Compile Data Set for Download or QSAR
Report error Found 133 Enz. Inhib. hit(s) with Target = 'Botulinum neurotoxin type A2 [1-425]'
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 23274BDBM23274(BMCL176463 Compound 2 | BMC173072 Compound 2 | (2E...)
Affinity DataIC50: 410nMpH: 7.4 T: 2°CAssay Description:Recombinant BoNT LC/A activity was measured in black 96-well microtiter plates by use of a Molecular Devices (Sunnyvale, CA) SpectraMax GeminiEM plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 23290BDBM23290((2E)-3-[4-chloro-2-(trifluoromethyl)phenyl]-N-hydr...)
Affinity DataIC50: 600nMpH: 7.4 T: 2°CAssay Description:Recombinant BoNT LC/A activity was measured in black 96-well microtiter plates by use of a Molecular Devices (Sunnyvale, CA) SpectraMax GeminiEM plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2008
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 23285BDBM23285((2E)-3-(2-bromo-4-chlorophenyl)-N-hydroxyprop-2-en...)
Affinity DataIC50: 700nMpH: 7.4 T: 2°CAssay Description:Recombinant BoNT LC/A activity was measured in black 96-well microtiter plates by use of a Molecular Devices (Sunnyvale, CA) SpectraMax GeminiEM plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2008
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 23289BDBM23289((2E)-3-(4-chloro-2-methylphenyl)-N-hydroxyprop-2-e...)
Affinity DataIC50: 800nMpH: 7.4 T: 2°CAssay Description:Recombinant BoNT LC/A activity was measured in black 96-well microtiter plates by use of a Molecular Devices (Sunnyvale, CA) SpectraMax GeminiEM plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2008
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 23274BDBM23274(BMCL176463 Compound 2 | BMC173072 Compound 2 | (2E...)
Affinity DataIC50: 900nMpH: 7.4 T: 2°CAssay Description:Recombinant BoNT LC/A activity was measured in black 96-well microtiter plates by use of a Molecular Devices (Sunnyvale, CA) SpectraMax GeminiEM plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 23292BDBM23292((2E)-3-(4-chloro-2-nitrophenyl)-N-hydroxyprop-2-en...)
Affinity DataIC50: 2.00E+3nMpH: 7.4 T: 2°CAssay Description:Recombinant BoNT LC/A activity was measured in black 96-well microtiter plates by use of a Molecular Devices (Sunnyvale, CA) SpectraMax GeminiEM plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2008
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 23274BDBM23274(BMCL176463 Compound 2 | BMC173072 Compound 2 | (2E...)
Affinity DataIC50: 2.40E+3nMpH: 7.4 T: 2°CAssay Description:Reactions between recombinant BoNTA-LC and fluorescent peptide substrate were carried out in 96-well microplates. Reaction progress was measured cont...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 28913BDBM28913(N-[3-(4-nitrophenyl)-1H-pyrazol-5-yl]-2-sulfanylac...)
Affinity DataIC50: 2.90E+3nMpH: 7.4 T: 2°CAssay Description:Reactions between recombinant BoNTA-LC and fluorescent peptide substrate were carried out in 96-well microplates. Reaction progress was measured cont...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 23275BDBM23275(3-(2,4-dichlorophenyl)-N-hydroxypropanamide | Cinn...)
Affinity DataIC50: 3.10E+3nMpH: 7.4 T: 2°CAssay Description:Recombinant BoNT LC/A activity was measured in black 96-well microtiter plates by use of a Molecular Devices (Sunnyvale, CA) SpectraMax GeminiEM plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2008
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 23299BDBM23299(N-{3-[bis({3-[(7-chloroquinolin-4-yl)amino]propyl}...)
Affinity DataIC50: 3.20E+3nMpH: 7.3 T: 2°CAssay Description:Botox A catalyzed the hydrolysis of substrate peptide between residues 11 (glutamine) and 12 (arginine), corresponding to residues 197 and 198 of SNA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2008
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 23284BDBM23284((2E)-3-(4-chloro-2-fluorophenyl)-N-hydroxyprop-2-e...)
Affinity DataIC50: 4.40E+3nMpH: 7.4 T: 2°CAssay Description:Recombinant BoNT LC/A activity was measured in black 96-well microtiter plates by use of a Molecular Devices (Sunnyvale, CA) SpectraMax GeminiEM plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2008
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 28906BDBM28906(N-[3-(4-chlorophenyl)-1H-pyrazol-5-yl]-2-sulfanyla...)
Affinity DataIC50: 4.80E+3nMpH: 7.4 T: 2°CAssay Description:Reactions between recombinant BoNTA-LC and fluorescent peptide substrate were carried out in 96-well microplates. Reaction progress was measured cont...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 23287BDBM23287((2E)-3-[4-chloro-2-(methylsulfanyl)phenyl]-N-hydro...)
