Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 595 hits in this display
IC50: 0.400nMAssay Description:Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50185127((3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en...)
BDBM50233538(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
BDBM50233538(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
BDBM50233538(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
BDBM50329192((3beta,18beta,20beta)-3-Acetoxy-N-methyl-N-hydroxy...)
BDBM50329192((3beta,18beta,20beta)-3-Acetoxy-N-methyl-N-hydroxy...)
BDBM50174298(3-(4-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)bicy...)
BDBM50329187((3alpha,18beta,20beta)-3-Methoxyamino-11-oxo-olean...)IC50: 4.90nMAssay Description:Inhibition of human recombinant 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-3H]-cortisol to cortisone by scintillation c...More data for this Ligand-Target Pair
BDBM50340378(3-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1...)IC50: 7.5nMAssay Description:Inhibition of human microsomal 11beta-HSD2 assessed as inhibition of conversion of radiolabeled cortisone to radiolabeled cortisol by cell-based assa...More data for this Ligand-Target Pair
BDBM50112133(CHEMBL3609861 | US9464044, 71)
BDBM50306423(2-{1'-[(adamantan-2-yl)carbamoyl]-5-methyl-2,3-dih...)
BDBM50340431((4-(1H-imidazol-4-yl)piperidin-1-yl)(3,4-dihydroqu...)
BDBM50340432((4-(1H-imidazol-4-yl)piperidin-1-yl)(3-methyl-2H-b...)
BDBM642875((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-2,4a,6a...)
BDBM50339805((3beta,18beta,20beta)-[3-(1,2,4-Oxadiazole-5(2H)-o...)IC50: 11nMAssay Description:Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-[3H]cortisol to cortisone after 10 mins by scintillation...More data for this Ligand-Target Pair
BDBM50339809((5aR,7aR,7bS,9aS,12S,13aR,15aR,15bS)-2,3,4,5,5a,6,...)IC50: 11nMAssay Description:Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-[3H]cortisol to cortisone after 10 mins by scintillation...More data for this Ligand-Target Pair
BDBM642880((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(Ben...)IC50: 12.6nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM50329188((3beta,18beta,20beta)-3-Methoxyamino-11-oxo-olean-...)IC50: 14.5nMAssay Description:Inhibition of human recombinant 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-3H]-cortisol to cortisone by scintillation c...More data for this Ligand-Target Pair
BDBM50339811((3beta,18beta,20beta)-N-Hydroxy-N-methyl-[3-(1,2,4...)IC50: 15nMAssay Description:Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-[3H]cortisol to cortisone after 10 mins by scintillation...More data for this Ligand-Target Pair
BDBM50339812(CHEMBL1689283 | N-[(3beta,18beta,20beta)-3-Hydroxy...)IC50: 17nMAssay Description:Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-[3H]cortisol to cortisone after 10 mins by scintillation...More data for this Ligand-Target Pair
BDBM642882((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-((Cy...)IC50: 20nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM50193790(6-((1-cycloheptyl-4,4-dimethyl-5-oxopyrrolidin-3-y...)
IC50: 30nMAssay Description:Inhibition of human microsomal 11beta-HSD2 assessed as inhibition of conversion of radiolabeled cortisone to radiolabeled cortisol by cell-based assa...More data for this Ligand-Target Pair
BDBM50340386(3-(4-(ethylsulfonylmethyl)bicyclo[2.2.2]octan-1-yl...)IC50: 31nMAssay Description:Inhibition of human microsomal 11beta-HSD2 assessed as inhibition of conversion of radiolabeled cortisone to radiolabeled cortisol by cell-based assa...More data for this Ligand-Target Pair
BDBM642894((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-Acet...)IC50: 31.6nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM642889((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-acet...)IC50: 31.6nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM50339808(CHEMBL1689279 | N-[(5aR,7aR,7bS,9aS,12S,13aR,15aR,...)IC50: 33nMAssay Description:Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-[3H]cortisol to cortisone after 10 mins by scintillation...More data for this Ligand-Target Pair
BDBM50339813(CHEMBL1689284 | N-[(3beta,18beta,20beta)-3,11-Diox...)IC50: 45nMAssay Description:Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-[3H]cortisol to cortisone after 10 mins by scintillation...More data for this Ligand-Target Pair
BDBM50188387((2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-amino-2...)
BDBM50329193((3beta,18beta,20beta)-3-Acetoxy-N-hydroxy-11-oxo-o...)IC50: 61.1nMAssay Description:Inhibition of human recombinant 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-3H]-cortisol to cortisone by scintillation c...More data for this Ligand-Target Pair
BDBM642893((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-acet...)IC50: 63.1nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM642901((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-[(2-...)IC50: 63.1nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM642892((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(ace...)IC50: 79.4nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
IC50: <100nMAssay Description:Inhibition of human full-length 11beta-HSD2 expressed in HEK293 cells using cortisol as substrate after 2 hrs by LC-MS analysisMore data for this Ligand-Target Pair
IC50: <100nMAssay Description:Inhibition of human full-length 11beta-HSD2 expressed in HEK293 cells using cortisol as substrate after 2 hrs by LC-MS analysisMore data for this Ligand-Target Pair
IC50: 100nMAssay Description:Inhibition of human full-length 11beta-HSD2 expressed in HEK293 cells using cortisol as substrate after 2 hrs by LC-MS analysisMore data for this Ligand-Target Pair
IC50: 100nMAssay Description:Inhibition of human full-length 11beta-HSD2 expressed in HEK293 cells using cortisol as substrate after 2 hrs by LC-MS analysisMore data for this Ligand-Target Pair
IC50: <100nMAssay Description:Inhibition of human full-length 11beta-HSD2 expressed in HEK293 cells using cortisol as substrate after 2 hrs by LC-MS analysisMore data for this Ligand-Target Pair
BDBM642877((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-2,4a,6a...)IC50: 100nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM50339806((3beta,18beta,20beta)-N-[-3-(Acetoxy)-11-oxo-30-no...)IC50: 104nMAssay Description:Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-[3H]cortisol to cortisone after 10 mins by scintillation...More data for this Ligand-Target Pair
BDBM50329195((2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-N,10-dihyd...)IC50: 122nMAssay Description:Inhibition of human recombinant 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-3H]-cortisol to cortisone by scintillation c...More data for this Ligand-Target Pair
BDBM642909((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-2,4a,6a...)IC50: 126nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM642913((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-[4-(...)IC50: 126nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM642915(2-(3-((1-PEG-1H-1,2,3-triazol-4-yl)methoxy)-4-nitr...)IC50: 126nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM642898((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(2-H...)IC50: 158nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM50247012(3beta-O-Succinyl-18-beta-glycyrrhetinic acid | Car...)
BDBM50174285(3-(4-pentylbicyclo[2.2.2]octan-1-yl)-5,6,7,8,9,10-...)IC50: 180nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50174285(3-(4-pentylbicyclo[2.2.2]octan-1-yl)-5,6,7,8,9,10-...)
BDBM50339807(CHEMBL1689277 | N-[(3beta,18beta,20beta)-3-(Acetox...)IC50: 194nMAssay Description:Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-[3H]cortisol to cortisone after 10 mins by scintillation...More data for this Ligand-Target Pair
BDBM642907((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-((me...)IC50: 200nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM642891((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(ace...)IC50: 200nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM50188385((2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-acetoxy...)
BDBM50174279(3-(4-(3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl)bicy...)
BDBM642911((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-((di...)IC50: 251nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM642890((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(ace...)IC50: 251nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM642879((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(ben...)IC50: 251nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM50233538(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
IC50: 257nMAssay Description:Inhibition of human recombinant 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-3H]-cortisol to cortisone by scintillation c...More data for this Ligand-Target Pair
BDBM50233538(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
IC50: 257nMAssay Description:Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-[3H]cortisol to cortisone after 10 mins by scintillation...More data for this Ligand-Target Pair
BDBM50329191((2S,4aS,6aS,6bR,8aR,12aS,12bR,14bR,E)-10-(methoxyi...)IC50: 268nMAssay Description:Inhibition of human recombinant 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-3H]-cortisol to cortisone by scintillation c...More data for this Ligand-Target Pair
BDBM50188386(2-((3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-(met...)
BDBM50340383(5-(4-(5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a...)IC50: 290nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50329190((18beta,20beta)-3,11-Dioxo-olean-12-en-29-oic acid...)IC50: 329nMAssay Description:Inhibition of human recombinant 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-3H]-cortisol to cortisone by scintillation c...More data for this Ligand-Target Pair
BDBM50224221(5-cyclopentyl-2-(2-fluorophenylamino)thiazol-4(5H)...)
