Compile Data Set for Download or QSAR
Report error Found 155 of affinity data for UniProtKB/TrEMBL: E7EQC8
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50526580BDBM50526580(CHEMBL4549036)
Affinity DataEC50:  530nMAssay Description:Inhibition of 8Fluo-cAMP binding to recombinant human His-tagged EPAC1 (157 to 881 residues) expressed in Escherichia coli measured after 5 mins by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511915BDBM50511915(CHEMBL4517829)
Affinity DataIC50: 900nMAssay Description:Binding affinity to GST-tagged recombinant EPAC1 CNBD (169 to 318 residues) (unknown origin) expressed in Escherichia coli BL21 Star (DE3) incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 81292BDBM81292(8-Bromoadenosine 3',5'-cyclic monophosphat...)
Affinity DataEC50:  1.09E+3nMAssay Description:Inhibition of 8Fluo-cAMP binding to recombinant human His-tagged EPAC1 (157 to 881 residues) expressed in Escherichia coli measured after 5 mins by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511914BDBM50511914(CHEMBL4576925)
Affinity DataIC50: 2.20E+3nMAssay Description:Binding affinity to GST-tagged recombinant EPAC1 CNBD (169 to 318 residues) (unknown origin) expressed in Escherichia coli BL21 Star (DE3) incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50450837BDBM50450837(CHEMBL397985 | 8-pCPT-2''-O-Me-cAMP)
Affinity DataEC50:  2.20E+3nMAssay Description:Activation of EPAC1 DEP1 deletion mutant (unknown origin) expressed in mouse NIH-3T3-A14 cells assessed as increase in Rap1b- fluorescent nucleotide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50098793BDBM50098793(CHEMBL3593342)
Affinity DataIC50: 2.40E+3nMAssay Description:Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2016
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50098793BDBM50098793(CHEMBL3593342)
Affinity DataIC50: 2.40E+3nMAssay Description:Displacement of 8-NBD-cAMP from recombinant human EPAC1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50098719BDBM50098719(CHEMBL3593329)
Affinity DataIC50: 2.40E+3nMAssay Description:Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2016
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50098719BDBM50098719(CHEMBL3593329)
Affinity DataIC50: 2.40E+3nMAssay Description:Displacement of 8-NBD-cAMP from recombinant human EPAC1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 517670BDBM517670(NY0460 | US11124489, Compound 14)
Affinity DataIC50: 2.40E+3nMAssay Description:To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241941BDBM50241941(CHEMBL4103080)
Affinity DataIC50: 2.40E+3nMAssay Description:Antagonist activity at recombinant human full length EPAC1 assessed as inhibition of EPAC1-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2019
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50526579BDBM50526579(CHEMBL4442766)
Affinity DataEC50:  2.54E+3nMAssay Description:Inhibition of 8Fluo-cAMP binding to recombinant human His-tagged EPAC1 (157 to 881 residues) expressed in Escherichia coli measured after 5 mins by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50098787BDBM50098787(CHEMBL3593468)
Affinity DataIC50: 2.60E+3nMAssay Description:Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2016
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50098793BDBM50098793(CHEMBL3593342)
Affinity DataIC50: 2.70E+3nMAssay Description:Antagonist activity at recombinant human full length EPAC1 assessed as inhibition of EPAC1-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2019
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241952BDBM50241952(CHEMBL4099528)
Affinity DataIC50: 2.70E+3nMAssay Description:Antagonist activity at recombinant human full length EPAC1 assessed as inhibition of EPAC1-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2019
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 517689BDBM517689(NY0562 | US11124489, Compound 33)
Affinity DataIC50: 2.70E+3nMAssay Description:To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50526578BDBM50526578(CHEMBL4468490)
Affinity DataEC50:  2.75E+3nMAssay Description:Inhibition of 8Fluo-cAMP binding to recombinant human His-tagged EPAC1 (157 to 881 residues) expressed in Escherichia coli measured after 5 mins by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 517688BDBM517688(NY0561 | US11124489, Compound 32)
Affinity DataIC50: 3.00E+3nMAssay Description:To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241961BDBM50241961(CHEMBL4081514)
Affinity DataIC50: 3.00E+3nMAssay Description:Antagonist activity at recombinant human full length EPAC1 assessed as inhibition of EPAC1-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2019
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50011360BDBM50011360(CHEMBL3260990)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of EPAC1 (unknown origin) assessed as cAMP-mediated GEF activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50011360BDBM50011360(CHEMBL3260990)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of EPAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50280395BDBM50280395(CHEMBL4171480)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of recombinant human GST-tagged EPAC1 (149 to 881 residues) expressed in Escherichia coli Rosetta 2(DE3) assessed as reduction in guanine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2020
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 517684BDBM517684(NY0725 | US11124489, Compound 26)
Affinity DataIC50: 3.60E+3nMAssay Description:To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241957BDBM50241957(CHEMBL4100650)
Affinity DataIC50: 3.60E+3nMAssay Description:Antagonist activity at recombinant human full length EPAC1 assessed as inhibition of EPAC1-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2019
