Affinity DataKi: 0.200nMAssay Description:Inhibition of Rock2 (unknown origin) by Kinase Glo luminescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Inhibition of Rock1 (unknown origin) by Kinase Glo luminescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Inhibition of Rock1 (unknown origin) by Kinase Glo luminescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Inhibition of Rock2 (unknown origin) by Kinase Glo luminescence assayMore data for this Ligand-Target Pair
Affinity DataKi: <2nMAssay Description:Displacement of [3H]-PGE2 from human EP4 receptor transfected with HEK293 cells assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Inhibition of Rock2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Displacement of [3H]-PGE2 from human EP4 receptor transfected with HEK293 cells assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.60nMAssay Description:Binding affinity to EP2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin)More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
Affinity DataIC50: 0.230nMAssay Description:Inhibition of 5-HT in Wistar rat synaptosomes assessed as [3H]-5-HT reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Affinity DataIC50: 0.290nMAssay Description:Inhibition of N-terminal GST-tagged human FLT3 (564 to 993 residues) cytoplasmic domain expressed in baculovirus expression system by ELISAMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of FLT3 D835H mutant (unknown origin)More data for this Ligand-Target Pair
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of NAE (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of PDE-5A (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Affinity DataIC50: 0.730nMAssay Description:Inhibition of N-terminal GST-tagged human AXL (464 to 885 residues) cytoplasmic domain expressed in baculovirus expression system by ELISAMore data for this Ligand-Target Pair
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.955nMAssay Description:Inhibition of recombinant human APPBP1/UBA3 expressed in Escherichia coli assessed as Ub/Ubl thioester transferMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of human reninMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin) using MBP as substrate after 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of angiotensin 2 (unknown origin)More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of 5-HT in Wistar rat synaptosomes assessed as [3H]-5-HT reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Agonist activity at human EP4 receptor expressed in CHO cells co-transfected with CRE-beta-lactamase reporter gene assessed as increase in intracellu...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin) using MBP as substrate after 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Agonist activity at human EP4 receptor expressed in CHO cells co-transfected with CRE-beta-lactamase reporter gene assessed as increase in intracellu...More data for this Ligand-Target Pair
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Inhibition of rat COMTMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Inhibition of PDE-5A (unknown origin)More data for this Ligand-Target Pair
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Affinity DataIC50: 2.80nMAssay Description:Inhibition of recombinant GST-tagged human PDE9A2 expressed in insect cells using cGMP as substrate after 1 hr by IMAP TR-FRET assayMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Inhibition of 5-HT in Wistar rat synaptosomes assessed as [3H]-5-HT reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Affinity DataIC50: 3.80nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human PDE3A (484 to 1141 residues) expressed in Sf9 cells using cAMP as substrate after 60 mins by IM...More data for this Ligand-Target Pair
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of NAE1/UBA3 in human HCT-116 cells assessed as reduction in Ubc12-NEDD8 level incubated for 24 hrs by immunoblot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 4.70nMAssay Description:Inhibition of PDE-5A (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of neutral endopeptidase (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of FLT3 (unknown origin) phosphorylation by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of FLT3 (unknown origin) using MBP as substrate after 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human full length Pim-1 using KKRNRTLTV as substrate after 40 mins by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
Affinity DataIC50: 9.90nMAssay Description:Inhibition of DAT in Wistar rat synaptosomes assessed as [3H]-DA reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of 5-HT in Wistar rat synaptosomes assessed as [3H]-5-HT reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human norepinephrine transporter assessed as reduction in [3H]-NA reuptakeMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human 5-HT transporter expressed in HEK293 cells assessed as reduction in [3H]-5-HT reuptakeMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human 5-HT transporter expressed in HEK293 cells assessed as reduction in [3H]-5-HT reuptakeMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human DA transporter assessed as reduction in [3H]-DA reuptakeMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of DAT in Wistar rat synaptosomes assessed as [3H]-DA reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of human reninMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human norepinephrine transporter assessed as reduction in [3H]-NA reuptakeMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human 5-HT transporter expressed in HEK293 cells assessed as reduction in [3H]-5-HT reuptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of Rock2 (unknown origin)More data for this Ligand-Target Pair
TargetLymphokine-activated killer T-cell-originated protein kinase(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of TOPK (unknown origin) using MBP as substrate after 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant human DA transporter assessed as reduction in [3H]-DA reuptakeMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant human norepinephrine transporter assessed as reduction in [3H]-NA reuptakeMore data for this Ligand-Target Pair