Affinity DataIC50: 5.10E+3nMpH: 7.4 T: 2°CAssay Description:Recombinant BoNT LC/A activity was measured in black 96-well microtiter plates by use of a Molecular Devices (Sunnyvale, CA) SpectraMax GeminiEM plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2008
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 28876BDBM28876(2-[(5Z)-5-{[1,3-bis(4-bromophenyl)-1H-pyrazol-4-yl...)
Affinity DataIC50: 5.45E+3nMAssay Description:The fluorescence peptide cleavage assay was performed in a 96-well plate in which each reaction mixture contained MAPKKide, LF (List Biological Labor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 28917BDBM28917(N-[3-(3-chlorophenyl)-1H-pyrazol-5-yl]-2-sulfanyla...)
Affinity DataIC50: 5.60E+3nMpH: 7.4 T: 2°CAssay Description:Reactions between recombinant BoNTA-LC and fluorescent peptide substrate were carried out in 96-well microplates. Reaction progress was measured cont...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 28911BDBM28911(N-[3-(4-bromophenyl)-1H-pyrazol-5-yl]-2-sulfanylac...)
Affinity DataIC50: 6.60E+3nMpH: 7.4 T: 2°CAssay Description:Reactions between recombinant BoNTA-LC and fluorescent peptide substrate were carried out in 96-well microplates. Reaction progress was measured cont...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 23298BDBM23298(methyl (4R)-4-[(2S,5R,7S,9R,14R,15R,16S)-5-({2-[(7...)
Affinity DataIC50: 7.00E+3nMpH: 7.3 T: 2°CAssay Description:Botox A catalyzed the hydrolysis of substrate peptide between residues 11 (glutamine) and 12 (arginine), corresponding to residues 197 and 198 of SNA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 23298BDBM23298(methyl (4R)-4-[(2S,5R,7S,9R,14R,15R,16S)-5-({2-[(7...)
Affinity DataIC50: 7.00E+3nMpH: 7.3 T: 2°CAssay Description:Botox A catalyzed the hydrolysis of substrate peptide between residues 11 (glutamine) and 12 (arginine), corresponding to residues 197 and 198 of SNA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2008
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 28918BDBM28918(2-sulfanyl-N-{3-[2-(trifluoromethyl)phenyl]-1H-pyr...)
Affinity DataIC50: 7.20E+3nMpH: 7.4 T: 2°CAssay Description:Reactions between recombinant BoNTA-LC and fluorescent peptide substrate were carried out in 96-well microplates. Reaction progress was measured cont...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 23260BDBM23260(1-{[({[2-(4-methoxyphenyl)ethyl]carbamoyl}methyl)(...)
Affinity DataIC50: 7.60E+3nMpH: 7.4 T: 2°CAssay Description:Recombinant BoNT LC/A activity was measured in black 96-well microtiter plates by use of a Molecular Devices (Sunnyvale, CA) SpectraMax GeminiEM plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2008
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 28875BDBM28875(2-[(5Z)-5-{[1,3-bis(4-chlorophenyl)-1H-pyrazol-4-y...)
Affinity DataIC50: 8.18E+3nMAssay Description:The fluorescence peptide cleavage assay was performed in a 96-well plate in which each reaction mixture contained MAPKKide, LF (List Biological Labor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 23286BDBM23286((2E)-3-(4-chloro-2-methoxyphenyl)-N-hydroxyprop-2-...)
Affinity DataIC50: 9.00E+3nMpH: 7.4 T: 2°CAssay Description:Recombinant BoNT LC/A activity was measured in black 96-well microtiter plates by use of a Molecular Devices (Sunnyvale, CA) SpectraMax GeminiEM plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2008
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 28850BDBM28850(2-[(5Z)-5-{[5-(3-nitrophenyl)furan-2-yl]methyliden...)
Affinity DataIC50: 9.72E+3nMAssay Description:The fluorescence peptide cleavage assay was performed in a 96-well plate in which each reaction mixture contained MAPKKide, LF (List Biological Labor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 28912BDBM28912(2-sulfanyl-N-{3-[4-(trifluoromethyl)phenyl]-1H-pyr...)
Affinity DataIC50: 1.00E+4nMpH: 7.4 T: 2°CAssay Description:Reactions between recombinant BoNTA-LC and fluorescent peptide substrate were carried out in 96-well microplates. Reaction progress was measured cont...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 23296BDBM23296(JMC514388 Compound 6 | (2S,5R,7S,9R,14R,15R,16S)-1...)
Affinity DataIC50: 1.00E+4nMpH: 7.3 T: 2°CAssay Description:Botox A catalyzed the hydrolysis of substrate peptide between residues 11 (glutamine) and 12 (arginine), corresponding to residues 197 and 198 of SNA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 23296BDBM23296(JMC514388 Compound 6 | (2S,5R,7S,9R,14R,15R,16S)-1...)
Affinity DataIC50: 1.00E+4nMpH: 7.3 T: 2°CAssay Description:Botox A catalyzed the hydrolysis of substrate peptide between residues 11 (glutamine) and 12 (arginine), corresponding to residues 197 and 198 of SNA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2008
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 28852BDBM28852(2-[(5Z)-5-{[5-(3,4-dichlorophenyl)furan-2-yl]methy...)
Affinity DataIC50: 1.11E+4nMAssay Description:The fluorescence peptide cleavage assay was performed in a 96-well plate in which each reaction mixture contained MAPKKide, LF (List Biological Labor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 28845BDBM28845(2-[(5Z)-5-{[5-(2-chloro-4-nitrophenyl)furan-2-yl]m...)
Affinity DataIC50: 1.18E+4nMAssay Description:The fluorescence peptide cleavage assay was performed in a 96-well plate in which each reaction mixture contained MAPKKide, LF (List Biological Labor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 24727BDBM24727([2-(adamantan-1-yl)ethyl]({2-[(7-chloroquinolin-4-...)
Affinity DataIC50: 1.18E+4nMpH: 7.3 T: 2°CAssay Description:Botox A catalyzed the hydrolysis of substrate peptide between residues 11 (glutamine) and 12 (arginine), corresponding to residues 197 and 198 of SNA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 23294BDBM23294((2E)-3-(4-chloro-2-cyanophenyl)-N-hydroxyprop-2-en...)
Affinity DataIC50: 1.20E+4nMpH: 7.4 T: 2°CAssay Description:Recombinant BoNT LC/A activity was measured in black 96-well microtiter plates by use of a Molecular Devices (Sunnyvale, CA) SpectraMax GeminiEM plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2008
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 23265BDBM23265(6-ethyl-1-[(4-methylphenyl)methyl]-4-[(2E)-3-pheny...)
Affinity DataIC50: 1.25E+4nMpH: 7.4 T: 2°CAssay Description:Recombinant BoNT LC/A activity was measured in black 96-well microtiter plates by use of a Molecular Devices (Sunnyvale, CA) SpectraMax GeminiEM plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2008
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 23291BDBM23291((2E)-3-(4-chloro-2-hydroxyphenyl)-N-hydroxyprop-2-...)
Affinity DataIC50: 1.30E+4nMpH: 7.4 T: 2°CAssay Description:Recombinant BoNT LC/A activity was measured in black 96-well microtiter plates by use of a Molecular Devices (Sunnyvale, CA) SpectraMax GeminiEM plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2008
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 28919BDBM28919(2-sulfanyl-N-{3-[3-(trifluoromethyl)phenyl]-1H-pyr...)
Affinity DataIC50: 1.30E+4nMpH: 7.4 T: 2°CAssay Description:Reactions between recombinant BoNTA-LC and fluorescent peptide substrate were carried out in 96-well microplates. Reaction progress was measured cont...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 28910BDBM28910(N-[3-(4-fluorophenyl)-1H-pyrazol-5-yl]-2-sulfanyla...)
Affinity DataIC50: 1.35E+4nMpH: 7.4 T: 2°CAssay Description:Reactions between recombinant BoNTA-LC and fluorescent peptide substrate were carried out in 96-well microplates. Reaction progress was measured cont...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 23259BDBM23259(1-({[({[3-fluoro-5-(trifluoromethyl)phenyl]methyl}...)
Affinity DataIC50: 1.43E+4nMpH: 7.4 T: 2°CAssay Description:Recombinant BoNT LC/A activity was measured in black 96-well microtiter plates by use of a Molecular Devices (Sunnyvale, CA) SpectraMax GeminiEM plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2008
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 28909BDBM28909(N-(3-phenyl-1H-pyrazol-5-yl)-2-sulfanylacetamide |...)
Affinity DataIC50: 1.45E+4nMpH: 7.4 T: 2°CAssay Description:Reactions between recombinant BoNTA-LC and fluorescent peptide substrate were carried out in 96-well microplates. Reaction progress was measured cont...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 23295BDBM23295((2E)-3-(4-chlorophenyl)-N-hydroxyprop-2-enamide | ...)
Affinity DataIC50: 1.50E+4nMpH: 7.4 T: 2°CAssay Description:Recombinant BoNT LC/A activity was measured in black 96-well microtiter plates by use of a Molecular Devices (Sunnyvale, CA) SpectraMax GeminiEM plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 23293BDBM23293((2E)-3-(4-chloro-2-methanesulfonylphenyl)-N-hydrox...)
Affinity DataIC50: 1.70E+4nMpH: 7.4 T: 2°CAssay Description:Recombinant BoNT LC/A activity was measured in black 96-well microtiter plates by use of a Molecular Devices (Sunnyvale, CA) SpectraMax GeminiEM plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2008
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 23297BDBM23297(JMC514388 Compound 7 | methyl (4R)-4-[(2S,5S,7S,9R...)
Affinity DataIC50: 1.70E+4nMpH: 7.3 T: 2°CAssay Description:Botox A catalyzed the hydrolysis of substrate peptide between residues 11 (glutamine) and 12 (arginine), corresponding to residues 197 and 198 of SNA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 23297BDBM23297(JMC514388 Compound 7 | methyl (4R)-4-[(2S,5S,7S,9R...)
Affinity DataIC50: 1.70E+4nMpH: 7.3 T: 2°CAssay Description:Botox A catalyzed the hydrolysis of substrate peptide between residues 11 (glutamine) and 12 (arginine), corresponding to residues 197 and 198 of SNA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2008
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 24725BDBM24725((adamantan-1-ylmethyl)({2-[(7-chloroquinolin-4-yl)...)
Affinity DataIC50: 1.89E+4nMpH: 7.3 T: 2°CAssay Description:Botox A catalyzed the hydrolysis of substrate peptide between residues 11 (glutamine) and 12 (arginine), corresponding to residues 197 and 198 of SNA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 23261BDBM23261(1-{[({[2-(3-methoxyphenyl)ethyl]carbamoyl}methyl)[...)
Affinity DataIC50: 1.91E+4nMpH: 7.4 T: 2°CAssay Description:Recombinant BoNT LC/A activity was measured in black 96-well microtiter plates by use of a Molecular Devices (Sunnyvale, CA) SpectraMax GeminiEM plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2008
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 28851BDBM28851(2-[(5Z)-5-{[5-(3-chlorophenyl)furan-2-yl]methylide...)
Affinity DataIC50: 1.99E+4nMAssay Description:The fluorescence peptide cleavage assay was performed in a 96-well plate in which each reaction mixture contained MAPKKide, LF (List Biological Labor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 28884BDBM28884(2-[(5Z)-4-oxo-5-({1-phenyl-3-[4-(piperidine-1-sulf...)
Affinity DataIC50: 2.01E+4nMAssay Description:The fluorescence peptide cleavage assay was performed in a 96-well plate in which each reaction mixture contained MAPKKide, LF (List Biological Labor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 28914BDBM28914(N-[3-(4-methylphenyl)-1H-pyrazol-5-yl]-2-sulfanyla...)
Affinity DataIC50: 2.10E+4nMpH: 7.4 T: 2°CAssay Description:Reactions between recombinant BoNTA-LC and fluorescent peptide substrate were carried out in 96-well microplates. Reaction progress was measured cont...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 23278BDBM23278(6-chloro-N-hydroxynaphthalene-2-carboxamide | hydr...)
Affinity DataIC50: 2.10E+4nMpH: 7.4 T: 2°CAssay Description:Recombinant BoNT LC/A activity was measured in black 96-well microtiter plates by use of a Molecular Devices (Sunnyvale, CA) SpectraMax GeminiEM plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2008
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 23288BDBM23288((2E)-3-(2-amino-4-chlorophenyl)-N-hydroxyprop-2-en...)
Affinity DataIC50: 2.50E+4nMpH: 7.4 T: 2°CAssay Description:Recombinant BoNT LC/A activity was measured in black 96-well microtiter plates by use of a Molecular Devices (Sunnyvale, CA) SpectraMax GeminiEM plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2008
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 28916BDBM28916(N-[3-(2-chlorophenyl)-1H-pyrazol-5-yl]-2-sulfanyla...)
Affinity DataIC50: 2.60E+4nMpH: 7.4 T: 2°CAssay Description:Reactions between recombinant BoNTA-LC and fluorescent peptide substrate were carried out in 96-well microplates. Reaction progress was measured cont...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 28882BDBM28882(2-[(5Z)-5-{[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol...)
Affinity DataIC50: 2.64E+4nMAssay Description:The fluorescence peptide cleavage assay was performed in a 96-well plate in which each reaction mixture contained MAPKKide, LF (List Biological Labor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 24724BDBM24724((adamantan-1-ylmethyl)({3-[(7-chloroquinolin-4-yl)...)
Affinity DataIC50: 3.20E+4nMpH: 7.3 T: 2°CAssay Description:Botox A catalyzed the hydrolysis of substrate peptide between residues 11 (glutamine) and 12 (arginine), corresponding to residues 197 and 198 of SNA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
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