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TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50380632(CHEMBL2017057)
Affinity DataKi:  243nMAssay Description:Inhibition of human recombinant PDE7A1 assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50380636(CHEMBL2017060)
Affinity DataKi:  269nMAssay Description:Inhibition of human recombinant PDE7A1 assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50380638(CHEMBL2017062)
Affinity DataKi:  507nMAssay Description:Inhibition of human recombinant PDE7A1 assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50380637(CHEMBL2017061)
Affinity DataKi:  550nMAssay Description:Inhibition of human recombinant PDE7A1 assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM23620(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)
Affinity DataKi:  600nMAssay Description:Inhibition of human phosphodiesterase 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50380635(CHEMBL2017059)
Affinity DataKi:  613nMAssay Description:Inhibition of human recombinant PDE7A1 assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50380641(CHEMBL2017065)
Affinity DataKi:  2.47E+3nMAssay Description:Inhibition of human recombinant PDE7A1 assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50380633(CHEMBL2017087)
Affinity DataKi:  3.70E+3nMAssay Description:Inhibition of human recombinant PDE7A1 assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50380656(CHEMBL2017080)
Affinity DataKi:  3.76E+3nMAssay Description:Inhibition of human recombinant PDE7A1 assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50380643(CHEMBL2017067)
Affinity DataKi:  3.77E+3nMAssay Description:Inhibition of human recombinant PDE7A1 assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50027176(2-Acetoxy-Benzoic Acid | 3-Isobutyl-Methylxanthine...)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of human phosphodiesterase 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50380640(CHEMBL2017064)
Affinity DataKi:  4.60E+3nMAssay Description:Inhibition of human recombinant PDE7A1 assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50380642(CHEMBL2017066)
Affinity DataKi:  4.60E+3nMAssay Description:Inhibition of human recombinant PDE7A1 assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50380653(CHEMBL2017078)
Affinity DataKi:  5.54E+3nMAssay Description:Inhibition of human recombinant PDE7A1 assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385902(CHEMBL2041596)
Affinity DataKi:  5.91E+3nMAssay Description:Competitive inhibition of human recombinant PDE7A1 using 5 nM to 2 uM cAMP as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50380662(CHEMBL2017086)
Affinity DataKi:  5.98E+3nMAssay Description:Inhibition of human recombinant PDE7A1 assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50380634(CHEMBL2017058)
Affinity DataKi:  6.12E+3nMAssay Description:Inhibition of human recombinant PDE7A1 assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50380650(CHEMBL2017075)
Affinity DataKi:  6.94E+3nMAssay Description:Inhibition of human recombinant PDE7A1 assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385903(CHEMBL2041614)
Affinity DataKi:  7.22E+3nMAssay Description:Competitive inhibition of human recombinant PDE7A1 using 5 nM to 2 uM cAMP as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50380657(CHEMBL2017081)
Affinity DataKi:  7.50E+3nMAssay Description:Inhibition of human recombinant PDE7A1 assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50048241((3S,4S)-3-Acetyl-4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataKi:  7.90E+3nMAssay Description:Inhibition of human Phosphodiesterase 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362036(CHEMBL1939915)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]cAMP from PDE7A1 by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362035(CHEMBL1939914)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]cAMP from PDE7A1 by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362047(CHEMBL1940057)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]cAMP from PDE7A1 by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362043(CHEMBL1940053)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]cAMP from PDE7A1 by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362046(CHEMBL1940056)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]cAMP from PDE7A1 by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362048(CHEMBL1940058)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]cAMP from PDE7A1 by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362033(CHEMBL1939912)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]cAMP from PDE7A1 by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50380655(CHEMBL2016583)
Affinity DataKi:  1.01E+4nMAssay Description:Inhibition of human recombinant PDE7A1 assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50380645(CHEMBL2017069)
Affinity DataKi:  1.11E+4nMAssay Description:Inhibition of human recombinant PDE7A1 assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50042053(CHEMBL3360172)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of PDE7A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50042036(CHEMBL3360170)
Affinity DataIC50:  0.680nMAssay Description:Inhibition of PDE7A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50032547(CHEMBL3354181)
Affinity DataIC50:  1nMAssay Description:Inhibition of human PDE7A1 expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50042037(CHEMBL3360169)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of PDE7A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50042035(CHEMBL3360171)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of PDE7A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50381287(CHEMBL2019020)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [3H]-cAMP from human recombinant PDE7AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM116309(US8637528, OM69)
Affinity DataIC50:  1.30nMpH: 8.0Assay Description:The assay method used was a scintillation proximity assay (SPA) (obtained from GE Healthcare, Product Code TRKQ7100), with [3H]-cGMP as the substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50068286(CHEMBL3403373)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50068283(CHEMBL3403371)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM140128(US8901315, 256)
Affinity DataIC50:  2nMpH: 7.5 T: 4°CAssay Description:The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50032540(CHEMBL3354179)
Affinity DataIC50:  2nMAssay Description:Inhibition of human PDE7A1 expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50032540(CHEMBL3354179)
Affinity DataIC50:  2nMAssay Description:Inhibition of PDE7A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50042039(CHEMBL3360167)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of PDE7A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50032543(CHEMBL3354180)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human PDE7A1 expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50068285(CHEMBL3403372)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50397056(CHEMBL2171440)
Affinity DataIC50:  3nMAssay Description:Inhibition of cloned human recombinant PDE7A assessed as [3H]cAMP hydrolysis by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM140095(US8901315, 179)
Affinity DataIC50:  3.10nMpH: 7.5 T: 4°CAssay Description:The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50068287(CHEMBL3403346)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50151638(8''-chloro-5''-(5-hydroxy-1,2,4-oxadiazol-3-ylmeth...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM140100(US8901315, 190)
Affinity DataIC50:  3.5nMpH: 7.5 T: 4°CAssay Description:The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...More data for this Ligand-Target Pair
In DepthDetails US Patent


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