Compile Data Set for Download or QSAR
Report error Found 43 Enz. Inhib. hit(s) with all data for entry = 50006449
TargetBDNF/NT-3 growth factors receptor(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 374727BDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.0500nMAssay Description:Displacement of [3H]-diprenorphine from human delta opioid receptor after 120 mins by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 374727BDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.0700nMAssay Description:Displacement of [3H]-diprenorphine from human delta opioid receptor after 120 mins by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetNT-3 growth factor receptor(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 374727BDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.100nMAssay Description:Displacement of [3H]-diprenorphine from human delta opioid receptor after 120 mins by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetHepatocyte growth factor receptor(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146167BDBM50146167(Capmatinib | INC-280 | INCB-28060 | NVP-INC280 | U...)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of human Nav1.2 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 469269BDBM469269(US10807985, Compound 44 | US20250129067, Compound ...)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of human Nav1.4 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 469269BDBM469269(US10807985, Compound 44 | US20250129067, Compound ...)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of human Nav1.4 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 435010BDBM435010(US10584114, Compound 130 | US11279688, Compound 13...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human Nav1.2 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetFibroblast growth factor receptor 1/2/3/4(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human Nav1.3 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human Nav1.3 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMedPDB3D3D Structure (crystal)
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 435010BDBM435010(US10584114, Compound 130 | US11279688, Compound 13...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human Nav1.2 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 435010BDBM435010(US10584114, Compound 130 | US11279688, Compound 13...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human Nav1.2 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 435010BDBM435010(US10584114, Compound 130 | US11279688, Compound 13...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human Nav1.2 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetFibroblast growth factor receptor 2(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human Nav1.3 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMedPDB3D3D Structure (crystal)
TargetHigh affinity nerve growth factor receptor(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 374727BDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.830nMAssay Description:Displacement of [3H]-diprenorphine from human delta opioid receptor after 120 mins by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMedPDB3D3D Structure (crystal)
TargetHigh affinity nerve growth factor receptor(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 158154BDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human Nav1.5 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 3(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human Nav1.3 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 118299BDBM118299(US8653092, 67)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human Nav1.1 assessed as tonic block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 158154BDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human Nav1.5 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetTyrosine-protein kinase BTK(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594747BDBM50594747(Pirtobrutinib | Loxo-305 | LOXO-305 | LY-3527727 |...)
Affinity DataIC50: 3.70nMAssay Description:Displacement of [3H]-diprenorphine from human kappa opioid receptor after 120 mins by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50436459BDBM50436459(CHEMBL2396661)
Affinity DataIC50: 4nMAssay Description:Inhibition of human Nav1.5 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMedPDB3D3D Structure (crystal)
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50436459BDBM50436459(CHEMBL2396661)
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]-diprenorphine from human delta opioid receptor after 120 mins by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMedPDB3D3D Structure (crystal)
TargetNT-3 growth factor receptor(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 158154BDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human Nav1.5 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
LigandChemical structure of BindingDB Monomer ID 50458159BDBM50458159(Nirogacestat | PF 03084014 | PF 3084014 | PF-03084...)
Affinity DataIC50: 6.20nMAssay Description:Displacement of [3H]-diprenorphine from human delta opioid receptor after 120 mins by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 158154BDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human Nav1.4 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594747BDBM50594747(Pirtobrutinib | Loxo-305 | LOXO-305 | LY-3527727 |...)
Affinity DataIC50: 8.5nMAssay Description:Displacement of [3H]-diprenorphine from human kappa opioid receptor after 120 mins by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 373040BDBM373040(US9896418, Compound 289 | US10597366, Compound 289)
Affinity DataIC50: 9nMAssay Description:Inhibition of human Nav1.1 assessed as inactivated-state block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMedPDB3D3D Structure (crystal)
TargetGTPase KRas(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50539763BDBM50539763(Adagrasib | Mrtx-849 | Mrtx849)
Affinity DataIC50: 10nMAssay Description:Inhibition of human Nav1.1 assessed as 10 Hz block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMedPDB3D3D Structure (crystal)
TargetMast/stem cell growth factor receptor Kit(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177716BDBM50177716(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human Nav1.4 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 118299BDBM118299(US8653092, 67)
Affinity DataIC50: 11nMAssay Description:Inhibition of human Nav1.1 assessed as tonic block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594747BDBM50594747(Pirtobrutinib | Loxo-305 | LOXO-305 | LY-3527727 |...)
Affinity DataIC50: 12nMAssay Description:Displacement of [3H]-diprenorphine from human delta opioid receptor after 120 mins by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 158154BDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human Nav1.4 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50355497BDBM50355497(AZD-6244 | CHEMBL1614701)
Affinity DataIC50: 14nMAssay Description:Inhibition of human Nav1.3 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMedPDB3D3D Structure (crystal)
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177716BDBM50177716(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human Nav1.4 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMedPDB3D3D Structure (crystal)
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 184556BDBM184556(US9150579, B1)
Affinity DataIC50: 22nMAssay Description:Inhibition of human Nav1.1 assessed as 10 Hz block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetFibroblast growth factor receptor 4(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human Nav1.3 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetALK tyrosine kinase receptor(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50170079BDBM50170079(CHEMBL3805002)
Affinity DataIC50: 30nMAssay Description:Inhibition of human Nav1.5 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetALK tyrosine kinase receptor(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50170078BDBM50170078(CHEMBL3806196)
Affinity DataIC50: 100nMAssay Description:Inhibition of human Nav1.5 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50170079BDBM50170079(CHEMBL3805002)
Affinity DataIC50: 200nMAssay Description:Inhibition of human Nav1.6 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 118299BDBM118299(US8653092, 67)
Affinity DataIC50: 244nMAssay Description:Displacement of [3H]-diprenorphine from human delta opioid receptor after 120 mins by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 118299BDBM118299(US8653092, 67)
Affinity DataIC50: 424nMAssay Description:Displacement of [3H]-diprenorphine from human delta opioid receptor after 120 mins by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50170078BDBM50170078(CHEMBL3806196)
Affinity DataIC50: 900nMAssay Description:Inhibition of human Nav1.6 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetCasein kinase I isoform epsilon(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 184556BDBM184556(US9150579, B1)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human Nav1.2 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetGTPase KRas(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514402BDBM50514402(CHEMBL4535757 | US11345701, Compound Amg-510)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of human Nav1.1 assessed as inactivated-state block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed