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Found 111 with Last Name = 'tong' and Initial = 'r'
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50546246(CHEMBL4753043 | US11608319, Compound AR-13503)
Affinity DataKi:  0.200nMAssay Description:Inhibition of Rock2 (unknown origin) by Kinase Glo luminescence assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50546246(CHEMBL4753043 | US11608319, Compound AR-13503)
Affinity DataKi:  0.200nMAssay Description:Inhibition of Rock1 (unknown origin) by Kinase Glo luminescence assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50546247(AR-11324 FREE BASE | AR-13324 | Netarsudil | US114...)
Affinity DataKi:  1nMAssay Description:Inhibition of Rock1 (unknown origin) by Kinase Glo luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50546247(AR-11324 FREE BASE | AR-13324 | Netarsudil | US114...)
Affinity DataKi:  1nMAssay Description:Inhibition of Rock2 (unknown origin) by Kinase Glo luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))TBA
LigandPNGBDBM50610937(CHEMBL5272661)
Affinity DataKi: <2nMAssay Description:Displacement of [3H]-PGE2 from human EP4 receptor transfected with HEK293 cells assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50546247(AR-11324 FREE BASE | AR-13324 | Netarsudil | US114...)
Affinity DataKi:  2nMAssay Description:Inhibition of Rock2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))TBA
LigandPNGBDBM50181298(5-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)p...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-PGE2 from human EP4 receptor transfected with HEK293 cells assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))TBA
LigandPNGBDBM50506546(Omidenepag | UR-7276)
Affinity DataKi:  3.60nMAssay Description:Binding affinity to EP2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM185149(1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol...)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149945(CHEMBL3770205)
Affinity DataIC50:  0.230nMAssay Description:Inhibition of 5-HT in Wistar rat synaptosomes assessed as [3H]-5-HT reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM144315(Gilteritinib | US11512074, Example T-9 | US8969336...)
Affinity DataIC50:  0.290nMAssay Description:Inhibition of N-terminal GST-tagged human FLT3 (564 to 993 residues) cytoplasmic domain expressed in baculovirus expression system by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM185149(1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of FLT3 D835H mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50594972(CHEMBL5177755)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of NAE (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))TBA
LigandPNGBDBM50608288(CHEMBL5278739)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of PDE-5A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM144315(Gilteritinib | US11512074, Example T-9 | US8969336...)
Affinity DataIC50:  0.730nMAssay Description:Inhibition of N-terminal GST-tagged human AXL (464 to 885 residues) cytoplasmic domain expressed in baculovirus expression system by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM320991(4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamo...)
Affinity DataIC50:  0.955nMAssay Description:Inhibition of recombinant human APPBP1/UBA3 expressed in Escherichia coli assessed as Ub/Ubl thioester transferMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRenin(Homo sapiens (Human))TBA
LigandPNGBDBM50608292(CHEMBL5281613)
Affinity DataIC50:  1nMAssay Description:Inhibition of human reninMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50515042(CHEMBL4593398)
Affinity DataIC50:  1nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin) using MBP as substrate after 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50608290(CHEMBL5272027)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of angiotensin 2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149944(CHEMBL3770202)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of 5-HT in Wistar rat synaptosomes assessed as [3H]-5-HT reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))TBA
LigandPNGBDBM50181298(5-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)p...)
Affinity DataIC50:  2nMAssay Description:Agonist activity at human EP4 receptor expressed in CHO cells co-transfected with CRE-beta-lactamase reporter gene assessed as increase in intracellu...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50515042(CHEMBL4593398)
Affinity DataIC50:  2nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin) using MBP as substrate after 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))TBA
LigandPNGBDBM50610937(CHEMBL5272661)
Affinity DataIC50:  2nMAssay Description:Agonist activity at human EP4 receptor expressed in CHO cells co-transfected with CRE-beta-lactamase reporter gene assessed as increase in intracellu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50108877((3,4-Dihydroxy-5-nitro-phenyl)-p-tolyl-methanone |...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of rat COMTMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))TBA
LigandPNGBDBM50608289(CHEMBL5266963)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of PDE-5A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50462275(CHEMBL4249954)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of recombinant GST-tagged human PDE9A2 expressed in insect cells using cGMP as substrate after 1 hr by IMAP TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149947(CHEMBL3770126)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of 5-HT in Wistar rat synaptosomes assessed as [3H]-5-HT reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50210628(CHEMBL3946861)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human PDE3A (484 to 1141 residues) expressed in Sf9 cells using cAMP as substrate after 60 mins by IM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataIC50:  4nMAssay Description:Inhibition of NAE1/UBA3 in human HCT-116 cells assessed as reduction in Ubc12-NEDD8 level incubated for 24 hrs by immunoblot analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))TBA
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of PDE-5A (unknown origin)More data for this Ligand-Target Pair
TargetNeprilysin(Homo sapiens (Human))TBA
LigandPNGBDBM50608290(CHEMBL5272027)
Affinity DataIC50:  5nMAssay Description:Inhibition of neutral endopeptidase (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50515043(E-6201 | E6201 | ER-806201)
Affinity DataIC50:  5nMAssay Description:Inhibition of FLT3 (unknown origin) phosphorylation by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50515042(CHEMBL4593398)
Affinity DataIC50:  5nMAssay Description:Inhibition of FLT3 (unknown origin) using MBP as substrate after 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50364776(CHEMBL1952141 | CHEMBL1952329)
Affinity DataIC50:  7nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human full length Pim-1 using KKRNRTLTV as substrate after 40 mins by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149946(CHEMBL3770400)
Affinity DataIC50:  9.90nMAssay Description:Inhibition of DAT in Wistar rat synaptosomes assessed as [3H]-DA reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149946(CHEMBL3770400)
Affinity DataIC50:  10nMAssay Description:Inhibition of 5-HT in Wistar rat synaptosomes assessed as [3H]-5-HT reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50337911((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dim...)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant human norepinephrine transporter assessed as reduction in [3H]-NA reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149942(CHEMBL3770663)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant human 5-HT transporter expressed in HEK293 cells assessed as reduction in [3H]-5-HT reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50337911((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dim...)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant human 5-HT transporter expressed in HEK293 cells assessed as reduction in [3H]-5-HT reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149940(CHEMBL3770651 | US10562878, Compound 203)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant human DA transporter assessed as reduction in [3H]-DA reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149944(CHEMBL3770202)
Affinity DataIC50:  13nMAssay Description:Inhibition of DAT in Wistar rat synaptosomes assessed as [3H]-DA reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))TBA
LigandPNGBDBM50608291(CHEMBL5275558)
Affinity DataIC50:  14nMAssay Description:Inhibition of human reninMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149940(CHEMBL3770651 | US10562878, Compound 203)
Affinity DataIC50:  17nMAssay Description:Inhibition of recombinant human norepinephrine transporter assessed as reduction in [3H]-NA reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149941(CHEMBL3769872)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant human 5-HT transporter expressed in HEK293 cells assessed as reduction in [3H]-5-HT reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50087135(CHEMBL3426621)
Affinity DataIC50:  19nMAssay Description:Inhibition of Rock2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLymphokine-activated killer T-cell-originated protein kinase(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50515042(CHEMBL4593398)
Affinity DataIC50:  21nMAssay Description:Inhibition of TOPK (unknown origin) using MBP as substrate after 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149941(CHEMBL3769872)
Affinity DataIC50:  21nMAssay Description:Inhibition of recombinant human DA transporter assessed as reduction in [3H]-DA reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50210177(ONX-0803 | Pacritinib | SB-1518 | SB1518)
Affinity DataIC50:  22nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50210177(ONX-0803 | Pacritinib | SB-1518 | SB1518)
Affinity DataIC50:  23nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149941(CHEMBL3769872)
Affinity DataIC50:  33nMAssay Description:Inhibition of recombinant human norepinephrine transporter assessed as reduction in [3H]-NA reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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