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Report error Found 134 Enz. Inhib. hit(s) with Target = 'Proteasome subunit beta type-10'
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50526811BDBM50526811(Kzr-616)
Affinity DataIC50: 0.131nMAssay Description:Inhibition of 20S proteasome beta 2i (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329819BDBM50329819((R)-1-((2S,3R)-3-hydroxy-2-(6-phenylpicolinamido)b...)
Affinity DataIC50: 10nMAssay Description:Inhibition of 20S proteasome beta 2i (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50277889BDBM50277889(CHEMBL451887 | CARFILZOMIB)
Affinity DataIC50: 13nMAssay Description:Inhibition of human 20S immunoproteasome beta-2i subunit using Ac-RLR-AMC as substrate preincubated for 2 hrs followed by substrate addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50426994BDBM50426994(CHEMBL2326533)
Affinity DataIC50: 20nMAssay Description:Inhibition of 20S immunoproteasome beta 2 in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50426994BDBM50426994(CHEMBL2326533)
Affinity DataIC50: 28nMAssay Description:Inhibition of human 20S immunoproteasome beta-2 using Bz-VGR-AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50517612BDBM50517612(CHEMBL4577205)
Affinity DataIC50: 57nMAssay Description:Inhibition of 20S immunoproteasome beta 2 in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50529640BDBM50529640(CHEMBL4452892)
Affinity DataIC50: 71nMAssay Description:Inhibition of MECL1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50529640BDBM50529640(CHEMBL4452892)
Affinity DataIC50: 71nMAssay Description:Inhibition of MECL1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50526813BDBM50526813(CHEMBL4465456)
Affinity DataIC50: 97nMAssay Description:Inhibition of 20S proteasome beta 2i (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50526813BDBM50526813(CHEMBL4465456)
Affinity DataIC50: 97nMAssay Description:Inhibition of MECL1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50526813BDBM50526813(CHEMBL4465456)
Affinity DataIC50: 97nMAssay Description:Inhibition of MECL1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50517607BDBM50517607(CHEMBL4590398)
Affinity DataIC50: 110nMAssay Description:Inhibition of 20S immunoproteasome beta 2 in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50517612BDBM50517612(CHEMBL4577205)
Affinity DataIC50: 124nMAssay Description:Inhibition of 20S immunoproteasome beta 2 in intact human RPMI8226 cells after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50274036BDBM50274036(CHEMBL4128478)
Affinity DataIC50: 130nMAssay Description:Inhibition of human 20S immunoproteasome beta-2 using Bz-VGR-AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50550642BDBM50550642(CHEMBL4787081)
Affinity DataIC50: 130nMAssay Description:Inhibition of human 20S immunoproteasome beta 2 subunit trypsin-like activity using fluorogenic peptide Ac-WLR-AMC as substrate in presence of PA28al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50517643BDBM50517643(CHEMBL4451682)
Affinity DataIC50: 140nMAssay Description:Inhibition of 20S immunoproteasome beta 2 in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Mouse)
Kezar Life Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50526813BDBM50526813(CHEMBL4465456)
Affinity DataIC50: 159nMAssay Description:Inhibition of MECL1 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50517604BDBM50517604(CHEMBL4513509)
Affinity DataIC50: 159nMAssay Description:Inhibition of 20S immunoproteasome beta 2 in intact human RPMI8226 cells after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Mouse)
Kezar Life Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50526813BDBM50526813(CHEMBL4465456)
Affinity DataIC50: 159nMAssay Description:Inhibition of MECL1 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50517629BDBM50517629(CHEMBL4446214)
Affinity DataIC50: 180nMAssay Description:Inhibition of 20S immunoproteasome beta 2 in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50517604BDBM50517604(CHEMBL4513509)
Affinity DataIC50: 190nMAssay Description:Inhibition of 20S immunoproteasome beta 2 in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50274033BDBM50274033(CHEMBL4128898)
Affinity DataIC50: 200nMAssay Description:Inhibition of human 20S immunoproteasome beta-2 using Bz-VGR-AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50274034BDBM50274034(CHEMBL4128074)
Affinity DataIC50: 210nMAssay Description:Inhibition of human 20S immunoproteasome beta-2 using Bz-VGR-AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50517609BDBM50517609(CHEMBL4440581)
Affinity DataIC50: 230nMAssay Description:Inhibition of 20S immunoproteasome beta 2 in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50274041BDBM50274041(CHEMBL4127967)
Affinity DataIC50: 300nMAssay Description:Inhibition of human 20S immunoproteasome beta-2 using Bz-VGR-AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50550643BDBM50550643(CHEMBL4749207)
Affinity DataIC50: 300nMAssay Description:Inhibition of human 20S immunoproteasome beta 2 subunit trypsin-like activity using fluorogenic peptide Ac-WLR-AMC as substrate in presence of PA28al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Mouse)
