BindingDB PrimarySearch

Found 126 with Last Name = 'pareek' and Initial = 'h'

Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371616((R)-4-(2-(6-Fluoropyridin-3-yl)-4-(trifluoromethyl...)

IC50: 0.110nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM50545552(CHEMBL4646742)

IC50: 0.400nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM50545560(CHEMBL4634421)

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM50545558(CHEMBL4642748)

IC50: 0.5nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM50545563(CHEMBL4636838)

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371523((R)-N-(6-Fluoropyridin-2-yl)-4-(2-(1-methyl-1H-pyr...)

IC50: 0.600nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM50545567(CHEMBL4649638)

IC50: 0.800nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371635((R)-4-(2-(1H-1,2,3-Triazol-1-yl)-4-(trifluoromethy...)

IC50: 1.10nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371776((R)-4-(2-(6-methylpyridin-3-yl)-4-(trifluoromethyl...)

IC50: 1.40nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371648((R)-N-(6-Fluoropyridin-2-yl)-4-(2-(2-methyloxazol-...)

IC50: 1.60nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM50545554(CHEMBL4635247)

PDB Reactome pathway KEGG
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371652((R)-4-(2-(2-methyloxazol-4-yl)-4-(trifluoromethyl)...)

IC50: 1.80nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371770((R)-4-(2-(5-fluoropyridin-2-yl)-4-(trifluoromethyl...)

IC50: 2.10nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371697(N-(6-fluoropyridin-2-yl)-4-(2-morpholino-4-(triflu...)

IC50: 2.30nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM50545556(CHEMBL4639228)

PDB Reactome pathway KEGG
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371768((R)-4-(2-(5-fluoropyridin-2-yl)-4-(trifluoromethyl...)

IC50: 2.70nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371614((R)-4-(2-(6-Fluoropyridin-3-yl)-4-(trifluoromethyl...)

IC50: 2.80nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371695(4-(2-morpholino-4-(trifluoromethyl)phenyl)-N-(pyri...)

IC50: 3nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371584((R)-4-(2-(1-Methyl-1H-pyrazol-5-yl)-4-(trifluorome...)

IC50: 4.30nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM50545561(CHEMBL4641467)

IC50: 4.5nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM50545566(CHEMBL4642855)

IC50: 6.20nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371540((R)-N-(4-Fluoropyridin-2-yl)-4-(2-(1-methyl-1H-pyr...)

IC50: 6.5nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371780(N-(6-fluoropyridin-2-yl)-4-(2-(6-methylpyridin-3-y...)

IC50: 6.60nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM50545570(CHEMBL4633186)

IC50: 6.90nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM50545568(CHEMBL4632456)

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371693((R)-4-(2-morpholino-4-(trifluoromethyl)phenyl)-N-(...)

IC50: 7.20nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM50545564(CHEMBL4639688)

IC50: 7.80nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Interleukin-2(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM50575333(CHEMBL4857063)

IC50: 8nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371777(N-(5-fluoropyrimidin-2-yl)-4-(2-(6-methylpyridin-3...)

IC50: 8.30nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371778(4-(2-(6-methylpyridin-3-yl)-4-(trifluoromethyl)phe...)

IC50: 8.70nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM50545569(CHEMBL4637997)

IC50: 10nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Interleukin-2(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM50575331(CHEMBL4868242)

IC50: 11nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371772((R)-4-(2-(5-fluoropyridin-2-yl)-4-(trifluoromethyl...)

IC50: 12nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371694(N-(5-fluoropyrimidin-2-yl)-4-(2-morpholino-4-(trif...)

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Interleukin-2(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM50575332(CHEMBL4869725)

IC50: 14nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371811(4-(2-(1,1-dioxidothiomorpholino)-4-(trifluoromethy...)

IC50: 15nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM50545559(CHEMBL4642271)

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371612((R)-4-(2-(6-Fluoropyridin-3-yl)-4-(trifluoromethyl...)

IC50: 16nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells assessed as V1/2 of slow inactivation at 10 Hz frequency at -120 mV holding potential by single ...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371590((R)-4-(2-(1-Methyl-1H-pyrazol-5-yl)-4-(trifluorome...)

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371590((R)-4-(2-(1-Methyl-1H-pyrazol-5-yl)-4-(trifluorome...)

IC50: 18nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371580((R)-N-(5-Fluoropyridin-2-yl)-4-(2-(1-methyl-1H-pyr...)

IC50: 20nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371612((R)-4-(2-(6-Fluoropyridin-3-yl)-4-(trifluoromethyl...)

IC50: 21nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371582((R)-N-(5-Fluoropyrimidin-2-yl)-4-(2-(1-methyl-1H-p...)

IC50: 24nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371646((R)-N-(5-Fluoropyrimidin-2-yl)-4-(2-(2-methyloxazo...)

IC50: 26nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371620((R)-4-(4'-Fluoro-5-(trifluoromethyl)-[1,1'-bipheny...)

IC50: 30nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM371590((R)-4-(2-(1-Methyl-1H-pyrazol-5-yl)-4-(trifluorome...)

IC50: 30nMAssay Description:Use-dependent inhibition of human Nav1.7 expressed in HEK293 cells at 25 pulse 10 Hz frequency at -120 mV holding potential by manual patch clamp ass...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Interleukin-2(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM50575328(CHEMBL4868367)

IC50: 32nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Sodium channel protein type 9 subunit alpha(Mus musculus)
Lupin

Curated by ChEMBL

BDBM371590((R)-4-(2-(1-Methyl-1H-pyrazol-5-yl)-4-(trifluorome...)

IC50: 33nMAssay Description:Inhibition of mouse Nav1.7 expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20 mins follo...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Sodium channel protein type 9 subunit alpha(Mus musculus)
Lupin

Curated by ChEMBL

BDBM50545569(CHEMBL4637997)

PDB Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL

BDBM50545569(CHEMBL4637997)

IC50: 33nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells assessed as V1/2 of slow inactivation at 10 Hz frequency at -120 mV holding potential by single ...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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