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TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50496943(CHEMBL3236471 | US20240174621, Example AR-25)
Affinity DataKd:  0.100nMAssay Description:The assay is not in detail.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50496943(CHEMBL3236471 | US20240174621, Example AR-25)
Affinity DataKd:  0.100nMAssay Description:Kd is measured using surface plasmon resonance assays using a BIACORER-2000 or a BIACORE-3000 (BIAcore, Inc., Piscataway, NJ) at 25 C. with immobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM25391([2-(4-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-ind...)
Affinity DataKd:  0.160nMAssay Description:Binding affinity to human N-His6-tagged B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM25628(2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5...)
Affinity DataKd:  0.180nMAssay Description:Binding constant for BRAF(V600E) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM25628(2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5...)
Affinity DataKd:  0.190nMAssay Description:Binding constant for BRAF kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM25391([2-(4-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-ind...)
Affinity DataKd:  0.300nMpH: 7.5 T: 2°CAssay Description:The kinase enzyme, fluorescent ligand and a variable concentration of test compound are incubated together to reach thermodynamic equilibrium under c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM25391([2-(4-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-ind...)
Affinity DataKd:  0.300nMAssay Description:Binding affinity at bRaf kinase in fluorescent ligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50457446(CHEMBL4212692)
Affinity DataKd:  0.330nMAssay Description:Binding affinity to DNA-tagged BRAF (unknown origin) V600E mutant by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50457446(CHEMBL4212692)
Affinity DataKd:  0.370nMAssay Description:Binding affinity to DNA-tagged BRAF (unknown origin) by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM26055(N-[2-(dimethylamino)ethyl]-4-[(1E)-1-(hydroxyimino...)
Affinity DataKd:  0.5nMpH: 7.5 T: 2°CAssay Description:The kinase enzyme, fluorescent ligand and a variable concentration of test compound are incubated together to reach thermodynamic equilibrium under c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM26042({1-[(4-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-in...)
Affinity DataKd:  0.5nMpH: 7.5 T: 2°CAssay Description:The kinase enzyme, fluorescent ligand and a variable concentration of test compound are incubated together to reach thermodynamic equilibrium under c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM26049([2-(4-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-ind...)
Affinity DataKd:  0.5nMpH: 7.5 T: 2°CAssay Description:The kinase enzyme, fluorescent ligand and a variable concentration of test compound are incubated together to reach thermodynamic equilibrium under c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM677074(US20240174621, Example 1 | (3R)-N-[2-cyano-4-fluor...)
Affinity DataKd:  0.600nMAssay Description:The assay is not in detail.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM677074(US20240174621, Example 1 | (3R)-N-[2-cyano-4-fluor...)
Affinity DataKd:  0.600nMAssay Description:Kd is measured using surface plasmon resonance assays using a BIACORER-2000 or a BIACORE-3000 (BIAcore, Inc., Piscataway, NJ) at 25 C. with immobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM26050([2-(4-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-ind...)
Affinity DataKd:  0.700nMpH: 7.5 T: 2°CAssay Description:The kinase enzyme, fluorescent ligand and a variable concentration of test compound are incubated together to reach thermodynamic equilibrium under c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM26051([2-(4-{5-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-ind...)
Affinity DataKd:  0.900nMpH: 7.5 T: 2°CAssay Description:The kinase enzyme, fluorescent ligand and a variable concentration of test compound are incubated together to reach thermodynamic equilibrium under c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50176337(5-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2,3...)
Affinity DataKd:  1.30nMAssay Description:Binding affinity at bRaf kinase in fluorescent ligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM26048(N-{3-[(dimethylamino)methyl]phenyl}-4-[(1E)-1-(hyd...)
Affinity DataKd:  1.30nMpH: 7.5 T: 2°CAssay Description:The kinase enzyme, fluorescent ligand and a variable concentration of test compound are incubated together to reach thermodynamic equilibrium under c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM88120(US9694016, 1156 | US10245267, Example 1156 | US107...)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to wild-type human partial length BRAF (S429 to E741 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM677076(US20240174621, Example 2 | (3S)-N-[2-cyano-4-fluor...)
Affinity DataKd:  1.30nMAssay Description:The assay is not in detail.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM26047(4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl...)
Affinity DataKd:  1.40nMpH: 7.5 T: 2°CAssay Description:The kinase enzyme, fluorescent ligand and a variable concentration of test compound are incubated together to reach thermodynamic equilibrium under c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM26044((1E)-5-[2-(piperidin-4-yl)-5-(pyridin-4-yl)-1H-imi...)
Affinity DataKd:  1.70nMpH: 7.5 T: 2°CAssay Description:The kinase enzyme, fluorescent ligand and a variable concentration of test compound are incubated together to reach thermodynamic equilibrium under c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50176335(5-(2-tert-butyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)...)
Affinity DataKd:  2nMAssay Description:Binding affinity at bRaf kinase in fluorescent ligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50514785(CHEMBL4443903)
Affinity DataKd:  2nMAssay Description:Binding affinity to DNA-tagged BRAF (unknown origin) V600E mutant by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM26052([2-(4-{5-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-ind...)
Affinity DataKd:  2.40nMpH: 7.5 T: 2°CAssay Description:The kinase enzyme, fluorescent ligand and a variable concentration of test compound are incubated together to reach thermodynamic equilibrium under c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM26053((1E)-5-[5-(piperidin-4-yl)-2-(pyridin-4-yl)furan-3...)