Kezar Life Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50529640BDBM50529640(CHEMBL4452892)
Affinity DataIC50: 305nMAssay Description:Inhibition of MECL1 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Mouse)
Kezar Life Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50529640BDBM50529640(CHEMBL4452892)
Affinity DataIC50: 305nMAssay Description:Inhibition of MECL1 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50273999BDBM50273999(CHEMBL4129702)
Affinity DataIC50: 360nMAssay Description:Inhibition of human 20S immunoproteasome beta-2 using Bz-VGR-AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50517611BDBM50517611(CHEMBL4544868)
Affinity DataIC50: 380nMAssay Description:Inhibition of 20S immunoproteasome beta 2 in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50274010BDBM50274010(CHEMBL4126411)
Affinity DataIC50: 395nMAssay Description:Inhibition of human 20S immunoproteasome beta-2 using Bz-VGR-AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50274011BDBM50274011(CHEMBL4125911)
Affinity DataIC50: 400nMAssay Description:Inhibition of human 20S immunoproteasome beta-2 using Bz-VGR-AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50426994BDBM50426994(CHEMBL2326533)
Affinity DataIC50: 410nMAssay Description:Inhibition of 20S immunoproteasome beta 2 in human RPMI8226 cell lysates after 1 hr by coomassie brilliant blue staining-based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099662BDBM50099662(CHEMBL3319481)
Affinity DataIC50: 410nMAssay Description:Inhibition of proteasome subunit beta-2i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2016
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50517596BDBM50517596(CHEMBL4450505)
Affinity DataIC50: 420nMAssay Description:Inhibition of 20S immunoproteasome beta 2 in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Mouse)
Kezar Life Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50526811BDBM50526811(Kzr-616)
Affinity DataIC50: 522nMAssay Description:Inhibition of MECL1 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Mouse)
Kezar Life Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50526811BDBM50526811(Kzr-616)
Affinity DataIC50: 522nMAssay Description:Inhibition of MECL1 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50069989BDBM50069989(CHEMBL325041 | (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...)
Affinity DataIC50: 540nMAssay Description:Inhibition of human 20S immunoproteasome beta 2 subunit trypsin-like activity using fluorogenic peptide Ac-WLR-AMC as substrate in presence of PA28al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50007203BDBM50007203(CHEMBL3237875)
Affinity DataIC50: 590nMAssay Description:Inhibition of proteasome subunit beta-2i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2016
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50007203BDBM50007203(CHEMBL3237875)
Affinity DataIC50: 590nMAssay Description:Inhibition of proteasome subunit beta-2i in human RPMI8226 cells using BODIPY-epoxomicin by fluorescent densitometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2016
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50277889BDBM50277889(CHEMBL451887 | CARFILZOMIB)
Affinity DataIC50: 620nMAssay Description:Inhibition of 20S proteasome beta 2i (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50526811BDBM50526811(Kzr-616)
Affinity DataIC50: 623nMAssay Description:Inhibition of MECL1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50526811BDBM50526811(Kzr-616)
Affinity DataIC50: 623nMAssay Description:Inhibition of MECL1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Mouse)
Kezar Life Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50007203BDBM50007203(CHEMBL3237875)
Affinity DataIC50: 699nMAssay Description:Inhibition of MECL1 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Mouse)
Kezar Life Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50007203BDBM50007203(CHEMBL3237875)
Affinity DataIC50: 699nMAssay Description:Inhibition of MECL1 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50464963BDBM50464963(CHEMBL4292640)
Affinity DataIC50: 820nMAssay Description:Inhibition of human 20S immunoproteasome beta-2 using BocLRR-AMC as substrate incubated for 15 mins measured for 45 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099662BDBM50099662(CHEMBL3319481)
Affinity DataIC50: 900nMAssay Description:Inhibition of proteasome subunit beta-2i in human RPMI8226 cells using BODIPY-epoxomicin by fluorescent densitometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2016
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50007203BDBM50007203(CHEMBL3237875)
Affinity DataIC50: 902nMAssay Description:Inhibition of MECL1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50007203BDBM50007203(CHEMBL3237875)
Affinity DataIC50: 902nMAssay Description:Inhibition of MECL1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50007203BDBM50007203(CHEMBL3237875)
Affinity DataIC50: 911nMAssay Description:Inhibition of MECL1 in human MOLT4 cell lysate after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2019
Entry Details Article
PubMed
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