BDBM28700 2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropionic acid::2-{4-[(4-chlorophenyl)carbonyl]phenoxy}-2-methylpropanoic acid::CHEMBL981::FENOFIBRIC ACID::FIBRICOR::Fenofibrate::LF 153::alpha-1081::procetofenic acid

SMILES CC(C)(C(=O)O)Oc1ccc(cc1)C(=O)c2ccc(cc2)Cl

InChI Key InChIKey=MQOBSOSZFYZQOK-UHFFFAOYSA-N

Data  7 KI  15 IC50  15 Kd  33 EC50

PDB links: 4 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 70 hits for monomerid = 28700   

TargetFatty acid-binding protein, liver(Rat)
Monash University

Curated by ChEMBL
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataKd:  94nMAssay Description:Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 5 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetFatty acid-binding protein, liver(Rat)
Monash University

Curated by ChEMBL
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataKd:  100nMAssay Description:Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 10 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetFatty acid-binding protein, liver(Rat)
Monash University

Curated by ChEMBL
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataKd:  160nMAssay Description:Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 15 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetFatty acid-binding protein, liver(Rat)
Monash University

Curated by ChEMBL
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataKd:  220nMAssay Description:Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 20 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetFatty acid-binding protein, liver(Human)
Texas A&M University

LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataKi:  250nMAssay Description:A solution of the L-FABP (500 nM) and ANS (35 µM) was titrated with phytanic acid (0-6.4 µM) or fenofibrate (0-6 µM for the rat L-FABP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2014
Entry Details Article
PubMed
TargetFatty acid-binding protein, liver [T94A](Human)
Texas A&M University

LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataKi:  310nMAssay Description:A solution of the L-FABP (500 nM) and ANS (35 µM) was titrated with phytanic acid (0-6.4 µM) or fenofibrate (0-6 µM for the rat L-FABP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2014
Entry Details Article
PubMed
TargetFatty acid-binding protein, liver(Rat)
Monash University

Curated by ChEMBL
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataKi:  334nMAssay Description:Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP high binding affinity site expressed in Escherichia coli BL21 by co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetFatty acid-binding protein, liver(Rat)
Monash University

Curated by ChEMBL
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataKd:  340nMAssay Description:Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 25 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetFatty acid-binding protein, liver(Rat)
Monash University

Curated by ChEMBL
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataKd:  360nMAssay Description:Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 30 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetFatty acid-binding protein, liver(Rat)
Monash University

Curated by ChEMBL
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataKd:  420nMAssay Description:Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 37 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetFatty acid-binding protein, intestinal(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of 1-anilinonaphthalene-8-sulphonic acid from I-FABPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataEC50:  2.65E+3nMAssay Description:Activity at human PPARalpha in CV1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataEC50:  4.50E+3nMAssay Description:Binding affinity to histidine-tagged human PPARalpha-LBD assessed as recruitment of co-activator peptide fluorescein-labeled PGC1alpha after 2 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFatty acid-binding protein, liver(Rat)
Monash University

Curated by ChEMBL
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataKi:  5.80E+3nMAssay Description:A solution of the L-FABP (500 nM) and ANS (35 µM) was titrated with phytanic acid (0-6.4 µM) or fenofibrate (0-6 µM for the rat L-FABP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2014
Entry Details Article
PubMed
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataEC50:  9.20E+3nMAssay Description:Agonist activity at human recombinant PPARalpha by transactivation of TK-MH100x4-LUC reporter gene in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataEC50: >1.00E+4nMAssay Description:Displacement of tritium labeled ligand from human PPARalpha by SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl-butyric acid from hPPARalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataIC50: 1.00E+4nMAssay Description:Mean inhibitory concentration against human peroxisome proliferator-activated receptor gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at human liver PPAR alpha expressed in HEK293 cells by PPAR-GAL4 transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor delta(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at human placenta PPAR delta expressed in HEK293 cells by PPAR-GAL4 transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataIC50: 1.00E+4nMAssay Description:Mean inhibitory concentration against human peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of tritium labeled ligand from human PPARgamma by SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]2-methyl-2-(4-{3-propyl-(5-pyridin-2yl-thiophene-2-sulfonyl)-amino]-pro-pyl}-phenoxy)-propionic acid from human PPARgammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataEC50: >1.00E+4nMAssay Description:Effective concentration against human Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataEC50: >1.00E+4nMAssay Description:Mean effective concentration against human peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of tritium labeled ligand from human PPARalpha by SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataEC50:  1.20E+4nMAssay Description:Agonist activity at human PPARalpha ligand binding domain expressed in COS-1 cells co-transfected with Gal4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataEC50:  1.20E+4nMAssay Description:Partial agonist activity at human PPARalpha expressed in CHO cells co-transfected with Gal4-responsive luciferase reporter plasmid after 24 hrs by tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataEC50:  1.30E+4nMAssay Description:Cotransfection activity of compound against human Peroxisome proliferator activated receptor alpha was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataEC50:  1.50E+4nMAssay Description:Effective concentration against human Peroxisome proliferator activated receptor alpha in Gal4 transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor alpha(Mouse)
Glaxo Wellcome Research & Development

