Di-tert-butyl-phenyl)-cyclopropy...)
Show SMILES C\C(\C=C\CC1(CC1)c1cc(cc(c1)C(C)(C)C)C(C)(C)C)=C/C(O)=O
Show InChI InChI=1S/C24H34O2/c1-17(13-21(25)26)9-8-10-24(11-12-24)20-15-18(22(2,3)4)14-19(16-20)23(5,6)7/h8-9,13-16H,10-12H2,1-7H3,(H,25,26)/b9-8+,17-13+
Affinity DataEC50:  23nMAssay Description:Transcriptional activation in CV-1 cells expresing mouse Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50122350((2E,4E)-3-Methyl-6-[1-(5,5,8,8-tetramethyl-5,6,7,8...)
Show SMILES C\C(\C=C\CC1(CCCC1)c1ccc2c(c1)C(C)(C)CCC2(C)C)=C/C(O)=O
Show InChI InChI=1S/C26H36O2/c1-19(17-23(27)28)9-8-14-26(12-6-7-13-26)20-10-11-21-22(18-20)25(4,5)16-15-24(21,2)3/h8-11,17-18H,6-7,12-16H2,1-5H3,(H,27,28)/b9-8+,19-17+
Affinity DataEC50:  24nMAssay Description:Transcriptional activation in CV-1 cells expresing mouse Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50032675(4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaph...)
Show SMILES Cc1cc2c(cc1C(=C)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)
Affinity DataEC50:  25nMAssay Description:Effective concentration against retinoid receptor isoform (RXR gamma) expressed in CV-1 cellsMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50290194((2E,4E)-3-Methyl-5-[(1S,2S)-2-(5,5,8,8-tetramethyl...)
Show SMILES C\C(\C=C\[C@@H]1CCC[C@@H]1c1ccc2c(c1)C(C)(C)CCC2(C)C)=C/C(O)=O
Show InChI InChI=1S/C25H34O2/c1-17(15-23(26)27)9-10-18-7-6-8-20(18)19-11-12-21-22(16-19)25(4,5)14-13-24(21,2)3/h9-12,15-16,18,20H,6-8,13-14H2,1-5H3,(H,26,27)/b10-9+,17-15+/t18-,20-/m0/s1
Affinity DataEC50:  25nMAssay Description:Inhibition of [3H]-9-cis-RA binding to Retinoid X receptor RXR betaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50080524(1-Isopropyl-4,4-dimethyl-1,2,3,4-tetrahydro-quinol...)
Show SMILES CCOC(=O)c1ccc(OC(=O)c2ccc3N(CCC(C)(C)c3c2)C(C)C)cc1
Show InChI InChI=1S/C24H29NO4/c1-6-28-22(26)17-7-10-19(11-8-17)29-23(27)18-9-12-21-20(15-18)24(4,5)13-14-25(21)16(2)3/h7-12,15-16H,6,13-14H2,1-5H3
Affinity DataEC50:  27nMAssay Description:Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50122352((2E,4E)-3-Methyl-6-[1-(3,5,5,8,8-pentamethyl-5,6,7...)
Show SMILES C\C(\C=C\CC1(CC1)c1cc2c(cc1C)C(C)(C)CCC2(C)C)=C/C(O)=O
Show InChI InChI=1S/C25H34O2/c1-17(14-22(26)27)8-7-9-25(12-13-25)19-16-21-20(15-18(19)2)23(3,4)10-11-24(21,5)6/h7-8,14-16H,9-13H2,1-6H3,(H,26,27)/b8-7+,17-14+
Affinity DataEC50:  36nMAssay Description:Transcriptional activation in CV-1 cells expresing mouse Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50040016(4-[1-(3-Chloro-5,5,8,8-tetramethyl-5,6,7,8-tetrahy...)
Show SMILES CC1(C)CCC(C)(C)c2cc(C(=C)c3ccc(cc3)C(O)=O)c(Cl)cc12
Show InChI InChI=1S/C23H25ClO2/c1-14(15-6-8-16(9-7-15)21(25)26)17-12-18-19(13-20(17)24)23(4,5)11-10-22(18,2)3/h6-9,12-13H,1,10-11H2,2-5H3,(H,25,26)
Affinity DataEC50:  36nMAssay Description:Effective concentration against retinoid receptor isoform (RXR gamma) expressed in CV-1 cellsMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50290191(3-Methyl-5-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahy...)
Show SMILES C\C(\C=C\C1=C(CCC1)c1ccc2c(c1)C(C)(C)CCC2(C)C)=C/C(O)=O
Show InChI InChI=1S/C25H32O2/c1-17(15-23(26)27)9-10-18-7-6-8-20(18)19-11-12-21-22(16-19)25(4,5)14-13-24(21,2)3/h9-12,15-16H,6-8,13-14H2,1-5H3,(H,26,27)/b10-9+,17-15+
Affinity DataEC50:  40nMAssay Description:Inhibition of [3H]-9-cis-RA binding to Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50082041(4-iminomethylphenyl 4,4-dimethyl-6-chromanecarboxy...)
Show SMILES CC1(C)CCOc2ccc(cc12)C(=O)Oc1ccc(C=NNC(N)=S)cc1
Show InChI InChI=1S/C20H21N3O3S/c1-20(2)9-10-25-17-8-5-14(11-16(17)20)18(24)26-15-6-3-13(4-7-15)12-22-23-19(21)27/h3-8,11-12H,9-10H2,1-2H3,(H3,21,23,27)
Affinity DataEC50:  42nMAssay Description:Transcriptional activation of CV-1 cells expressing murine Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50064252((2Z,4E,6E)-8-[3-Ethyl-2-isopropyl-cyclohex-2-en-(E...)
Show SMILES CCC1=C(C(C)C)\C(CCC1)=C\C(\C)=C\C=C\C(\C)=C/C(O)=O
Show InChI InChI=1S/C21H30O2/c1-6-18-11-8-12-19(21(18)15(2)3)13-16(4)9-7-10-17(5)14-20(22)23/h7,9-10,13-15H,6,8,11-12H2,1-5H3,(H,22,23)/b10-7+,16-9+,17-14-,19-13+
Affinity DataEC50:  42nMAssay Description:Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50040012(4-[1-(3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahyd...)
Show SMILES CC1(C)CCC(C)(C)c2cc(C(=C)c3ccc(cc3)C(O)=O)c(Br)cc12
Show InChI InChI=1S/C23H25BrO2/c1-14(15-6-8-16(9-7-15)21(25)26)17-12-18-19(13-20(17)24)23(4,5)11-10-22(18,2)3/h6-9,12-13H,1,10-11H2,2-5H3,(H,25,26)
Affinity DataEC50:  43nMAssay Description:Effective concentration against retinoid receptor isoform (RXR gamma) expressed in CV-1 cellsMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50290188((2E,4E)-3-Methyl-5-[(1S,2R)-1-methyl-2-(5,5,8,8-te...)
Show SMILES C\C(\C=C\[C@]1(C)CCC[C@@H]1c1ccc2c(c1)C(C)(C)CCC2(C)C)=C/C(O)=O
Show InChI InChI=1S/C26H36O2/c1-18(16-23(27)28)11-13-26(6)12-7-8-20(26)19-9-10-21-22(17-19)25(4,5)15-14-24(21,2)3/h9-11,13,16-17,20H,7-8,12,14-15H2,1-6H3,(H,27,28)/b13-11+,18-16+/t20-,26+/m1/s1
Affinity DataEC50:  44nMAssay Description:Effective potency in transcriptional activation assay in CV-1 cells expressing Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50032674(4-[2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Show SMILES Cc1cc2c(cc1C1(CO1)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O3/c1-15-12-19-20(23(4,5)11-10-22(19,2)3)13-18(15)24(14-27-24)17-8-6-16(7-9-17)21(25)26/h6-9,12-13H,10-11,14H2,1-5H3,(H,25,26)
Affinity DataEC50:  47nMAssay Description:Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.More data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50080525(1,4,4,7-Tetramethyl-1,2,3,4-tetrahydro-quinoline-6...)