BDBM642884((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(Met...)IC50: 398nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM642886((2S,4aS,6aS,6bR,8aR,9S,10R,12aS,12bR,14bR)-10-(ace...)IC50: 398nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
IC50: 400nMAssay Description:Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50329189((3beta,18beta,20beta)-3-(Acetylamino)-11-oxo-olean...)IC50: 458nMAssay Description:Inhibition of human recombinant 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-3H]-cortisol to cortisone by scintillation c...More data for this Ligand-Target Pair
BDBM50340389(3-(4-((4-chlorophenoxy)methyl)bicyclo[2.2.2]octan-...)IC50: 460nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50442531(11BETA-HYDROXYPROGESTERONE)IC50: 490nMAssay Description:Inhibition of human recombinant 11beta-HSD2 expressed in HEK293 cells assessed as inhibition of [1,2,6,7-3H]-cortisol to [3H]cortisone preincubated f...More data for this Ligand-Target Pair
BDBM642876((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-2,4a,6a...)IC50: 501nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM642888((2S,4aS,6aS,6bR,8aR,9S,10R,12aS,12bR,14bR)-10-(ace...)IC50: 501nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM642900((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-[(2-...)IC50: 501nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM642871((2S,4aS,6aS,6bR,8aS,10S,12aS,12bR,14bR)-2,4a,6a,6b...)IC50: 501nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM642872((2S,4aS,6aS,6bR,8aS,10S,12aS,12bR,14bR)-2,4a,6a,6b...)IC50: 501nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM642876((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-2,4a,6a...)
IC50: 501nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM50306422(2-{1'-[(adamantan-2-yl)carbamoyl]-4-methyl-2,3-dih...)
BDBM50224202(5-cyclohexyl-2-(2-fluorophenylamino)thiazol-4(5H)-...)
BDBM13772(2-(2-chloro-4-fluorophenoxy)-2-methyl-N-[(1R,2S,5R...)
BDBM13773((1R,3R,4S,7S)-4-[2-(2-chlorophenoxy)-2-methylpropa...)IC50: 580nMAssay Description:The in Vitro 11beta-HSD2 dehydrogenase assays were developed using the cell lysates that had the full length human or mouse 11beta-HSD2 cDNA over exp...More data for this Ligand-Target Pair
BDBM50193796(3,3-dimethyl-1-[5-(1H-tetrazol-5-yl)-adamantan-2-y...)
BDBM50188385((2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-acetoxy...)
IC50: 750nMAssay Description:Inhibition of human recombinant 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-3H]-cortisol to cortisone by scintillation c...More data for this Ligand-Target Pair
BDBM50188385((2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-acetoxy...)
IC50: 750nMAssay Description:Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-[3H]cortisol to cortisone after 10 mins by scintillation...More data for this Ligand-Target Pair
BDBM642887((2S,4aS,6aS,6bR,8aR,9S,10R,12aS,12bR,14bR)-10-(ace...)IC50: 794nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM642873((2S,4aS,6aS,6bR,8aS,10S,12aS,12bR,14bR)-2,4a,6a,6b...)IC50: 794nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM642903((2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-2,4a,6a,6b...)IC50: 1.00E+3nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
IC50: 1.00E+3nMAssay Description:Inhibition of human full-length 11beta-HSD2 expressed in HEK293 cells using cortisol as substrate after 2 hrs by LC-MS analysisMore data for this Ligand-Target Pair
BDBM50340396(5-(4-(4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,...)IC50: >1.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
IC50: 1.05E+3nMAssay Description:Inhibition of human recombinant 11beta-HSD2 expressed in HEK293 cells assessed as inhibition of [1,2,6,7-3H]-cortisol to [3H]cortisone preincubated f...More data for this Ligand-Target Pair
BDBM642885((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(ace...)IC50: 1.26E+3nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM642897((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-[(2-...)IC50: 1.26E+3nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM50340798(3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-(4-(th...)
BDBM50174281(4-methyl-3-(4-pentylbicyclo[2.2.2]octan-1-yl)-5-(2...)IC50: 1.30E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50340391(3-(4-(4-fluoropentyl)bicyclo[2.2.2]octan-1-yl)-4-m...)IC50: 1.30E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM642904((2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-(2-{[5-...)IC50: 1.59E+3nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM642881((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(cyc...)IC50: 1.59E+3nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM50340392(4-methyl-3-(4-(2-(2,2,2-trifluoroethylsulfonyl)eth...)IC50: 1.60E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50193789(4-[3,3-dimethyl-2-oxo-4-(4-[1,2,4]triazol-1-yl-phe...)
BDBM13757((1R,3R,4S,7S)-4-[2-(2-chlorophenoxy)-2-methylpropa...)IC50: 1.80E+3nMAssay Description:The in Vitro 11beta-HSD2 dehydrogenase assays were developed using the cell lysates that had the full length human or mouse 11beta-HSD2 cDNA over exp...More data for this Ligand-Target Pair
BDBM50193784(4-[4-(4-imidazol-1-yl-phenoxymethyl)-3,3-dimethyl-...)
BDBM50329194((3beta,18beta,20beta)-3-Hydroxy-N-methoxy-11-oxo-o...)IC50: 2.13E+3nMAssay Description:Inhibition of human recombinant 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-3H]-cortisol to cortisone by scintillation c...More data for this Ligand-Target Pair
IC50: 2.20E+3nMAssay Description:Inhibition of human recombinant 11beta-HSD2 expressed in HEK293 cells assessed as inhibition of [1,2,6,7-3H]-cortisol to [3H]cortisone preincubated f...More data for this Ligand-Target Pair
BDBM50340806(3-chloro-4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-met...)
BDBM50188388((R)-2-((2S,4aR,6S,6aS,6bR,8aR,10S,12aS,12bR,14bR)-...)
IC50: 2.41E+3nMAssay Description:Inhibition of human recombinant 11beta-HSD2 expressed in HEK293 cells assessed as inhibition of [1,2,6,7-3H]-cortisol to [3H]cortisone preincubated f...More data for this Ligand-Target Pair
BDBM50297909(4-[(3-Chlorophenylsulfonamido)methyl]-N-cyclohepty...)IC50: 2.49E+3nMAssay Description:Inhibition of human microsomal 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximi...More data for this Ligand-Target Pair
BDBM50224208(2-(2-chlorophenylamino)-5-isopropylthiazol-4(5H)-o...)
BDBM642912((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-[4-(...)IC50: 2.51E+3nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
IC50: 2.69E+3nMAssay Description:Inhibition of human recombinant 11beta-HSD2 expressed in HEK293 cells assessed as inhibition of [1,2,6,7-3H]-cortisol to [3H]cortisone preincubated f...More data for this Ligand-Target Pair
BDBM50239401(3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]tria...)
BDBM50239401(3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]tria...)
BDBM50239401(3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]tria...)
BDBM50340791(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,...)
BDBM642870((2S,4aS,6aS,6bR,8aS,10S,12aS,12bR,14bR)-2,4a,6a,6b...)IC50: 3.16E+3nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM50197412(CHEMBL241711 | N-(5-carbamoylmethanesulfonyl-adama...)
BDBM13758((1R,3R,4S,7S)-4-[2-(3-chlorophenoxy)-2-methylpropa...)IC50: 3.50E+3nMAssay Description:The in Vitro 11beta-HSD2 dehydrogenase assays were developed using the cell lysates that had the full length human or mouse 11beta-HSD2 cDNA over exp...More data for this Ligand-Target Pair
BDBM50195304(CHEMBL220282 | N-(5-hydroxy-adamantan-2-yl)-2-pipe...)
BDBM50188390(4-((5R,10S,13R,14R)-3-acetoxy-4,4,10,13,14-pentame...)
BDBM642902((2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-(carbox...)IC50: 3.98E+3nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM642874((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-2,4a,6a...)IC50: 3.98E+3nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM50340799(3-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H...)
BDBM50340800(3-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H...)
BDBM50340801(2-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,...)
BDBM50340802(2-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H...)
BDBM50340803(2-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H...)
BDBM50340804(2-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,...)
BDBM50340805(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,...)
BDBM50340831(2-(3-chloro-4-(5-(1-(4-chlorophenyl)-3-fluorocyclo...)
BDBM50260706(3-(1-(4-chlorophenyl)cyclobutyl)-5-(4-fluorophenyl...)
BDBM50260705(3-(3-chlorophenyl)-5-(1-(4-chlorophenyl)cyclobutyl...)
BDBM50260704(3-(2-chlorophenyl)-5-(1-(4-chlorophenyl)cyclobutyl...)
BDBM50260670(3-(4-chlorophenyl)-5-(1-(4-chlorophenyl)cyclobutyl...)
BDBM50260669(3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-(3-(tr...)
BDBM50260668(3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-(2-(tr...)
BDBM50260667(3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-(4-(tr...)
BDBM50260666(3-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,...)
BDBM50260625(2-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,...)
BDBM50260624(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,...)
BDBM50260623(3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-phenyl...)
BDBM50339810(1-((2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-2,4a,6a...)IC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-[3H]cortisol to cortisone after 10 mins by scintillation...More data for this Ligand-Target Pair
BDBM50340394(5-(4-(4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,...)IC50: 4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50340395(3-(4-(4-methoxybutyl)bicyclo[2.2.2]octan-1-yl)-4-m...)IC50: 4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50340397(3-(4-(4,4-difluoropentyl)bicyclo[2.2.2]octan-1-yl)...)IC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50340398(3-(4-(ethoxymethyl)bicyclo[2.2.2]octan-1-yl)-4-met...)IC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50340399(4-methyl-3-(4-((4-(methylsulfonyl)phenoxy)methyl)b...)IC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50340387(CHEMBL1761144 | N-((4-(4-methyl-5-(2-(trifluoromet...)IC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50340384(CHEMBL1761309 | N-((4-(4-methyl-5-(2-(trifluoromet...)IC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50340380(CHEMBL1761310 | N-((4-(4-methyl-5-(2-(trifluoromet...)IC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50340400(3-(4-(2-(ethylthio)ethyl)bicyclo[2.2.2]octan-1-yl)...)IC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50340371(3-(4-(2-(ethylsulfinyl)ethyl)bicyclo[2.2.2]octan-1...)IC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50340378(3-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1...)
