Compile Data Set for Download or QSAR
Report error Found 9077 for UniProtKB: Q07820
LigandChemical structure of BindingDB Monomer ID 451126BDBM451126(US10676485, Example 36)
Affinity DataKi:  0.00100nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451115BDBM451115(US10676485, Example 25)
Affinity DataKi:  0.00300nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451129BDBM451129(US10676485, Example 39)
Affinity DataKi:  0.00400nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 673751BDBM673751(US20240150293, Example 987 | (1r,4S,4′R,8...)
Affinity DataKi:  0.00400nMAssay Description:The addition of a compound which binds competitively to the same site as the peptide will result in an increase in the fluorescence intensity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451099BDBM451099(US10676485, Example 9)
Affinity DataKi:  0.00500nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 470989BDBM470989(US10821115, Example 100135 | US10821115, Example 1...)
Affinity DataKi:  0.00600nMAssay Description:Inhibition of recombinant His6-tagged human MCL1 (171 to 327 residues) expressed in Escherichia coli and biotinylated Bim BH3 peptide interaction usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 451104BDBM451104(US10676485, Example 14)
Affinity DataKi:  0.00600nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50587659BDBM50587659(CHEMBL5186095)
Affinity DataKi:  0.00600nMAssay Description:Inhibition of recombinant His6-tagged human MCL1 (171 to 327 residues) expressed in Escherichia coli and biotinylated Bim BH3 peptide interaction usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 673652BDBM673652(US20240150293, Example 837 | Example 837A (2E)-3-(...)
Affinity DataKi:  0.00700nMAssay Description:The addition of a compound which binds competitively to the same site as the peptide will result in an increase in the fluorescence intensity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 673748BDBM673748(US20240150293, Example 984 | Example 984A (3R)-but...)
Affinity DataKi:  0.00700nMAssay Description:The addition of a compound which binds competitively to the same site as the peptide will result in an increase in the fluorescence intensity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451117BDBM451117(US10676485, Example 27)
Affinity DataKi:  0.00800nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451131BDBM451131(US10676485, Example 41)
Affinity DataKi:  0.00900nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 673736BDBM673736(US20240150293, Example 972 | (1r,3'S,4S,7′S)...)
Affinity DataKi:  0.00900nMAssay Description:The addition of a compound which binds competitively to the same site as the peptide will result in an increase in the fluorescence intensity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 668469BDBM668469(US20240124487, Compound 9)
Affinity DataKi:  0.00900nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 668463BDBM668463(US20240124487, Compound 3 | US20240124487, Compoun...)
Affinity DataKi:  0.00900nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 668466BDBM668466(US20240124487, Compound 6)
Affinity DataKi:  0.00900nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451139BDBM451139(US10676485, Example 49)
Affinity DataKi: <0.0100nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451097BDBM451097(US10676485, Example 7)
Affinity DataKi: <0.0100nMAssay Description:Binding affinity to Mcl-1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 668477BDBM668477(US20240124487, Compound 17 | US20240124487, Compou...)
Affinity DataKi:  0.0100nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 203875BDBM203875(7-(3-((4-Borono-3-formylphenoxy)methyl)-1,5-dimeth...)
Affinity DataKd:  0.0100nMAssay Description:Binding affinity to MCl-1 (unknown origin) assessed as binding affinity constant for state twoMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 451142BDBM451142(US10676485, Example 52)
Affinity DataKi: <0.0100nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 668470BDBM668470(US20240124487, Compound 10 | US20240124487, Compou...)
Affinity DataKi:  0.0100nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451141BDBM451141(US10676485, Example 51)
Affinity DataKi: <0.0100nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 673704BDBM673704(US20240150293, Example 921 | Example 921A methyl (...)
Affinity DataKi:  0.0110nMAssay Description:The addition of a compound which binds competitively to the same site as the peptide will result in an increase in the fluorescence intensity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 673658BDBM673658(US20240150293, Example 844 | Example 844A 3-chloro...)
Affinity DataKi:  0.0110nMAssay Description:The addition of a compound which binds competitively to the same site as the peptide will result in an increase in the fluorescence intensity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 685604BDBM685604(US20240239812, Compound 30 | US20240239812, Compou...)
Affinity DataKi:  0.0110nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451111BDBM451111(US10676485, Example 21)
Affinity DataKi:  0.0110nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451119BDBM451119(US10676485, Example 29)
Affinity DataKi:  0.0110nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 685600BDBM685600(US20240239812, Compound 26 | US20240239812, Compou...)
Affinity DataKi:  0.0110nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 668465BDBM668465(US20240124487, Compound 5)
Affinity DataKi:  0.0110nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 673728BDBM673728(US20240150293, Example 962 | Example 962A methyl (...)
Affinity DataKi:  0.0110nMAssay Description:The addition of a compound which binds competitively to the same site as the peptide will result in an increase in the fluorescence intensity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 668467BDBM668467(US20240124487, Compound 7)
Affinity DataKi:  0.0110nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 673725BDBM673725(US20240150293, Example 959 | Example 959A methyl (...)
Affinity DataKi:  0.0120nMAssay Description:The addition of a compound which binds competitively to the same site as the peptide will result in an increase in the fluorescence intensity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 470606BDBM470606(US10821115, Example 10 | US11224601, Example 10)
Affinity DataKi:  0.0120nMAssay Description:Inhibition of recombinant His6-tagged human MCL1 (171 to 327 residues) expressed in Escherichia coli and biotinylated Bim BH3 peptide interaction usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 673737BDBM673737(US20240150293, Example 973 | Example 973A (2S)-pro...)
Affinity DataKi:  0.0120nMAssay Description:The addition of a compound which binds competitively to the same site as the peptide will result in an increase in the fluorescence intensity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451135BDBM451135(US10676485, Example 45)
Affinity DataKi:  0.0120nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451105BDBM451105(US10676485, Example 15)
Affinity DataKi:  0.0130nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451137BDBM451137(US10676485, Example 47)
Affinity DataKi:  0.0130nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 668468BDBM668468(US20240124487, Compound 8)
Affinity DataKi:  0.0130nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 668486BDBM668486(US20240124487, Compound 27 | US20240124487, Compou...)
Affinity DataKi:  0.0130nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50627197BDBM50627197(CHEMBL5396628)
Affinity DataKi:  0.0130nMAssay Description:Displacement of Cy5-labeled BIM BH3 peptide (H3N-(C/Cy5Mal)-WIAQELRRIGDEFN-OH) from MCL-1 (unknown origin) assessed as inhibition constant incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 685582BDBM685582(US20240239812, Compound 6)
Affinity DataKi:  0.0140nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451130BDBM451130(US10676485, Example 40)
Affinity DataKi:  0.0140nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471064BDBM471064(US10821115, Example 100078 | US10821115, Example 1...)
Affinity DataKi:  0.0140nMAssay Description:Inhibition of recombinant His6-tagged human MCL1 (171 to 327 residues) expressed in Escherichia coli and biotinylated Bim BH3 peptide interaction usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 673735BDBM673735(US20240150293, Example 971 | Example 971A (2R)-pro...)
Affinity DataKi:  0.0140nMAssay Description:The addition of a compound which binds competitively to the same site as the peptide will result in an increase in the fluorescence intensity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 685604BDBM685604(US20240239812, Compound 30 | US20240239812, Compou...)
Affinity DataKi:  0.0140nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 470606BDBM470606(US10821115, Example 10 | US11224601, Example 10)
Affinity DataKi:  0.0150nMAssay Description:Binding affinity to Mcl-1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 668472BDBM668472(US20240124487, Compound 12 | US20240124487, Compou...)
Affinity DataKi:  0.0150nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451120BDBM451120(US10676485, Example 30)
Affinity DataKi:  0.0150nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50627203BDBM50627203(CHEMBL5307201)
Affinity DataKi:  0.0150nMAssay Description:Displacement of Cy5-labeled BIM BH3 peptide (H3N-(C/Cy5Mal)-WIAQELRRIGDEFN-OH) from MCL-1 (unknown origin) assessed as inhibition constant incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
Displayed 1 to 50 (of 9077 total ) | Next | Last >>
Jump to: