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Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 50008039
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM185149(1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol...)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM144315(Gilteritinib | US11512074, Example T-9 | US8969336...)
Affinity DataIC50:  0.290nMAssay Description:Inhibition of N-terminal GST-tagged human FLT3 (564 to 993 residues) cytoplasmic domain expressed in baculovirus expression system by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM185149(1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of FLT3 D835H mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase receptor UFO(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM144315(Gilteritinib | US11512074, Example T-9 | US8969336...)
Affinity DataIC50:  0.730nMAssay Description:Inhibition of N-terminal GST-tagged human AXL (464 to 885 residues) cytoplasmic domain expressed in baculovirus expression system by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50515042(CHEMBL4593398)
Affinity DataIC50:  1nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin) using MBP as substrate after 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50515042(CHEMBL4593398)
Affinity DataIC50:  2nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin) using MBP as substrate after 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50515042(CHEMBL4593398)
Affinity DataIC50:  5nMAssay Description:Inhibition of FLT3 (unknown origin) using MBP as substrate after 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50515043(E-6201 | E6201 | ER-806201)
Affinity DataIC50:  5nMAssay Description:Inhibition of FLT3 (unknown origin) phosphorylation by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-1(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50364776(CHEMBL1952141 | CHEMBL1952329)
Affinity DataIC50:  7nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human full length Pim-1 using KKRNRTLTV as substrate after 40 mins by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetLymphokine-activated killer T-cell-originated protein kinase(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50515042(CHEMBL4593398)
Affinity DataIC50:  21nMAssay Description:Inhibition of TOPK (unknown origin) using MBP as substrate after 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50210177(ONX-0803 | Pacritinib | SB-1518 | SB1518)
Affinity DataIC50:  22nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50210177(ONX-0803 | Pacritinib | SB-1518 | SB1518)
Affinity DataIC50:  23nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM185149(1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol...)
Affinity DataIC50:  35nMAssay Description:Inhibition of FLT3 ITD/D835H double mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM185149(1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol...)
Affinity DataIC50:  35nMAssay Description:Inhibition of FLT3 ITD/D835Y double mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50364776(CHEMBL1952141 | CHEMBL1952329)
Affinity DataIC50:  44nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50515043(E-6201 | E6201 | ER-806201)
Affinity DataIC50:  50nMAssay Description:Inhibition of MEK1 (unknown origin) phosphorylation by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-3(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50364776(CHEMBL1952141 | CHEMBL1952329)
Affinity DataIC50:  69nMAssay Description:Inhibition of N-terminal 6His-tagged recombinant human Pim-3 using KKRNRTLTV as substrate after 40 mins by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50135482(1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...)
Affinity DataIC50:  70nMAssay Description:Inhibition of IKK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM482158(BDBM50242742 | TAE684)
Affinity DataIC50:  120nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM15138(5-indazolyl pyridine 11g | 5-{5-[(2S)-2-amino-3-ph...)
Affinity DataIC50:  134nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50515041(CHEMBL4125960)
Affinity DataIC50:  149nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRAC-alpha serine/threonine-protein kinase(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM15138(5-indazolyl pyridine 11g | 5-{5-[(2S)-2-amino-3-ph...)
Affinity DataIC50:  180nMAssay Description:Inhibition of AKT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlatelet-derived growth factor receptor beta(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM13535(4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin...)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant N-terminal His6-tagged human PDGFR-beta (557 to end residues) using EAIYAAPFAKKK as substrate after 10 mins in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM482158(BDBM50242742 | TAE684)
Affinity DataIC50:  218nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM13535(4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin...)
Affinity DataIC50:  220nMAssay Description:Inhibition of N-terminal GST-tagged human FLT3 (563 to 993 residues) cytoplasmic domain expressed in baculovirus infected sf9 cells using EAIYAAPFAKK...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-2(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50364776(CHEMBL1952141 | CHEMBL1952329)
Affinity DataIC50:  363nMAssay Description:Inhibition of human Pim-2 expressed in Escherichia coli cells using KKRNRTLTV as substrate after 40 mins by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase Fes/Fps(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50515040(CHEMBL4474361)
Affinity DataIC50:  494nMAssay Description:Inhibition of FES (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase Fes/Fps(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50515041(CHEMBL4125960)
Affinity DataIC50:  527nMAssay Description:Inhibition of FES (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50515041(CHEMBL4125960)
Affinity DataIC50:  536nMAssay Description:Inhibition of wild type FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM482158(BDBM50242742 | TAE684)
Affinity DataIC50:  536nMAssay Description:Inhibition of wild type FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase Fes/Fps(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM482158(BDBM50242742 | TAE684)
Affinity DataIC50:  569nMAssay Description:Inhibition of FES (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50135482(1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...)
Affinity DataIC50:  618nMAssay Description:Inhibition of wild type FLT3 (unknown origin) expressed in mouse BAF3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50515040(CHEMBL4474361)
Affinity DataIC50:  642nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50515040(CHEMBL4474361)
Affinity DataIC50:  1.39E+3nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50515040(CHEMBL4474361)
Affinity DataIC50:  3.14E+3nMAssay Description:Inhibition of wild type FLT3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50515041(CHEMBL4125960)
Affinity DataIC50:  3.65E+3nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50515044(CHEMBL4444272)
Affinity DataKd:  3.20nMAssay Description:Binding affinity to FLT3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-1(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50515044(CHEMBL4444272)
Affinity DataKd:  2.90nMAssay Description:Binding affinity to Pim-1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50326053(CHEMBL608533 | PKC-412 | US20240132489, Compound S...)
Affinity DataKd:  11nMAssay Description:Binding affinity to N-terminal GST-tagged human FLT3 (563 to 993 residues) cytoplasmic domain expressed in baculovirus infected sf9 cells using poly ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase receptor TYRO3(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50326053(CHEMBL608533 | PKC-412 | US20240132489, Compound S...)
Affinity DataKd:  88nMAssay Description:Inhibition of SKY (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-3(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50515044(CHEMBL4444272)
Affinity DataKd:  0.400nMAssay Description:Binding affinity to Pim-3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-2(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50515044(CHEMBL4444272)
Affinity DataKd:  3.10nMAssay Description:Binding affinity to Pim-2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed