BindingDB logo
myBDB logout

Patent code US10464947

Compile Data Set for Download or QSAR

Found 570 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
BRD4 - BD1


(Homo sapiens (Human))
BDBM318669
PNG
(US10464947, Example 197 | US9624241, Example 197 |...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(N3CCCN(CC3)C(=O)OC(C)(C)C)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C29H34N6O4/c1-18-24(19(2)39-32-18)20-10-11-22-25-26(20)37-17-23(21-9-6-7-12-30-21)35(25)27(31-22)33-13-8-14-34(16-15-33)28(36)38-29(3,4)5/h6-7,9-12,23H,8,13-17H2,1-5H3/t23-/m1/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM318673
PNG
(N-{(3R)-1-[(4S)-7-(3,5- dimethylisoxazol-4-yl)-4-p...)
Show SMILES CC(=O)N[C@@H]1CCN(C1)c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23
Show InChI InChI=1S/C25H26N6O3/c1-14-22(15(2)34-29-14)18-7-8-20-23-24(18)33-13-21(19-6-4-5-10-26-19)31(23)25(28-20)30-11-9-17(12-30)27-16(3)32/h4-8,10,17,21H,9,11-13H2,1-3H3,(H,27,32)/t17-,21-/m1/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM318682
PNG
(N-{(3R)-1-[(4S)-7-(3,5- dimethylisoxazol-4-yl)-4-p...)
Show SMILES CC(C)C(=O)N[C@@H]1CCN(C1)c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23
Show InChI InChI=1S/C27H30N6O3/c1-15(2)26(34)29-18-10-12-32(13-18)27-30-21-9-8-19(23-16(3)31-36-17(23)4)25-24(21)33(27)22(14-35-25)20-7-5-6-11-28-20/h5-9,11,15,18,22H,10,12-14H2,1-4H3,(H,29,34)/t18-,22-/m1/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM420103
PNG
(N-{(3R)-1-[(4S)-7-(3,5- dimethylisoxazol-4-yl)-4-p...)
Show SMILES Cc1oncc1-c1ccc2nc(N3CC[C@H](C3)NC(=O)C3CCC3)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C27H28N6O3/c1-16-20(13-29-36-16)19-8-9-22-24-25(19)35-15-23(21-7-2-3-11-28-21)33(24)27(31-22)32-12-10-18(14-32)30-26(34)17-5-4-6-17/h2-3,7-9,11,13,17-18,23H,4-6,10,12,14-15H2,1H3,(H,30,34)/t18-,23-/m1/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM420103
PNG
(N-{(3R)-1-[(4S)-7-(3,5- dimethylisoxazol-4-yl)-4-p...)
Show SMILES Cc1oncc1-c1ccc2nc(N3CC[C@H](C3)NC(=O)C3CCC3)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C27H28N6O3/c1-16-20(13-29-36-16)19-8-9-22-24-25(19)35-15-23(21-7-2-3-11-28-21)33(24)27(31-22)32-12-10-18(14-32)30-26(34)17-5-4-6-17/h2-3,7-9,11,13,17-18,23H,4-6,10,12,14-15H2,1H3,(H,30,34)/t18-,23-/m1/s1
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM318686
PNG
(N-{(3R)-1-[(4S)-7-(3,5- dimethylisoxazol-4-yl)-4-p...)
Show SMILES CCS(=O)(=O)N[C@@H]1CCN(C1)c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23
Show InChI InChI=1S/C25H28N6O4S/c1-4-36(32,33)29-17-10-12-30(13-17)25-27-20-9-8-18(22-15(2)28-35-16(22)3)24-23(20)31(25)21(14-34-24)19-7-5-6-11-26-19/h5-9,11,17,21,29H,4,10,12-14H2,1-3H3/t17-,21-/m1/s1
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM318694
PNG
(N-{(3R)-1-[(4S)-7-(3,5- dimethylisoxazol-4-yl)-4-p...)
Show SMILES CN([C@@H]1CCN(C1)c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23)C(C)=O
Show InChI InChI=1S/C26H28N6O3/c1-15-23(16(2)35-29-15)19-8-9-21-24-25(19)34-14-22(20-7-5-6-11-27-20)32(24)26(28-21)31-12-10-18(13-31)30(4)17(3)33/h5-9,11,18,22H,10,12-14H2,1-4H3/t18-,22-/m1/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM318695
PNG
((4S)-2-(4-acetylpiperazin-1-yl)-7-(3,5- dimethylis...)
