Found 126 with Last Name = 'sonntag' and Initial = 's' TargetGenome polyprotein [1394-1440]/[1476-1660,T1585M](Dengue virus 3 (strain S221/03))
Novartis Institute For Tropical Diseases
Novartis Institute For Tropical Diseases
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2 (strain TSV01))
Novartis Institute For Tropical Diseases
Novartis Institute For Tropical Diseases
Affinity DataIC50: 1.10E+3nM Kd: 7.70E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
TargetGenome polyprotein [1394-1440]/[1476-1660](Dengue virus 4 (H241))
Novartis Institute For Tropical Diseases
Novartis Institute For Tropical Diseases
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
TargetGenome polyprotein [1394-1440]/[1476-1660](Dengue virus 4 (H241))
Novartis Institute For Tropical Diseases
Novartis Institute For Tropical Diseases
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
Affinity DataIC50: 1.52E+3nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase SAM siteMore data for this Ligand-Target Pair
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2 (strain TSV01))
Novartis Institute For Tropical Diseases
Novartis Institute For Tropical Diseases
Affinity DataIC50: 1.60E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
TargetGenome polyprotein [1394-1440]/[1476-1660,T1585M](Dengue virus 3 (strain S221/03))
Novartis Institute For Tropical Diseases
Novartis Institute For Tropical Diseases
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
TargetGenome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M](Dengue virus 1(Hawaii))
Novartis Institute For Tropical Diseases
Novartis Institute For Tropical Diseases
Affinity DataIC50: 2.00E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
TargetGenome polyprotein [1394-1440]/[1476-1660](Dengue virus 4 (H241))
Novartis Institute For Tropical Diseases
Novartis Institute For Tropical Diseases
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
TargetGenome polyprotein [1424-1463]/[1502-1685](West Nile virus (WNV))
Novartis Institute For Tropical Diseases
Novartis Institute For Tropical Diseases
Affinity DataIC50: 2.20E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2 (strain TSV01))
Novartis Institute For Tropical Diseases
Novartis Institute For Tropical Diseases
Affinity DataIC50: 2.30E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
TargetGenome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M](Dengue virus 1(Hawaii))
Novartis Institute For Tropical Diseases
Novartis Institute For Tropical Diseases
Affinity DataIC50: 2.72E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
Affinity DataIC50: 2.81E+3nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase RNA siteMore data for this Ligand-Target Pair
Affinity DataIC50: 2.91E+3nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase SAM siteMore data for this Ligand-Target Pair
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase at 8 nM enzyme concentrationMore data for this Ligand-Target Pair
TargetGenome polyprotein [1424-1463]/[1502-1685](West Nile virus (WNV))
Novartis Institute For Tropical Diseases
Novartis Institute For Tropical Diseases
Affinity DataIC50: 3.60E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
Affinity DataIC50: 4.29E+3nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase SAM siteMore data for this Ligand-Target Pair
Affinity DataIC50: 4.34E+3nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase by spin-down assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.42E+3nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase RNA siteMore data for this Ligand-Target Pair
Affinity DataIC50: 4.47E+3nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase SAM site with 0.1 % TX100More data for this Ligand-Target Pair
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase RNA siteMore data for this Ligand-Target Pair
Affinity DataIC50: 4.91E+3nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase RNA site with 0.1 % TX100More data for this Ligand-Target Pair
TargetGenome polyprotein [1424-1463]/[1502-1685](West Nile virus (WNV))
Novartis Institute For Tropical Diseases
Novartis Institute For Tropical Diseases
Affinity DataIC50: 5.20E+3nM Kd: 4.60E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2 (strain TSV01))
Novartis Institute For Tropical Diseases
Novartis Institute For Tropical Diseases
Affinity DataIC50: 5.80E+3nM Kd: 1.86E+4nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2 (strain TSV01))
Novartis Institute For Tropical Diseases
Novartis Institute For Tropical Diseases
Affinity DataIC50: 6.00E+3nM Kd: 7.20E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
TargetGenome polyprotein [1424-1463]/[1502-1685](West Nile virus (WNV))
Novartis Institute For Tropical Diseases
Novartis Institute For Tropical Diseases
Affinity DataIC50: 6.20E+3nM Kd: 7.00E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
Affinity DataIC50: 6.22E+3nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase by spin-down assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.83E+3nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase RNA siteMore data for this Ligand-Target Pair
Affinity DataIC50: 7.11E+3nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase RNA siteMore data for this Ligand-Target Pair
Affinity DataIC50: 7.14E+3nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase RNA site with 0.1 % TX100More data for this Ligand-Target Pair
Affinity DataIC50: 7.14E+3nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase at 80 nM enzyme concentrationMore data for this Ligand-Target Pair
Affinity DataIC50: 7.56E+3nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase RNA siteMore data for this Ligand-Target Pair
Affinity DataIC50: 7.62E+3nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase at 8 nM enzyme concentrationMore data for this Ligand-Target Pair
TargetGenome polyprotein [1394-1440]/[1476-1660,T1585M](Dengue virus 3 (strain S221/03))
Novartis Institute For Tropical Diseases
Novartis Institute For Tropical Diseases
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
Affinity DataIC50: 7.99E+3nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase RNA siteMore data for this Ligand-Target Pair
TargetGenome polyprotein [1394-1440]/[1476-1660](Dengue virus 4 (H241))
Novartis Institute For Tropical Diseases
Novartis Institute For Tropical Diseases
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
TargetGenome polyprotein [1394-1440]/[1476-1660,T1585M](Dengue virus 3 (strain S221/03))
Novartis Institute For Tropical Diseases
Novartis Institute For Tropical Diseases
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
TargetGenome polyprotein [1394-1440]/[1476-1660,T1585M](Dengue virus 3 (strain S221/03))
Novartis Institute For Tropical Diseases
Novartis Institute For Tropical Diseases
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
Affinity DataIC50: 8.78E+3nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase SAM siteMore data for this Ligand-Target Pair
Affinity DataIC50: 8.81E+3nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase RNA siteMore data for this Ligand-Target Pair
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2 (strain TSV01))
Novartis Institute For Tropical Diseases
Novartis Institute For Tropical Diseases
Affinity DataIC50: 8.90E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
Affinity DataIC50: 9.28E+3nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase RNA siteMore data for this Ligand-Target Pair
Affinity DataIC50: 9.46E+3nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase SAM site with 0.1 % TX100More data for this Ligand-Target Pair
Affinity DataIC50: 9.62E+3nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase SAM siteMore data for this Ligand-Target Pair
Affinity DataIC50: 9.84E+3nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase SAM siteMore data for this Ligand-Target Pair
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2 (strain TSV01))
Novartis Institute For Tropical Diseases
Novartis Institute For Tropical Diseases
Affinity DataIC50: 1.02E+4nM Kd: 1.63E+4nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase at 80 nM enzyme concentrationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase by spin-down assayMore data for this Ligand-Target Pair
TargetGenome polyprotein [1424-1463]/[1502-1685](West Nile virus (WNV))
Novartis Institute For Tropical Diseases
Novartis Institute For Tropical Diseases
Affinity DataIC50: 1.06E+4nM Kd: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
Affinity DataIC50: 1.07E+4nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase by spin-down assayMore data for this Ligand-Target Pair
