BDBM50106635 (+/-)-2,3-bis(4-hydroxyphenyl)propanenitrile::2,3-Bis-(4-hydroxy-phenyl)-propionitrile::2,3-bis(4-hydroxyphenyl)propanenitrile::CHEMBL334773::DIARYLPROPIONITRILE
SMILES Oc1ccc(CC(C#N)c2ccc(O)cc2)cc1
InChI Key InChIKey=GHZHWDWADLAOIQ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 24 hits for monomerid = 50106635
Affinity DataEC50: 20nMAssay Description:Transcriptional potency (EC50) at Human estrogen receptor alphaMore data for this Ligand-Target Pair
Affinity DataEC50: 0.660nMAssay Description:Agonist activity at human ER-beta transfected in HEC-1 cells assessed as transcriptional activation incubated for 24 hrs by dual luciferase reporter ...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataEC50: 0.850nMAssay Description:Agonist activity at ERbeta expressed in human HEC1 cells assessed as transcriptional potency after 24 hrs by luciferase-beta galactosidase reporter g...More data for this Ligand-Target Pair
Affinity DataEC50: 66nMAssay Description:Agonist activity at ERalpha expressed in human HEC1 cells assessed as transcriptional potency after 24 hrs by luciferase-beta galactosidase reporter ...More data for this Ligand-Target Pair
Affinity DataEC50: 208nMAssay Description:Agonist activity at human ERalpha expressed in U2OS cells coexpressing pCMX-hSRC3 assessed as luciferase activity after 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.70nMAssay Description:Agonist activity at human ERbeta expressed in U2OS cells coexpressing pCMX-hSRC3 assessed as luciferase activity after 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 304nMAssay Description:Agonist activity at human ERalpha expressed in HEC-1 cells coexpressing beta-gal assessed as luciferase activity after 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.30nMAssay Description:Agonist activity at human ERbeta expressed in HEC-1 cells coexpressing beta-gal assessed as luciferase activity after 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 876nMAssay Description:Agonist activity at human N-His6-tagged terbium-labelled ERalpha ligand binding domain expressed in Escherichia coli BL21 cells assessed as recruitme...More data for this Ligand-Target Pair
Affinity DataEC50: 16.7nMAssay Description:Agonist activity at human N-His6-tagged terbium-labelled ERbeta ligand binding domain expressed in Escherichia coli BL21 cells assessed as recruitmen...More data for this Ligand-Target Pair
Affinity DataEC50: 3.40nMAssay Description:Agonist activity at human N-His6-tagged terbium-labelled NRID-SRC3 of ERalpha ligand binding domain expressed in Escherichia coli BL21 cells after 1 ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.710nMAssay Description:Agonist activity at human N-His6-tagged terbium-labelled NRID-SRC3 of ERbeta ligand binding domain expressed in Escherichia coli BL21 cells after 1 h...More data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:Estrogenic activity at ERbeta (unknown origin) expressed in human MDA-MB-231/beta41 cells after 18 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 80nMAssay Description:Estrogenic activity at ERalpha in human Ishikawa cells assessed as induction of alkaline phosphatase activity using p-nitrophenol as substrate treate...More data for this Ligand-Target Pair
Affinity DataEC50: 7.20E+5nMAssay Description:Activation of human ERbeta assessed as induction of transcriptional activation incubated for 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 8.90E+5nMAssay Description:Activation of human ERbeta assessed as induction of transcriptional activation by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.90nMAssay Description:Binding affinity to human GST-tagged estrogen receptor beta ligand binding domain after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.10nMAssay Description:Agonist activity at estrogen receptor beta (unknown origin) after 22 hrs by cell-based luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Antagonist activity at estrogen receptor beta (unknown origin) assessed as inhibition of estradiol-induced response after 22 hrs by cell-based lucife...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Antagonist activity at estrogen receptor alpha (unknown origin) assessed as inhibition of estradiol-induced response after 22 hrs by cell-based lucif...More data for this Ligand-Target Pair
Affinity DataEC50: 2.30E+3nMAssay Description:Agonist activity at estrogen receptor alpha (unknown origin) after 22 hrs by cell-based luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.820nMAssay Description:Agonist activity at human ERbeta receptor expressed in HEK293T cells transfected with pGL4.27-(ERE)3-Luc assessed as transcriptional activation measu...More data for this Ligand-Target Pair
Affinity DataEC50: 2.39E+3nMAssay Description:Agonist activity at human ERalpha receptor expressed in HEK293T cells transfected with pGL4.27-(ERE)3-Luc assessed as transcriptional activation meas...More data for this Ligand-Target Pair
Affinity DataEC50: 6nMAssay Description:Transcriptional potency (EC50) at Human estrogen receptor BetaMore data for this Ligand-Target Pair