Show SMILES CC(=O)N1CCN(CC1)c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23
Show InChI InChI=1S/C25H26N6O3/c1-15-22(16(2)34-28-15)18-7-8-20-23-24(18)33-14-21(19-6-4-5-9-26-19)31(23)25(27-20)30-12-10-29(11-13-30)17(3)32/h4-9,21H,10-14H2,1-3H3/t21-/m1/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM318695
PNG
((4S)-2-(4-acetylpiperazin-1-yl)-7-(3,5- dimethylis...)
Show SMILES CC(=O)N1CCN(CC1)c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23
Show InChI InChI=1S/C25H26N6O3/c1-15-22(16(2)34-28-15)18-7-8-20-23-24(18)33-14-21(19-6-4-5-9-26-19)31(23)25(27-20)30-12-10-29(11-13-30)17(3)32/h4-9,21H,10-14H2,1-3H3/t21-/m1/s1
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM318698
PNG
((4S)-7-(3,5-dimethylisoxazol-4-yl)-2-[4- (2-oxo-2-...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(N3CCN(CC(=O)N4CCCC4)CC3)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C29H33N7O3/c1-19-26(20(2)39-32-19)21-8-9-23-27-28(21)38-18-24(22-7-3-4-10-30-22)36(27)29(31-23)35-15-13-33(14-16-35)17-25(37)34-11-5-6-12-34/h3-4,7-10,24H,5-6,11-18H2,1-2H3/t24-/m1/s1
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM318702
PNG
(N-{1-[(4S)-7-(3,5-dimethylisoxazol-4- yl)-4-pyridi...)
Show SMILES CCC(=O)NC1CN(C1)c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23
Show InChI InChI=1S/C25H26N6O3/c1-4-21(32)27-16-11-30(12-16)25-28-19-9-8-17(22-14(2)29-34-15(22)3)24-23(19)31(25)20(13-33-24)18-7-5-6-10-26-18/h5-10,16,20H,4,11-13H2,1-3H3,(H,27,32)/t20-/m1/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM318702
PNG
(N-{1-[(4S)-7-(3,5-dimethylisoxazol-4- yl)-4-pyridi...)
Show SMILES CCC(=O)NC1CN(C1)c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23
Show InChI InChI=1S/C25H26N6O3/c1-4-21(32)27-16-11-30(12-16)25-28-19-9-8-17(22-14(2)29-34-15(22)3)24-23(19)31(25)20(13-33-24)18-7-5-6-10-26-18/h5-10,16,20H,4,11-13H2,1-3H3,(H,27,32)/t20-/m1/s1
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM318704
PNG
(N-{1-[(4S)-7-(3,5-dimethylisoxazol-4- yl)-4-pyridi...)
Show SMILES COCC(=O)NC1CN(C1)c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23
Show InChI InChI=1S/C25H26N6O4/c1-14-22(15(2)35-29-14)17-7-8-19-23-24(17)34-12-20(18-6-4-5-9-26-18)31(23)25(28-19)30-10-16(11-30)27-21(32)13-33-3/h4-9,16,20H,10-13H2,1-3H3,(H,27,32)/t20-/m1/s1
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM318705
PNG
(N-{1-[(4S)-7-(3,5-dimethylisoxazol-4- yl)-4-pyridi...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(N3CC(C3)NC(=O)C3CC3)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C26H26N6O3/c1-14-22(15(2)35-30-14)18-8-9-20-23-24(18)34-13-21(19-5-3-4-10-27-19)32(23)26(29-20)31-11-17(12-31)28-25(33)16-6-7-16/h3-5,8-10,16-17,21H,6-7,11-13H2,1-2H3,(H,28,33)/t21-/m1/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM318708
PNG
(N-{1-[(4S)-7-(3,5-dimethylisoxazol-4- yl)-4-pyridi...)
Show SMILES CCS(=O)(=O)NC1CN(C1)c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23
Show InChI InChI=1S/C24H26N6O4S/c1-4-35(31,32)28-16-11-29(12-16)24-26-19-9-8-17(21-14(2)27-34-15(21)3)23-22(19)30(24)20(13-33-23)18-7-5-6-10-25-18/h5-10,16,20,28H,4,11-13H2,1-3H3/t20-/m1/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM318709
PNG
(N-{1-[(4S)-7-(3,5-dimethylisoxazol-4- yl)-4-pyridi...)