Curated by ChEMBL
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataEC50:  1.80E+4nMAssay Description:Compound was tested for its agonist activity against murine Peroxisome proliferator activated receptor alpha-Gal4 chimeric receptor transfected CV-1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFatty acid-binding protein, liver(Rat)
Monash University

Curated by ChEMBL
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataKd:  1.80E+4nMAssay Description:Binding affinity to rat recombinant L-FABP low affinity site expressed in Escherichia coli BL21(DE3) at 5 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetFatty acid-binding protein, liver(Rat)
Monash University

Curated by ChEMBL
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataKd:  1.90E+4nMAssay Description:Binding affinity to rat recombinant L-FABP low affinity site expressed in Escherichia coli BL21(DE3) at 10 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetFatty acid-binding protein, liver(Rat)
Monash University

Curated by ChEMBL
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataKd:  2.00E+4nMAssay Description:Binding affinity to rat recombinant L-FABP low affinity site expressed in Escherichia coli BL21(DE3) at 15 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetFatty acid-binding protein, liver(Rat)
Monash University

Curated by ChEMBL
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataKd:  2.30E+4nMAssay Description:Binding affinity to rat recombinant L-FABP low affinity site expressed in Escherichia coli BL21(DE3) at 20 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibitory activity against human Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFatty acid-binding protein, liver(Rat)
Monash University

Curated by ChEMBL
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataKd:  2.40E+4nMAssay Description:Binding affinity to rat recombinant L-FABP low affinity site expressed in Escherichia coli BL21(DE3) at 25 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human Peroxisome proliferator activated receptor gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFatty acid-binding protein, liver(Rat)
Monash University

Curated by ChEMBL
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataKd:  2.70E+4nMAssay Description:Binding affinity to rat recombinant L-FABP low affinity site expressed in Escherichia coli BL21(DE3) at 30 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetFatty acid-binding protein, liver(Rat)
Monash University

Curated by ChEMBL
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataKi:  2.75E+4nMAssay Description:Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP low binding affinity site expressed in Escherichia coli BL21 by com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetFatty acid-binding protein, liver(Rat)
Monash University

Curated by ChEMBL
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataKd:  2.80E+4nMAssay Description:Binding affinity to rat recombinant L-FABP low affinity site expressed in Escherichia coli BL21(DE3) at 37 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetFatty acid-binding protein, liver(Rat)
Monash University

Curated by ChEMBL
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataKd:  2.90E+4nMAssay Description:Binding affinity to rat recombinant L-FABP low affinity site expressed in Escherichia coli BL21(DE3) at 42 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataEC50:  3.00E+4nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataEC50:  3.00E+4nMAssay Description:Agonist activity at PPARalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataEC50:  3.00E+4nMAssay Description:Agonist activity at GAL4-tagged human PPARalpha ligand binding domain expressed in human HepG2 cells assessed as receptor transactivation by lucifera...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataEC50:  3.00E+4nMAssay Description:Agonist activity at human PPARalpha expressed in monkey CV1 cells by transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataEC50:  3.00E+4nMAssay Description:Compound was tested for agonist activity on human Peroxisome proliferator activated receptor alpha-Gal4 chimeric receptor in transfected CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataEC50:  3.21E+4nMAssay Description:In vitro transactivation of human Peroxisome proliferator activated receptor alpha (hPPARalpha)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of human Peroxisome proliferator activated receptor alpha bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
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