Compile Data Set for Download or QSAR
Report error Found 657 for UniProtKB: Q92542
LigandPNGBDBM50185404((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-1-...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM29004((2R)-2-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)
Affinity DataEC50:  0.0600nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM29005((2R)-2-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)
Affinity DataEC50:  0.0600nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50185410((4aS,6S,8aR)-6-(4-chloro-benzenesulfonyl)-6-(2,5-d...)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50185411((4aS,6S,8aR)-6-(4-chloro-benzenesulfonyl)-6-(2,5-d...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50410179(CHEMBL2096800)
Affinity DataIC50: 0.140nMAssay Description:Inhibitory activity against Gamma-secretase in HeLa cells expressing APP-reporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM28989(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataEC50:  0.150nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM50185407((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-3-...)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50135575((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)
Affinity DataIC50: 0.200nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50185414((4aS,6S,8aR)-6-(4-chloro-benzenesulfonyl)-6-(2,5-d...)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM28987(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataEC50:  0.25nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM50185405((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-3-...)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM29011((2R)-2-[(4-chlorobenzene)(2,5-dichlorophenyl)sulfo...)
Affinity DataEC50:  0.270nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50135589((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)
Affinity DataIC50: 0.300nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM29012(N-[(4R)-4-{[5-chloro-2-(hydroxymethyl)phenyl](4-ch...)
Affinity DataEC50:  0.320nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM28980(1-[({4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoro...)
Affinity DataEC50:  0.360nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM50185413((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-6-...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50185408((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-6-...)
Affinity DataIC50: 0.410nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM29009((2R)-2-[(4-chlorobenzene)(2,5-dichlorophenyl)sulfo...)
Affinity DataEC50:  0.410nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM29010((2R)-2-[(4-chlorobenzene)(2,5-dichlorophenyl)sulfo...)
Affinity DataEC50:  0.480nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50135578(4-{3-[(S)-3-(3,4-Difluoro-phenyl)-2-methyl-propion...)
Affinity DataIC50: 0.490nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50171224(Cyclic sulfamide | CHEMBL196215)
Affinity DataIC50: 0.5nMAssay Description:Inhibitory concentration against gamma-secretase in whole cell SH-SY5Y assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM28976(2-{1-[(4-chlorobenzene)sulfonyl]-4-{[(2-methoxyben...)
Affinity DataEC50:  0.510nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM28966({4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluorophen...)
Affinity DataEC50:  0.510nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM29013(4-chloro-N-[5-chloro-2-(hydroxymethyl)phenyl]-N-[(...)
Affinity DataEC50:  0.510nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM28986(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataEC50:  0.650nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM28975(2-[({4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoro...)
Affinity DataEC50:  0.650nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM28988(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataEC50:  0.660nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM29008((2R)-2-[(5-chloro-2-fluorophenyl)(4-chlorobenzene)...)
Affinity DataEC50:  0.660nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50185406((4aS,6S,8aR)-6-(4-chloro-benzenesulfonyl)-6-(2,5-d...)
Affinity DataIC50: 0.760nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM28985(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataEC50:  0.820nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM50135579((S)-N-[(S)-5-Benzo[1,3]dioxol-5-yl-1-(2-hydroxy-et...)
Affinity DataIC50: 0.900nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50185412((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-6-...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM29001((2R)-2-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)
Affinity DataEC50:  0.930nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM28971(1-({4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluorop...)
Affinity DataEC50:  1nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM50223758(CHEMBL58925)
Affinity DataIC50: 1nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2018
Entry Details Article
PubMed
LigandPNGBDBM50157959(5-Chloro-thiophene-2-sulfonic acid [5-((E)-3-morph...)
Affinity DataIC50: 1nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM28968(({4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluorophe...)
Affinity DataEC50:  1nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM50171213(Cyclic sulfamide | CHEMBL194788)
Affinity DataIC50: 1nMAssay Description:Inhibitory concentration against gamma-secretase in whole cell SH-SY5Y assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM28979({4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluorophen...)
Affinity DataEC50:  1.10nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM50185409((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-6-...)
Affinity DataIC50: 1.17nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50135584((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)
Affinity DataIC50: 1.20nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM29007((2R)-2-[(4-chlorobenzene)(2,5-difluorophenyl)sulfo...)
Affinity DataEC50:  1.20nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM28967(N-({4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluorop...)
Affinity DataEC50:  1.30nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM50185403((+/-)-(4aS,6R,8aS)-3-tert-butyl-6-(4-chloro-benzen...)
Affinity DataIC50: 1.39nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM28972(2-{1-[(4-chlorobenzene)sulfonyl]-4-[(cyclopropanes...)
Affinity DataEC50:  1.40nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM28970([({4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataEC50:  1.70nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM29000((2R)-2-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)
Affinity DataEC50:  1.80nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50135586((S)-N-((S)-5-Benzo[1,3]dioxol-5-yl-1-methylcarbamo...)
Affinity DataIC50: 1.80nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50135582((S)-N-((S)-5-Benzo[1,3]dioxol-5-yl-2-oxo-2,3-dihyd...)
Affinity DataIC50: 1.80nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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