IC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50340382(4-methyl-3-(4-(2-(methylsulfonyl)ethyl)bicyclo[2.2...)IC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50340374(4-methyl-3-(4-(2-(propylsulfonyl)ethyl)bicyclo[2.2...)IC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50340372(3-(4-(2-(isopropylsulfonyl)ethyl)bicyclo[2.2.2]oct...)IC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50340375(3-(4-(2-(tert-butylsulfonyl)ethyl)bicyclo[2.2.2]oc...)IC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50340373(4-methyl-3-(4-(2-(phenylsulfonyl)ethyl)bicyclo[2.2...)IC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50174280(3-(4-(3-methyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]...)
BDBM50174294(CHEMBL200876 | methyl 4-(5,6,7,8,9,10-hexahydro-[1...)
BDBM50261010(3-(3-Chloro-2'-ethanesulfonyl-biphenyl-4-yl)-5-[1-...)
BDBM50260937(3-(3-Chloro-4'-methanesulfonyl-biphenyl-4-yl)-5-[1...)
BDBM50260939(3-(3-Chloro-3'-methanesulfonyl-biphenyl-4-yl)-5-[1...)
BDBM50239407(3-(1-(4-chlorophenyl)cyclobutyl)-5,6,7,8,9,10-hexa...)
BDBM50239276(3-Adamantan-1-yl-4-methyl-5-phenyl-4H-[1,2,4]triaz...)
BDBM50260882(3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-(4-(th...)
BDBM50260881(3-(4-(1H-pyrrol-1-yl)phenyl)-5-(1-(4-chlorophenyl)...)
BDBM50260879(3-(4-(1H-imidazol-1-yl)phenyl)-5-(1-(4-chloropheny...)
BDBM50260878(3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-(4-phe...)
BDBM50260825(3-(4-tert-butylphenyl)-5-(1-(4-chlorophenyl)cyclob...)
BDBM50260824(3-(4-benzylphenyl)-5-(1-(4-chlorophenyl)cyclobutyl...)
BDBM50260823(3-[1-(4-Chloro-phenyl)-cyclobutyl]-5-(4'-fluoro-bi...)
BDBM50260822(3-Biphenyl-3-yl-5-[1-(4-chloro-phenyl)-cyclobutyl]...)
BDBM50260797(3-Biphenyl-4-yl-5-[1-(4-chloro-phenyl)-cyclobutyl]...)
BDBM50260796(3-(1-(4-chlorophenyl)cyclobutyl)-5-(4-cyclopropoxy...)
BDBM50260795(3-(1-(4-chlorophenyl)cyclobutyl)-5-(3-fluoro-4-met...)
BDBM50260794(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,...)
BDBM50260793(3-(1-(4-chlorophenyl)cyclobutyl)-5-(2,4-dichloroph...)
BDBM50260749(3-(1-(4-chlorophenyl)cyclobutyl)-5-(2-methoxypheny...)
BDBM50260748(3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-o-toly...)
BDBM50260747(3-(1-(4-chlorophenyl)cyclobutyl)-5-(4-iodophenyl)-...)
BDBM50260746(3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-(2-(tr...)
BDBM50260745(3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-(4-(tr...)
BDBM50260708(3-(1-(4-chlorophenyl)cyclobutyl)-5-(3-fluorophenyl...)
BDBM50260707(3-(1-(4-chlorophenyl)cyclobutyl)-5-(2-fluorophenyl...)
BDBM50239401(3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]tria...)
BDBM50239407(3-(1-(4-chlorophenyl)cyclobutyl)-5,6,7,8,9,10-hexa...)
BDBM50239276(3-Adamantan-1-yl-4-methyl-5-phenyl-4H-[1,2,4]triaz...)
BDBM50340376(3-(4-(2-(4-fluorophenylsulfonyl)ethyl)bicyclo[2.2....)IC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50340377(4-methyl-3-(2-(trifluoromethyl)phenyl)-5-(4-(2-(tr...)IC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50340386(3-(4-(ethylsulfonylmethyl)bicyclo[2.2.2]octan-1-yl...)
IC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50340401(3-(4-(3-(ethylsulfonyl)propyl)bicyclo[2.2.2]octan-...)IC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50340402(3-(4-(4-(ethylsulfonyl)butyl)bicyclo[2.2.2]octan-1...)IC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50340379(3-(2-chlorophenyl)-5-(4-(2-(ethylsulfonyl)ethyl)bi...)IC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50340390(3-(3-chlorophenyl)-5-(4-(2-(ethylsulfonyl)ethyl)bi...)IC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50340393(3-(4-chlorophenyl)-5-(4-(2-(ethylsulfonyl)ethyl)bi...)IC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50340403(3-chloro-4-(5-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2...)IC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50340381(3-(2-bromophenyl)-5-(4-(2-(ethylsulfonyl)ethyl)bic...)IC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50340385(3-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1...)IC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50340388(3-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1...)IC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50340809(3-Adamantan-1-yl-5,6,7,8,9,10-hexahydro-[1,2,4]tri...)
BDBM50239407(3-(1-(4-chlorophenyl)cyclobutyl)-5,6,7,8,9,10-hexa...)
BDBM50260623(3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-phenyl...)
BDBM50260797(3-Biphenyl-4-yl-5-[1-(4-chloro-phenyl)-cyclobutyl]...)
BDBM50340810(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,...)
BDBM50340811(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,...)
BDBM50340822(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,...)
BDBM50340823(CHEMBL1760674 | N-tert-butyl-4-(5-(1-(4-chlorophen...)
BDBM50340824(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,...)
BDBM50340825(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,...)
BDBM50340826(CHEMBL1760677 | azetidin-1-yl(4-(5-(1-(4-chlorophe...)
BDBM50340827((4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1...)
BDBM50340828((4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1...)
BDBM50340829(3-chloro-4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-met...)
BDBM50340830(3-chloro-4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-met...)
BDBM50340792(CHEMBL1760683 | N-(4-(5-(1-(4-chlorophenyl)cyclobu...)
BDBM50340793(CHEMBL1760684 | N-(4-(5-(1-(4-chlorophenyl)cyclobu...)
BDBM50340794(CHEMBL1760685 | N-(4-(5-(1-(4-chlorophenyl)cyclobu...)
BDBM50340795(CHEMBL1760686 | N-(4-(5-(1-(4-chlorophenyl)cyclobu...)
BDBM50340796(CHEMBL1760687 | N-(4-(5-(1-(4-chlorophenyl)cyclobu...)
BDBM50340807(CHEMBL1760689 | N-(3-chloro-4-(5-(1-(4-chloropheny...)
BDBM50340808(CHEMBL1760690 | N-(3-chloro-4-(5-(1-(4-chloropheny...)
BDBM50340812(5-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H...)
BDBM50340813(5-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H...)
BDBM50340814(5-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H...)
BDBM50340815(5-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H...)
BDBM50340816(2-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H...)
BDBM50340817(6-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H...)
BDBM50340818(3-chloro-6-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-...)
BDBM50340819(6-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H...)
BDBM50340820(4-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H...)
BDBM50340821(4-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H...)
BDBM50340797(3-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H...)
BDBM50260908(3-(3-chloro-4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-...)
IC50: 4.21E+3nMAssay Description:Inhibition of human recombinant 11beta-HSD2 expressed in HEK293 cells assessed as inhibition of [1,2,6,7-3H]-cortisol to [3H]cortisone preincubated f...More data for this Ligand-Target Pair
BDBM50224216(2-(2-chlorophenylamino)-5-cyclopentylthiazol-4(5H)...)
BDBM50224203(2-(2-chlorophenylamino)-5-cyclohexylthiazol-4(5H)-...)
BDBM13767((1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropa...)IC50: 5.30E+3nMAssay Description:The in Vitro 11beta-HSD2 dehydrogenase assays were developed using the cell lysates that had the full length human or mouse 11beta-HSD2 cDNA over exp...More data for this Ligand-Target Pair
BDBM50197418(2-(2-chloro-phenoxy)-N-(5-methanesulfonyl-adamanta...)
BDBM50197399(2-(2-chloro-phenoxy)-2-methyl-N-(5-sulfamoyl-adama...)
IC50: 5.85E+3nMAssay Description:Inhibition of human recombinant 11beta-HSD2 expressed in HEK293 cells assessed as inhibition of [1,2,6,7-3H]-cortisol to [3H]cortisone preincubated f...More data for this Ligand-Target Pair
BDBM50306421(2-{1'-[(adamantan-2-yl)carbamoyl]-2,3-dihydrospiro...)