Show SMILES CC(C)S(=O)(=O)NC1CN(C1)c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23
Show InChI InChI=1S/C25H28N6O4S/c1-14(2)36(32,33)29-17-11-30(12-17)25-27-20-9-8-18(22-15(3)28-35-16(22)4)24-23(20)31(25)21(13-34-24)19-7-5-6-10-26-19/h5-10,14,17,21,29H,11-13H2,1-4H3/t21-/m1/s1
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM318712
PNG
(N-{1-[(4S)-7-(3,5-dimethylisoxazol-4- yl)-4-pyridi...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(N3CCC(CC3)NC(=O)C(F)(F)F)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C26H25F3N6O3/c1-14-21(15(2)38-33-14)17-6-7-19-22-23(17)37-13-20(18-5-3-4-10-30-18)35(22)25(32-19)34-11-8-16(9-12-34)31-24(36)26(27,28)29/h3-7,10,16,20H,8-9,11-13H2,1-2H3,(H,31,36)/t20-/m1/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM318713
PNG
(N-{1-[(4S)-7-(3,5-dimethylisoxazol-4- yl)-4-pyridi...)
Show SMILES CCC(=O)NC1CCN(CC1)c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23
Show InChI InChI=1S/C27H30N6O3/c1-4-23(34)29-18-10-13-32(14-11-18)27-30-21-9-8-19(24-16(2)31-36-17(24)3)26-25(21)33(27)22(15-35-26)20-7-5-6-12-28-20/h5-9,12,18,22H,4,10-11,13-15H2,1-3H3,(H,29,34)/t22-/m1/s1
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM318713
PNG
(N-{1-[(4S)-7-(3,5-dimethylisoxazol-4- yl)-4-pyridi...)
Show SMILES CCC(=O)NC1CCN(CC1)c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23
Show InChI InChI=1S/C27H30N6O3/c1-4-23(34)29-18-10-13-32(14-11-18)27-30-21-9-8-19(24-16(2)31-36-17(24)3)26-25(21)33(27)22(15-35-26)20-7-5-6-12-28-20/h5-9,12,18,22H,4,10-11,13-15H2,1-3H3,(H,29,34)/t22-/m1/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM318722
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-9-(hydroxymethyl)-4-...)
Show SMILES Cc1noc(C)c1-c1cc(CO)c2[nH]c(=O)n3C(COc1c23)c1ccccn1
Show InChI InChI=1/C20H18N4O4/c1-10-16(11(2)28-23-10)13-7-12(8-25)17-18-19(13)27-9-15(24(18)20(26)22-17)14-5-3-4-6-21-14/h3-7,15,25H,8-9H2,1-2H3,(H,22,26)
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM318453
PNG
(US10464947, Example 1B | US9624241, Example 1A | U...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)c1ccccc1
Show InChI InChI=1/C20H17N3O3/c1-11-17(12(2)26-22-11)14-8-9-15-18-19(14)25-10-16(23(18)20(24)21-15)13-6-4-3-5-7-13/h3-9,16H,10H2,1-2H3,(H,21,24)
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM318460
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-3-yl-4,5-d...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)c1cccnc1
Show InChI InChI=1/C19H16N4O3/c1-10-16(11(2)26-22-10)13-5-6-14-17-18(13)25-9-15(23(17)19(24)21-14)12-4-3-7-20-8-12/h3-8,15H,9H2,1-2H3,(H,21,24)
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM318463
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-4-(2,4-difluoropheny...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)c1ccc(F)cc1F
Show InChI InChI=1/C20H15F2N3O3/c1-9-17(10(2)28-24-9)13-5-6-15-18-19(13)27-8-16(25(18)20(26)23-15)12-4-3-11(21)7-14(12)22/h3-7,16H,8H2,1-2H3,(H,23,26)
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM318465
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-1-(2-morpholin-4-yle...)
Show SMILES Cc1noc(C)c1-c1ccc2n(CCN3CCOCC3)c(=O)n3C(COc1c23)c1ccccc1
Show InChI InChI=1/C26H28N4O4/c1-17-23(18(2)34-27-17)20-8-9-21-24-25(20)33-16-22(19-6-4-3-5-7-19)30(24)26(31)29(21)11-10-28-12-14-32-15-13-28/h3-9,22H,10-16H2,1-2H3
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM318467
PNG
(7-(3-Methyl-1H-pyrazol-4-yl)-4-phenyl-4,5-dihydroi...)
