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Found 289 with Last Name = 'weng' and Initial = 'l'
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50519725(CHEMBL4513768)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of wild type FLT3 (unknown origin) expressed in HEK293T cells assessed as decrease in FLT3 phosphorylation at 0.1 to 1000 nM after 1 hr by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50519725(CHEMBL4513768)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of wild type FLT3 D835Y mutant (unknown origin) expressed in HEK293T cells assessed as decrease in FLT3 D835Y phosphorylation at 0.1 to 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50519725(CHEMBL4513768)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of wild type FLT3 ITD mutant (unknown origin) expressed in HEK293T cells assessed as decrease in FLT3 ITD phosphorylation at 0.1 to 1000 n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50595147(CHEMBL5205840)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human11beta-HSD1 in human PBMC cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50595148(CHEMBL5202600)
Affinity DataIC50:  1nMAssay Description:Inhibition of human11beta-HSD1 in human PBMC cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50595161(CHEMBL5172072)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human11beta-HSD1 in human PBMC cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50595158(CHEMBL5203601)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human11beta-HSD1 in human PBMC cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50595152(CHEMBL5187458)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human11beta-HSD1 in human PBMC cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50595147(CHEMBL5205840)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of 11beta-HSD1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50519725(CHEMBL4513768)
Affinity DataIC50:  3nMAssay Description:Inhibition of human C-src using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50595159(CHEMBL5175978)
Affinity DataIC50:  3nMAssay Description:Inhibition of 11beta-HSD1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50595157(CHEMBL5188613)
Affinity DataIC50:  3nMAssay Description:Inhibition of human11beta-HSD1 in human PBMC cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50595161(CHEMBL5172072)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of 11beta-HSD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50595159(CHEMBL5175978)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human11beta-HSD1 in human PBMC cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50595144(CHEMBL5183831)
Affinity DataIC50:  4nMAssay Description:Inhibition of 11beta-HSD1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50595156(CHEMBL5187680)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of human11beta-HSD1 in human PBMC cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50595162(CHEMBL5187093)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of human11beta-HSD1 in human PBMC cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50519725(CHEMBL4513768)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of human TRKA using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50595160(CHEMBL5194632)
Affinity DataIC50:  5nMAssay Description:Inhibition of 11beta-HSD1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50595158(CHEMBL5203601)
Affinity DataIC50:  5nMAssay Description:Inhibition of 11beta-HSD1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50:  5nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50595160(CHEMBL5194632)
Affinity DataIC50:  5nMAssay Description:Inhibition of human11beta-HSD1 in human PBMC cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50589350(CHEMBL5192382)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of 11beta-HSD1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50595141(CHEMBL5201898)
Affinity DataIC50:  6nMAssay Description:Inhibition of 11beta-HSD1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50595136(CHEMBL5177277)
Affinity DataIC50:  7nMAssay Description:Inhibition of 11beta-HSD1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50239401(3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]tria...)
Affinity DataIC50:  7.70nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50595162(CHEMBL5187093)
Affinity DataIC50:  7.70nMAssay Description:Inhibition of 11beta-HSD1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50595143(CHEMBL5183130)
Affinity DataIC50:  8nMAssay Description:Inhibition of 11beta-HSD1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50595157(CHEMBL5188613)
Affinity DataIC50:  8nMAssay Description:Inhibition of 11beta-HSD1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50595148(CHEMBL5202600)
Affinity DataIC50:  8nMAssay Description:Inhibition of 11beta-HSD1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50595154(CHEMBL5173694)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of human11beta-HSD1 in human PBMC cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50595154(CHEMBL5173694)
Affinity DataIC50:  10nMAssay Description:Inhibition of 11beta-HSD1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246861(3-[1-(6- chloropyridin-2- yl)pyrrolidin-3-yl]-3- [...)
Affinity DataIC50: <10nMAssay Description:Assays are carried out at room temperature in 50 mM HEPES, pH 7.4, 5 mM MgCl2, 50 mM NaCl, 5 mM DTT and CHAPS 0.04%. Reactions are initiated by the a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246864(3-(1- [1,3]oxazolo[5,4- b]pyridin-2- ylpyrrolidin-...)
Affinity DataIC50: <10nMAssay Description:Assays are carried out at room temperature in 50 mM HEPES, pH 7.4, 5 mM MgCl2, 50 mM NaCl, 5 mM DTT and CHAPS 0.04%. Reactions are initiated by the a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246866(4-[(4-{3-cyano-2-[4- (7H-pyrrolo[2,3- d]pyrimidin-...)
Affinity DataIC50: <10nMAssay Description:Assays are carried out at room temperature in 50 mM HEPES, pH 7.4, 5 mM MgCl2, 50 mM NaCl, 5 mM DTT and CHAPS 0.04%. Reactions are initiated by the a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246867(4-[(4-{3-cyano-2-[3- (7H-pyrrolo[2,3- d]pyrimidin-...)