BDBM50306421(2-{1'-[(adamantan-2-yl)carbamoyl]-2,3-dihydrospiro...)
BDBM50188387((2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-amino-2...)
IC50: 6.26E+3nMAssay Description:Inhibition of full-length human 11beta-HSD2 expressed in HEK293 microsomal fraction using [3H]cortisone as substrate after 2 hr by scintillation prox...More data for this Ligand-Target Pair
BDBM50197408(2-(3-chloro-phenoxy)-2-methyl-N-(5-sulfamoyl-adama...)
BDBM50188385((2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-acetoxy...)
IC50: 6.76E+3nMAssay Description:Inhibition of human recombinant 11beta-HSD2 expressed in HEK293 cells assessed as inhibition of [1,2,6,7-3H]-cortisol to [3H]cortisone preincubated f...More data for this Ligand-Target Pair
BDBM50329315((R)-3-(3-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
BDBM642883((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(met...)IC50: 7.94E+3nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM50195289(1-piperidin-1-yl-cyclopropanecarboxylic acid (5-hy...)
BDBM50329316((R)-3-(5-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
BDBM72094(1-(2,3-Dihydro-indol-1-yl)-2-(5,6-diphenyl-[1,2,4]...)
BDBM50306434(CHEMBL606420 | N-(adamantan-2-yl)-7-bromo-3-(2-hyd...)
BDBM50197404(2-(2,6-dichloro-4-fluoro-phenoxy)-2-methyl-N-(5-su...)
IC50: 9.58E+3nMAssay Description:Inhibition of full-length human 11beta-HSD2 expressed in HEK293 microsomal fraction using [3H]cortisone as substrate after 2 hr by scintillation prox...More data for this Ligand-Target Pair
BDBM22456(2-(cycloheptylamino)-5-ethyl-5-methyl-4,5-dihydro-...)
BDBM22457(2-(cycloheptylamino)-5-methyl-5-propyl-4,5-dihydro...)IC50: >1.00E+4nMAssay Description:The assay was performed at room temperature in a 96-well microtiter plate containing substrate mixture [3H]cortisol/NAD+, inhibitors, and 11beta-HSD2...More data for this Ligand-Target Pair
BDBM22458(2-(cyclooctylamino)-5-ethyl-5-methyl-4,5-dihydro-1...)IC50: >1.00E+4nMAssay Description:The assay was performed at room temperature in a 96-well microtiter plate containing substrate mixture [3H]cortisol/NAD+, inhibitors, and 11beta-HSD2...More data for this Ligand-Target Pair
BDBM22459(2-(cyclooctylamino)-5-methyl-5-propyl-4,5-dihydro-...)IC50: >1.00E+4nMAssay Description:The assay was performed at room temperature in a 96-well microtiter plate containing substrate mixture [3H]cortisol/NAD+, inhibitors, and 11beta-HSD2...More data for this Ligand-Target Pair
BDBM22462(2-Amino-1,3-thiazol-4(5H)-one, 5f | 2-{bicyclo[2.2...)IC50: >1.00E+4nMAssay Description:The assay was performed at room temperature in a 96-well microtiter plate containing substrate mixture [3H]cortisol/NAD+, inhibitors, and 11beta-HSD2...More data for this Ligand-Target Pair
BDBM22465(2-Amino-1,3-thiazol-4(5H)-one, 6g | 2-{bicyclo[2.2...)IC50: >1.00E+4nMAssay Description:The assay was performed at room temperature in a 96-well microtiter plate containing substrate mixture [3H]cortisol/NAD+, inhibitors, and 11beta-HSD2...More data for this Ligand-Target Pair
BDBM22466(2-Amino-1,3-thiazol-4(5H)-one, 5h | 5-ethyl-5-meth...)IC50: >1.00E+4nMAssay Description:The assay was performed at room temperature in a 96-well microtiter plate containing substrate mixture [3H]cortisol/NAD+, inhibitors, and 11beta-HSD2...More data for this Ligand-Target Pair
BDBM22470(2-(cyclooctylamino)-5,5-diethyl-4,5-dihydro-1,3-th...)IC50: >1.00E+4nMAssay Description:The assay was performed at room temperature in a 96-well microtiter plate containing substrate mixture [3H]cortisol/NAD+, inhibitors, and 11beta-HSD2...More data for this Ligand-Target Pair
BDBM22471(2-(cyclooctylamino)-1-thia-3-azaspiro[4.4]non-2-en...)IC50: >1.00E+4nMAssay Description:The assay was performed at room temperature in a 96-well microtiter plate containing substrate mixture [3H]cortisol/NAD+, inhibitors, and 11beta-HSD2...More data for this Ligand-Target Pair
BDBM22472(2-Amino-1,3-thiazol-4(5H)-one, 7b | 5,5-diethyl-2-...)IC50: >1.00E+4nMAssay Description:The assay was performed at room temperature in a 96-well microtiter plate containing substrate mixture [3H]cortisol/NAD+, inhibitors, and 11beta-HSD2...More data for this Ligand-Target Pair
BDBM22473(2-(hexahydro-2,5-methanopentalen-3a(1H)-ylamino)-1...)IC50: >1.00E+4nMAssay Description:The assay was performed at room temperature in a 96-well microtiter plate containing substrate mixture [3H]cortisol/NAD+, inhibitors, and 11beta-HSD2...More data for this Ligand-Target Pair
BDBM50384526(CHEMBL2036421 | US9073906, 3)
BDBM50384527(CHEMBL2036422 | US9073906, 5)IC50: >1.00E+4nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
IC50: >1.00E+4nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
BDBM50384529(CHEMBL2036424 | US9073906, 2)IC50: >1.00E+4nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
IC50: >1.00E+4nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
IC50: >1.00E+4nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
IC50: >1.00E+4nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
IC50: >1.00E+4nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
IC50: >1.00E+4nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
IC50: >1.00E+4nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
IC50: >1.00E+4nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
IC50: >1.00E+4nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
IC50: >1.00E+4nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
IC50: >1.00E+4nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
IC50: >1.00E+4nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
IC50: >1.00E+4nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
IC50: >1.00E+4nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
IC50: >1.00E+4nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
IC50: >1.00E+4nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
IC50: >1.00E+4nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
IC50: >1.00E+4nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
IC50: >1.00E+4nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
IC50: >1.00E+4nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
BDBM50117900(3-Chloro-2-methyl-N-{4-[2-(4-methyl-piperazin-1-yl...)
BDBM50117901(2-(2-(3-chloro-2-methylphenylsulfonamido)thiazol-4...)
IC50: >1.00E+4nMAssay Description:Inhibition of human recombinant 11beta-HSD-2 expressed in HEK293 EBNA cells assessed as reduction in cortisone formation ESI mass spectroscopyMore data for this Ligand-Target Pair
IC50: >1.00E+4nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells using NADPH assessed as conversion of cortisone to cortisol by cell-based assayMore data for this Ligand-Target Pair
IC50: >1.00E+4nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells using NADPH assessed as conversion of cortisone to cortisol by cell-based assayMore data for this Ligand-Target Pair
IC50: >1.00E+4nMAssay Description:Inhibition of human 11beta-HSD1 using microsomal fraction and NADPH assessed as conversion of cortisone to cortisol by biochemical enzyme assayMore data for this Ligand-Target Pair
BDBM50193792(3-benzyl-1-cyclohexylpyrrolidin-2-one | CHEMBL2182...)
BDBM50193799(1-(2-adamantyl)-3-benzylpyrrolidin-2-one | CHEMBL2...)
BDBM50193794(3-benzyl-1-(5-hydroxy-adamantan-2-yl)-pyrrolidin-2...)
BDBM50195486(CHEMBL222317 | ethyl 2-((3R,5S)-4-(4-amino-3,5-dic...)
BDBM50195484(1-((2R,6R)-1-(4-amino-3,5-dichlorobenzoyl)-2,6-dim...)
BDBM50195491((4-amino-3,5-dichlorophenyl)(3-benzyl-3,6-diaza-bi...)
BDBM50195482((4-amino-3,5-dichlorophenyl)((2R,6S)-2,6-dimethyl-...)
BDBM50195498(CHEMBL426208 | methyl 2-((1s,4s)-4-(4-amino-3,5-di...)
BDBM50195483(CHEMBL373547 | N-adamantan-1-yl-4-amino-3,5-dichlo...)
BDBM50195500((4-amino-3,5-dichlorophenyl)(4-(5-(trifluoromethyl...)
BDBM50195505(CHEMBL223506 | ethyl 2-((3R,5S)-4-(4-amino-3,5-dic...)
BDBM50195499((4-amino-3,5-dichlorophenyl)((2R,6S)-4-(2-methoxyp...)
BDBM50195487(4-amino-3,5-dichloro-N-cyclopentyl-N-cyclopropylbe...)
BDBM50195503(4-amino-N-((1s,4s)-4-(benzylcarbamoyl)cyclohexyl)-...)
BDBM50195497((4-amino-3,5-dichlorophenyl)((2R,6S)-4-(3-aminopyr...)
BDBM50195501((4-amino-3,5-dichlorophenyl)(piperidin-1-yl)methan...)