Show SMILES Cc1n[nH]cc1-c1ccc2[nH]c(=O)n3C(COc1c23)c1ccccc1
Show InChI InChI=1/C19H16N4O2/c1-11-14(9-20-22-11)13-7-8-15-17-18(13)25-10-16(23(17)19(24)21-15)12-5-3-2-4-6-12/h2-9,16H,10H2,1H3,(H,20,22)(H,21,24)
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM318471
PNG
(4-Cyclohexyl-7-(3,5-dimethylisoxazol-4-yl)-4,5-dih...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)C1CCCCC1
Show InChI InChI=1/C20H23N3O3/c1-11-17(12(2)26-22-11)14-8-9-15-18-19(14)25-10-16(23(18)20(24)21-15)13-6-4-3-5-7-13/h8-9,13,16H,3-7,10H2,1-2H3,(H,21,24)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM318475
PNG
(2-{2-[7-(3,5-Dimethylisoxazol-4-yl)-2-oxo-1,2,4,5-...)
Show SMILES CCNC(=O)COc1ccccc1C1COc2c(ccc3[nH]c(=O)n1c23)-c1c(C)noc1C
Show InChI InChI=1/C24H24N4O5/c1-4-25-20(29)12-31-19-8-6-5-7-15(19)18-11-32-23-16(21-13(2)27-33-14(21)3)9-10-17-22(23)28(18)24(30)26-17/h5-10,18H,4,11-12H2,1-3H3,(H,25,29)(H,26,30)
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM318730
PNG
(9-(anilinomethyl)-7-(3,5-dimethylisoxazol- 4-yl)-4...)
Show SMILES Cc1noc(C)c1-c1cc(CNc2ccccc2)c2[nH]c(=O)n3C(COc1c23)c1ccccn1
Show InChI InChI=1/C26H23N5O3/c1-15-22(16(2)34-30-15)19-12-17(13-28-18-8-4-3-5-9-18)23-24-25(19)33-14-21(31(24)26(32)29-23)20-10-6-7-11-27-20/h3-12,21,28H,13-14H2,1-2H3,(H,29,32)
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM318479
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-N-isopropyl-4-phenyl...)
Show SMILES CC(C)Nc1nc2ccc(-c3c(C)noc3C)c3OCC(c4ccccc4)n1c23
Show InChI InChI=1/C23H24N4O2/c1-13(2)24-23-25-18-11-10-17(20-14(3)26-29-15(20)4)22-21(18)27(23)19(12-28-22)16-8-6-5-7-9-16/h5-11,13,19H,12H2,1-4H3,(H,24,25)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM318480
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-N-methyl-4-phenyl-4,...)
Show SMILES CNc1nc2ccc(-c3c(C)noc3C)c3OCC(c4ccccc4)n1c23
Show InChI InChI=1/C21H20N4O2/c1-12-18(13(2)27-24-12)15-9-10-16-19-20(15)26-11-17(14-7-5-4-6-8-14)25(19)21(22-3)23-16/h4-10,17H,11H2,1-3H3,(H,22,23)
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM318483
PNG
(2-{[7-(3,5-Dimethylisoxazol-4-yl)-4-phenyl-4,5-dih...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(NCCO)n3C(COc1c23)c1ccccc1
Show InChI InChI=1/C22H22N4O3/c1-13-19(14(2)29-25-13)16-8-9-17-20-21(16)28-12-18(15-6-4-3-5-7-15)26(20)22(24-17)23-10-11-27/h3-9,18,27H,10-12H2,1-2H3,(H,23,24)
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM318502
PNG
(1-[7-(3,5-Dimethylisoxazol-4-yl)- 4-phenyl-4,5-dih...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(N3CCC(O)CC3)n3C(COc1c23)c1ccccc1
Show InChI InChI=1/C25H26N4O3/c1-15-22(16(2)32-27-15)19-8-9-20-23-24(19)31-14-21(17-6-4-3-5-7-17)29(23)25(26-20)28-12-10-18(30)11-13-28/h3-9,18,21,30H,10-14H2,1-2H3
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM318503
PNG
(1-[7-(3,5-Dimethylisoxazol-4-yl)- 4-phenyl-4,5-dih...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(N3CCCC(O)C3)n3C(COc1c23)c1ccccc1
Show InChI InChI=1/C25H26N4O3/c1-15-22(16(2)32-27-15)19-10-11-20-23-24(19)31-14-21(17-7-4-3-5-8-17)29(23)25(26-20)28-12-6-9-18(30)13-28/h3-5,7-8,10-11,18,21,30H,6,9,12-14H2,1-2H3
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM318506
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-4-(1-oxidopyridin-2-...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)c1cccc[n+]1[O-]
Show InChI InChI=1/C19H16N4O4/c1-10-16(11(2)27-21-10)12-6-7-13-17-18(12)26-9-15(23(17)19(24)20-13)14-5-3-4-8-22(14)25/h3-8,15H,9H2,1-2H3,(H,20,24)
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM318514
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-9-methyl-4-phenyl-4,...)
