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Found 298 with Last Name = 'takayama' and Initial = 't'
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305129(6-(2-aminoethoxy)-2-(4-phenoxyphenyl)-9,10-dihydro...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305140(7-(2-aminoethoxy)-2-(4-phenoxyphenyl)-9,10-dihydro...)
Affinity DataIC50:  0.410nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305119(7-(2-(dimethylamino)ethoxy)-2-(4-hydroxyphenyl)-9,...)
Affinity DataIC50:  0.440nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305131(6-(3-(dimethylamino)propoxy)-2-(4-phenoxyphenyl)-9...)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305139(6-(2-(4-methylpiperazin-1-yl)ethoxy)-2-(4-phenoxyp...)
Affinity DataIC50:  0.550nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305117(7-(2-morpholinoethoxy)-2-(4-phenoxyphenyl)-9,10-di...)
Affinity DataIC50:  0.560nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305126(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305126(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)
Affinity DataIC50:  0.720nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305142(7-(2-hydroxyethoxy)-2-(4-phenoxyphenyl)-9,10-dihyd...)
Affinity DataIC50:  0.75nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305138(6-(2-morpholinoethoxy)-2-(4-phenoxyphenyl)-9,10-di...)
Affinity DataIC50:  0.770nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305121(7-(2-(dimethylamino)ethoxy)-2-(4-(phenylamino)phen...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305125(2-(4-(3-(2,6-dichlorophenyl)ureido)phenyl)-7-(2-(d...)
Affinity DataIC50:  0.940nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305135(2-(3-carbamoyl-2-(4-phenoxyphenyl)-9,10-dihydro-4H...)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305122(2-(4-(2,6-dichlorobenzylamino)phenyl)-7-(2-(dimeth...)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305141(7-(3-(dimethylamino)propoxy)-2-(4-phenoxyphenyl)-9...)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305118(7-(2-(4-methylpiperazin-1-yl)ethoxy)-2-(4-phenoxyp...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305130(6-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305143(7-(2-amino-2-oxoethoxy)-2-(4-phenoxyphenyl)-9,10-d...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305132(6-(2-hydroxyethoxy)-2-(4-phenoxyphenyl)-9,10-dihyd...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305134(6-(2-amino-2-oxoethoxy)-2-(4-phenoxyphenyl)-9,10-d...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305126(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of CskMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305123(CHEMBL595625 | benzyl 4-(3-carbamoyl-7-(2-(dimethy...)
Affinity DataIC50:  2nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305124(7-(2-(dimethylamino)ethoxy)-2-(4-(3-phenylureido)p...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305128(7-methoxy-2-(4-phenoxyphenyl)-9,10-dihydro-4H-benz...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402166(CHEMBL2207988)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305145(2-(4-phenoxyphenyl)-7-(pyridin-3-ylmethoxy)-9,10-d...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50381818(CHEMBL2023644)
Affinity DataIC50:  3.20nMAssay Description:Displacement of 3H-PGD2 from human CRTH2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50381818(CHEMBL2023644)
Affinity DataIC50:  3.20nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 transfected in CHO cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50381815(CHEMBL2023641)
Affinity DataIC50:  3.20nMAssay Description:Displacement of 3H-PGD2 from human CRTH2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50381819(CHEMBL2023645)
Affinity DataIC50:  3.40nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 transfected in CHO cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50381819(CHEMBL2023645)
Affinity DataIC50:  3.40nMAssay Description:Displacement of 3H-PGD2 from human CRTH2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50381815(CHEMBL2023641)
Affinity DataIC50:  3.5nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 transfected in CHO cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50444231(CHEMBL3093591)
Affinity DataIC50:  3.70nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 transfected in CHO cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50444223(CHEMBL3093607)
Affinity DataIC50:  3.80nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 transfected in CHO cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305136(6-(2-oxopropoxy)-2-(4-phenoxyphenyl)-9,10-dihydro-...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305120(2-(4-aminophenyl)-7-(2-(dimethylamino)ethoxy)-9,10...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50381825(CHEMBL2023651)
Affinity DataIC50:  4nMAssay Description:Displacement of 3H-PGD2 from human CRTH2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50381825(CHEMBL2023651)
Affinity DataIC50:  4nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 transfected in CHO cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50381814(CHEMBL2023640)
Affinity DataIC50:  4nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 transfected in CHO cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50381814(CHEMBL2023640)
Affinity DataIC50:  4nMAssay Description:Displacement of 3H-PGD2 from human CRTH2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50381815(CHEMBL2023641)
Affinity DataIC50:  4.20nMAssay Description:Antagonist activity at human CRTH2 transfected in human KB8 cells assessed as inhibition of PGD2-induced increase in intracellular Ca2+ by fluo-4AM d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402175(CHEMBL2208016)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305146(4-amino-5-(2,6-difluorobenzoyl)-2-(4-phenoxyphenyl...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of CskMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305127(6-methoxy-2-(4-phenoxyphenyl)-9,10-dihydro-4H-benz...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50381821(CHEMBL2023647)
Affinity DataIC50:  4.90nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 transfected in CHO cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50381821(CHEMBL2023647)
Affinity DataIC50:  4.90nMAssay Description:Displacement of 3H-PGD2 from human CRTH2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50444219(CHEMBL3093594)
Affinity DataIC50:  5.20nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 transfected in CHO cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50444233(CHEMBL3093589)
Affinity DataIC50:  5.20nMAssay Description:Antagonist activity at human CRTH2 transfected in human KB8 cells assessed as inhibition of PGD2-induced increase in intracellular Ca2+ by fluo-4AM d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305144(2-(4-phenoxyphenyl)-7-(pyridin-2-ylmethoxy)-9,10-d...)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402168(CHEMBL2208237)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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