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Found 59 with Last Name = 'puar' and Initial = 'ms'
TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50366495((+)butaclamol | CHEMBL1255588)
Affinity DataKi:  0.600nMAssay Description:Potency was measured by the displacement of [3H]spiperone binding to human D2 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  3.60nMAssay Description:Potency was measured by the displacement of [3H]spiperone binding to human D2 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticleDrugBank

TargetD(4) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  3.80nMAssay Description:Potency was measured by the displacement of [3H]-spiperone binding to human D4 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(4) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  72nMAssay Description:Potency was measured by the displacement of [3H]-spiperone binding to human D4 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticleDrugBank

TargetD(4) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50366495((+)butaclamol | CHEMBL1255588)
Affinity DataKi:  185nMAssay Description:Potency was measured by the displacement of [3H]-spiperone binding to human D4 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  250nMAssay Description:Potency was measured by the displacement of [3H]spiperone binding to human D2 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticleDrugBank

TargetD(4) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291683(1-(3,4-Dihydroxy-benzyl)-2-methyl-1,2,3,4-tetrahyd...)
Affinity DataKi:  350nMAssay Description:Potency was measured by the displacement of [3H]-spiperone binding to human D4 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(4) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291681(2,3-Dihydro-1H-indol-5-ol | CHEMBL19331)
Affinity DataKi:  500nMAssay Description:Potency was measured by the displacement of [3H]spiperone binding to human D2 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(4) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50450614(CHEMBL2303762)
Affinity DataKi:  1.20E+3nMAssay Description:Potency was measured by the displacement of [3H]-spiperone binding to human D4 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291683(1-(3,4-Dihydroxy-benzyl)-2-methyl-1,2,3,4-tetrahyd...)
Affinity DataKi:  1.90E+3nMAssay Description:Potency was measured by the displacement of [3H]spiperone binding to human D2 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(4) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50027331(1-(3,4-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquino...)
Affinity DataKi:  2.50E+3nMAssay Description:Potency was measured by the displacement of [3H]-spiperone binding to human D4 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(4) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50242856((1R)-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquin...)
Affinity DataKi:  3.10E+3nMAssay Description:Potency was measured by the displacement of [3H]-spiperone binding to human D4 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50027331(1-(3,4-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquino...)
Affinity DataKi:  3.40E+3nMAssay Description:Potency was measured by the displacement of [3H]spiperone binding to human D2 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50242856((1R)-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquin...)
Affinity DataKi:  3.90E+3nMAssay Description:Potency was measured by the displacement of [3H]spiperone binding to human D2 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291684(1-Methyl-1,2,3,4-tetrahydro-isoquinoline-6,7-diol ...)
Affinity DataKi:  5.40E+3nMAssay Description:Potency was measured by the displacement of [3H]spiperone binding to human D2 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(4) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291684(1-Methyl-1,2,3,4-tetrahydro-isoquinoline-6,7-diol ...)
Affinity DataKi:  6.40E+3nMAssay Description:Potency was measured by the displacement of [3H]-spiperone binding to human D4 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291681(2,3-Dihydro-1H-indol-5-ol | CHEMBL19331)
Affinity DataKi:  9.40E+3nMAssay Description:Potency was measured by the displacement of [3H]spiperone binding to human D2 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50450614(CHEMBL2303762)
Affinity DataKi:  1.14E+4nMAssay Description:Potency was measured by the displacement of [3H]-spiperone binding to human D4 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
Affinity DataKi: >1.70E+4nMAssay Description:Potency was measured by the displacement of [3H]spiperone binding to human D2 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(4) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
Affinity DataKi: >3.50E+4nMAssay Description:Potency was measured by the displacement of [3H]-spiperone binding to human D4 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50292438(1,-(4-amino-5-oxotridecane-1,13-diyl)diguanidine |...)
Affinity DataIC50:  6nMAssay Description:Displacement of QNB from muscarinic M2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50292438(1,-(4-amino-5-oxotridecane-1,13-diyl)diguanidine |...)
Affinity DataIC50:  7nMAssay Description:Displacement of QNB from muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50292438(1,-(4-amino-5-oxotridecane-1,13-diyl)diguanidine |...)
Affinity DataIC50:  10nMAssay Description:Displacement of QNB from muscarinic M4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetT-cell surface glycoprotein CD4(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50123450(CHEMBL3143464 | Chloropeptin I analogue)
Affinity DataIC50:  130nMAssay Description:Inhibitory concentration against CD4-gp120 binding in the absence of fetal bovine serum (FBS); Range is 0.13-0.5 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetT-cell surface glycoprotein CD4(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50366855(CHEMBL525803 | Chloropeptin)
Affinity DataIC50:  130nMAssay Description:Inhibitory concentration against CD4-gp120 binding in the absence of fetal bovine serum (FBS); Range is 0.13-0.5 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetT-cell surface glycoprotein CD4(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50123449(CHEMBL437996 | Chloropeptin II | ISOCOMPLESTATIN)
