144 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
BMS-933043, a Selectivea7 nAChR Partial Agonist for the Treatment of Cognitive Deficits Associated with Schizophrenia.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb
Development of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes] asa7 Nicotinic Receptor Agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb Research and Development
Synthesis and biological activities of indolizine derivatives as alpha-7 nAChR agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Peking University
Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for thea3ß4 nicotinic acetylcholine receptor subtype.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Recent developments in novel antidepressants targetinga4ß2-nicotinic acetylcholine receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Illinois At Chicago
Dicarba analogues ofa-conotoxin RgIA. Structure, stability, and activity at potential pain targets.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Monash University (Parkville Campus)
Chalcones as positive allosteric modulators ofa7 nicotinic acetylcholine receptors: a new target for a privileged structure.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Instituto De Qu£Mica M£Dica (Iqm-Csic)
Semisynthetic analogues of toxiferine I and their pharmacological properties ata7 nAChRs, muscle-type nAChRs, and the allosteric binding site of muscarinic M2 receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The German University In Cairo
Discovery of novel 2-((pyridin-3-yloxy)methyl)piperazines asa7 nicotinic acetylcholine receptor modulators for the treatment of inflammatory disorders.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Critical Therapeutics
Design, synthesis, and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Copenhagen
Derivatives of dibenzothiophene for positron emission tomography imaging ofa7-nicotinic acetylcholine receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The Johns Hopkins University School of Medicine
Characterization of a novela-conotoxin TxID from Conus textile that potently blocks rata3ß4 nicotinic acetylcholine receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Hainan University
The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: the influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Bonn
Expeditious synthesis, enantiomeric resolution, and enantiomer functional characterization of (4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (4BP-TQS): an allosteric agonist-positive allosteric modulator of α7 nicotinic acetylcholine receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Northeastern University
Design, synthesis, and activity of a series of arylpyrid-3-ylmethanones as type I positive allosteric modulators of a7 nicotinic acetylcholine receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of California Irvine
Novel nicotinic acetylcholine receptor agonists containing carbonyl moiety as a hydrogen bond acceptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Targacept
Synthesis and evaluation of a conditionally-silent agonist for thea7 nicotinic acetylcholine receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Florida
8-Benzamidochromen-4-one-2-carboxylic acids: potent and selective agonists for the orphan G protein-coupled receptor GPR35.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Bonn
Neonicotinic analogues: selective antagonists fora4ß2 nicotinic acetylcholine receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Chile
Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging ofa7 nicotinic acetylcholine receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Helmholtz-Zentrum Dresden-Rossendorf
(+)-Laburnamine, a natural selective ligand and partial agonist for the?4?2 nicotinic receptor subtype.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide (SEN15924, WAY-361789).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Siena Biotech
Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Vu University Amsterdam
Deconstruction of thea4ß2 nicotinic acetylcholine receptor positive allosteric modulator desformylflustrabromine.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Virginia Commonwealth University
Surface plasmon resonance biosensor based fragment screening using acetylcholine binding protein identifies ligand efficiency hot spots (LE hot spots) by deconstruction of nicotinic acetylcholine receptora7 ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Vu University Amsterdam
Identification of novel alpha7 nAChR positive allosteric modulators with the use of pharmacophore in silico screening methods.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Discovery of (2S,3R)-N-[2-(Pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a selectivea7 nicotinic acetylcholine receptor agonist, for the treatment of cognitive disorders.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Targacept
Discovery of highly potent and selectivea4ß2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Illinois At Chicago
N-[5-(5-fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): a medicinal chemistry effort toward ana7 nicotinic acetylcholine receptor agonist preclinical candidate.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Siena Biotech
Structure-activity studies of 7-heteroaryl-3-azabicyclo[3.3.1]non-6-enes: a novel class of highly potent nicotinic receptor ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Targacept
Discovery of 3-(5-chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selectivea4ß2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Targacept
Synthesis and nicotinic receptor activity of chemical space analogues of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide (PNU-282,987) and 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester (SSR180711).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Berne
Diazaspirocyclic compounds as selective ligands for thea4ß2 nicotinic acetylcholine receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Targacept
The discovery of 2-fluoro-N-(3-fluoro-4-(5-((4-morpholinobutyl)amino)-1,3,4-oxadiazol-2-yl)phenyl)benzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing efficacy in the novel object recognition model of cognition enhancement.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
A novel series of [3.2.1] azabicyclic biaryl ethers as alpha3beta4 and alpha6/4beta4 nicotinic receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
Structure-activity relationships of N-substituted ligands for the alpha7 nicotinic acetylcholine receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Abbott Laboratories
Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Abbott Laboratories
Novel acetylcholine and carbamoylcholine analogues: development of a functionally selective alpha4beta2 nicotinic acetylcholine receptor agonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Copenhagen
Modeling binding modes of alpha7 nicotinic acetylcholine receptor with ligands: the roles of Gln117 and other residues of the receptor in agonist binding.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Kentucky
Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the alpha7 nicotinic acetylcholine receptor: in vitro and in vivo activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
Allosteric modulators of the alpha7 nicotinic acetylcholine receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Abbott Laboratories
Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of California
Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal alpha7 nicotinic acetylcholine receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Copenhagen
Quinuclidines as selective agonists for alpha-7 nicotinic acetylcholine receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Florida
Synthesis and pharmacological characterization of exo-2-(2'-chloro-5-pyridinyl)-7-(endo and exo)-aminobicyclo[2.2.1]heptanes as novel epibatidine analogues.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Research Triangle Institute
3,5-Bicyclic aryl piperidines: a novel class of alpha4beta2 neuronal nicotinic receptor partial agonists for smoking cessation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
High affinity ligands for the alpha7 nicotinic receptor that show no cross-reactivity with the 5-HT3 receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eli Lilly
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The Danish University of Pharmaceutical Sciences
In pursuit of alpha4beta2 nicotinic receptor partial agonists for smoking cessation: carbon analogs of (-)-cytisine.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
2-(2-Piperidyl)- and 2-(2-pyrrolidyl)chromans as nicotine agonists: synthesis and preliminary pharmacological characterization.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Minnesota
Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Abbott Laboratories
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Abbott Laboratories
Structure activity studies of ring E analogues of methyllycaconitine. Part 2: Synthesis of antagonists to the alpha3beta4* nicotinic acetylcholine receptors through modifications to the ester.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Ohio University
The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Astrazeneca
SAR ofa7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Abbott Laboratories
Synthesis and binding affinity ata4ß2 anda7 nicotinic acetylcholine receptors of new analogs of epibatidine and epiboxidine containing the 7-azabicyclo[2.2.1]hept-2-ene ring system.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
New spirocyclic¿²-isoxazoline derivatives related to selective agonists ofa7 neuronal nicotinic acetylcholine receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Vu University Amsterdam
Synthesis and biological activity of a novel class nicotinic acetylcholine receptors (nAChRs) ligands structurally related to anatoxin-a.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Ferrara
Discovery of non-peptide, small molecule antagonists ofa9a10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Kentucky
Exploring a7-Nicotinic Receptor Ligand Diversity by Scaffold Enumeration from the Chemical Universe Database GDB.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Synthesis and structure-analgesic activity relationships of a novel series of monospirocyclopiperazinium salts (MSPZ).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Peking University
Syntheses and structure-activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel alpha7 neuronal nicotinic receptor (NNR) ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Abbott Laboratories
Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Abbott Laboratories
Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Institute
Gamma-lactams--a novel scaffold for highly potent and selective alpha 7 nicotinic acetylcholine receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Novartis Institutes For Biomedical Research
Carbamoylcholine analogs as nicotinic acetylcholine receptor agonists--structural modifications of 3-(dimethylamino)butyl dimethylcarbamate (DMABC).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Copenhagen University
Discovery and optimization of substituted piperidines as potent, selective, CNS-penetrant alpha4beta2 nicotinic acetylcholine receptor potentiators.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Amgen
Synthesis of poison-frog alkaloids 233A, 235U, and 251AA and their inhibitory effects on neuronal nicotinic acetylcholine receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Toyama
Synthesis of desformylflustrabromine and its evaluation as an alpha4beta2 and alpha7 nACh receptor modulator.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Virginia Commonwealth University
Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Chile
Selective Penicillamine Substitution Enables Development of a Potent Analgesic Peptide that Acts through a Non-Opioid-Based Mechanism.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Utah
Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb
Mechanism of Action and Structure-Activity Relationship of ?-Conotoxin Mr1.1 at the Human ?9?10 Nicotinic Acetylcholine Receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Ocean University of China
From 2-Triethylammonium Ethyl Ether of 4-Stilbenol (MG624) to Selective Small-Molecule Antagonists of Human ?9?10 Nicotinic Receptor by Modifications at the Ammonium Ethyl Residue.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Synthesis of full-length homodimer ?D-VxXXB that targets human ?7 nicotinic acetylcholine receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The University of Queensland
6'-Methylpyrido[3,4-b]norhomotropane: synthesis and outstanding potency in relation to the alpha4beta2 nicotinic receptor pharmacophore model.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of California
Engineered Conotoxin Differentially Blocks and Discriminates Rat and Human ?7 Nicotinic Acetylcholine Receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Hainan University
Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Emory University
Discovery of Methylene Thioacetal-Incorporated ?-RgIA Analogues as Potent and Stable Antagonists of the Human ?9?10 Nicotinic Acetylcholine Receptor for the Treatment of Neuropathic Pain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Utah
Sensitivity of neuronal nicotinic acetylcholine receptors to the opiate antagonists naltrexone and naloxone: receptor blockade and up-regulation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Maryland
Novel Spiropiperidine Allosteric Modulators of Nicotinic Acetylcholine Receptors for Treating Central Nervous System Disorders.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Smith, Gambrell & Russell
Synthesis and Biological Evaluation of Novel Triazine Derivatives as Positive Allosteric Modulators of ?7 Nicotinic Acetylcholine Receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Peking University
HTS-based discovery and optimization of novel positive allosteric modulators of the ?7 nicotinic acetylcholine receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Gedeon Richter
Computational and Functional Mapping of Human and Rat ?6?4 Nicotinic Acetylcholine Receptors Reveals Species-Specific Ligand-Binding Motifs.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Veterans Affairs Medical Center
Design, synthesis, and electrophysiological evaluation of NS6740 derivatives: Exploration of the structure-activity relationship for alpha7 nicotinic acetylcholine receptor silent activation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Milan
Optical control of muscular nicotinic channels with azocuroniums, photoswitchable azobenzenes bearing two N-methyl-N-carbocyclic quaternary ammonium groups.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Consejo Superior De Investigaciones Cient�Ficas (Iqm-Csic)
Discovery of novel positive allosteric modulators of the ?7 nicotinic acetylcholine receptor: Scaffold hopping approach.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Gedeon Richter
5-Azidoepibatidine: an exceptionally potent photoaffinity ligand for neuronal alpha 4 beta 2 and alpha 7 nicotinic acetylcholine receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of California
Design, synthesis and biological activities of piperidine-spirooxadiazole derivatives as ?7 nicotinic receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Peking University
Discovery and Preclinical Evaluation of BMS-986242, a Potent, Selective Inhibitor of Indoleamine-2,3-dioxygenase 1.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol Myers Squibb Research and Development
Development of Conformationally Constrained ?-RgIA Analogues as Stable Peptide Antagonists of Human ?9?10 Nicotinic Acetylcholine Receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Utah
Varying Chirality Across Nicotinic Acetylcholine Receptor Subtypes: Selective Binding of Quinuclidine Triazole Compounds.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Mahidol University
Synthesis, Pharmacological Characterization, and Structure-Activity Relationships of Noncanonical Selective Agonists for ?7 nAChRs.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of California-San Diego
New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of ?7 and ?3* Nicotinic Receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Florence
Medicinal properties of terpenes found in Cannabis sativa and Humulus lupulus.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Univerisity of Eastern Finland (Uef)
Discovery of fused heterocyclic carboxamide derivatives as novel ?7-nAChR agonists: Synthesis, preliminary SAR and biological evaluation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Peking University
Molecular recognition in nicotinic acetylcholine receptors: the importance of pi-cation interactions.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Targacept
Synthesis and nicotinic acetylcholine receptor in vivo binding properties of 2-fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine: a new positron emission tomography ligand for nicotinic receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Cea
Chemical conversion of nicotinamide into type I positive allosteric modulator of ?7 nAChRs.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Peking University
Discovery, cocrystallization and biological evaluation of novel piperidine derivatives as high affinity Ls-AChBP ligands possessing ?7 nAChR activities.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Fudan University
Structure and Activity Studies of Disulfide-Deficient Analogues of ?O-Conotoxin GeXIVA.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Hainan University
Dimerization of ?-Conotoxins as a Strategy to Enhance the Inhibition of the Human ?7 and ?9?10 Nicotinic Acetylcholine Receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Ocean University of China
Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of ?7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure-Activity Relationship and Preclinical Characterization.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Lupin
Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Julius Maximilian University of W£Rzburg
Di- and heptavalent nicotinic analogues to interfere with ?7 nicotinic acetylcholine receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Abbott Laboratories
Novel 5-(quinuclidin-3-ylmethyl)-1,2,4-oxadiazoles to investigate the activation of the ?7 nicotinic acetylcholine receptor subtype: Synthesis and electrophysiological evaluation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Milan
Design and Synthesis of Novel Positive Allosteric Modulators of ?7 Nicotinic Acetylcholine Receptors with the Ability To Rescue Auditory Gating Deficit in Mice.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Peking University
Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of California
Identification of novel ?7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric ?7 receptor ligand binding domain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bezmialem Vakif University
Potent Antiglioblastoma Agents by Hybridizing the Onium-Alkyloxy-Stilbene Based Structures of an ?7-nAChR, ?9-nAChR Antagonist and of a Pro-Oxidant Mitocan.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Absolute Configuration and Pharmacology of the Poison Frog Alkaloid Phantasmidine.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Indiana State University
Drimane Sesquiterpenoids Noncompetitively Inhibit Human ?4?2 Nicotinic Acetylcholine Receptors with Higher Potency Compared to Human ?3?4 and ?7 Subtypes.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
California Northstate University College of Medicine
Allosteric Modulators of Nicotinic Acetylcholine Receptors Useful for the Treatment of Cognitive Impairment.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Temple University
Progress in the discovery of small molecule modulators of the Cys-loop superfamily receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Amgen
Design and synthesis of a novel series of (1'S,2R,4'S)-3H-4'-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2'-bicyclo[2.2.2]octanes] with high affinity for the ?7 neuronal nicotinic receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb Pharmaceutical Research Institute
Dual Nicotinic Acetylcholine Receptor ?4?2 Antagonists/?7 Agonists: Synthesis, Docking Studies, and Pharmacological Evaluation of Tetrahydroisoquinolines and Tetrahydroisoquinolinium Salts.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Copenhagen
Development of spiroguanidine-derived?7 neuronal nicotinic receptor partial agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb Research and Development
Structure, synthesis and biological properties of the pentacyclic guanidinium alkaloids.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Nc State University
Sulfonium as a Surrogate for Ammonium: A New?7 Nicotinic Acetylcholine Receptor Partial Agonist with Desensitizing Activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Florida
New chemotypes as Trypanosoma cruzi triosephosphate isomerase inhibitors: a deeper insight into the mechanism of inhibition.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Universidad De La Republica
Insights into distinct modulation of a7 and a7ß2 nicotinic acetylcholine receptors by the volatile anesthetic isoflurane.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
University of Pittsburgh
FABP1: A Novel Hepatic Endocannabinoid and Cannabinoid Binding Protein.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Avanti Polar Lipids
Cloning and functional expression of the guinea pig neuropeptide Y Y2 receptor.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Uppsala University