BDBM50195488(CHEMBL374487 | N-((1s,4s)-4-((2-(dimethylamino)eth...)
BDBM50195481((1s,4s)-ethyl 4-(4-amino-3,5-dichloro-N-cyclopropy...)
BDBM50195494((4-amino-3,5-dichlorophenyl)(5-benzyl-1,5-diazocan...)
BDBM50195489(4-amino-3,5-dichloro-N-cyclopropyl-N-((1s,4s)-4-(p...)
BDBM50195502(CHEMBL221261 | N-((1s,4s)-4-((cyclohexylmethyl)car...)
BDBM50195492(3-((2R,4R)-1-(4-amino-3,5-dichlorobenzoyl)-2-methy...)
BDBM50195504((4-amino-3,5-dichlorophenyl)(1,3,3-trimethyl-6-aza...)
BDBM50195496((4-amino-3,5-dichlorophenyl)((2R,6S)-2,6-dimethylp...)
BDBM50195495(3-((2R,6R)-1-(4-amino-3,5-dichlorobenzoyl)-2,6-dim...)
BDBM50195507((4-amino-3,5-dichlorophenyl)((2R,6S)-2,6-dimethyl-...)
BDBM50195490(2-((1s,4s)-4-(4-amino-3,5-dichloro-N-cyclopropylbe...)
BDBM50195485(4-amino-3,5-dichloro-N-cyclohexyl-N-cyclopropylben...)
BDBM50195493(4-amino-3,5-dichloro-N-cyclopropyl-N-((1s,4s)-4-(1...)
BDBM50195506((4-amino-3,5-dichloro-phenyl)-(2-aza-tricyclo[3.3....)
BDBM50195294(4-({1-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazi...)
BDBM50195298(4-[2-(3,3-difluoro-piperidin-1-yl)-butyrylamino]-a...)
BDBM50195291(4-{2-methyl-2-[4-(5-trifluoromethyl-pyridin-2-yl)-...)
BDBM50195292(4-({1-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazi...)
BDBM50202089(CHEMBL373889 | N-[(Z)-5-hydroxy-2-adamantyl]-2-{4-...)
BDBM50273857(2-((S)-1-(4-fluorophenyl)ethylamino)-5-(2-hydroxyp...)
BDBM50273859(2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(1-hydroxyc...)
BDBM50273858(2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(1-hydroxyc...)
BDBM50273456((S)-5-(2-Hydroxypropan-2-yl)-5-methyl-2-{1-[2-(tri...)
BDBM50273455(2-[(S)-1-(2-Chlorophenyl)ethylamino]-5-(2-hydroxyp...)
BDBM50273454(2-[(S)-1-(2-Fluorophenyl)ethylamino]-5-(2-hydroxyp...)
BDBM50294764(3,3-Dimethyl-pentanedioic acid cyclopropylamide(5-...)IC50: >1.00E+4nMAssay Description:Inhibition of human recombinant 11beta-HSD2 expressed in Escherichia coli assessed as cortisol level after 60 mins by HTRF assayMore data for this Ligand-Target Pair
BDBM50294783(3,3-Dimethyl-pentanedioic acid(5-carbamoyl-adamant...)IC50: >1.00E+4nMAssay Description:Inhibition of human recombinant 11beta-HSD2 expressed in Escherichia coli assessed as cortisol level after 60 mins by HTRF assayMore data for this Ligand-Target Pair
BDBM50306421(2-{1'-[(adamantan-2-yl)carbamoyl]-2,3-dihydrospiro...)
BDBM50306424(2-{1'-[(adamantan-2-yl)carbamoyl]-6-methyl-2,3-dih...)
BDBM50306425(2-{1'-[(adamantan-2-yl)carbamoyl]-7-methyl-2,3-dih...)
BDBM50306426(2-{1'-[(adamantan-2-yl)carbamoyl]-5-chloro-2,3-dih...)
BDBM50306427(2-{1'-[(adamantan-2-yl)carbamoyl]-6-chloro-2,3-dih...)
BDBM50306428(2-{1'-[(adamantan-2-yl)carbamoyl]-7-chloro-2,3-dih...)
BDBM50306429(2-{1'-[(adamantan-2-yl)carbamoyl]-7-bromo-2,3-dihy...)
BDBM50306430(2-[(3S)-1'-[(adamantan-2-yl)carbamoyl]-7-bromo-2,3...)
BDBM50306431(2-[(3R)-1'-[(adamantan-2-yl)carbamoyl]-7-bromo-2,3...)
BDBM50306432(CHEMBL601210 | N-(adamantan-2-yl)-7-bromo-3-[(meth...)
BDBM50319665((S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2-ylamino)-...)
BDBM50340433((3-(1H-pyrazol-4-yl)pyrrolidin-1-yl)(4-(5-(4-metho...)
BDBM50353386(CHEMBL1829763 | US8592410, 88 | US8592410, Compara...)IC50: >1.00E+4nMAssay Description:Inhibition of human 11 beta-HSD2 expressed in CHO cells assessed as conversion of [3H]cortisol to [3H]cortisone after 1 hr by HPLCMore data for this Ligand-Target Pair
BDBM50340433((3-(1H-pyrazol-4-yl)pyrrolidin-1-yl)(4-(5-(4-metho...)
BDBM50297908(4-[(3-Chlorophenylsulfonamido)methyl]-N-cyclohepty...)IC50: >1.00E+4nMAssay Description:Inhibition of human microsomal 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximi...More data for this Ligand-Target Pair
BDBM50243671((S)-N-(trans-4-Fluorocyclohexyl)-4-(1,1,1-trifluor...)
BDBM28365(CHEMBL512355 | N-[4-(2-cyanoethyl)cyclohexyl]-N-cy...)
BDBM28361(N-cyclopropyl-N-[4-(pyridin-3-yl)cyclohexyl]-4-[(2...)
BDBM50243635((S)-N-[trans-4-(4-Cyanophenyl)cyclohexyl]-4-[1,1,1...)
BDBM50243634((S)-N-(cis-4-Phenyl)cyclohexyl-4-(1,1,1-trifluoro-...)
BDBM50243633((S)-N-(trans-4-Phenyl)cyclohexyl-4-(1,1,1-trifluor...)
BDBM50243632((S)-N-Cyclohexyl-4-(1,1,1-trifluoro-2-hydroxypropa...)
IC50: >1.00E+4nMAssay Description:Inhibition of full-length human 11beta-HSD2 expressed in HEK293 microsomal fraction using [3H]cortisone as substrate after 2 hr by scintillation prox...More data for this Ligand-Target Pair
BDBM642878((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-[(2-...)IC50: <1.00E+4nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM642895((2S,4aS,6aS,6bR,9R,10S,12aS,12bR,14bR)-9-[(carboxy...)IC50: <1.00E+4nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM642896((2S,4aS,6aS,6bR,8aR,9R,10S,12aS,12bR,14bR)-10-Hydr...)IC50: 1.00E+4nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM642899((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-[(2-...)IC50: <1.00E+4nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM642905((2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-2,4a,6a,6b...)IC50: 1.00E+4nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM642906((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-[(me...)IC50: <1.00E+4nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM642908((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-2,4a,6a...)IC50: <1.00E+4nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM642910((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-{[2-...)IC50: <1.00E+4nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM642914((2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-2,4a,6a...)IC50: <1.00E+4nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
BDBM50192797(2-(4-chloro-phenoxy)-N-[(1R,2S,5S,7S)-5-(1H-imidaz...)
IC50: 1.13E+4nMAssay Description:Inhibition of human 11beta-HSD2 overexpressed in microsomal fraction of HEK293 cells using [3H]-cortisol as substrate by scintillation proximity assa...More data for this Ligand-Target Pair
BDBM13769(2-(4-chlorophenoxy)-2-methyl-N-[(1R,2S,5R,7S)-5-{[...)IC50: 1.20E+4nMAssay Description:The in Vitro 11beta-HSD2 dehydrogenase assays were developed using the cell lysates that had the full length human or mouse 11beta-HSD2 cDNA over exp...More data for this Ligand-Target Pair
BDBM13760((1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropa...)IC50: 1.20E+4nMAssay Description:The in Vitro 11beta-HSD2 dehydrogenase assays were developed using the cell lysates that had the full length human or mouse 11beta-HSD2 cDNA over exp...More data for this Ligand-Target Pair
BDBM13766((1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropa...)IC50: 1.30E+4nMAssay Description:The in Vitro 11beta-HSD2 dehydrogenase assays were developed using the cell lysates that had the full length human or mouse 11beta-HSD2 cDNA over exp...More data for this Ligand-Target Pair
BDBM50193787(4-[3,3-dmethyl-2-oxo-4-(5-trifluoromethyl-pyridin-...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
BDBM50197407(2-(2-chloro-4-fluoro-phenoxy)-2-methyl-N-[5-(3-mor...)
BDBM50195295(4-({1-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazi...)
BDBM50192800(2-(4-chloro-phenoxy)-N-((1R,2S,5S,7S)-5-isoxazol-5...)
BDBM50197409(2-(2-chloro-4-fluoro-phenoxy)-N-(5-ethanesulfonyl-...)
