Affinity DataKi: 1.70nMAssay Description:Inhibition of human recombinant IDE expressed in CHO cells in presence of [125I]-insulin by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant IDE exosite (unknown origin) expressed in Escherichia coli using insulin as substrate incubated for 4 hrs by AlphaLisa assa...More data for this Ligand-Target Pair
TargetType II NADH:quinone oxidoreductase Ndh(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Cnrs
Curated by ChEMBL
Cnrs
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of Mycobacterium tuberculosis recombinant type II NADH dehydrogenase ndh expressed in Escherichia coli assessed as rate of NADH oxidation ...More data for this Ligand-Target Pair
TargetType II NADH:quinone oxidoreductase Ndh(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Cnrs
Curated by ChEMBL
Cnrs
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of Mycobacterium tuberculosis recombinant type II NADH dehydrogenase ndh expressed in Escherichia coli assessed as rate of NADH oxidation ...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant IDE expressed in Escherichia coli BL21 (DE3) cells using insulin as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
TargetType II NADH:quinone oxidoreductase Ndh(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Cnrs
Curated by ChEMBL
Cnrs
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inhibition of Mycobacterium tuberculosis recombinant type II NADH dehydrogenase ndh expressed in Escherichia coli assessed as rate of NADH oxidation ...More data for this Ligand-Target Pair
TargetType II NADH:quinone oxidoreductase Ndh(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Cnrs
Curated by ChEMBL
Cnrs
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibition of Mycobacterium tuberculosis recombinant type II NADH dehydrogenase ndh expressed in Escherichia coli assessed as rate of NADH oxidation ...More data for this Ligand-Target Pair
TargetType II NADH:quinone oxidoreductase Ndh(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Cnrs
Curated by ChEMBL
Cnrs
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of Mycobacterium smegmatis MC2 155 recombinant type II NADH dehydrogenase ndh expressed in Escherichia coli assessed as rate of NADH oxida...More data for this Ligand-Target Pair
TargetType II NADH:quinone oxidoreductase Ndh(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Cnrs
Curated by ChEMBL
Cnrs
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of Mycobacterium smegmatis MC2 155 recombinant type II NADH dehydrogenase ndh expressed in Escherichia coli assessed as rate of NADH oxida...More data for this Ligand-Target Pair
TargetType II NADH:quinone oxidoreductase Ndh(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Cnrs
Curated by ChEMBL
Cnrs
Curated by ChEMBL
Affinity DataIC50: 42nMAssay Description:Inhibition of Mycobacterium smegmatis MC2 155 recombinant type II NADH dehydrogenase ndh expressed in Escherichia coli assessed as rate of NADH oxida...More data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Inhibition of human recombinant IDE expressed in Escherichia coli BL21 (DE3) cells using ATTO 655- Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substra...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of N-terminal His6-tagged mouse recombinant IDE Escherichia coli BL21 (DE3) cells using fluorogenic peptide Mca-RPPGFSAFK(Dnp)-OH as subst...More data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Inhibition of human recombinant IDE expressed in Escherichia coli BL21 (DE3) cells using insulin as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
TargetType II NADH:quinone oxidoreductase NdhA(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Cnrs
Curated by ChEMBL
Cnrs
Curated by ChEMBL
Affinity DataIC50: 57nMAssay Description:Inhibition of Mycobacterium smegmatis MC2 155 recombinant ndhA assessed as rate of NADH oxidation in the presence of an electron acceptor menadioneMore data for this Ligand-Target Pair
TargetType II NADH:quinone oxidoreductase NdhA(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Cnrs
Curated by ChEMBL
Cnrs
Curated by ChEMBL
Affinity DataIC50: 59nMAssay Description:Inhibition of Mycobacterium smegmatis MC2 155 recombinant ndhA assessed as rate of NADH oxidation in the presence of an electron acceptor menadioneMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of wild type human IDE catalytic site using insulin as substrate preincubated for 10 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
TargetType II NADH:quinone oxidoreductase Ndh(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Cnrs
Curated by ChEMBL
Cnrs
Curated by ChEMBL
Affinity DataIC50: 88nMAssay Description:Inhibition of Mycobacterium smegmatis MC2 155 recombinant type II NADH dehydrogenase ndh expressed in Escherichia coli assessed as rate of NADH oxida...More data for this Ligand-Target Pair
TargetType II NADH:quinone oxidoreductase NdhA(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Cnrs
Curated by ChEMBL
Cnrs
Curated by ChEMBL
Affinity DataIC50: 96nMAssay Description:Inhibition of Mycobacterium smegmatis MC2 155 recombinant ndhA assessed as rate of NADH oxidation in the presence of an electron acceptor menadioneMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of IDE exosite and catalytic site (unknown origin)More data for this Ligand-Target Pair
TargetType II NADH:quinone oxidoreductase Ndh(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Cnrs
Curated by ChEMBL
Cnrs
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of Mycobacterium tuberculosis recombinant type II NADH dehydrogenase ndh expressed in Escherichia coli assessed as rate of NADH oxidation ...More data for this Ligand-Target Pair