Affinity DataIC50: <10nMAssay Description:Assays are carried out at room temperature in 50 mM HEPES, pH 7.4, 5 mM MgCl2, 50 mM NaCl, 5 mM DTT and CHAPS 0.04%. Reactions are initiated by the a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246868(US10053465, 7 | US10065963, Compound 7 | US1012515...)
Affinity DataIC50: <10nMAssay Description:Assays are carried out at room temperature in 50 mM HEPES, pH 7.4, 5 mM MgCl2, 50 mM NaCl, 5 mM DTT and CHAPS 0.04%. Reactions are initiated by the a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246869(4-{3-(Cyanomethyl)- 3-[4-(7H-pyrrolo[2,3- d]pyrimi...)
Affinity DataIC50: <10nMAssay Description:Assays are carried out at room temperature in 50 mM HEPES, pH 7.4, 5 mM MgCl2, 50 mM NaCl, 5 mM DTT and CHAPS 0.04%. Reactions are initiated by the a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246870(US10053465, 9 | US10065963, Compound 9 | US1012515...)
Affinity DataIC50: <10nMAssay Description:Assays are carried out at room temperature in 50 mM HEPES, pH 7.4, 5 mM MgCl2, 50 mM NaCl, 5 mM DTT and CHAPS 0.04%. Reactions are initiated by the a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246871(US10053465, 10 | US10065963, Compound 10 | US10125...)
Affinity DataIC50: <10nMAssay Description:Assays are carried out at room temperature in 50 mM HEPES, pH 7.4, 5 mM MgCl2, 50 mM NaCl, 5 mM DTT and CHAPS 0.04%. Reactions are initiated by the a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246872(US10053465, 11 | US10065963, Compound 11 | US10125...)
Affinity DataIC50: <10nMAssay Description:Assays are carried out at room temperature in 50 mM HEPES, pH 7.4, 5 mM MgCl2, 50 mM NaCl, 5 mM DTT and CHAPS 0.04%. Reactions are initiated by the a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246873(US10053465, 12 | US10065963, Compound 12 | US10125...)
Affinity DataIC50: <10nMAssay Description:Assays are carried out at room temperature in 50 mM HEPES, pH 7.4, 5 mM MgCl2, 50 mM NaCl, 5 mM DTT and CHAPS 0.04%. Reactions are initiated by the a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246874(US10053465, 13 | US10065963, Compound 13 | US10125...)
Affinity DataIC50: <10nMAssay Description:Assays are carried out at room temperature in 50 mM HEPES, pH 7.4, 5 mM MgCl2, 50 mM NaCl, 5 mM DTT and CHAPS 0.04%. Reactions are initiated by the a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246875(4-(4-{3- [(dimethylamino) methyl]-5- fluorophenoxy...)
Affinity DataIC50: <10nMAssay Description:Assays are carried out at room temperature in 50 mM HEPES, pH 7.4, 5 mM MgCl2, 50 mM NaCl, 5 mM DTT and CHAPS 0.04%. Reactions are initiated by the a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246876(5-{3-(cyanomethyl)- 3-[4-(7H-pyrrolo[2,3- d]pyrimi...)
Affinity DataIC50: <10nMAssay Description:Assays are carried out at room temperature in 50 mM HEPES, pH 7.4, 5 mM MgCl2, 50 mM NaCl, 5 mM DTT and CHAPS 0.04%. Reactions are initiated by the a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246877(4-{3-(cyanomethyl)- 3-[4-(7H-pyrrolo[2,3- d]pyrimi...)
Affinity DataIC50: <10nMAssay Description:Assays are carried out at room temperature in 50 mM HEPES, pH 7.4, 5 mM MgCl2, 50 mM NaCl, 5 mM DTT and CHAPS 0.04%. Reactions are initiated by the a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM262166(5-{3-(cyanomethyl)- 3-[4-(1H-pyrrolo[2,3- b]pyridi...)
Affinity DataIC50: <10nMAssay Description:Assays are carried out at room temperature in 50 mM HEPES, pH 7.4, 5 mM MgCl2, 50 mM NaCl, 5 mM DTT and CHAPS 0.04%. Reactions are initiated by the a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246879(US10053465, 18 | US10065963, Compound 18 | US10125...)
Affinity DataIC50: <10nMAssay Description:Assays are carried out at room temperature in 50 mM HEPES, pH 7.4, 5 mM MgCl2, 50 mM NaCl, 5 mM DTT and CHAPS 0.04%. Reactions are initiated by the a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246880(US10053465, 19 | US10065963, Compound 19 | US10125...)
Affinity DataIC50: <10nMAssay Description:Assays are carried out at room temperature in 50 mM HEPES, pH 7.4, 5 mM MgCl2, 50 mM NaCl, 5 mM DTT and CHAPS 0.04%. Reactions are initiated by the a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246881(US10053465, 20 | US10065963, Compound 20 | US10125...)
Affinity DataIC50: <10nMAssay Description:Assays are carried out at room temperature in 50 mM HEPES, pH 7.4, 5 mM MgCl2, 50 mM NaCl, 5 mM DTT and CHAPS 0.04%. Reactions are initiated by the a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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