Show SMILES CCOC(=O)c1ccc(OC(=O)c2cc3c(cc2C)N(C)CCC3(C)C)cc1
Show InChI InChI=1S/C23H27NO4/c1-6-27-21(25)16-7-9-17(10-8-16)28-22(26)18-14-19-20(13-15(18)2)24(5)12-11-23(19,3)4/h7-10,13-14H,6,11-12H2,1-5H3
Affinity DataEC50:  49nMAssay Description:Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM31892(9-cis retinoic acid | 9C-RA | CHEMBL705 | Panretin...)
Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O
Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+
Affinity DataEC50:  124nMAssay Description:Transcriptional activation in CV-1 cells expresing mouse Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50290193(3-Methyl-5-[2-(3,5,5,8,8-pentamethyl-5,6,7,8-tetra...)
Show SMILES C\C(\C=C\C1=C(CCC1)c1cc2c(cc1C)C(C)(C)CCC2(C)C)=C/C(O)=O
Show InChI InChI=1S/C26H34O2/c1-17(14-24(27)28)10-11-19-8-7-9-20(19)21-16-23-22(15-18(21)2)25(3,4)12-13-26(23,5)6/h10-11,14-16H,7-9,12-13H2,1-6H3,(H,27,28)/b11-10+,17-14+
Affinity DataEC50:  128nMAssay Description:Effective potency in transcriptional activation assay in CV-1 cells expressing Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50040017(4-[1-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahyd...)
Show SMILES CCc1cc2c(cc1C(=C)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C25H30O2/c1-7-17-14-21-22(25(5,6)13-12-24(21,3)4)15-20(17)16(2)18-8-10-19(11-9-18)23(26)27/h8-11,14-15H,2,7,12-13H2,1,3-6H3,(H,26,27)
Affinity DataEC50:  136nMAssay Description:Effective concentration against retinoid receptor isoform (RXR gamma) expressed in CV-1 cellsMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50290189((2E,4E)-3-Methyl-5-[(1S,2S)-4-methylene-2-(5,5,8,8...)
Show SMILES C\C(\C=C\[C@@H]1CC(=C)C[C@@H]1c1ccc2c(c1)C(C)(C)CCC2(C)C)=C/C(O)=O
Show InChI InChI=1S/C26H34O2/c1-17(15-24(27)28)7-8-19-13-18(2)14-21(19)20-9-10-22-23(16-20)26(5,6)12-11-25(22,3)4/h7-10,15-16,19,21H,2,11-14H2,1,3-6H3,(H,27,28)/b8-7+,17-15+/t19-,21+/m1/s1
Affinity DataEC50:  204nMAssay Description:Effective potency in transcriptional activation assay in CV-1 cells expressing Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50290190((2E,4E)-3-Methyl-5-[(1R,2S)-4-methylene-2-(5,5,8,8...)
Show SMILES C\C(\C=C\[C@H]1CC(=C)C[C@@H]1c1ccc2c(c1)C(C)(C)CCC2(C)C)=C/C(O)=O
Show InChI InChI=1S/C26H34O2/c1-17(15-24(27)28)7-8-19-13-18(2)14-21(19)20-9-10-22-23(16-20)26(5,6)12-11-25(22,3)4/h7-10,15-16,19,21H,2,11-14H2,1,3-6H3,(H,27,28)/b8-7+,17-15+/t19-,21-/m0/s1
Affinity DataEC50:  212nMAssay Description:Inhibition of [3H]-9-cis-RA binding to Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50040013(4-(3-Chloro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro...)
Show SMILES CC1(C)CCC(C)(C)c2cc(C(=O)c3ccc(cc3)C(O)=O)c(Cl)cc12
Show InChI InChI=1S/C22H23ClO3/c1-21(2)9-10-22(3,4)17-12-18(23)15(11-16(17)21)19(24)13-5-7-14(8-6-13)20(25)26/h5-8,11-12H,9-10H2,1-4H3,(H,25,26)
Affinity DataEC50:  225nMAssay Description:Effective concentration against retinoid receptor isoform (RXR gamma) expressed in CV-1 cellsMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50040021(4-[1-(3-Isopropyl-5,5,8,8-tetramethyl-5,6,7,8-tetr...)
