Compile Data Set for Download or QSAR
Report error Found 1437 Enz. Inhib. hit(s) with Target = 'Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]'
LigandChemical structure of BindingDB Monomer ID 449686BDBM449686(US10703733, Example 299 | US10988451, Example 298 ...)
Affinity DataIC50: 0.0160nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449620BDBM449620(US10703733, Example 233 | US10988451, Example 233)
Affinity DataIC50: 0.0160nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449627BDBM449627(US10703733, Example 240 | US10988451, Example 240)
Affinity DataIC50: 0.0180nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449659BDBM449659(US10703733, Example 272 | US10988451, Example 272 ...)
Affinity DataIC50: 0.0180nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449730BDBM449730(US10703733, Example 343 | US10988451, Example 343 ...)
Affinity DataIC50: 0.0190nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 493822BDBM493822(US10988451, Example 292)
Affinity DataIC50: 0.0200nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449559BDBM449559(US10703733, Example 172 | US10988451, Example 172 ...)
Affinity DataIC50: 0.0220nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449749BDBM449749(US10703733, Example 362 | US10988451, Example 362 ...)
Affinity DataIC50: 0.0240nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449698BDBM449698(US10703733, Example 311 | US10988451, Example 311 ...)
Affinity DataIC50: 0.0240nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449548BDBM449548(US10703733, Example 161 | US10988451, Example 161 ...)
Affinity DataIC50: 0.0250nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471418BDBM471418(US10821115, Example 100433 | US11224601, Example 1...)
Affinity DataIC50: 0.0260nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449736BDBM449736(US10703733, Example 349 | US10988451, Example 349 ...)
Affinity DataIC50: 0.0260nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449687BDBM449687(US10703733, Example 300 | US10988451, Example 300 ...)
Affinity DataIC50: 0.0260nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449617BDBM449617(US10703733, Example 230 | US10988451, Example 230)
Affinity DataIC50: 0.0270nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449670BDBM449670(US10703733, Example 283 | US10988451, Example 283 ...)
Affinity DataIC50: 0.0290nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449637BDBM449637(US10703733, Example 250 | US10988451, Example 250)
Affinity DataIC50: 0.0290nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449729BDBM449729(US10703733, Example 342 | US10988451, Example 342 ...)
Affinity DataIC50: 0.0290nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449696BDBM449696(US10703733, Example 309 | US10988451, Example 309 ...)
Affinity DataIC50: 0.0290nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449674BDBM449674(US10703733, Example 287 | US10988451, Example 287 ...)
Affinity DataIC50: 0.0290nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449654BDBM449654(US10703733, Example 267 | US10988451, Example 267 ...)
Affinity DataIC50: 0.0300nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449717BDBM449717(US10703733, Example 330 | US10988451, Example 330 ...)
Affinity DataIC50: 0.0300nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 493759BDBM493759(US10988451, Example 229 | US11643400, Example 229)
Affinity DataIC50: 0.0300nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449577BDBM449577(US10703733, Example 194 | US10703733, Example 190 ...)
Affinity DataIC50: 0.0300nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449677BDBM449677(US10703733, Example 290 | US10988451, Example 290 ...)
Affinity DataIC50: 0.0300nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449733BDBM449733(US10703733, Example 346 | US10988451, Example 346 ...)
Affinity DataIC50: 0.0310nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471530BDBM471530(US10821115, Example 100547 | US11224601, Example 1...)
Affinity DataIC50: 0.0310nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449695BDBM449695(US10703733, Example 308 | US10988451, Example 308 ...)
Affinity DataIC50: 0.0310nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 470886BDBM470886(US10821115, Example 271 | (1S,3'R,6'R,7'S,8'E,11'S...)
Affinity DataIC50: 0.0310nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449727BDBM449727(US10703733, Example 340 | US10988451, Example 340 ...)
Affinity DataIC50: 0.0310nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449757BDBM449757(US10703733, Example 376 | US10988451, Example 376 ...)
Affinity DataIC50: 0.0310nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449547BDBM449547(US10703733, Example 195 | US10703733, Example 160 ...)
Affinity DataIC50: 0.0310nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449728BDBM449728(US10703733, Example 341 | US10988451, Example 341 ...)
Affinity DataIC50: 0.0320nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449631BDBM449631(US10703733, Example 244 | US10988451, Example 244)
Affinity DataIC50: 0.0320nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471007BDBM471007(US10821115, Example 100293 | US10821115, Example 1...)
Affinity DataIC50: 0.0320nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449558BDBM449558(US10703733, Example 171 | US10988451, Example 171 ...)
Affinity DataIC50: 0.0330nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471293BDBM471293(US10821115, Example 100308 | US10821115, Example 1...)
Affinity DataIC50: 0.0330nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 493827BDBM493827(US10988451, Example 297 | US11643400, Example 297)
Affinity DataIC50: 0.0330nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449625BDBM449625(US10703733, Example 238 | US10988451, Example 238)
Affinity DataIC50: 0.0330nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 493719BDBM493719(US10988451, Example 189)
Affinity DataIC50: 0.0330nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449704BDBM449704(US10703733, Example 317 | US10988451, Example 317 ...)
Affinity DataIC50: 0.0340nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449622BDBM449622(US10703733, Example 235 | US10988451, Example 235)
Affinity DataIC50: 0.0350nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449552BDBM449552(US10703733, Example 165 | US10988451, Example 165 ...)
Affinity DataIC50: 0.0350nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 470885BDBM470885(US10821115, Example 270 | US11224601, Example 270)
Affinity DataIC50: 0.0350nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449707BDBM449707(US10703733, Example 320 | US10988451, Example 320)
Affinity DataIC50: 0.0350nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449738BDBM449738(US10703733, Example 351 | US10988451, Example 351 ...)
Affinity DataIC50: 0.0350nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449801BDBM449801(US10703733, Example 422 | US10988451, Example 422)
Affinity DataIC50: 0.0350nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449538BDBM449538(US10703733, Example 151 | US10988451, Example 151 ...)
Affinity DataIC50: 0.0360nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449547BDBM449547(US10703733, Example 195 | US10703733, Example 160 ...)
Affinity DataIC50: 0.0360nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449638BDBM449638(US10703733, Example 251 | US10988451, Example 251 ...)
Affinity DataIC50: 0.0370nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 449732BDBM449732(US10703733, Example 345 | US10988451, Example 345 ...)
Affinity DataIC50: 0.0370nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

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