Found 481 with Last Name = 'aubele' and Initial = 'dl' 
Affinity DataIC50: 0.130nMAssay Description:Inhibition of gamma-secretase in human IMR32 cell membrane using APP as substrate after 2 hrs by ELISAMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.170nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.210nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.220nMAssay Description:Inhibition of gamma-secretase in human IMR32 cell membrane using APP as substrate after 2 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 0.240nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.260nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.260nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.260nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.280nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of gamma-secretase in human IMR32 cell membrane using APP as substrate after 2 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 0.310nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.340nMAssay Description:Inhibition of gamma-secretase in human IMR32 cell membrane using APP as substrate after 2 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 0.360nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.370nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of gamma-secretase in human IMR32 cell membrane using APP as substrate after 2 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 0.410nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.420nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.440nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.460nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Imago Pharmaceuticals
US Patent
Imago Pharmaceuticals
US Patent
Affinity DataIC50: 0.5nMpH: 7.5 T: 2°CAssay Description:Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...More data for this Ligand-Target Pair
Affinity DataIC50: 0.520nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.570nMAssay Description:Inhibition of gamma-secretase in human IMR32 cell membrane using APP as substrate after 2 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 0.580nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.620nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.650nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.670nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.740nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.760nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.930nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Imago Pharmaceuticals
US Patent
Imago Pharmaceuticals
US Patent
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...More data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Imago Pharmaceuticals
US Patent
Imago Pharmaceuticals
US Patent
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...More data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Imago Pharmaceuticals
US Patent
Imago Pharmaceuticals
US Patent
Affinity DataIC50: 1nMAssay Description:Inhibition of wild type GST-tagged LRRK2 (970 to 2527 amino acid residues) (unknown origin) assessed as inhibition of biotinylated-LRRKtide phosphory...More data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Imago Pharmaceuticals
US Patent
Imago Pharmaceuticals
US Patent
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...More data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Imago Pharmaceuticals
US Patent
Imago Pharmaceuticals
US Patent
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of gamma-secretase in human IMR32 cell membrane using APP as substrate after 2 hrs by ELISAMore data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Imago Pharmaceuticals
US Patent
Imago Pharmaceuticals
US Patent
Affinity DataIC50: 1nMAssay Description:Inhibition of wild type GST-tagged LRRK2 (970 to 2527 amino acid residues) (unknown origin) assessed as inhibition of biotinylated-LRRKtide phosphory...More data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Imago Pharmaceuticals
US Patent
Imago Pharmaceuticals
US Patent
Affinity DataIC50: 1nMAssay Description:Inhibition of wild type GST-tagged LRRK2 (970 to 2527 amino acid residues) (unknown origin) assessed as inhibition of biotinylated-LRRKtide phosphory...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of gamma-secretase in human IMR32 cell membrane using APP as substrate after 2 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of gamma-secretase in human IMR32 cell membrane using Notch as substrate after 2 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of gamma-secretase in human IMR32 cell membrane using APP as substrate after 2 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibition of gamma-secretase in human IMR32 cell membrane using APP as substrate after 2 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibition of gamma-secretase in human IMR32 cell membrane using APP as substrate after 2 hrs by ELISAMore data for this Ligand-Target Pair