Show SMILES CC(C)c1cc2c(cc1C(=C)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C26H32O2/c1-16(2)20-14-22-23(26(6,7)13-12-25(22,4)5)15-21(20)17(3)18-8-10-19(11-9-18)24(27)28/h8-11,14-16H,3,12-13H2,1-2,4-7H3,(H,27,28)
Affinity DataEC50:  227nMAssay Description:Effective concentration against retinoid receptor isoform (RXR gamma) expressed in CV-1 cellsMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50040015(4-[1-(3-Methoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrah...)
Show SMILES COc1cc2c(cc1C(=C)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O3/c1-15(16-7-9-17(10-8-16)22(25)26)18-13-19-20(14-21(18)27-6)24(4,5)12-11-23(19,2)3/h7-10,13-14H,1,11-12H2,2-6H3,(H,25,26)
Affinity DataEC50:  230nMAssay Description:Effective concentration against retinoid receptor isoform (RXR gamma) expressed in CV-1 cellsMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50032668(4-[2-Methyl-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetra...)
Show SMILES CC(C)=C(c1ccc(cc1)C(O)=O)c1cc2c(cc1C)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C26H32O2/c1-16(2)23(18-8-10-19(11-9-18)24(27)28)20-15-22-21(14-17(20)3)25(4,5)12-13-26(22,6)7/h8-11,14-15H,12-13H2,1-7H3,(H,27,28)
Affinity DataEC50:  240nMAssay Description:Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.More data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50032667(4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1C(=O)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H26O3/c1-14-12-18-19(23(4,5)11-10-22(18,2)3)13-17(14)20(24)15-6-8-16(9-7-15)21(25)26/h6-9,12-13H,10-11H2,1-5H3,(H,25,26)
Affinity DataEC50:  246nMAssay Description:Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.More data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50032667(4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1C(=O)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H26O3/c1-14-12-18-19(23(4,5)11-10-22(18,2)3)13-17(14)20(24)15-6-8-16(9-7-15)21(25)26/h6-9,12-13H,10-11H2,1-5H3,(H,25,26)
Affinity DataEC50:  246nMAssay Description:Effective concentration against retinoid receptor isoform (RXR gamma) expressed in CV-1 cellsMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50040011(4-(3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-...)
Show SMILES CC1(C)CCC(C)(C)c2cc(C(=O)c3ccc(cc3)C(O)=O)c(Br)cc12
Show InChI InChI=1S/C22H23BrO3/c1-21(2)9-10-22(3,4)17-12-18(23)15(11-16(17)21)19(24)13-5-7-14(8-6-13)20(25)26/h5-8,11-12H,9-10H2,1-4H3,(H,25,26)
Affinity DataEC50:  261nMAssay Description:Effective concentration against retinoid receptor isoform (RXR gamma) expressed in CV-1 cellsMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50082042(CHEMBL139536 | N-(2,2,4,4-Tetramethyl-thiochroman-...)
Show SMILES COC(=O)c1ccc(cc1)C(=O)Nc1ccc2SC(C)(C)CC(C)(C)c2c1
Show InChI InChI=1S/C22H25NO3S/c1-21(2)13-22(3,4)27-18-11-10-16(12-17(18)21)23-19(24)14-6-8-15(9-7-14)20(25)26-5/h6-12H,13H2,1-5H3,(H,23,24)
Affinity DataEC50:  302nMAssay Description:Transcriptional activation of CV-1 cells expressing murine Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50032677(4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Show SMILES CC(c1ccc(cc1)C(O)=O)c1cc2c(cc1C)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H30O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14,16H,11-12H2,1-6H3,(H,25,26)
Affinity DataEC50:  340nMAssay Description:Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.More data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50040018(4-(3-Isopropyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahy...)
Show SMILES CC(C)c1cc2c(cc1C(=O)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C25H30O3/c1-15(2)18-13-20-21(25(5,6)12-11-24(20,3)4)14-19(18)22(26)16-7-9-17(10-8-16)23(27)28/h7-10,13-15H,11-12H2,1-6H3,(H,27,28)
Affinity DataEC50:  357nMAssay Description:Effective concentration against retinoid receptor isoform (RXR gamma) expressed in CV-1 cellsMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50040014(4-[1-(3-Fluoro-5,5,8,8-tetramethyl-5,6,7,8-tetrahy...)