BDBM50193785((3r,9r)-9-(4-((5-cyanopyridin-2-yloxy)methyl)-3,3-...)
BDBM50193785((3r,9r)-9-(4-((5-cyanopyridin-2-yloxy)methyl)-3,3-...)
BDBM50197402(2-(4-chloro-phenoxy)-2-methyl-N-(5-sulfamoyl-adama...)
BDBM50192685((3s,9s)-9-(2-(4-chlorophenoxy)-2-methylpropanamido...)
BDBM50193795(34-(4-((5-cyanopyridin-2-yloxy)methyl)-3,3-dimethy...)
BDBM13755((1R,3R,4S,7S)-4-(2-methyl-2-phenoxypropanamido)ada...)IC50: 1.70E+4nMAssay Description:The in Vitro 11beta-HSD2 dehydrogenase assays were developed using the cell lysates that had the full length human or mouse 11beta-HSD2 cDNA over exp...More data for this Ligand-Target Pair
BDBM50197413(2-(3-chloro-phenoxy)-N-(5-methanesulfonyl-adamanta...)
BDBM13761((1R,3R,4S,7S)-4-[2-(4-methoxyphenoxy)-2-methylprop...)IC50: 1.80E+4nMAssay Description:The in Vitro 11beta-HSD2 dehydrogenase assays were developed using the cell lysates that had the full length human or mouse 11beta-HSD2 cDNA over exp...More data for this Ligand-Target Pair
BDBM50202092(CHEMBL386029 | N-[(E)-5-fluoro-2-adamantyl]-2-{4-[...)
BDBM13762(4-({[(1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methyl...)IC50: 2.00E+4nMAssay Description:The in Vitro 11beta-HSD2 dehydrogenase assays were developed using the cell lysates that had the full length human or mouse 11beta-HSD2 cDNA over exp...More data for this Ligand-Target Pair
BDBM13768(N-[(1R,2S,5R,7S)-5-[(carbamoylmethyl)carbamoyl]ada...)IC50: 2.00E+4nMAssay Description:The in Vitro 11beta-HSD2 dehydrogenase assays were developed using the cell lysates that had the full length human or mouse 11beta-HSD2 cDNA over exp...More data for this Ligand-Target Pair
BDBM50070942((-)-Epigallocatechin gallate | (-)-Epigallocatechi...)
BDBM50197417(2-(4-chloro-2-fluoro-phenoxy)-N-(5-methanesulfonyl...)
BDBM50195290(4-{2-methyl-2-[4-(5-trifluoromethyl-pyridin-2-yl)-...)
BDBM13756((1R,3R,4S,7S)-4-(2-methyl-2-phenoxypropanamido)ada...)IC50: 2.30E+4nMAssay Description:The in Vitro 11beta-HSD2 dehydrogenase assays were developed using the cell lysates that had the full length human or mouse 11beta-HSD2 cDNA over exp...More data for this Ligand-Target Pair
BDBM50193786(4-[4-(5-cyano-pyridin-2-yloxymethyl)-3,3-dimethyl-...)
BDBM50195288(4-{2-cyclopropyl-2-[4-(5-trifluoromethyl-pyridin-2...)
BDBM13770(2-(4-chlorophenoxy)-N-[(1R,2S,5R,7S)-5-(hydroxymet...)IC50: 2.50E+4nMAssay Description:The in Vitro 11beta-HSD2 dehydrogenase assays were developed using the cell lysates that had the full length human or mouse 11beta-HSD2 cDNA over exp...More data for this Ligand-Target Pair
BDBM50197410(2-methyl-N-(5-sulfamoyl-adamantan-2-yl)-2-(2-trifl...)
IC50: 2.55E+4nMAssay Description:Inhibition of human 11beta-HSD2 overexpressed in microsomal fraction of HEK293 cells using [3H]-cortisol as substrate by scintillation proximity assa...More data for this Ligand-Target Pair
BDBM13764((1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropa...)IC50: 2.60E+4nMAssay Description:The in Vitro 11beta-HSD2 dehydrogenase assays were developed using the cell lysates that had the full length human or mouse 11beta-HSD2 cDNA over exp...More data for this Ligand-Target Pair
BDBM50197414(2-(2-chloro-4-fluoro-phenoxy)-N-(5-methanesulfonyl...)
BDBM50195300(4-({1-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazi...)
BDBM50192672((3r,9r)-9-(2-methyl-2-(4-(5-(trifluoromethyl)pyrid...)
BDBM50192682((3r,8r)-8-(2-methyl-2-(4-(5-(trifluoromethyl)pyrid...)
BDBM13765((1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropa...)IC50: >3.00E+4nMAssay Description:The in Vitro 11beta-HSD2 dehydrogenase assays were developed using the cell lysates that had the full length human or mouse 11beta-HSD2 cDNA over exp...More data for this Ligand-Target Pair
BDBM13759((1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropa...)IC50: 3.00E+4nMAssay Description:The in Vitro 11beta-HSD2 dehydrogenase assays were developed using the cell lysates that had the full length human or mouse 11beta-HSD2 cDNA over exp...More data for this Ligand-Target Pair
BDBM50192683((3s,9s)-9-(2-methyl-2-(4-(5-(trifluoromethyl)pyrid...)
BDBM50193797(4-(3-benzyl-2-oxo-pyrrolidin-1-yl)-adamantane-1-ca...)
BDBM50193783((1R,7S,8r)-ethyl 4-(4-((5-cyanopyridin-2-yloxy)met...)
BDBM50192677((1R,7S,8r)-4-(2-methyl-2-(4-(5-(trifluoromethyl)py...)
BDBM50392216(CHEMBL2153191 | US8673938, 7)
BDBM50192681(CHEMBL218246 | N-(5-cyanocyclooctyl)-2-methyl-2-(4...)
BDBM50188391(4-(2,4-dichlorophenyl)-2-hydroxy-3-(4-methoxy-3-me...)
BDBM50192672((3r,9r)-9-(2-methyl-2-(4-(5-(trifluoromethyl)pyrid...)
BDBM50195299(4-({1-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazi...)
BDBM50192788(2-(4-chloro-phenoxy)-2-methyl-N-[(1R,2S,5S,7S)-5-(...)
IC50: 4.07E+4nMAssay Description:Inhibition of human 11beta-HSD2 overexpressed in microsomal fraction of HEK293 cells using [3H]-cortisol as substrate by scintillation proximity assa...More data for this Ligand-Target Pair
BDBM50188386(2-((3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-(met...)
BDBM50192791(2-(5-bromo-pyridin-2-yloxy)-N-((1R,2S,5R,7S)-5-car...)
BDBM13763((1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropa...)IC50: 5.00E+4nMAssay Description:The in Vitro 11beta-HSD2 dehydrogenase assays were developed using the cell lysates that had the full length human or mouse 11beta-HSD2 cDNA over exp...More data for this Ligand-Target Pair
BDBM50195286(4-({1-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazi...)
BDBM50192801(CHEMBL220414 | {(1R,4S,5R,7S)-4-[2-(4-chloro-pheno...)
BDBM50192787(CHEMBL219136 | N-[(1R,2S,5S,7S)-5-(5-amino-4H-[1,2...)
BDBM50202093(2-[3-(2-fluoro-phenoxy)-azetidin-1-yl]-N-(5-hydrox...)
BDBM50197401(2-methyl-2-phenoxy-N-(5-sulfamoyl-adamantan-2-yl)-...)
BDBM50197406(2-(4-chloro-phenoxy)-N-(5-dimethylsulfamoyl-adaman...)
BDBM50202087(CHEMBL374728 | N-[(1R,3S)-5-hydroxy-2-adamantyl]-2...)
BDBM50197405(2-(4-chloro-phenoxy)-N-(5-methanesulfonyl-adamanta...)
BDBM50195293(4-{2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin...)
BDBM50192673(2-(4-chloro-phenoxy)-N-(1-hydroxy-2-oxa-tricyclo[3...)
BDBM50197419(2-(4-chloro-phenoxy)-2-methyl-N-(5-methylsulfamoyl...)
BDBM50192674(4-(2-methyl-2-(4-(5-(trifluoromethyl)pyridin-2-yl)...)
BDBM50193791(4-[3,3-dimethyl-2-oxo-4-(5-trifluoromethyl-pyridin...)
BDBM50248569((1-(((R)-3-methyl-4-(4-((S)-1,1,1-trifluoro-2-hydr...)