Affinity DataIC50: 330nMAssay Description:Inhibition of human recombinant IDE harboring C110L/C171S/C178A/C257V/C414L/C573N/C590S/C789S/C812A/C819A/C904S/C966N/C974A mutant expressed in Esche...More data for this Ligand-Target Pair
TargetType II NADH:quinone oxidoreductase NdhA(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Cnrs
Curated by ChEMBL
Cnrs
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Inhibition of Mycobacterium smegmatis MC2 155 recombinant ndhA assessed as rate of NADH oxidation in the presence of an electron acceptor menadioneMore data for this Ligand-Target Pair
TargetType II NADH:quinone oxidoreductase Ndh(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Cnrs
Curated by ChEMBL
Cnrs
Curated by ChEMBL
Affinity DataIC50: 340nMAssay Description:Inhibition of Mycobacterium tuberculosis recombinant type II NADH dehydrogenase ndh expressed in Escherichia coli assessed as rate of NADH oxidation ...More data for this Ligand-Target Pair
TargetType II NADH:quinone oxidoreductase Ndh(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Cnrs
Curated by ChEMBL
Cnrs
Curated by ChEMBL
Affinity DataIC50: 470nMAssay Description:Inhibition of Mycobacterium smegmatis MC2 155 recombinant type II NADH dehydrogenase ndh expressed in Escherichia coli assessed as rate of NADH oxida...More data for this Ligand-Target Pair
TargetType II NADH:quinone oxidoreductase Ndh(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Cnrs
Curated by ChEMBL
Cnrs
Curated by ChEMBL
Affinity DataIC50: 890nMAssay Description:Inhibition of Mycobacterium smegmatis MC2 155 recombinant type II NADH dehydrogenase ndh expressed in Escherichia coli assessed as rate of NADH oxida...More data for this Ligand-Target Pair
TargetType II NADH:quinone oxidoreductase NdhA(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Cnrs
Curated by ChEMBL
Cnrs
Curated by ChEMBL
Affinity DataIC50: 980nMAssay Description:Inhibition of Mycobacterium smegmatis MC2 155 recombinant ndhA assessed as rate of NADH oxidation in the presence of an electron acceptor menadioneMore data for this Ligand-Target Pair
TargetType II NADH:quinone oxidoreductase NdhA(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Cnrs
Curated by ChEMBL
Cnrs
Curated by ChEMBL
Affinity DataIC50: 2.34E+3nMAssay Description:Inhibition of Mycobacterium smegmatis MC2 155 recombinant ndhA assessed as rate of NADH oxidation in the presence of an electron acceptor menadioneMore data for this Ligand-Target Pair
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human recombinant IDE expressed in Escherichia coli BL21 (DE3) cells using ATTO 655- Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substra...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human recombinant IDE expressed in Escherichia coli BL21 (DE3) cells using ATTO 655- Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substra...More data for this Ligand-Target Pair
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Homo sapiens (Human))
Univ. Lille
Curated by ChEMBL
Univ. Lille
Curated by ChEMBL
Affinity DataIC50: 5.30E+4nMAssay Description:Inhibition of human recombinant DDAH1 reduction in L-citrulline formation using ADMA as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant IDE expressed in Escherichia coli BL21 (DE3) cells using ATTO 655- Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substra...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant IDE expressed in Escherichia coli BL21 (DE3) cells using ATTO 655- Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substra...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant IDE harboring C110L/C171S/C178A/C257V/C414L/C573N/C590S/C789S/C812A/C819A/C904S/C966N/C974A mutant expressed in Esche...More data for this Ligand-Target Pair
Affinity DataEC50: 21nMAssay Description:Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Universities Of Lille
Curated by ChEMBL
Universities Of Lille
Curated by ChEMBL
Affinity DataEC50: 470nMAssay Description:Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.68E+3nMAssay Description:Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 68nMAssay Description:Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 12nMAssay Description:Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.800nMAssay Description:Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 180nMAssay Description:Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Universities Of Lille
Curated by ChEMBL
Universities Of Lille
Curated by ChEMBL
Affinity DataEC50: 1.11E+3nMAssay Description:Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Universities Of Lille
Curated by ChEMBL
Universities Of Lille
Curated by ChEMBL
Affinity DataEC50: >4.50E+3nMAssay Description:Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Universities Of Lille
Curated by ChEMBL
Universities Of Lille
Curated by ChEMBL
Affinity DataEC50: 337nMAssay Description:Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Universities Of Lille
Curated by ChEMBL
Universities Of Lille
Curated by ChEMBL
Affinity DataEC50: 24nMAssay Description:Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Universities Of Lille
Curated by ChEMBL
Universities Of Lille
Curated by ChEMBL
Affinity DataEC50: 238nMAssay Description:Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.800nMAssay Description:Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 44nMAssay Description:Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 91nMAssay Description:Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 507nMAssay Description:Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 40nMAssay Description:Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayMore data for this Ligand-Target Pair