Affinity DataKd:  2.40nMpH: 7.5 T: 2°CAssay Description:The kinase enzyme, fluorescent ligand and a variable concentration of test compound are incubated together to reach thermodynamic equilibrium under c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50514785(CHEMBL4443903)
Affinity DataKd:  2.40nMAssay Description:Binding affinity to DNA-tagged BRAF (unknown origin) by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM26041(2-chloro-5-[2-phenyl-5-(pyridin-4-yl)-1H-imidazol-...)
Affinity DataKd:  2.40nMpH: 7.5 T: 2°CAssay Description:The kinase enzyme, fluorescent ligand and a variable concentration of test compound are incubated together to reach thermodynamic equilibrium under c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM26041(2-chloro-5-[2-phenyl-5-(pyridin-4-yl)-1H-imidazol-...)
Affinity DataKd:  2.40nMAssay Description:Binding affinity at bRaf kinase in fluorescent ligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50514788(CHEMBL4440761)
Affinity DataKd:  2.60nMAssay Description:Binding affinity to DNA-tagged BRAF (unknown origin) by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM26054((1E)-5-{5-[1-(2-methoxyethyl)piperidin-4-yl]-2-(py...)
Affinity DataKd:  2.70nMpH: 7.5 T: 2°CAssay Description:The kinase enzyme, fluorescent ligand and a variable concentration of test compound are incubated together to reach thermodynamic equilibrium under c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50514788(CHEMBL4440761)
Affinity DataKd:  2.70nMAssay Description:Binding affinity to DNA-tagged BRAF (unknown origin) V600E mutant by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50629712(CHEMBL5440394)
Affinity DataKd:  2.80nMAssay Description:Binding affinity to BRAF V600E mutant in human WM278 cells by KINOMEscann Kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50176329(2-chloro-5-(2-(furan-2-yl)-5-(pyridin-4-yl)-1H-imi...)
Affinity DataKd:  4.20nMAssay Description:Binding affinity at bRaf kinase in fluorescent ligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM6568(PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...)
Affinity DataKd:  4.40nMAssay Description:Binding constant for BRAF(V600E) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50176334(5-(2-(1-amino-2-methylpropan-2-yl)-5-(pyridin-4-yl...)
Affinity DataKd:  4.80nMAssay Description:Binding affinity at bRaf kinase in fluorescent ligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM26043(2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5...)
Affinity DataKd:  4.90nMpH: 7.5 T: 2°CAssay Description:The kinase enzyme, fluorescent ligand and a variable concentration of test compound are incubated together to reach thermodynamic equilibrium under c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50176317(4-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)benz...)
Affinity DataKd:  5nMAssay Description:Binding affinity at bRaf kinase in fluorescent ligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50514787(CHEMBL4449322)
Affinity DataKd:  5.10nMAssay Description:Binding affinity to DNA-tagged BRAF (unknown origin) by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM26040(5-{2-[4-(aminomethyl)phenyl]-5-(pyridin-4-yl)-1H-i...)
Affinity DataKd:  5.30nMAssay Description:Binding affinity at bRaf kinase in fluorescent ligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM6568(PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...)
Affinity DataKd:  5.70nMAssay Description:Binding constant for BRAF kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50176321(5-(5-(2-aminopyrimidin-4-yl)-2-phenyl-1H-imidazol-...)
Affinity DataKd:  5.70nMAssay Description:Binding affinity at bRaf kinase in fluorescent ligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50176319(2-chloro-4-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-...)
Affinity DataKd:  6nMAssay Description:Binding affinity at bRaf kinase in fluorescent ligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM26045((1E)-5-{2-[1-(2-methoxyethyl)piperidin-4-yl]-5-(py...)
Affinity DataKd:  6.30nMpH: 7.5 T: 2°CAssay Description:The kinase enzyme, fluorescent ligand and a variable concentration of test compound are incubated together to reach thermodynamic equilibrium under c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM26056((1E)-5-[5-(morpholin-4-ylmethyl)-2-(pyridin-4-yl)f...)
Affinity DataKd:  7.20nMpH: 7.5 T: 2°CAssay Description:The kinase enzyme, fluorescent ligand and a variable concentration of test compound are incubated together to reach thermodynamic equilibrium under c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50514787(CHEMBL4449322)
Affinity DataKd:  7.30nMAssay Description:Binding affinity to DNA-tagged BRAF (unknown origin) V600E mutant by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50077961(3-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)-pheno...)
Affinity DataKd:  8nMAssay Description:Binding affinity at bRaf kinase in fluorescent ligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50514786(CHEMBL4541406)
Affinity DataKd:  9.5nMAssay Description:Binding affinity to DNA-tagged BRAF (unknown origin) by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50396483(PLX-4032 | RG 7204 | Ro 5185426 | VEMURAFENIB | US...)
Affinity DataKd:  10nMAssay Description:Binding affinity to BRAF V600E mutant in human WM278 cells by KINOMEscann Kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50176320(N-(2-(4-(4-chloro-3-hydroxyphenyl)-5-(pyridin-4-yl...)
Affinity DataKd:  10nMAssay Description:Binding affinity at bRaf kinase in fluorescent ligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
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