BDBM13771(2-{[(1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylp...)IC50: >1.00E+5nMAssay Description:The in Vitro 11beta-HSD2 dehydrogenase assays were developed using the cell lysates that had the full length human or mouse 11beta-HSD2 cDNA over exp...More data for this Ligand-Target Pair
BDBM29830(spiro-carboxamide scaffold, 3)
BDBM29832(spiro-carboxamide scaffold, 5)IC50: >1.00E+5nMpH: 7.8 T: 2°CAssay Description:11beta-HSD2 enzyme activity was assessed in buffer containing NAD, test compound, and human recombinant 11beta-HSD2 expressed in E. coli. Reaction wa...More data for this Ligand-Target Pair
BDBM29833(spiro-carboxamide scaffold, 6)IC50: >1.00E+5nMpH: 7.8 T: 2°CAssay Description:11beta-HSD2 enzyme activity was assessed in buffer containing NAD, test compound, and human recombinant 11beta-HSD2 expressed in E. coli. Reaction wa...More data for this Ligand-Target Pair
BDBM29840(spiro-carboxamide scaffold, 13)IC50: >1.00E+5nMpH: 7.8 T: 2°CAssay Description:11beta-HSD2 enzyme activity was assessed in buffer containing NAD, test compound, and human recombinant 11beta-HSD2 expressed in E. coli. Reaction wa...More data for this Ligand-Target Pair
BDBM50192676((3r,9r)-9-(2-methyl-2-(4-(5-(trifluoromethyl)pyrid...)
BDBM50192686(4-(2-(4-chlorophenoxy)-2-methylpropanamido)bicyclo...)
BDBM50192684((3s,9s)-9-(2-(5-cyanopyridin-2-yloxy)-2-methylprop...)
BDBM50192679((3r,9r)-9-(2-(4-chlorophenoxy)-2-methylpropanamido...)
BDBM50192671(2-(4-chlorophenoxy)-N-(5-cyanocyclooctyl)-2-methyl...)
BDBM50192675((7r,9r)-9-(2-(4-chlorophenoxy)-2-methylpropanamido...)
BDBM50192785(CHEMBL385176 | N-((1R,2S,5R,7S)-5-carbamoylmethyl-...)
BDBM50192790(2-(4-chloro-phenoxy)-N-[(1R,2S,5S,7S)-5-(N-hydroxy...)
BDBM50192793(3-{(1R,4S,5R,7S)-4-[2-(4-chloro-phenoxy)-2-methyl-...)
BDBM50192794(CHEMBL216977 | N-((1R,2S,5R,7S)-5-carbamoylmethyl-...)
IC50: >1.00E+5nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO cells using [3H]-Cortisone as substrate incubated for 30 mins prior to substrate addition measured a...More data for this Ligand-Target Pair
IC50: >1.00E+5nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO cells using [3H]-Cortisone as substrate incubated for 30 mins prior to substrate addition measured a...More data for this Ligand-Target Pair
IC50: >1.00E+5nMAssay Description:Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
BDBM50192795(CHEMBL219081 | N-((1R,2S,5R,7S)-5-carbamoylmethyl-...)
BDBM50192799(CHEMBL375979 | N-((1R,2S,5R,7S)-5-carbamoylmethyl-...)
BDBM50192792(CHEMBL219348 | N-((1R,2S,5R,7S)-5-carbamoylmethyl-...)
BDBM50192789(2-(4-chloro-phenoxy)-2-methyl-N-[(1S,2S,5R,7S)-5-(...)
BDBM50192796(CHEMBL219575 | N-[(1R,2S,5S,7S)-5-(5-amino-4-cyano...)
BDBM50192798(CHEMBL219349 | N-((1R,2S,5R,7S)-5-carbamoylmethyl-...)
BDBM50192786(CHEMBL216976 | N-((1R,2S,5R,7S)-5-carbamoylmethyl-...)
BDBM50193788((3s,9s)-9-(4-((5-cyanopyridin-2-yloxy)methyl)-3,3-...)
BDBM50197400(2-(4-fluoro-2-methoxy-phenoxy)-N-(5-methanesulfony...)
BDBM50197403(CHEMBL393167 | N-(5-methanesulfonyl-adamantan-2-yl...)
BDBM50197411(2-phenyl-N-(5-sulfamoyl-adamantan-2-yl)-isobutyram...)
BDBM50197416(2-(2-chloro-4-fluoro-phenoxy)-2-methyl-N-(5-sulfam...)
BDBM50195303(4-[2-(3,3-difluoro-piperidin-1-yl)-butyrylamino]-a...)
BDBM50195302(4-{2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin...)
BDBM50195301(4-{2-cyclopropyl-2-[4-(5-trifluoromethyl-pyridin-2...)
BDBM50195287(4-({1-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazi...)
BDBM50195297(1-piperidin-1-yl-cyclopropanecarboxylic acid (5-hy...)
BDBM50202094(CHEMBL375341 | N-(5-hydroxy-adamantan-2-yl)-2-(3-t...)
BDBM50202099(CHEMBL218358 | N-[(Z)-5-fluoro-2-adamantyl]-2-{4-[...)
BDBM50202098(CHEMBL218143 | N-(1-hydroxy-adamantan-2-yl)-2-[4-(...)
BDBM50202091(CHEMBL384364 | N-adamantan-2-yl-2-[4-(3-cyano-pyri...)
BDBM50202097(CHEMBL424937 | N-[(E)-5-hydroxy-2-adamantyl]-2-met...)
BDBM50202086(CHEMBL219142 | N-[(E)-5-hydroxy-2-adamantyl]-2-{4-...)
BDBM50202106(CHEMBL218758 | E-(2S)-(3R-fluoro-pyrrolidin-1-yl)-...)
BDBM50202095(CHEMBL415429 | E-(2R)-(3R-fluoro-pyrrolidin-1-yl)-...)
BDBM50202102(CHEMBL375156 | N-(5-Hydroxy-adamantan-2-yl)-2-[4-(...)
BDBM50212530(2-(phenylsulfonyl)-1-p-tolylethanone | CHEMBL39280...)
BDBM50117901(2-(2-(3-chloro-2-methylphenylsulfonamido)thiazol-4...)
BDBM50167716(CHEMBL383820 | N-(4-(4-(trifluoromethyl)phenyl)oxa...)
BDBM50167718(2-(phenylsulfonyl)-1-(4-(trifluoromethyl)phenyl)et...)
BDBM50212525(1-(4-fluorophenyl)-2-(phenylsulfonyl)ethanone | CH...)
BDBM50212535(1-(4-methoxyphenyl)-2-(phenylsulfonyl)ethanone | C...)
BDBM50212534(1-(3-methoxyphenyl)-2-(phenylsulfonyl)ethanone | C...)
BDBM50212531(1-(4-chlorophenyl)-2-(phenylsulfonyl)ethanone | CH...)
BDBM50167718(2-(phenylsulfonyl)-1-(4-(trifluoromethyl)phenyl)et...)
BDBM50167717(3-Chloro-2-methyl-N-(4-phenyl-oxazol-2-yl)-benzene...)
BDBM50117901(2-(2-(3-chloro-2-methylphenylsulfonamido)thiazol-4...)
BDBM50167724(CHEMBL372623 | N-[4-(4,5-Dimethyl-oxazol-2-ylsulfa...)
BDBM50167721(CHEMBL425022 | N-(4-Phenyl-oxazol-2-yl)-benzenesul...)
BDBM50167720(CHEMBL197151 | N-(4-Biphenyl-4-yl-oxazol-2-yl)-ben...)
BDBM50167723(3-Chloro-N-[4-(4-cyano-phenyl)-oxazol-2-yl]-2-meth...)
