Compile Data Set for Download or QSAR
Report error Found 43 Enz. Inhib. hit(s) with Target = 'Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha/beta'
LigandChemical structure of BindingDB Monomer ID 528352BDBM528352(US11180503, Example 10 | 9-([1,1'-bi(cyclopropan)]...)
Affinity DataIC50: 611nMAssay Description:The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of human PDE6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 528351BDBM528351(US11180503, Example 9 | 9-([1,1'- Bi(cyclopropan)]...)
Affinity DataIC50: 982nMAssay Description:The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of human PDE6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 528349BDBM528349(US11180503, Example 7 | 9-([1,1'- Bi(cyclopropan)]...)
Affinity DataIC50: 1.20E+3nMAssay Description:The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of human PDE6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 573146BDBM573146(US11453673, Example 8)
Affinity DataIC50: 2.66E+3nMAssay Description:Table 7: The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 528355BDBM528355(US11180503, Example 13 | 9-([1,1'-bi(cyclopropan)]...)
Affinity DataIC50: 2.99E+3nMAssay Description:The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of human PDE6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 528354BDBM528354(US11180503, Example 12 | 5-Butyl-3- (hydroxymethyl...)
Affinity DataIC50: 3.06E+3nMAssay Description:The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of human PDE6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 528350BDBM528350(US11180503, Example 8 | 5-butyl-3-ethyl-9-(1-methy...)
Affinity DataIC50: 3.29E+3nMAssay Description:The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of human PDE6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 528331BDBM528331(US11180503, Example 1 | 9-([1,1'-bi(cyclopropan)]-...)
Affinity DataIC50: 3.45E+3nMAssay Description:The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of human PDE6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 528353BDBM528353(US11180503, Example 11 | 9-([1,1'-bi(cyclopropan)]...)
Affinity DataIC50: 3.85E+3nMAssay Description:The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of human PDE6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 573150BDBM573150(US11453673, Example 12)
Affinity DataIC50: 7.62E+3nMAssay Description:Table 7: The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 528348BDBM528348(US11180503, Example 6 | 5-butyl-3-methyl-9-(1-meth...)
Affinity DataIC50: 9.59E+3nMAssay Description:The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of human PDE6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50258898BDBM50258898(CHEMBL4064344)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human PDE6A/PDE6B expressed in insect cells using [3H]cGMP as substrate preincubated for 30 mins followed by substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50180268BDBM50180268(CHEMBL3814662)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PDE6ABMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50258268BDBM50258268(CHEMBL4059831 | US11419874, Example 21)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human PDE6A/PDE6B expressed in baculovirus infected Sf9 cell expression system using [3H]cGMP as substrate preincubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 573154BDBM573154(US11453673, Example 15)
Affinity DataIC50: 1.00E+4nMAssay Description:Table 7: The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 573155BDBM573155(US11453673, Example 16)
Affinity DataIC50: 1.00E+4nMAssay Description:Table 7: The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 573152BDBM573152(US11453673, Example 13)
Affinity DataIC50: 1.00E+4nMAssay Description:Table 7: The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 573153BDBM573153(US11453673, Example 14)
Affinity DataIC50: 1.00E+4nMAssay Description:Table 7: The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 562229BDBM562229(US11401274, Example 3 | 1-([1,1′-bi(cyclopro...)
Affinity DataIC50: 1.00E+4nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 562231BDBM562231(US11401274, Example 4 | 1-([1,1′-bi(cyclopro...)
Affinity DataIC50: 1.00E+4nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 562227BDBM562227(US11401274, Example 1 | 1-([1,1′-bi(cyclopro...)
Affinity DataIC50: 1.00E+4nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 562228BDBM562228(US11401274, Example 2 | 1-([1,1′-bi(cyclopro...)
Affinity DataIC50: 1.00E+4nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 562239BDBM562239(US11401274, Example 7 | 1-([1,1′-bi(cyclopro...)
Affinity DataIC50: 1.00E+4nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 562247BDBM562247(US11401274, Example 8 | 1-([1,1′-bi(cyclopro...)
Affinity DataIC50: 1.00E+4nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 562235BDBM562235(US11401274, Example 5 | 1-([1,1′-bi(cyclopro...)
Affinity DataIC50: 1.00E+4nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 562236BDBM562236(US11401274, Example 6 | 1-(1-cyclopropylcyclopropy...)
Affinity DataIC50: 1.00E+4nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 573136BDBM573136(US11453673, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Table 7: The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 573138BDBM573138(US11453673, Example 4)
Affinity DataIC50: 1.00E+4nMAssay Description:Table 7: The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 573134BDBM573134(US11453673, Example 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Table 7: The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 573135BDBM573135(US11453673, Example 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Table 7: The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 573145BDBM573145(US11453673, Example 7)
Affinity DataIC50: 1.00E+4nMAssay Description:Table 7: The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 528333BDBM528333(US11180503, Example 3 | 9-([1,1'- Bi(cyclopropan)]...)
Affinity DataIC50: 1.00E+4nMAssay Description:The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of human PDE6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 573139BDBM573139(US11453673, Example 5)
Affinity DataIC50: 1.00E+4nMAssay Description:Table 7: The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 528332BDBM528332(US11180503, Example 2 | 5-Butyl-3- methyl-9-(1- (t...)
Affinity DataIC50: 1.00E+4nMAssay Description:The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of human PDE6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 573144BDBM573144(US11453673, Example 6)
Affinity DataIC50: 1.00E+4nMAssay Description:Table 7: The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 528334BDBM528334(US11180503, Example 4 | rac-9-([1,1''- Bi(cyclopro...)
Affinity DataIC50: 1.00E+4nMAssay Description:The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of human PDE6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 573149BDBM573149(US11453673, Example 11)
Affinity DataIC50: 1.00E+4nMAssay Description:Table 7: The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 528334BDBM528334(US11180503, Example 4 | rac-9-([1,1''- Bi(cyclopro...)
Affinity DataIC50: 1.00E+4nMAssay Description:The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of human PDE6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 528347BDBM528347(US11180503, Example 5 | 9-([1,1'-bi(cylopropan)]-1...)
Affinity DataIC50: 1.00E+4nMAssay Description:The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of human PDE6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 573147BDBM573147(US11453673, Example 9)
Affinity DataIC50: 1.00E+4nMAssay Description:Table 7: The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 528334BDBM528334(US11180503, Example 4 | rac-9-([1,1''- Bi(cyclopro...)
Affinity DataIC50: 1.00E+4nMAssay Description:The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of human PDE6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 573148BDBM573148(US11453673, Example 10)
Affinity DataIC50: 1.00E+4nMAssay Description:Table 7: The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50258896BDBM50258896(CHEMBL4060569 | US11419874, TAK-915)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human PDE6A/PDE6B expressed in insect cells using [3H]cGMP as substrate preincubated for 30 mins followed by substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2019
Entry Details Article
PubMed