Show SMILES Cc1noc(C)c1-c1cc(C)c2[nH]c(=O)n3C(COc1c23)c1ccccc1
Show InChI InChI=1/C21H19N3O3/c1-11-9-15(17-12(2)23-27-13(17)3)20-19-18(11)22-21(25)24(19)16(10-26-20)14-7-5-4-6-8-14/h4-9,16H,10H2,1-3H3,(H,22,25)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM318552
PNG
(US10464947, Example 98 | US9624241, Example 98 | t...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(C3=CCN(C3)C(=O)OC(C)(C)C)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1/C28H29N5O4/c1-16-23(17(2)37-31-16)19-9-10-21-24-25(19)35-15-22(20-8-6-7-12-29-20)33(24)26(30-21)18-11-13-32(14-18)27(34)36-28(3,4)5/h6-12,22H,13-15H2,1-5H3/t22-/s2
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM318557
PNG
((4S)-2-(1-Acetylpiperidin-4-yl)-7-(3,5-dimethyliso...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(C3CCNCC3)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1/C24H25N5O2/c1-14-21(15(2)31-28-14)17-6-7-19-22-23(17)30-13-20(18-5-3-4-10-26-18)29(22)24(27-19)16-8-11-25-12-9-16/h3-7,10,16,20,25H,8-9,11-13H2,1-2H3/t20-/s2
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM318563
PNG
((4S)-2-(1-Acetylpiperidin-4-yl)-7-(3,5-dimethyliso...)
Show SMILES CC(=O)N1CCC(CC1)c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23
Show InChI InChI=1/C26H27N5O3/c1-15-23(16(2)34-29-15)19-7-8-21-24-25(19)33-14-22(20-6-4-5-11-27-20)31(24)26(28-21)18-9-12-30(13-10-18)17(3)32/h4-8,11,18,22H,9-10,12-14H2,1-3H3/t22-/s2
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM318564
PNG
((4S)-2-(1-acetyl-1,2,3,6-tetrahydropyridin- 4-yl)-...)
Show SMILES CC(=O)N1CCC(=CC1)c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23
Show InChI InChI=1S/C26H25N5O3/c1-15-23(16(2)34-29-15)19-7-8-21-24-25(19)33-14-22(20-6-4-5-11-27-20)31(24)26(28-21)18-9-12-30(13-10-18)17(3)32/h4-9,11,22H,10,12-14H2,1-3H3/t22-/m1/s1
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM318565
PNG
((4S)-2-[1-(cyclopropylcarbonyl)piperidin- 4-yl]-7-...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(C3CCN(CC3)C(=O)C3CC3)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C28H29N5O3/c1-16-24(17(2)36-31-16)20-8-9-22-25-26(20)35-15-23(21-5-3-4-12-29-21)33(25)27(30-22)18-10-13-32(14-11-18)28(34)19-6-7-19/h3-5,8-9,12,18-19,23H,6-7,10-11,13-15H2,1-2H3/t23-/m1/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM318566
PNG
((4S)-7-(3,5-dimethylisoxazol-4-yl)-2-[1- (methylsu...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(C3CCN(CC3)S(C)(=O)=O)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C25H27N5O4S/c1-15-22(16(2)34-28-15)18-7-8-20-23-24(18)33-14-21(19-6-4-5-11-26-19)30(23)25(27-20)17-9-12-29(13-10-17)35(3,31)32/h4-8,11,17,21H,9-10,12-14H2,1-3H3/t21-/m1/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM318567
PNG
((4S)-2-(1-acetylpyrrolidin-3-yl)-7-(3,5- dimethyli...)