IC50: 2.84E+5nMAssay Description:Inhibition of human 11beta-HSD2 overexpressed in microsomal fraction of HEK293 cells using [3H]-cortisol as substrate by scintillation proximity assa...More data for this Ligand-Target Pair
IC50: 3.00E+5nMAssay Description:Inhibition of human 11beta-HSD2 overexpressed in microsomal fraction of HEK293 cells using [3H]-cortisol as substrate by scintillation proximity assa...More data for this Ligand-Target Pair
IC50: >5.00E+5nMAssay Description:Inhibition of 11beta-HSD2 (unknown origin) expressed in HEK293 cells using cortisone as substrate measured after 2 hrs in presence of NAD+ by HTRF as...More data for this Ligand-Target Pair
IC50: >5.00E+5nMAssay Description:Inhibition of 11beta-HSD2 (unknown origin) expressed in HEK293 cells using cortisone as substrate measured after 2 hrs in presence of NAD+ by HTRF as...More data for this Ligand-Target Pair
IC50: >5.00E+5nMAssay Description:Inhibition of 11beta-HSD2 (unknown origin) expressed in HEK293 cells using cortisone as substrate measured after 2 hrs in presence of NAD+ by HTRF as...More data for this Ligand-Target Pair
IC50: >5.00E+5nMAssay Description:Inhibition of 11beta-HSD2 (unknown origin) expressed in HEK293 cells using cortisone as substrate measured after 2 hrs in presence of NAD+ by HTRF as...More data for this Ligand-Target Pair
IC50: >5.00E+5nMAssay Description:Inhibition of 11beta-HSD2 (unknown origin) expressed in HEK293 cells using cortisone as substrate measured after 2 hrs in presence of NAD+ by HTRF as...More data for this Ligand-Target Pair
IC50: >5.00E+5nMAssay Description:Inhibition of 11beta-HSD2 (unknown origin) expressed in HEK293 cells using cortisone as substrate measured after 2 hrs in presence of NAD+ by HTRF as...More data for this Ligand-Target Pair
IC50: >5.00E+5nMAssay Description:Inhibition of 11beta-HSD2 (unknown origin) expressed in HEK293 cells using cortisone as substrate measured after 2 hrs in presence of NAD+ by HTRF as...More data for this Ligand-Target Pair
IC50: >5.00E+5nMAssay Description:Inhibition of 11beta-HSD2 (unknown origin) expressed in HEK293 cells using cortisone as substrate measured after 2 hrs in presence of NAD+ by HTRF as...More data for this Ligand-Target Pair
IC50: >5.00E+5nMAssay Description:Inhibition of 11beta-HSD2 (unknown origin) expressed in HEK293 cells using cortisone as substrate measured after 2 hrs in presence of NAD+ by HTRF as...More data for this Ligand-Target Pair
IC50: >5.00E+5nMAssay Description:Inhibition of 11beta-HSD2 (unknown origin) expressed in HEK293 cells using cortisone as substrate measured after 2 hrs in presence of NAD+ by HTRF as...More data for this Ligand-Target Pair
IC50: >5.00E+5nMAssay Description:Inhibition of 11beta-HSD2 (unknown origin) expressed in HEK293 cells using cortisone as substrate measured after 2 hrs in presence of NAD+ by HTRF as...More data for this Ligand-Target Pair
IC50: >5.00E+5nMAssay Description:Inhibition of 11beta-HSD2 (unknown origin) expressed in HEK293 cells using cortisone as substrate measured after 2 hrs in presence of NAD+ by HTRF as...More data for this Ligand-Target Pair
IC50: >5.00E+5nMAssay Description:Inhibition of 11beta-HSD2 (unknown origin) expressed in HEK293 cells using cortisone as substrate measured after 2 hrs in presence of NAD+ by HTRF as...More data for this Ligand-Target Pair
IC50: >5.00E+5nMAssay Description:Inhibition of 11beta-HSD2 (unknown origin) expressed in HEK293 cells using cortisone as substrate measured after 2 hrs in presence of NAD+ by HTRF as...More data for this Ligand-Target Pair
IC50: >5.00E+5nMAssay Description:Inhibition of 11beta-HSD2 (unknown origin) expressed in HEK293 cells using cortisone as substrate measured after 2 hrs in presence of NAD+ by HTRF as...More data for this Ligand-Target Pair
IC50: >5.00E+5nMAssay Description:Inhibition of 11beta-HSD2 (unknown origin) expressed in HEK293 cells using cortisone as substrate measured after 2 hrs in presence of NAD+ by HTRF as...More data for this Ligand-Target Pair
IC50: >5.00E+5nMAssay Description:Inhibition of 11beta-HSD2 (unknown origin) expressed in HEK293 cells using cortisone as substrate measured after 2 hrs in presence of NAD+ by HTRF as...More data for this Ligand-Target Pair
IC50: >5.00E+5nMAssay Description:Inhibition of 11beta-HSD2 (unknown origin) expressed in HEK293 cells using cortisone as substrate measured after 2 hrs in presence of NAD+ by HTRF as...More data for this Ligand-Target Pair
BDBM29864(N-(Pyridin-2-yl) arylsulfonamide, 26)IC50: >5.00E+5nMAssay Description:Inhibition of 11beta-HSD2 (unknown origin) expressed in HEK293 cells using cortisone as substrate measured after 2 hrs in presence of NAD+ by HTRF as...More data for this Ligand-Target Pair
IC50: >1.00E+6nMAssay Description:Inhibition of full length human 11beta-HSD2 expressed in HEK293 cells using cortisone as substrate incubated for 2 hrs by HTRF assay in presence of N...More data for this Ligand-Target Pair
IC50: >1.00E+6nMAssay Description:Inhibition of full length human 11beta-HSD2 expressed in HEK293 cells using cortisone as substrate incubated for 2 hrs by HTRF assay in presence of N...More data for this Ligand-Target Pair
IC50: >1.00E+6nMAssay Description:Inhibition of full length human 11beta-HSD2 expressed in HEK293 cells using cortisone as substrate incubated for 2 hrs by HTRF assay in presence of N...More data for this Ligand-Target Pair
IC50: >1.00E+6nMAssay Description:Inhibition of full length human 11beta-HSD2 expressed in HEK293 cells using cortisone as substrate incubated for 2 hrs by HTRF assay in presence of N...More data for this Ligand-Target Pair
IC50: >1.00E+6nMAssay Description:Inhibition of full length human 11beta-HSD2 expressed in HEK293 cells using cortisone as substrate incubated for 2 hrs by HTRF assay in presence of N...More data for this Ligand-Target Pair
IC50: >1.00E+6nMAssay Description:Inhibition of full length human 11beta-HSD2 expressed in HEK293 cells using cortisone as substrate incubated for 2 hrs by HTRF assay in presence of N...More data for this Ligand-Target Pair
IC50: >1.00E+6nMAssay Description:Inhibition of full length human 11beta-HSD2 expressed in HEK293 cells using cortisone as substrate incubated for 2 hrs by HTRF assay in presence of N...More data for this Ligand-Target Pair
IC50: >1.00E+6nMAssay Description:Inhibition of full length human 11beta-HSD2 expressed in HEK293 cells using cortisone as substrate incubated for 2 hrs by HTRF assay in presence of N...More data for this Ligand-Target Pair
IC50: >1.00E+6nMAssay Description:Inhibition of full length human 11beta-HSD2 expressed in HEK293 cells using cortisone as substrate incubated for 2 hrs by HTRF assay in presence of N...More data for this Ligand-Target Pair
IC50: >1.00E+6nMAssay Description:Inhibition of full length human 11beta-HSD2 expressed in HEK293 cells using cortisone as substrate incubated for 2 hrs by HTRF assay in presence of N...More data for this Ligand-Target Pair
IC50: >1.00E+6nMAssay Description:Inhibition of full length human 11beta-HSD2 expressed in HEK293 cells using cortisone as substrate incubated for 2 hrs by HTRF assay in presence of N...More data for this Ligand-Target Pair
IC50: >1.00E+6nMAssay Description:Inhibition of full length human 11beta-HSD2 expressed in HEK293 cells using cortisone as substrate incubated for 2 hrs by HTRF assay in presence of N...More data for this Ligand-Target Pair
IC50: >1.00E+6nMAssay Description:Inhibition of full length human 11beta-HSD2 expressed in HEK293 cells using cortisone as substrate incubated for 2 hrs by HTRF assay in presence of N...More data for this Ligand-Target Pair
IC50: >1.00E+6nMAssay Description:Inhibition of full length human 11beta-HSD2 expressed in HEK293 cells using cortisone as substrate incubated for 2 hrs by HTRF assay in presence of N...More data for this Ligand-Target Pair
IC50: >1.00E+6nMAssay Description:Inhibition of full length human 11beta-HSD2 expressed in HEK293 cells using cortisone as substrate incubated for 2 hrs by HTRF assay in presence of N...More data for this Ligand-Target Pair
IC50: >1.00E+6nMAssay Description:Inhibition of full length human 11beta-HSD2 expressed in HEK293 cells using cortisone as substrate incubated for 2 hrs by HTRF assay in presence of N...More data for this Ligand-Target Pair
BDBM50297910(4-[(3-Chlorophenylsulfonamido)methyl]-N-cyclohepty...)IC50: >1.00E+6nMAssay Description:Inhibition of human microsomal 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximi...More data for this Ligand-Target Pair
BDBM50297911(CHEMBL550065 | N-butyl-4-[(3-chlorophenylsulfonami...)IC50: >1.00E+6nMAssay Description:Inhibition of human microsomal 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximi...More data for this Ligand-Target Pair
BDBM50297912(4-[(3-Chlorophenylsulfonamido)methyl]-N-(1-adamant...)IC50: >1.00E+6nMAssay Description:Inhibition of human microsomal 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximi...More data for this Ligand-Target Pair
IC50: >1.00E+6nMAssay Description:Inhibition of full length human 11beta-HSD2 expressed in HEK293 cells using cortisone as substrate incubated for 2 hrs by HTRF assay in presence of N...More data for this Ligand-Target Pair
IC50: >1.00E+6nMAssay Description:Inhibition of full length human 11beta-HSD2 expressed in HEK293 cells using cortisone as substrate incubated for 2 hrs by HTRF assay in presence of N...More data for this Ligand-Target Pair
IC50: >1.00E+6nMAssay Description:Inhibition of full length human 11beta-HSD2 expressed in HEK293 cells using cortisone as substrate incubated for 2 hrs by HTRF assay in presence of N...More data for this Ligand-Target Pair
IC50: >1.00E+6nMAssay Description:Inhibition of full length human 11beta-HSD2 expressed in HEK293 cells using cortisone as substrate incubated for 2 hrs by HTRF assay in presence of N...More data for this Ligand-Target Pair
IC50: >1.00E+6nMAssay Description:Inhibition of full length human 11beta-HSD2 expressed in HEK293 cells using cortisone as substrate incubated for 2 hrs by HTRF assay in presence of N...More data for this Ligand-Target Pair
IC50: >1.00E+6nMAssay Description:Inhibition of full length human 11beta-HSD2 expressed in HEK293 cells using cortisone as substrate incubated for 2 hrs by HTRF assay in presence of N...More data for this Ligand-Target Pair