Compile Data Set for Download or QSAR
Report error Found 2792 Enz. Inhib. hit(s) with Target = 'Sodium channel protein type 8 subunit alpha'
LigandChemical structure of BindingDB Monomer ID 50240277BDBM50240277(CHEMBL4061793)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of human Nav1.6 alpha expressed in HEK293 cells incubated for 5 mins with 6 consecutive train pulses to -10 mV at 0.1 Hz and holding poten...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50240278BDBM50240278(CHEMBL4062780)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of human Nav1.6 alpha expressed in HEK293 cells incubated for 5 mins with 6 consecutive train pulses to -10 mV at 0.1 Hz and holding poten...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 630994BDBM630994(US11802122, Example 73A | US11802122, Example 73B ...)
Affinity DataIC50: 0.200nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621932BDBM621932(US20230312528, Example 73A | (S)-N-((R or S)-(3- c...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621933BDBM621933(US20230312528, Example 73B | (S)-N-((R or S)-(3- c...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 630994BDBM630994(US11802122, Example 73A | US11802122, Example 73B ...)
Affinity DataIC50: 0.200nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621911BDBM621911(US20230312528, Example 62B | (S)-N-((R or S)-(3- c...)
Affinity DataIC50: 0.400nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621910BDBM621910(US20230312528, Example 62A | US11802122, Example 6...)
Affinity DataIC50: 0.400nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621824BDBM621824(US20230312528, Example 17A | (S)-N-((R or S)-(4- c...)
Affinity DataIC50: 0.600nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 630957BDBM630957(US11802122, Example 17A | (S)-N-((R or S)-(4- chlo...)
Affinity DataIC50: 0.600nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621909BDBM621909(US20230312528, Example 61 | US11802122, Example 61...)
Affinity DataIC50: 0.700nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621909BDBM621909(US20230312528, Example 61 | US11802122, Example 61...)
Affinity DataIC50: 0.700nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50118514BDBM50118514(US9481677, 38 | CHEMBL3617063)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of full length human Nav1.6 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -35 mV by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 374028BDBM374028(US10246453, Example 295 | (S)-4-((1-benzylpyrrolid...)
Affinity DataIC50: 1nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 526223BDBM526223(4-((2-(azetidin-1-ylmethyl)benzyl)amino)-2,6-diflu...)
Affinity DataIC50: 1nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 526223BDBM526223(4-((2-(azetidin-1-ylmethyl)benzyl)amino)-2,6-diflu...)
Affinity DataIC50: 1nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 374028BDBM374028(US10246453, Example 295 | (S)-4-((1-benzylpyrrolid...)
Affinity DataIC50: 1nMAssay Description:Sodium currents were measured using the patch clamp technique in the whole-cell configuration using either a PatchXpress automated voltage clamp or m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 526220BDBM526220(4-((2-(azetidin-1-ylmethyl)benzyl)amino)-3-chloro-...)
Affinity DataIC50: 1nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 374028BDBM374028(US10246453, Example 295 | (S)-4-((1-benzylpyrrolid...)
Affinity DataIC50: 1nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 161329BDBM161329(US9163042, 1a | US9051270, 114 | US10087143, Compo...)
Affinity DataIC50: 1nMAssay Description:1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 374028BDBM374028(US10246453, Example 295 | (S)-4-((1-benzylpyrrolid...)
Affinity DataIC50: 1nMAssay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621868BDBM621868(US20230312528, Example 38 | US11802122, Example 38...)
Affinity DataIC50: 1.10nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621822BDBM621822(US20230312528, Example 16A | (S)-N-((R or S)-(3- c...)
Affinity DataIC50: 1.10nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621746BDBM621746(US11802122, Example 7A | US20230312522, Compound 1...)
Affinity DataIC50: 1.10nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621746BDBM621746(US11802122, Example 7A | US20230312522, Compound 1...)