Show SMILES CC(=O)N1CCC(C1)c1nc2ccc(-c3c(C)noc3C)c3OC[C@@H](c4ccccn4)n1c23
Show InChI InChI=1S/C25H25N5O3/c1-14-22(15(2)33-28-14)18-7-8-20-23-24(18)32-13-21(19-6-4-5-10-26-19)30(23)25(27-20)17-9-11-29(12-17)16(3)31/h4-8,10,17,21H,9,11-13H2,1-3H3/t17?,21-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM318570
PNG
((4S)-2-[1- (cyclopropylcarbonyl)pyrrolidin-3-yl]-7...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(C3CCN(C3)C(=O)C3CC3)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C27H27N5O3/c1-15-23(16(2)35-30-15)19-8-9-21-24-25(19)34-14-22(20-5-3-4-11-28-20)32(24)26(29-21)18-10-12-31(13-18)27(33)17-6-7-17/h3-5,8-9,11,17-18,22H,6-7,10,12-14H2,1-2H3/t18?,22-/m1/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM318570
PNG
((4S)-2-[1- (cyclopropylcarbonyl)pyrrolidin-3-yl]-7...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(C3CCN(C3)C(=O)C3CC3)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C27H27N5O3/c1-15-23(16(2)35-30-15)19-8-9-21-24-25(19)34-14-22(20-5-3-4-11-28-20)32(24)26(29-21)18-10-12-31(13-18)27(33)17-6-7-17/h3-5,8-9,11,17-18,22H,6-7,10,12-14H2,1-2H3/t18?,22-/m1/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM318571
PNG
((4S)-7-(3,5-dimethylisoxazol-4-yl)-2-[1- (methylsu...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(C3CCN(C3)S(C)(=O)=O)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C24H25N5O4S/c1-14-21(15(2)33-27-14)17-7-8-19-22-23(17)32-13-20(18-6-4-5-10-25-18)29(22)24(26-19)16-9-11-28(12-16)34(3,30)31/h4-8,10,16,20H,9,11-13H2,1-3H3/t16?,20-/m1/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM318572
PNG
((4S)-2-(1-acetyl-1,2,5,6-tetrahydropyridin- 3-yl)-...)
Show SMILES CC(=O)N1CCC=C(C1)c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23
Show InChI InChI=1S/C26H25N5O3/c1-15-23(16(2)34-29-15)19-9-10-21-24-25(19)33-14-22(20-8-4-5-11-27-20)31(24)26(28-21)18-7-6-12-30(13-18)17(3)32/h4-5,7-11,22H,6,12-14H2,1-3H3/t22-/m1/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM318584
PNG
(3-[7-(3,5-Dimethylisoxazol-4-yl)-2-oxo-1,2,4,5-tet...)
Show SMILES CNC(=O)c1ncccc1C1COc2c(ccc3[nH]c(=O)n1c23)-c1c(C)noc1C
Show InChI InChI=1/C21H19N5O4/c1-10-16(11(2)30-25-10)13-6-7-14-18-19(13)29-9-15(26(18)21(28)24-14)12-5-4-8-23-17(12)20(27)22-3/h4-8,15H,9H2,1-3H3,(H,22,27)(H,24,28)
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM318586
PNG
(4-[2-(Aminomethyl)pyridin-3-yl]-7-(3,5-dimethyliso...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)c1cccnc1CN
Show InChI InChI=1/C20H19N5O3/c1-10-17(11(2)28-24-10)13-5-6-14-18-19(13)27-9-16(25(18)20(26)23-14)12-4-3-7-22-15(12)8-21/h3-7,16H,8-9,21H2,1-2H3,(H,23,26)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM318589
PNG
(Single enantiomer of 3-[7-(3,5-dimethylisoxazol-4-...)
Show SMILES CCNC(=O)c1ncccc1C1COc2c(ccc3[nH]c(=O)n1c23)-c1c(C)noc1C
Show InChI InChI=1/C22H21N5O4/c1-4-23-21(28)18-13(6-5-9-24-18)16-10-30-20-14(17-11(2)26-31-12(17)3)7-8-15-19(20)27(16)22(29)25-15/h5-9,16H,4,10H2,1-3H3,(H,23,28)(H,25,29)
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM318593
PNG
((4S)-9-(Aminomethyl)-7-(3,5-dimethylisoxazol-4-yl)...)
Show SMILES Cc1noc(C)c1-c1cc(CN)c2[nH]c(=O)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1/C20H19N5O3/c1-10-16(11(2)28-24-10)13-7-12(8-21)17-18-19(13)27-9-15(25(18)20(26)23-17)14-5-3-4-6-22-14/h3-7,15H,8-9,21H2,1-2H3,(H,23,26)/t15-/s2
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10464947 (2019)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 570 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%