Affinity DataIC50:  130nMAssay Description:Inhibitory concentration against CD4-gp120 binding in the absence of fetal bovine serum (FBS); Range is 0.13-0.5 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50070315((3S,9S)-9-Benzyl-3-isobutyl-6-methyl-13-(1-methyl-...)
Affinity DataIC50:  300nMAssay Description:Compound was evaluated for inhibitory activity against cholesteryl ester transfer proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50286606((4aS,12bR)-11-Chloro-10-hydroxy-4,4,4a,12b-tetrame...)
Affinity DataIC50:  300nMAssay Description:Compound was tested for Cholesteryl ester transfer protein (CETP) inhibition by CETP-SPA assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetHistamine H3 receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50070217(3-(3-Bromo-4-methoxy-phenyl)-2-[(E)-hydroxyimino]-...)
Affinity DataIC50:  500nMAssay Description:Binding affinity to histamine H3 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50276581((+/-)-wiedendiol B | CHEMBL456619)
Affinity DataIC50:  600nMAssay Description:Compound was tested for CETP inhibition by a precipitation method to separate lipoproteins after incubation of radiolabeled HDL with LDL and CETP.More data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50292439(CHEMBL479224 | N-(1,13-diguanidino-5-oxotridecan-4...)
Affinity DataIC50:  910nMAssay Description:Displacement of QNB from muscarinic M4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50292439(CHEMBL479224 | N-(1,13-diguanidino-5-oxotridecan-4...)
Affinity DataIC50:  960nMAssay Description:Displacement of QNB from muscarinic M2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50285079(4-Methoxy-3-((S)-2,5,5,8a-tetramethyl-3,4,4a,5,6,7...)
Affinity DataIC50:  1.00E+3nMAssay Description:Compound was tested for CETP inhibition by a precipitation method to separate lipoproteins after incubation of radiolabeled HDL with LDL and CETP.More data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291681(2,3-Dihydro-1H-indol-5-ol | CHEMBL19331)
Affinity DataIC50:  1.03E+3nMAssay Description:Inhibitory concentration against binding of [3H]spiperone to human D2 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50292439(CHEMBL479224 | N-(1,13-diguanidino-5-oxotridecan-4...)
Affinity DataIC50:  1.41E+3nMAssay Description:Displacement of QNB from muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50290331(Acetic acid 2-acetoxy-6-(3-acetoxy-2,5-diformyl-be...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50450614(CHEMBL2303762)
Affinity DataIC50:  2.42E+3nMAssay Description:Inhibitory concentration against binding of [3H]spiperone to human D2 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPhospholipase A2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50292388(3,9-dihydroxy-2,10-diprenylpterocap-6a-ene | CHEMB...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of PLA2 in fMLP and A23187 ionophore-stimulated human HL60 cells assessed as effect on [3H]arachidonic acid releaseMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50290330(2-(2,3-Dihydroxy-benzoyl)-6-hydroxy-benzene-1,4-di...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50276581((+/-)-wiedendiol B | CHEMBL456619)
Affinity DataIC50:  5.00E+3nMAssay Description:Compound was tested for Cholesteryl ester transfer protein (CETP) inhibition by CETP-SPA assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50285079(4-Methoxy-3-((S)-2,5,5,8a-tetramethyl-3,4,4a,5,6,7...)
Affinity DataIC50:  5.00E+3nMAssay Description:Compound was tested for Cholesteryl ester transfer protein (CETP) inhibition by CETP-SPA assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPhospholipase A2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50241416((2S)-5,7-dihydroxy-2-[4-hydroxy-3,5-bis(3-methylbu...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of PLA2 in fMLP and A23187 ionophore-stimulated human HL60 cells assessed as effect on [3H]arachidonic acid releaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50240865((4aS,6aS,12aR,12bS)-10-Hydroxy-4,4,6a,12b-tetramet...)
Affinity DataIC50:  6.00E+3nMAssay Description:Compound was tested for Cholesteryl ester transfer protein (CETP) inhibition by CETP-SPA assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetHistamine H3 receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50292430(CHEMBL479515 | aerophobin-1)
Affinity DataIC50:  9.00E+3nMAssay Description:Binding affinity to histamine H3 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50292387(4'-hydroxy-6,3',5'-triprenylisoflavonone | CHEMBL4...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of PLA2 in fMLP and A23187 ionophore-stimulated human HL60 cells assessed as effect on [3H]arachidonic acid releaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50286611(5,5,9,10-tetramethyl-18-oxatetracyclo[8.8.0.01,6.0...)
Affinity DataIC50:  2.20E+4nMAssay Description:Compound was tested for Cholesteryl ester transfer protein (CETP) inhibition by CETP-SPA assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50286609(1-((4aS,12bR)-9,10-Diacetyl-4,4,4a,12b-tetramethyl...)
Affinity DataIC50:  2.30E+4nMAssay Description:Compound was tested for Cholesteryl ester transfer protein (CETP) inhibition by CETP-SPA assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50158841(4-Hydroxy-4H,6H-furo[3,2-c]pyran-2-one | 4-hydroxy...)
Affinity DataIC50:  2.46E+4nMAssay Description:In vitro antiviral activity against hepatitis C virus (HCV) NS3 protease using scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50242257(2-((1R,2S,4aS)-1,2,4a,5-Tetramethyl-1,2,3,4,4a,7,8...)
Affinity DataIC50:  2.50E+4nMAssay Description:Compound was tested for Cholesteryl ester transfer protein (CETP) inhibition by CETP-SPA assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50158797(Acetic acid 2-oxo-2,6-dihydro-4H-furo[3,2-c]pyran-...)
Affinity DataIC50:  3.67E+4nMAssay Description:In vitro antiviral activity against hepatitis C virus (HCV) NS3 protease using scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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