Affinity DataIC50: 1.10nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621868BDBM621868(US20230312528, Example 38 | US11802122, Example 38...)
Affinity DataIC50: 1.10nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 630941BDBM630941(US11802122, Example 13A | (4S)-N-[((R or S)-5- chl...)
Affinity DataIC50: 1.10nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 190233BDBM190233(US9174999, Table 1, Compound 1)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human Nav1.6 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 621816BDBM621816(US20230312528, Example 13A | (4S)-N-[((R or S)-5- ...)
Affinity DataIC50: 1.10nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 630953BDBM630953(US11802122, Example 16A | US11802122, Example 16B ...)
Affinity DataIC50: 1.10nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50597018BDBM50597018(CHEMBL5182397)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human Nav1.8 channel stably expressed in HEK293 cells assessed as sodium current flow at holding potential of -90mV by whole-cell volta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 621869BDBM621869(US20230312528, Example 39A | (S)-N-((R)-3-chloro-4...)
Affinity DataIC50: 1.30nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 631047BDBM631047(US11802122, Example 39A | (S)—N—((R)-3-c...)
Affinity DataIC50: 1.30nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 631027BDBM631027(US11802122, Example 33A | US11802122, Example 33B ...)
Affinity DataIC50: 1.30nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621859BDBM621859(US20230312528, Example 33A | (S)-N-((R)-(3-chloro-...)
Affinity DataIC50: 1.30nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621743BDBM621743(US11802122, Example 5A | BDBM621800 | US2023031252...)
Affinity DataIC50: 1.60nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621743BDBM621743(US11802122, Example 5A | BDBM621800 | US2023031252...)
Affinity DataIC50: 1.60nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 631055BDBM631055(US11802122, Example 41A | US11802122, Example 41B ...)
Affinity DataIC50: 1.70nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621873BDBM621873(US20230312528, Example 41A | (S)—N—((R)-...)
Affinity DataIC50: 1.70nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 458308BDBM458308((R)-3-fluoro-N-(6-fluoropyridin-2-yl)-4-methyl-5-(...)
Affinity DataIC50: 2nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 526227BDBM526227(5-chloro-2-fluoro-4-(((6-fluoro-1H-indazol-7-yl)me...)
Affinity DataIC50: 2nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 458518BDBM458518(4-((2-((7-azabicyclo[2.2.1]heptan-7-yl)methyl)-6-f...)
Affinity DataIC50: 2nMAssay Description:The following patch voltage clamp electrophysiology studies may be performed on representative compounds of the invention using human embryonic kidne...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 630925BDBM630925(US11802122, Example 9A | (S)—N—((R)-(3-c...)
Affinity DataIC50: 2nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 161373BDBM161373(US9051270, 158 | US10087143, Compound 158 | US9758...)
Affinity DataIC50: 2nMAssay Description:1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 630925BDBM630925(US11802122, Example 9A | (S)—N—((R)-(3-c...)
Affinity DataIC50: 2nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 374029BDBM374029(US10246453, Example 297 | (S)-4-((1-benzylpyrrolid...)
Affinity DataIC50: 2nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 374029BDBM374029(US10246453, Example 297 | (S)-4-((1-benzylpyrrolid...)
Affinity DataIC50: 2nMAssay Description:Sodium currents were measured using the patch clamp technique in the whole-cell configuration using either a PatchXpress automated voltage clamp or m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621808BDBM621808(US20230312528, Example 9A | (S)-N-((R)-(3-chloroph...)
Affinity DataIC50: 2nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 526197BDBM526197(4-((2-(azetidin-1-ylmethyl)-6-fluorobenzyl)amino)-...)
Affinity DataIC50: 2nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 458321BDBM458321((R)-3-fluoro-4-methyl-5-((1-(1-phenylethyl)piperid...)
Affinity DataIC50: 2nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

Displayed 1 to 50 (of 2792 total ) | Next | Last >>
Jump to: