Compile Data Set for Download or QSAR
Report error Found 838 Enz. Inhib. hit(s) with Target = 'C-C chemokine receptor type 4'
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278725BDBM50278725(CHEMBL4172769)
Affinity DataIC50: 0.316nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278758BDBM50278758(CHEMBL4167445)
Affinity DataIC50: 0.631nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50380881BDBM50380881(CHEMBL2018953)
Affinity DataKi:  0.794nMAssay Description:Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278799BDBM50278799(CHEMBL4162364)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50500893BDBM50500893(CHEMBL3797662)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Mouse)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278798BDBM50278798(CHEMBL4172635)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at mouse CCR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50500901BDBM50500901(CHEMBL3799266)
Affinity DataKi:  1.60nMAssay Description:Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50500908BDBM50500908(CHEMBL3797537)
Affinity DataKi:  2.5nMAssay Description:Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278793BDBM50278793(CHEMBL4160218)
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175665BDBM50175665((R)-(4-(4-(2,4-dichlorobenzylamino)pyrimidin-2-yl)...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278798BDBM50278798(CHEMBL4172635)
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50198429BDBM50198429((S)-(4-(4-(2,4-dichlorobenzylamino)pyrido[2,3-d]py...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human CCR4 expressed in CEMS529 cells assessed as effect on calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50380884BDBM50380884(CHEMBL2018954)
Affinity DataKi:  3.16nMAssay Description:Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Dog)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278798BDBM50278798(CHEMBL4172635)
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at dog CCR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50380884BDBM50380884(CHEMBL2018954)
Affinity DataKi:  3.20nMAssay Description:Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50500894BDBM50500894(CHEMBL3799578)
Affinity DataKi:  3.20nMAssay Description:Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50380884BDBM50380884(CHEMBL2018954)
Affinity DataIC50: 3.89nMAssay Description:Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50380884BDBM50380884(CHEMBL2018954)
Affinity DataIC50: 3.90nMAssay Description:Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50380884BDBM50380884(CHEMBL2018954)
Affinity DataIC50: 3.90nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50380884BDBM50380884(CHEMBL2018954)
Affinity DataIC50: 3.90nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278794BDBM50278794(CHEMBL4175323)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278798BDBM50278798(CHEMBL4172635)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human CCR4 expressed in HEK cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278797BDBM50278797(CHEMBL4160846)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50500902BDBM50500902(CHEMBL3798452)
Affinity DataKi:  4nMAssay Description:Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278727BDBM50278727(CHEMBL4173046)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Mouse)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50378979BDBM50378979(CHEMBL2011441)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at mouse CCR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50500896BDBM50500896(CHEMBL3799393)
Affinity DataKi:  5nMAssay Description:Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50380881BDBM50380881(CHEMBL2018953)
Affinity DataIC50: 5.5nMAssay Description:Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50380881BDBM50380881(CHEMBL2018953)
Affinity DataIC50: 5.5nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50380881BDBM50380881(CHEMBL2018953)
Affinity DataIC50: 5.5nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50380881BDBM50380881(CHEMBL2018953)
Affinity DataIC50: 5.5nMAssay Description:Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545768BDBM50545768(CHEMBL4641127)
Affinity DataIC50: 6nMAssay Description:Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50500896BDBM50500896(CHEMBL3799393)
Affinity DataEC50:  6.30nMAssay Description:Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490519BDBM50490519(CHEMBL2326625)
Affinity DataIC50: 6.30nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490515BDBM50490515(CHEMBL2326611)
Affinity DataIC50: 6.30nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490519BDBM50490519(CHEMBL2326625)
Affinity DataIC50: 6.30nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50198429BDBM50198429((S)-(4-(4-(2,4-dichlorobenzylamino)pyrido[2,3-d]py...)
Affinity DataIC50: 7nMAssay Description:Inhibition of MDC-induced chemotaxis in L1.2 cells expressing CCR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50500893BDBM50500893(CHEMBL3797662)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278801BDBM50278801(CHEMBL4165356)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50500894BDBM50500894(CHEMBL3799578)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175665BDBM50175665((R)-(4-(4-(2,4-dichlorobenzylamino)pyrimidin-2-yl)...)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50500901BDBM50500901(CHEMBL3799266)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278787BDBM50278787(CHEMBL4173861)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50380879BDBM50380879(CHEMBL2018968)
Affinity DataKi:  7.94nMAssay Description:Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545779BDBM50545779(CHEMBL4642563)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545782BDBM50545782(CHEMBL4637695)
Affinity DataIC50: 9nMAssay Description:Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50380880BDBM50380880(CHEMBL2018969)
Affinity DataKi:  10nMAssay Description:Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50380881BDBM50380881(CHEMBL2018953)
Affinity DataEC50:  10nMAssay Description:Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50398341BDBM50398341(CHEMBL2178575)
Affinity DataKi:  10nMAssay Description:Binding affinity to CCR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175665BDBM50175665((R)-(4-(4-(2,4-dichlorobenzylamino)pyrimidin-2-yl)...)
Affinity DataIC50: 10nMAssay Description:Calcium mobilization mediated by CCR4 receptor in CEMS529 cells by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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