Compile Data Set for Download or QSAR
Report error Found 372 Enz. Inhib. hit(s) with Target = 'Ileal sodium/bile acid cotransporter'
TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 77055BDBM77055(US9694018, 8 | US10093697, 8. | US10487111, Exampl...)
Affinity DataIC50: 0.110nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
US Patent

TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 77055BDBM77055(US9694018, 8 | US10093697, 8. | US10487111, Exampl...)
Affinity DataIC50: 0.110nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent

TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 77086BDBM77086(US9694018, 13 | US10093697, 13. | US10487111, Exam...)
Affinity DataIC50: 0.130nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent

TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 77086BDBM77086(US9694018, 13 | US10093697, 13. | US10487111, Exam...)
Affinity DataIC50: 0.130nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
US Patent

TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 420288BDBM420288(US10487111, Example 11.)
Affinity DataIC50: 0.150nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/20/2020
Entry Details
US Patent

TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 77080BDBM77080(US9694018, 11 | US10093697, 11.)
Affinity DataIC50: 0.150nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent

TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 77040BDBM77040(US9694018, 5 | US10093697, 5. | US10487111, Exampl...)
Affinity DataIC50: 0.160nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent

TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 77040BDBM77040(US9694018, 5 | US10093697, 5. | US10487111, Exampl...)
Affinity DataIC50: 0.160nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
US Patent

TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 77029BDBM77029(US9694018, 3 | US10093697, 3. | US10487111, Exampl...)
Affinity DataIC50: 0.180nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent

TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 77029BDBM77029(US9694018, 3 | US10093697, 3. | US10487111, Exampl...)
Affinity DataIC50: 0.180nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
US Patent

TargetIleal sodium/bile acid cotransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 159808BDBM159808(US9040518, 25 | BDBM50434850)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of rat ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 77074BDBM77074(US9694018, 10 | US10093697, 10. | US10487111, Exam...)
Affinity DataIC50: 0.200nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
US Patent

TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 77074BDBM77074(US9694018, 10 | US10093697, 10. | US10487111, Exam...)
Affinity DataIC50: 0.200nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent

TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 50140282BDBM50140282(CHEMBL363392 | CHEMBL17879 | 1-{4-[4-((4R,5R)-3,3-...)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 50140282BDBM50140282(CHEMBL363392 | CHEMBL17879 | 1-{4-[4-((4R,5R)-3,3-...)
Affinity DataIC50: 0.280nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Mouse)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 159808BDBM159808(US9040518, 25 | BDBM50434850)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of mouse ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 77083BDBM77083(US9694018, 12 | US10093697, 12. | US10487111, Exam...)
Affinity DataIC50: 0.300nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
US Patent

TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 77083BDBM77083(US9694018, 12 | US10093697, 12. | US10487111, Exam...)
Affinity DataIC50: 0.300nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent

TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 50172695BDBM50172695({2-[3-((4R,5R)-3,3-Dibutyl-7-dimethylamino-4-hydro...)
Affinity DataIC50: 0.300nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 77033BDBM77033(US9694018, 4 | US10093697, 4. | US10487111, Exampl...)
Affinity DataIC50: 0.350nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent

TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 77033BDBM77033(US9694018, 4 | US10093697, 4. | US10487111, Exampl...)
Affinity DataIC50: 0.350nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
US Patent

TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 77051BDBM77051(US9694018, 7 | US10093697, 7. | US10487111, Exampl...)
Affinity DataIC50: 0.360nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent

TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 77051BDBM77051(US9694018, 7 | US10093697, 7. | US10487111, Exampl...)
Affinity DataIC50: 0.360nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
US Patent

TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 76996BDBM76996(US9694018, 2 | US10487111, Example 2.)
Affinity DataIC50: 0.390nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
US Patent

TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 77074BDBM77074(US9694018, 10 | US10093697, 10. | US10487111, Exam...)
Affinity DataIC50: 0.390nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent

TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 76994BDBM76994(US9694018, 1 | US10093697, 1. | US10487111, Exampl...)
Affinity DataIC50: 0.450nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
US Patent

TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 76994BDBM76994(US9694018, 1 | US10093697, 1. | US10487111, Exampl...)
Affinity DataIC50: 0.450nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent

TargetIleal sodium/bile acid cotransporter(Mouse)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50434849BDBM50434849(CHEMBL2385105 | US9040518, 6)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of mouse ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 50172649BDBM50172649(1-{5-[4-((4R,5R)-3,3-Dibutyl-7-dimethylamino-4-hyd...)
Affinity DataIC50: 0.5nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 50172702BDBM50172702(4-[4-((4R,5R)-3,3-Dibutyl-7-dimethylamino-4-hydrox...)
Affinity DataIC50: 0.75nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 50370667BDBM50370667(CHEMBL555246)
Affinity DataIC50: 0.760nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Mouse)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50434846BDBM50434846(CHEMBL2387399 | US9040518, 35)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of mouse ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50434849BDBM50434849(CHEMBL2385105 | US9040518, 6)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of rat ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 50172668BDBM50172668(1-{4-[4-((4R,5R)-3,3-Dibutyl-7-dimethylamino-4-hyd...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 50172709BDBM50172709(1-{4-[4-((4R,5R)-3,3-Dibutyl-7-dimethylamino-4-hyd...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 159835BDBM159835(US9040518, 68)
Affinity DataIC50: 1nMT: 2°CAssay Description:On the day of the uptake experiment, 10 mM HEPES was added to Hank's Balanced Salt Solution, and the pH was adjusted to 7.4 with TRIS (HBSSH). The as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 77088BDBM77088(US9694018, 14 | US10093697, 14. | US10487111, Exam...)
Affinity DataIC50: 1.20nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent

TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 77088BDBM77088(US9694018, 14 | US10093697, 14. | US10487111, Exam...)
Affinity DataIC50: 1.20nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
US Patent

TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 50134416BDBM50134416(Trifluoro-acetate{4-[3-((8R,9R)-7,7-dibutyl-2-dime...)
Affinity DataIC50: 1.60nMAssay Description:In vitro inhibitory activity against uptake of [14C]taurocholate in baby hamster kidney cells transfected with cDNA from human Apical Sodium-Codepend...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 47370BDBM47370(BDBM50434858 | US9040518, 26)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of rat ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 50172681BDBM50172681((Carboxymethyl-{4-[4-((4R,5R)-3,3-dibutyl-7-dimeth...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 50172608BDBM50172608((4R,5R)-3,3-Dibutyl-7-dimethylamino-9-methoxy-5-(4...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in Baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 50172667BDBM50172667(4-[3-((4R,5R)-3,3-Dibutyl-7-dimethylamino-4-hydrox...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 159822BDBM159822(US9040518, 46)
Affinity DataIC50: 2nMT: 2°CAssay Description:On the day of the uptake experiment, 10 mM HEPES was added to Hank's Balanced Salt Solution, and the pH was adjusted to 7.4 with TRIS (HBSSH). The as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 159806BDBM159806(BDBM50434848 | US9040518, 23)
Affinity DataIC50: 2nMT: 2°CAssay Description:On the day of the uptake experiment, 10 mM HEPES was added to Hank's Balanced Salt Solution, and the pH was adjusted to 7.4 with TRIS (HBSSH). The as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 50172652BDBM50172652((4R,5R)-5-(3-Amino-phenyl)-3,3-dibutyl-7-dimethyla...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 50434847BDBM50434847(CHEMBL2387421 | US9040518, 3)
Affinity DataIC50: 2nMT: 2°CAssay Description:On the day of the uptake experiment, 10 mM HEPES was added to Hank's Balanced Salt Solution, and the pH was adjusted to 7.4 with TRIS (HBSSH). The as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 50370670BDBM50370670(CHEMBL540126)
Affinity DataIC50: 2nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 159806BDBM159806(BDBM50434848 | US9040518, 23)
Affinity DataIC50: 2nMAssay Description:Inhibition of human ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Albireo

US Patent
LigandChemical structure of BindingDB Monomer ID 50370669BDBM50370669(CHEMBL555022)
Affinity DataIC50: 2nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
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