Show SMILES CC1(C)CCC(C)(C)c2cc(C(=C)c3ccc(cc3)C(O)=O)c(F)cc12
Show InChI InChI=1S/C23H25FO2/c1-14(15-6-8-16(9-7-15)21(25)26)17-12-18-19(13-20(17)24)23(4,5)11-10-22(18,2)3/h6-9,12-13H,1,10-11H2,2-5H3,(H,25,26)
Affinity DataEC50:  383nMAssay Description:Effective concentration against retinoid receptor isoform (RXR gamma) expressed in CV-1 cellsMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50040010(4-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-...)
Show SMILES CCc1cc2c(cc1C(=O)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O3/c1-6-15-13-19-20(24(4,5)12-11-23(19,2)3)14-18(15)21(25)16-7-9-17(10-8-16)22(26)27/h7-10,13-14H,6,11-12H2,1-5H3,(H,26,27)
Affinity DataEC50:  384nMAssay Description:Effective concentration against retinoid receptor isoform (RXR gamma) expressed in CV-1 cellsMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50033079(4-[1-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-napht...)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(=C)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H26O2/c1-15(16-6-8-17(9-7-16)21(24)25)18-10-11-19-20(14-18)23(4,5)13-12-22(19,2)3/h6-11,14H,1,12-13H2,2-5H3,(H,24,25)
Affinity DataEC50:  404nMAssay Description:Effective concentration against retinoid receptor isoform (RXR gamma) expressed in CV-1 cellsMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50032676(4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1Oc1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C22H26O3/c1-14-12-17-18(22(4,5)11-10-21(17,2)3)13-19(14)25-16-8-6-15(7-9-16)20(23)24/h6-9,12-13H,10-11H2,1-5H3,(H,23,24)
Affinity DataEC50:  430nMAssay Description:Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.More data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50032663(4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1Cc1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H28O2/c1-15-12-19-20(23(4,5)11-10-22(19,2)3)14-18(15)13-16-6-8-17(9-7-16)21(24)25/h6-9,12,14H,10-11,13H2,1-5H3,(H,24,25)
Affinity DataEC50:  440nMAssay Description:Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.More data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50032662(4-[1-(1,1,2,3,3,6-Hexamethyl-indan-5-yl)-vinyl]-be...)
Show SMILES CC1C(C)(C)c2cc(C)c(cc2C1(C)C)C(=C)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H28O2/c1-14-12-20-21(24(6,7)16(3)23(20,4)5)13-19(14)15(2)17-8-10-18(11-9-17)22(25)26/h8-13,16H,2H2,1,3-7H3,(H,25,26)
Affinity DataEC50:  500nMAssay Description:Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.More data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50040024(4-[1-(3-Hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrah...)
Show SMILES CC1(C)CCC(C)(C)c2cc(C(=C)c3ccc(cc3)C(O)=O)c(O)cc12
Show InChI InChI=1S/C23H26O3/c1-14(15-6-8-16(9-7-15)21(25)26)17-12-18-19(13-20(17)24)23(4,5)11-10-22(18,2)3/h6-9,12-13,24H,1,10-11H2,2-5H3,(H,25,26)
Affinity DataEC50:  558nMAssay Description:Effective concentration against retinoid receptor isoform (RXR gamma) expressed in CV-1 cellsMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50032665(4-[1-(3,5,5-Trimethyl-5,6,7,8-tetrahydro-naphthale...)
Show SMILES Cc1cc2c(CCCC2(C)C)cc1C(=C)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H24O2/c1-14-12-20-18(6-5-11-22(20,3)4)13-19(14)15(2)16-7-9-17(10-8-16)21(23)24/h7-10,12-13H,2,5-6,11H2,1,3-4H3,(H,23,24)
Affinity DataEC50:  600nMAssay Description:Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.More data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50032670(4-[1-Methyl-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetra...)
Show SMILES Cc1cc2c(cc1C(C)(C)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C25H32O2/c1-16-14-20-21(24(4,5)13-12-23(20,2)3)15-19(16)25(6,7)18-10-8-17(9-11-18)22(26)27/h8-11,14-15H,12-13H2,1-7H3,(H,26,27)
Affinity DataEC50:  650nMAssay Description:Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.More data for this Ligand-Target Pair
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