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 517717BDBM517717(ZL0524 | US11124489, Entry 32)
Affinity DataIC50: 3.60E+3nMAssay Description:To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50452020BDBM50452020(CHEMBL4213611)
Affinity DataIC50: 3.60E+3nMAssay Description:Antagonist activity at recombinant full length EPAC1 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50098797BDBM50098797(CHEMBL3593471)
Affinity DataIC50: 4.00E+3nMAssay Description:Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2016
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50098796BDBM50098796(CHEMBL3593470)
Affinity DataIC50: 4.10E+3nMAssay Description:Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2016
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 517685BDBM517685(NY0726 | US11124489, Compound 27)
Affinity DataIC50: 4.20E+3nMAssay Description:To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241954BDBM50241954(CHEMBL4082655)
Affinity DataIC50: 4.20E+3nMAssay Description:Antagonist activity at recombinant human full length EPAC1 assessed as inhibition of EPAC1-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2019
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50280395BDBM50280395(CHEMBL4171480)
Affinity DataIC50: 4.20E+3nMAssay Description:Antagonist activity at recombinant human GST-fused EPAC1 (149 to 881 residues) expressed in Escherichia coli Rosetta (DE3) assessed as inhibition of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50098794BDBM50098794(CHEMBL3593341)
Affinity DataIC50: 4.30E+3nMAssay Description:Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2016
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50384264BDBM50384264(CHEMBL316966)
Affinity DataKd:  4.50E+3nMAssay Description:Binding affinity to GST-tagged human EPAC1 CNBD (149 to 318 residues) expressed in Escherichia coli BL21 (DE3) incubated for 30 mins by 8-NBD-cAMP ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241953BDBM50241953(CHEMBL4091792)
Affinity DataIC50: 4.60E+3nMAssay Description:Antagonist activity at recombinant human full length EPAC1 assessed as inhibition of EPAC1-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2019
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 517687BDBM517687(NY0495 | US11124489, Compound 31)
Affinity DataIC50: 4.60E+3nMAssay Description:To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511913BDBM50511913(CHEMBL4459738)
Affinity DataIC50: 4.60E+3nMAssay Description:Binding affinity to GST-tagged recombinant EPAC1 CNBD (169 to 318 residues) (unknown origin) expressed in Escherichia coli BL21 Star (DE3) incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511918BDBM50511918(CHEMBL4450888)
Affinity DataIC50: 4.80E+3nMAssay Description:Binding affinity to GST-tagged recombinant EPAC1 CNBD (169 to 318 residues) (unknown origin) expressed in Escherichia coli BL21 Star (DE3) incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511917BDBM50511917(CHEMBL4534834)
Affinity DataKd:  4.90E+3nMAssay Description:Binding affinity to GST-tagged human EPAC1 L273W mutant expressed in Escherichia coli BL21 (DE3) incubated for 30 mins by 8-NBD-cAMP based competitiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511918BDBM50511918(CHEMBL4450888)
Affinity DataEC50:  5.00E+3nMAssay Description:Activation of recombinant EPAC1 (149 to 881 residues) (unknown origin) assessed as stimulation of dissociation of fluorescent MANT-GDP from recombina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511915BDBM50511915(CHEMBL4517829)
Affinity DataEC50:  5.00E+3nMAssay Description:Activation of recombinant EPAC1 (149 to 881 residues) (unknown origin) assessed as stimulation of dissociation of fluorescent MANT-GDP from recombina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511914BDBM50511914(CHEMBL4576925)
Affinity DataEC50:  5.00E+3nMAssay Description:Activation of recombinant EPAC1 (149 to 881 residues) (unknown origin) assessed as stimulation of dissociation of fluorescent MANT-GDP from recombina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 517675BDBM517675(NY0541 | US11124489, Compound 17b)
Affinity DataIC50: 5.10E+3nMAssay Description:To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 517696BDBM517696(ZL0475 | US11124489, Entry 11)
Affinity DataIC50: 5.40E+3nMAssay Description:To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50452021BDBM50452021(CHEMBL4210825)
Affinity DataIC50: 5.40E+3nMAssay Description:Antagonist activity at recombinant full length EPAC1 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50452009BDBM50452009(CHEMBL4205201)
Affinity DataIC50: 5.50E+3nMAssay Description:Antagonist activity at recombinant full length EPAC1 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 517701BDBM517701(ZL0479 | US11124489, Entry 15)
Affinity DataIC50: 5.50E+3nMAssay Description:To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50280395BDBM50280395(CHEMBL4171480)
Affinity DataIC50: 5.50E+3nMAssay Description:Antagonist activity at recombinant full length EPAC1 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 517681BDBM517681(NY0654 | US11124489, Compound 23)
Affinity DataIC50: 5.60E+3nMAssay Description:To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451965BDBM50451965(CHEMBL4217436)
Affinity DataIC50: 5.60E+3nMAssay Description:Antagonist activity at recombinant full length EPAC1 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 517682BDBM517682(NY0655 | US11124489, Compound 24)
Affinity DataIC50: 5.60E+3nMAssay Description:To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

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