70 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
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2
Biosynthetic approaches to creating bioactive fungal metabolites: Pathway engineering and activation of secondary metabolism.
Riken Csrs
2
Functional 1,3a,6a-triazapentalene scaffold: Design of fluorescent probes for kinesin spindle protein (KSP).
University of Shizuoka
26
Structure-Guided Design of Novel l-Cysteine Derivatives as Potent KSP Inhibitors.
University of Shizuoka
27
Discovery of novel spiro 1,3,4-thiadiazolines as potent, orally bioavailable and brain penetrant KSP inhibitors.
Merck Research Laboratories
6
Synthetic studies on mitotic kinesin Eg5 inhibitors: synthesis and structure-activity relationships of novel 2,4,5-substituted-1,3,4-thiadiazoline derivatives.
Kyowa Hakko Kirin
1
Design, synthesis and anticancer evaluation of tetrahydro-ß-carboline-hydantoin hybrids.
TBA
54
Optimization of diaryl amine derivatives as kinesin spindle protein inhibitors.
Kyoto University
19
Synthesis, biological evaluation and molecular docking studies of flavone and isoflavone derivatives as a novel class of KSP (kinesin spindle protein) inhibitors.
Nanjing University
1
Resistance by allostery: a novel perspective for eg5-targeted drug design.
Korea Institute of Science and Technology
2
Mitotic kinesin Eg5 overcomes inhibition to the phase I/II clinical candidate SB743921 by an allosteric resistance mechanism.
The Beatson Institute For Cancer Research
20
Advances in the discovery of kinesin spindle protein (Eg5) inhibitors as antitumor agents.
Cairo University
49
Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models.
The Beatson Institute For Cancer Research
1
Discovery of coumarin-monastrol hybrid as potential antibreast tumor-specific agent.
Csir-Central Drug Research Institute
36
Doing the methylene shuffle--further insights into the inhibition of mitotic kinesin Eg5 with S-trityl L-cysteine.
University of Strathclyde
6
Receptor-ligand interaction-based virtual screening for novel Eg5/kinesin spindle protein inhibitors.
Korea Institute of Science and Technology
59
Triphenylbutanamines: kinesin spindle protein inhibitors with in vivo antitumor activity.
The Beatson Institute For Cancer Research
62
The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5.
Merck Serono
16
Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors.
Bristol Myers Squibb
1
Recent progress in biological activities of synthesized phenothiazines.
The Medical University of Silesia
64
Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent.
AstraZeneca
34
De novo design, synthesis and biological evaluation of 1,4-dihydroquinolin-4-ones and 1,2,3,4-tetrahydroquinazolin-4-ones as potent kinesin spindle protein (KSP) inhibitors.
China Pharmaceutical University
7
Synthesis and characterization of tritylthioethanamine derivatives with potent KSP inhibitory activity.
New Mexico State University
1
Synthesis and biological evaluation of conformationally flexible as well as restricted dimers of monastrol and related dihydropyrimidones.
Indian Institute of Chemical Technology
19
Structure-activity relationships of carboline and carbazole derivatives as a novel class of ATP-competitive kinesin spindle protein inhibitors.
Kyoto University
24
Structure-activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5.
Institute For Cancer Research
23
Design, synthesis and bioevaluation of dihydropyrazolo[3,4-b]pyridine and benzo[4,5]imidazo[1,2-a]pyrimidine compounds as dual KSP and Aurora-A kinase inhibitors for anti-cancer agents.
China Pharmaceutical University
3
Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol.
Institute For Cancer Research
28
Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds.
Kyoto University
30
Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP.
China Pharmaceutical University
30
The discovery of tetrahydro-beta-carbolines as inhibitors of the kinesin Eg5.
Novartis Institutes For Biomedical Research
38
Substituted benzimidazoles: A novel chemotype for small molecule hKSP inhibitors.
Schering-Plough Research Institute
26
Bis(hetero)aryl derivatives as unique kinesin spindle protein inhibitors.
University of Shizuoka
2
Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration.
Cnrs-Commissariat à
3
Discovery of novel KSP-targeting PROTACs with potent antitumor effects in vitro and in vivo.
Wuyi University
15
Design, Biological Characterization, and Discovery of Novel Cyclohexenyl Derivatives as Kinesin KIF18A Inhibitors for the Treatment of Ovarian Cancer.
Changchun Genescience Pharma
36
Pyrrole-containing hybrids as potential anticancer agents: An insight into current developments and structure-activity relationships.
Jiangxi Science & Technology Normal University
16
Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP.
Merck Research Laboratories
15
Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP.
Merck Research Laboratories
40
Discovery of 2-(3-Benzamidopropanamido)thiazole-5-carboxylate Inhibitors of the Kinesin HSET (KIFC1) and the Development of Cellular Target Engagement Probes.
Institute of Cancer Research
21
Synthesis and biological evaluation of L-cysteine derivatives as mitotic kinesin Eg5 inhibitors.
University of Shizuoka
7
Kinesin spindle protein (KSP) inhibitors. Part V: discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by beta-fluorination to overcome cellular efflux by P-glycoprotein.
Merck Research Laboratories
14
A comprehensive overview of β-carbolines and its derivatives as anticancer agents.
Xinyang Normal University
16
A review of synthetic bioactive tetrahydro-β-carbolines: A medicinal chemistry perspective.
Northwest A&F University
26
Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe.
Amgen
8
Kinesin spindle protein (KSP) inhibitors. Part 3: synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility.
Merck Research Laboratories
31
Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP.
Merck Research Laboratories
7
Design, synthesis, and evaluation of a novel prodrug, a S-trityl-
University of Shizuoka
3
Design, synthesis, and bioactivity of dihydropyrimidine derivatives as kinesin spindle protein inhibitors.
Tanta University
1
Design and synthesis of novel phenyl -1, 4-beta-carboline-hybrid molecules as potential anticancer agents.
Karnatak University
21
Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors.
University College London
6
Synthesis and anticancer activity of new dihydropyrimidinone derivatives.
Mansoura University
27
Design and synthesis of novel thiadiazole-thiazolone hybrids as potential inhibitors of the human mitotic kinesin Eg5.
University of Kwazulu-Natal (Ukzn)
5
Synthesis of N-(1-(6-acetamido-5-phenylpyrimidin-4-yl) piperidin-3-yl) amide derivatives as potential inhibitors for mitotic kinesin spindle protein.
Alagappa University
1
PHARMACEUTICALLY ACCEPTABLE SALT OF PYRAZOLOHETEROARYL DERIVATIVE AND CRYSTAL FORM THEREOF
Jiangsu Hengrui Pharmaceuticals
9
Phosphonate derivatives and methods of use thereof in the treatment of Alzheimer's disease
University of Kansas
42
Potent human immunodeficiency virus type 1 protease inhibitors that utilize noncoded D-amino acids as P2/P3 ligands.
Eli Lilly